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Hydraulic pressure inducing renal tubular epithelial-myofibroblast transdifferentiation in vitro

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第9期10卷 659-667页

作者： fei-yan li xi-sheng xiE Jun-ming FAN Zi li Jiang WU Rong ZHENG Department of Nephrology West China Hospital of Sichuan University Chengdu 610041 China State Key Laboratory of Biotherapy of Human Disease West China Hospital of Sichuan University Chengdu 610041 China Institute of Biomedical Engineering West China Center of Medical Sciences Sichuan University Chengdu 610041 China

Objective： The effects of hydraulic pressure on renal tubular epithelial-myofibroblast transdifferentiation （TEMT） were investigated. Methods： We applied hydraulic pressure （50 cmH2O） to normal rat kidney tubular epithelial cells （NRK52E） for different durations. Furthermore, different pressure magnitudes were applied to cells. The morphology, cytoskeleton, and expression ofmyofibroblastic marker protein and transforming growth factor-β1 （TGF-β1） of NRK52E cells were examined. Results Disorganized actin filaments and formation of curling clusters in actin were seen in the cytoplasm of pressurized cells. We verified that de novo expression α-smooth muscle actin induced by pressure, which indicated TEMT, was dependent on both the magnitude and duration of pressure. TGF-β1 expression was significantly upregulated under certain conditions, which implies that the induction of TEMT by hydraulic pressure is related with TGF-β1. Conclusion： We illustrate for the first time that hydraulic pressure can induce TEMT in a pressure magnitude- and duration-dependent manner, and that this TEMT is accompanied by TGF-β1 secretion.

关键词： Hydraulic pressure Tubular epithelial-myofibroblast transdifferentiation Transforming growth factor-β1 (TGF-β1)

Adsorption Behavior of CH2 and CH3 on Metal Clusters CUn （n=1-6）

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Chinese Journal of Chemical Physics 2008年第5期21卷 445-450页

作者： xi-hui Cheng Ming-xing Jin Zhan Hu fei-fei Hu Da-jun Ding Institute of Atomic and Molecular Physics Jilin University Changchun 130012 China

Using density functional theory with generalized gradient approximation and hybrid functional, we studied the properties of energy, charge population, and vibration of CH2 and CH3 adsorbed on Cun （n=1-6） clusters. The results show that the DFT calculation with the hybrid functional matches the experimental results better in both cases. The calculation results indicate that the adsorption of CH2 is stronger than that of CH3. During adsorption, the charges transfer from Cu to CH2 or CH3. The obtained vibrational frequencies for different modes of CH2 and CH3 adsorbed on Cun agree well with the experimental results for the adsorption on Cu（111） surface.

关键词： Adsorption CH2 CH3 Cu cluster

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing liu li-fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

A highly efficient humidity sensor based on lead(Ⅱ) coordination polymer via in-situ decarboxylation and hydrolysis synthesis

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Rare Metals 2022年第5期41卷 1652-1660页

作者： Hao Dong Le-xi Zhang Heng Xu Yan-Yan Yin Yi-fei liu li-Jian Bie School of Materials Science and Engineering Tianjin Key Laboratory for Photoelectric Materials and DevicesKey Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)National Demonstration Center for Experimental Function Materials EducationTianjin University of TechnologyTianjin 300384China Department of Environmental Science and Engineering Nankai University Binhai CollegeTianjin 300270China

Function-oriented design of coordination polymers is emerging as an attracting topic to explore their practical applications, e.g., gas/humidity sensing. However,the successful synthesis of new coordination polymers showing splendid sensing property is an urgent need in fields of materials and sensors, yet still at the initial *** this contribution, a new one-dimensional(1D) coordination polymer with formula of [Pb(TAA)(BA)(H_(2)O)]_(n)(namedasPbL,HTAA = 3-thiopheneaceticacid,HBA = benzoic acid) has been successfully synthesized by a hydrothermal method, which involves in-situ synthesis of both decarboxylation and hydrolysis. As an impedimetric humidity sensing material, this coordination polymer exhibits excellent humidity sensing performance including high response, fast response, small hysteresis, and good repeatability. In the total relative humidity range(11%–97%) at room temperature, it is worth noting that the sensitivity of the humidity sensor is as high as 1.18×10^(4),the response time is only 2 s, and the max humidity hysteresis is as small as 1.8%. At last, we discussed the sensing mechanism using the alternating current(AC) impedance technique at various relative humidity.

关键词： Lead Coordination polymer In-situ synthesis Humidity sensor

对抗性增强的图像块位平面拆分缩略图保留加密

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河南师范大学学报（自然科学版） 2025年第1期53卷 92-99页

作者：李名崔清晨王曦张静李文泽河南师范大学计算机与信息工程学院河南新乡453007 河南师范大学河南省教育人工智能与个性化学习重点实验室河南新乡453007

随着个人图像数量日益增加,云服务开始在图像存储方面发挥重要作用.然而,将图像上传到云端将会面临隐私威胁.传统的加密方案对图像进行简单加密就可以保护图像隐私,但它牺牲了图像内容的可用性.近年来,缩略图保留加密(thumbnail preserv... 详细信息

随着个人图像数量日益增加,云服务开始在图像存储方面发挥重要作用.然而,将图像上传到云端将会面临隐私威胁.传统的加密方案对图像进行简单加密就可以保护图像隐私,但它牺牲了图像内容的可用性.近年来,缩略图保留加密(thumbnail preserving encryption,TPE)被提出,通过加密后保持缩略图不变使云中图像在不被非法第三方肉眼识别的同时能对用户具有可用性.但是现有的TPE方案没有考虑到机器学习对图像的隐私威胁.基于此,提出了一种新的TPE方案,该方案在加密过程中从对抗深度学习模型识别图像这一全新的角度出发,提高了保护图像隐私信息的能力.实验表明,所提出的方案能够在图像对用户具有可用性的同时抵抗人类肉眼和深度神经网络识别图像.

关键词：图像加密对抗性可用性隐私性

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Advancements in plant regeneration and genetic transformation of grapevine(Vitis spp.)

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Journal of Integrative Agriculture 2021年第6期20卷 1407-1434页

作者： ZHANG xiu-ming WU Yi-fei li Zhi SONG Chang-bing WANG xi-ping Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China Ministry of Agriculture/State Key Laboratory of Crop Stress Biology in Arid Areas/College of HorticultureNorthwest A&F UniversityYang ling 712100P.R.China College of Biological Science and Engineering North Minzu UniversityYinchuan 750021P.R.China

Grapevine(Vitis spp.)is one of the most economically important fruit crops worldwide,and there is considerable interest in improving its major agronomic and enological traits in response to ever-changing agricultural environments and consumer *** genetic techniques in particular,associated with rapid technological advancements,provide an attractive alternative to conventional breeding approaches for developing new grapevine varieties with enhanced yield performance,quality,stress tolerance and disease *** date,several grapevine varieties have been transformed with genes associated with diverse functions through biolistic bombardment and/or Agrobacterium-mediated transformation,and transgenic grape lines have been obtained using established regeneration ***,a wide range of factors,including genotype,explant source and culture medium,have been shown to affect the efficiency of plant ***,the selection and use of acceptor materials,bacterial strain and cell density,selectable markers and selection methods also influence transformation *** paper provides an overview of recent advances in grapevine regeneration and genetic transformation and in-depth discussion of the major limiting factors,and discusses promising future strategies to develop robust plant regeneration and genetic transformation in grapevine.

关键词： grapevine organogenesis somatic embryogenesis plant regeneration genetic transformation

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Measurements of non-equilibrium and equilibrium temperature behind a strong shock wave in simulated martian atmosphere

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Acta Mechanica Sinica 2012年第5期28卷 1296-1302页

作者： xin lin xi-Long Yu fei li Shao-Hua Zhang Jian-Guo xin xin-Yu Zhang School of Optoelectronics Beijing Institute of Technology State Key Laboratory of High Temperature Gas Dynamics Institute of MechanicsChinese Academy of Sciences

Non-equilibrium radiation measurements behind strong shock wave for simulated Martian atmosphere are presented in this paper. The shock wave is established in a hydrogen oxygen combustion driven shock tube. Time- resolved spectra of the Av = 0 sequence of the B^2∑^＋ → X^2∑^＋ electronic transition of CN have been observed through optical emission spectroscopy （OES）. A new method, which is based on fitting high resolution spectrum for rotational and vibrational temperatures measurement, is proposed to diag- nose temperature distribution behind the shock wave. It is estimated that the current scheme has the maximum deviation less than 8% （lσ） for vibrational temperature measurement through detailed analysis of the influence of the uncertainties of spectroscopic constants and spectral resolution. Radiation structure of the shock layer, including induction, relaxation and equilibrium process, and corresponding rotational and vibrational temperatures are obtained through time gating OES diagnostics with sub-microsecond temporal resolution. The present extensive results will strongly benefit the reaction rate estimation and computational fluid dynamics （CFD） code validation in high enthalpy Mars reentry chemistry.

关键词： Radiation measurements - Shock wave Marsre-entry Rotational temperature Vibrational temperature

Complex Wave Excitations in Generalized Broer-Kaup System

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Communications in Theoretical Physics 2007年第4X期48卷 657-661页

作者： ZHENG Chun-Long fei Jin-xi College of Mathematics and Physics Lishui University Lishui 323000 China Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China

Starting from an improved projective method and a linear variable separation approach, new families of variable separation solutions （including solltary wave solutlons, periodic wave solutions and rational function solutions） with arbitrary functions [or the （2＋ 1）-dimensional general/zed Broer-Kaup （GBK） system are derived. Usually, in terms of solitary wave solutions and/or rational function solutions, one can find abundant important localized excitations. However, based on the derived periodic wave solution in this paper, we reveal some complex wave excitations in the （2＋1）-dimensional GBK system, which describe solitons moving on a periodic wave background. Some interesting evolutional properties for these solitary waves propagating on the periodic wave bactground are also briefly discussed.

关键词： improved projective method GBK system exact solution complex wave excitation