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Structures,Components and Functions of Secretory Tissues in Houttuynia cordata

Journal of Integrative Plant Biology 2007年第12期49卷 1734-1745页

作者： xi-Lu ni Li Peng Wen-Zhe Liu College of Life Sciences Northwest University Xi'an 710069 China College of Life Sciences Ningxia University Yinchuan 750021 China

Houttuynia cordata Thunb., traditionally used as a therapeutic plant in folk medicine, has shown antioxidant and anticancer activities. The species, as a core component of paleoherbs, is normally characterized based on the presence of different types of secretory tissue： oil cells, three types of secretory cells and glandular hairs. The aim of this work was to study the structural, componential, and the functional characteristics of the secretory tissues in both the floral and vegetative parts. The results indicate that oil cells and secretory cells are distributed in all organs of the plant, while glandular hairs are situated on the aerial stems and leaves. Both oil cells and glandular hairs initiate from the protoderm, but their developmental processes are different. Although three types of secretory cells initiate from different primary meristems, the developmental patterns of different secretory cells are the same. Also, although the origins of secretory cells are different from oil cells, their early developmental processes are the same. Histochemical results show that oil cells, secretory cells and glandular hairs produce flavonoids, phenolic compounds, tannins, lipids, aldehyde and ketone-compounds. In addition, there are terpenoids and pectic-like substances in oil cells, alkaloids in secretory cells of aerial stems, and terpenoids and alkaloids in glandular hairs. These compounds play very important roles in protecting plants from being eaten by herbivores （herbivory） and infected by microbial pathogens. The oil cell and secretory cell, as unicellular secretory tissues, are intermediates between the primitive surface glandular and secretory cavity and canal during the evolution of secretory structures.

关键词： components functions glandular hairs Houttuynia cordata oil cells secretory ceils secretory tissues structures.

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Characterization of NPR1 Genes from Norton and Cabernet Sauvignon Grapevine

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Journal of Integrative Agriculture 2013年第7期12卷 1152-1161页

作者： ZHANG Yi-ming ni xi-lu MA Hui-qin Wenping Qiu Department of Fruit Tree Sciences College of Agriculture and Biotechnology China Agricultural University The Center for Grapevine Biotechnology William H. Darr School of Agriculture Missouri State University ningxia Forestry Institute State Key Laboratory of Seedling Bioengineering College of Life Science Northwest University

Non-expressor of pathogenesis-related genes 1 （NPR1） plays a significant role in the defense responses of plants to pathogens by regulating the expression of defense-related genes. In the present study, we isolated two NPR1 genes from Vitis aestivalis cv. Norton and Vitis vinifera cv. Cabernet Sauvignon, which were referred to as VaNPR1.1 and VvNPR1. 1-CS, respectively. They encode a protein of 584 amino acids with a predicted molecular weight of 64.8 kDa and a theoretical isoelectric point （pI） of 5.74. The predicted amino acid sequences of VaNPR1.1 and VvNPR1.1-CS differ by only one amino acid. Over-expression of VaNPR1.1 gene in Arabidopsis npr1-1 mutant plants restores the transcriptional expression of AtPR-1 gene, though not to the full scale. This result demonstrated that a grapevine VaNPR1.1 possesses a similar function to the Arabidopsis NPR1 in the regulation of defense-related genes. Over-expression of VaNPR1.1 in transgenic Arabidopsis plant increased tolerance to salinity, but had no effect on the drought tolerance. We conclude that VaNPR1.1 is a functional ortholog of AtNPR1 and also involved in grapevine＇s response to the salt stress.

关键词： NPR1 pathogenesis-related genee over-expression transgenic Arabidopsis

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Localization and Dynamic Change of Saikosaponin in Root of Bupleurum chinense

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Journal of Integrative Plant Biology 2008年第8期50卷 951-957页

作者： Ling-Ling Tan xia Cai Zheng-Hai Hu xi-Lu ni Key Laboratory of Resource Biology and Biotechnology in West China (Northwest University) Ministry of Education Xi'an 710069 China ningxia Forestry Institute Yinchuan 750004 China

Anatomical, histochemical and phytochemical methods were used to investigate the structure, the localization and content changes of total saikosaponin and saikosaponin-a of the roots of Bupleurum chinense DC. at different developmental stages. Results showed that saikosaponin was mainly distributed in pericycle and primary phloem in the young root; but in the mature root, it was mainly distributed in vascular cambium and secondary phloem. During the whole growth period from the pre-blossom, blossom, fruit, and fruit mature periods until the pre-withering period, it was in the fruit mature period that both the total saikosaponin content and the saikosaponin-a content reached the highest level. So the last 20 d of October was considered as the right collecting season for the drug of B. chinense. In addition, the quality of 1-year-old drug was better than that of 2-year-old drug due to its higher saikosaponin content. On the other hand, judging from the external characteristics of the drug, the one with an acerose taproot and more lateral roots was of better quality. The results offered theoretical bases for selecting medicinal material of high quality and determining the most appropriate harvesting stage and part of B. chinense.

关键词： Bupleurum chinense content dynamic change localization saikosaponin-a structure of root total saikosaponin

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Effects of HMGA2 on malignant degree,invasion,metastasis,proliferation and cellular morphology of ovarian cancer cells

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Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 289-292页

作者： Yan-ni xi xiao-Yan xin Hong-Mei Ye Department of Gynecology and Obstetrics 2nd Hospital of Yulin xijing Hospital of the Fourth Military Medical University

Objective:To analyze effects of high mobility group AT-hook 2(HMGA2)on malignant degree,invasion,metastasis,proliferation and cellular morphology of ovarian cancer ***:Three methods were applied to observe the effect on HMGA2 expression in ovarian cancer cells and ovarian epithelial ***:After the application of siRNA-HMGA2,number of T29A2-cell clones was decreased,there was significant difference compared with the negative control *** application of let-7c,number of T29A2+cell clones was decreased significantly,however,after the application of Anti-let-7,the number of clones restored,and there was no significant difference compared with the negative control *** interference,the number of T29A2-cells which passed through Matrigel polycarbonate membrane were significantly lower than the negative control *** the treatment of siRNA-HMGA2,let-7c and sh-HMGA2respectively,growth and proliferation of T29A2-,T29A2+and SKOV3 were slower,and the phenomenon was most obvious in *** interference of HMGA2 induced mesenchymalepithelial changes in the morphology of ***:HMGA2 can promote malignant transformation of ovarian cancer cells,enhance cell invasion and metastasis,and promote cell growth and proliferation of ovarian cancer cells,which can cause ovarian cancer to progress rapidly and affect the quality of life.

关键词： High mobility group AT-hook 2 Ovarian cancer invasion Proliferation Morphology

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Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis

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Neural Regeneration Research 2022年第4期17卷 911-919页

作者： Yan Lu Qi Shan Mei Ling xi-an ni Su-Su Mao Bin Yu Qian-Qian Cao Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina School of Life Sciences Nantong UniversityNantongJiangsu ProvinceChina

Peripheral nerve injury repair requires a certain degree of cooperation between axon regeneration and Wallerian ***,investigating how axon regeneration and degeneration work together to repair peripheral nerve injury may uncover the molecular mechanisms and signal cascades underlying peripheral nerve repair and provide potential strategies for improving the low axon regeneration capacity of the central nervous *** this study,we applied weighted gene co-expression network analysis to identify differentially expressed genes in proximal and distal sciatic nerve segments from rats with sciatic nerve *** identified 31 and 15 co-expression modules from the proximal and distal sciatic nerve segments,*** enrichment analysis revealed that the differentially expressed genes in proximal modules promoted regeneration,while the differentially expressed genes in distal modules promoted ***,we constructed hub gene networks for selected modules and identified a key hub gene,Kif22,which was up-regulated in both nerve *** vitro experiments confirmed that Kif22 knockdown inhibited proliferation and migration of Schwann cells by modulating the activity of the extracellular signal-regulated kinase signaling ***,our findings provide a comparative framework of gene modules that are co-expressed in injured proximal and distal sciatic nerve segments,and identify Kif22 as a potential therapeutic target for promoting peripheral nerve injury repair via Schwann cell proliferation and *** animal experiments were approved by the Institutional Animal Ethics Committee of Nantong University,China(approval No.S20210322-008)on March 22,2021.

关键词： axon regeneration extracellular signal-regulated kinase signaling pathway hub genes Kif22 peripheral nerve injury protein kinase Cα Schwann cells Wallerian degeneration weighted gene co-expression network analysis

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Monte Carlo method for evaluation of surface emission rate measurement uncertainty

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Nuclear Science and Techniques 2024年第7期35卷 126-136页

作者： Yuan-Qiao Li Min Lin Li-Jun Xu Rui Luo Yu-He Zhang Qian-xi ni Yun-Tao Liu China Institute of Atomic Energy Beijing102413China National Key Laboratory for Metrology and Calibration Techniques Beijing102413China Department of Radiation Oncology Hunan Cancer HospitalChangsha410031China The Affiliated Cancer Hospital of xiangya School of Medicine Central South UniversityChangsha410031China

The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter *** study used the Monte Carlo method (MCM) to validate the conventional Guide to the Expression of Uncertainty in Measurement (GUM) method.A dead time measurement model for the two-source method was established based on the characteristics of a single-channel measurement system,and the voltage threshold correction factor measurement function was indirectly obtained by fitting the threshold correction *** uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of *** MCM provided clear definitions for each input quantity and its uncertainty distribution,and the simulation training was realized with a complete and complex mathematical *** results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed the uncertainty’s consistency E_(n)<0.070 for the comparison of each source,and the uncertainty results of the GUM were all lower than those of the ***,the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.

关键词： Surface emission rate Monte Carlo method Metrology Probability distribution function Dead time Low-energy loss correction Least-squares method

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A Critical Approach to Media and Gender Studies in the Chinese Context

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Fudan Journal of the Humanities and Social Sciences 2011年第1期4卷 135-142页

作者： Lin xi Wu Dong-ni

In Western academia, social gender has become as much a fundamental concept for analysis that is widely used in various fields of humanities and social sciences to research as other concepts like class and race. These three terms have also become the three axial concepts to analyse social power in mass communication and institutions, as has been discussed in communication studies. Since the 1970s, media and gender studies as a discipline have become the camp for critical communication studies,

关键词：社会性别媒体语境中国社会科学大众传播学术界三轴向

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Evaluation of controlled attenuation parameter in assessing hepatic steatosis in patients with autoimmune liver diseases

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World Journal of Gastroenterology 2021年第1期27卷 80-91页

作者： xi-xi ni Min Lian Hui-Min Wu xiao-Yun Li Li Sheng Han Bao Qi Miao xiao xiao Can-Jie Guo Hai Li xiong Ma Jing Hua Department of Gastroenterology and Hepatology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Institute of Digestive DiseaseShanghai 200127China Department of Gastroenterology and Hepatology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Medicine Shanghai Jiao Tong UniversityShanghai Cancer InstituteShanghai Institute of Digestive DiseaseShanghai 200127China School of Medicine Shanghai Jiao Tong UniversityShanghai Institute of Digestive DiseaseShanghai 200127China Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Institute of Digestive DiseaseShanghai 200001China

BACKGROUND Hepatic steatosis commonly occurs in some chronic liver diseases and may affect disease *** To investigate the performance of controlled attenuation parameter(CAP)for the diagnosis of hepatic steatosis in patients with autoimmune liver diseases(AILDs).METHODS Patients who were suspected of having AILDs and underwent liver biopsy were consistently *** stiffness measurement(LSM)and CAP were performed by transient *** area under the receiver operating characteristic(AUROC)curve was used to evaluate the performance of CAP for diagnosing hepatic steatosis compared with *** Among 190 patients with biopsy-proven hepatic steatosis,69 were diagnosed with autoimmune hepatitis(AIH),18 with primary biliary cholangitis(PBC),and 27 with AIH-PBC overlap *** AUROCs of CAP for the diagnosis of steatosis in AILDS were 0.878(0.791-0.965)for S1,0.764(0.676-0.853)for S2,and 0.821(0.716-0.926)for *** CAP value was significantly related to hepatic steatosis grade(Pninvasive diagnostic method to evaluate hepatic steatosis in patients with *** of LSM combined with CAP may help to identify patients with AIH concomitant with NAFLD from those with NAFLD with autoimmune phenomena.

关键词： Controlled attenuation parameter Hepatic steatosis Autoimmune liver diseases Nonalcoholic fatty liver disease Liver stiffness measurement Autoimmune hepatitis

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Regulation of PPAR-γactivity in lipid-laden hepatocytes affects macrophage polarization and inflammation in nonalcoholic fatty liver disease

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World Journal of Hepatology 2022年第7期14卷 1365-1381页

作者： xiao-Yun Li Pei-Xuan Ji xi-xi ni Yu-xin Chen Li Sheng Min Lian Can-Jie Guo Jing Hua Department of Gastroenterology and Hepatology Renji HospitalSchool of MedicineShanghai Jiaotong UniversityNHC Key Laboratory of Digestive Diseases(Renji HospitalShanghai Jiaotong University School of Medicine)Shanghai 200127China

BACKGROUND Lipid metabolism disorder and inflammatory-immune activation are vital triggers in the pathogenesis of nonalcoholic fatty liver disease(NAFLD).Various studies have shown that PPAR-γexerts potent anti-inflammatory and immunomodulatory ***,little is known about the regulation of PPAR-γactivity in modulating cell crosstalk in *** To investigate whether the regulation of PPAR-γactivity in lipid-laden hepatocytes affects macrophage polarization and *** Primary hepatocytes were isolated from wild-type C57BL6/J mice or hepatocytespecific PPAR-γknockout mice and incubated with free fatty acids(FFAs).Macrophages were incubated with conditioned medium(CM)from lipid-laden hepatocytes with or without a PPAR-γ***-type C57BL/6J mice were fed a high-fat(HF)diet and administered *** Primary hepatocytes exhibited significant lipid deposition and increased ROS production after incubation with *** from lipid-laden hepatocytes promoted macrophage polarization to the M1 type and activation of the TLR4/NF-κB pathway.A PPAR-γagonist ameliorated oxidative stress and NLRP3 inflammasome activation in lipid-laden hepatocytes and subsequently prevented M1 macrophage ***-specific PPAR-γdeficiency aggravated oxidative stress and NLRP3 inflammasome activation in lipid-laden hepatocytes,which further promoted M1 macrophage *** administration improved oxidative stress and NLRP3 inflammasome activation in HF diet-induced NAFLD mice in *** Upregulation of PPAR-γactivity in hepatocytes alleviated NAFLD by modulating the crosstalk between hepatocytes and macrophages via the reactive oxygen species-NLRP3-IL-1βpathway.

关键词： Nonalcoholic fatty liver disease Hepatocyte Macrophage polarization PPAR-γ NLRP3 Oxidative stress

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Water Resources Operation and Management Model and Its Simulation Process Research

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Journal of Systems Science and Systems Engineering 2001年第3期13卷 328-338页

作者： MA Bin, xiE Jian-cang,\ ZHANG Yong-jin,\ SUN Yi,\ WANG ni xi′an University of Technology, xi′an 710048, China xi′an University of Technology Xi′an 710048 China

Based on the status quantity of water resources in xi′an region, a commentary on many math models is given for water resources operation and management, and the visual model is provided to solve practical problems. In this model, the information for decision is visible in GIS (Geographic Information Systems) and topological figures. With object orientation methods, the objects are described in proprieties, methods, relations and time periods. The simulation process of the model is developed with Delphi and MapInfo, and the real decision scheme could be examined and practice decision process can be simulated from which. Decision analysis conducted from visual conditions is believable. The exploration to visual model is a beginning of practice research, much more study of which still needs to do.

关键词： water resources operation and management visual decision simulation process object orientation method topological model

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