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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang xin Liu jian Zhang Ya gao Shuyue Li Cui Chang xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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一种基于显微多光谱宫颈细胞图像自动分割方法

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数据采集与处理 2004年第4期19卷 441-445页

作者：高细见曾立波吴琼水王殿成武汉大学电子信息学院武汉430072

介绍了一种基于多光谱宫颈显微图像自动分割方法。细胞涂片每一个局部区域经过显微镜放大后再通过电调谐光器件分别取出不同光谱波段的图像 ,经过 CCD送入计算机后得到该视场分析所需的多光谱图像。从所获得的多光谱图像中选择一定的波... 详细信息

介绍了一种基于多光谱宫颈显微图像自动分割方法。细胞涂片每一个局部区域经过显微镜放大后再通过电调谐光器件分别取出不同光谱波段的图像 ,经过 CCD送入计算机后得到该视场分析所需的多光谱图像。从所获得的多光谱图像中选择一定的波段图像对数变换相除、多阈值分割和形态学操作 ,最后获得宫颈细胞的胞浆和胞核覆盖层。本文首次将多光谱分析应用到宫颈显微图像分割中 ,具有分割准确、分割速度快、能够去除胞浆重叠和受外界干扰少的特点。

关键词：宫颈细胞胞浆显微细胞涂片取出首次再通波段电调谐光器件

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纳米多孔有机聚合物电化学应用研究

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高分子学报 2018年第5期28卷 559-570页

作者：陈东洋刘程王锦艳潘春跃喻桂朋蹇锡高中南大学化学化工学院长沙410083 大连理工大学精细化工国家重点实验室大连116012

纳米多孔有机聚合物(nanoporous organic polymers,NOPs)是一类由轻元素组成的新型高分子材料,具有比表面积大、孔容高、化学和物理性质稳定等优点,在电化学领域表现出巨大的应用潜力.其合成方法多样,孔结构可控,表面易修饰更推进了NOP... 详细信息

纳米多孔有机聚合物(nanoporous organic polymers,NOPs)是一类由轻元素组成的新型高分子材料,具有比表面积大、孔容高、化学和物理性质稳定等优点,在电化学领域表现出巨大的应用潜力.其合成方法多样,孔结构可控,表面易修饰更推进了NOPs在电化学应用的快速发展.本文总结了NOPs在电化学应用的研究进展,重点介绍NOPs的骨架改性和孔结构调控对电化学性能的影响,分析其分子结构和聚集态结构与性能的构效关系,展望了其在电化学领域未来的发展趋势.

关键词：纳米多孔有机聚合物电极材料电催化电化学性能

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含1,3,5-三嗪芳香二酸及其可溶性聚芳酰胺的合成

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高分子学报 2012年第8期22卷 870-875页

作者：李斌伍绍飞刘俊灵熊绍辉谭海军喻桂朋潘春跃蹇锡高中南大学化学化工学院长沙410083 大连理工大学精细化工国家重点实验室大连116012

以2,4-二氯-6-苯基-1,3,5-三嗪为原料,通过傅克和氧化反应制备了一种新型芳香二酸2,4-二(4-甲酸基苯基)-6-芳基-1,3,5-三嗪(PTDA),并采用1H-NMR,FTIR,MS和元素分析等对其结构进行了表征.利用正交试验,重点考察了氧化反应条件对产率的影... 详细信息

以2,4-二氯-6-苯基-1,3,5-三嗪为原料,通过傅克和氧化反应制备了一种新型芳香二酸2,4-二(4-甲酸基苯基)-6-芳基-1,3,5-三嗪(PTDA),并采用1H-NMR,FTIR,MS和元素分析等对其结构进行了表征.利用正交试验,重点考察了氧化反应条件对产率的影响,结果表明反应温度为25℃、反应时间为8 h、HAc与H2SO4摩尔比为10∶1、CrO3与PTDA配比为4∶1时,氧化产率最高,达81.3%.以PTDA和间苯二胺(BD)为原料,制备了新型含1,3,5-三嗪聚芳酰胺PPA,其特性黏数为0.49 dL/g.该聚酰胺表现出较好的溶解性能以及优异的热稳定性和机械性能,室温下可溶于N-甲基-2-吡咯烷酮、N,N-二甲基乙酰胺等溶剂中,由其溶液可制得透明薄膜;玻璃化转变温度达315℃,氮气中起始分解温度T5%为493℃,700℃下残炭率高达59%;薄膜的拉伸强度为82 MPa,断裂伸长率在8.2%,起始模量为2.3 GPa.

关键词： 1 3 5-三嗪聚芳酰胺高性能聚合物

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氮杂环单体的分子结构对共聚芳醚酮酮性能的影响

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高分子学报 2021年第9期52卷 1184-1191页

作者：刘乾王昭琪杨晓庆武楷文符少奎王旭张守海蹇锡高大连理工大学化工学院精细化工国家重点实验室辽宁省高性能树脂工程技术研究中心辽宁省高分子科学与工程重点实验室大连116024

合成4,4’-二苯基-7,7’-双(2,2’,3,3’)二氮杂萘(1,1’)酮(7,7-DBD)与4,4’-二苯基-6,7’-双(2,2’,3,3’)二氮杂萘(1,1’)酮(6,7-DBD)2种杂环单体,探究2种单体和4-(4-羟基苯基)-2,3-二氮杂萘酮与1,4-二(4-氟苯甲酰基)苯的共聚行为,得到2种侧苯基位置不同的氮杂环聚芳醚酮酮P-CDs与P-TDs.两者的特性黏度介于0.5~1.1 dL/g,P-CDs的特性黏度更高,制备更容易.P-CDs的玻璃化转变温度介于254~296℃,250℃的储能模量保持率高达67%,均高于相同共聚组成的P-TDs.2种聚合物可溶于N-甲基吡咯烷酮与1,1,2,2-四氯乙烷等有机溶剂中;拉伸模量介于1.56~1.78 GPa,拉伸强度介于50.1~102.9 MPa,断裂伸长率介于11.0%~18.1%,绝缘性基本一致.P-CDs的耐热性、溶解性、机械性能均优于P-TDs.故调整主链上侧基分布方式可以明显改变聚合物的耐热性、机械性能、溶解性和可制备性,为制备耐热等级更高且可溶解的高性能聚合物提供参考.

关键词：分子结构聚芳醚双二氮杂萘酮溶解性耐热性

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu xiao Feng xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong gao Yong Du Zhe Sun Weilin Xu jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng Liao Sha Liao Yu-Jiao gao xi Wang Li-Hong Guo Su Zheng Wu Yang Yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

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Variable Metric Method for Unconstrained Multiobjective Optimization Problems

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Journal of the Operations Research Society of China 2023年第3期11卷 409-438页

作者： jian Chen gao-xi Li xin-Min Yang Department of Mathematics Shanghai UniversityShanghai200444China School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing400067China National Center for Applied Mathematics of Chongqing and School of Mathematical SciencesChongqing Normal UniversityChongqing401331China

In this paper,we propose a variable metric method for unconstrained multiobjective optimization problems(MOPs).First,a sequence of points is generated using different positive definite matrices in the generic *** is proved that accumulation points of the sequence are Pareto critical ***,without convexity assumption,strong convergence is established for the proposed ***,we use a common matrix to approximate the Hessian matrices of all objective functions,along which a new nonmonotone line search technique is proposed to achieve a local superlinear convergence ***,several numerical results demonstrate the effectiveness of the proposed method.

关键词： Multiobjective optimization Variable metric method Pareto point Superlinear convergence

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Compressive strength prediction and optimization design of sustainable concrete based on squirrel search algorithm-extreme gradient boosting technique

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Frontiers of Structural and Civil Engineering 2023年第9期17卷 1310-1325页

作者： Enming LI Ning ZHANG Bin xi jian ZHOU xiaofeng gao ETSI Minas y Energía Universidad Politécnica de MadridMadrid 28003Spain Leibniz Institute of Ecological Urban and Regional Development(IOER) Dresden 01217Germany Department of Civil and Environmental Engineering Politecnico Di MilanoMilano 20133Italy School of Resources and Safety Engineering Central South UniversityChangsha 410083China Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment(Ministry of Education) College of Environment and EcologyChongqing UniversityChongqing 400045China

Concrete is the most commonly used construction ***,its production leads to high carbon dioxide(CO_(2))emissions and energy ***,developing waste-substitutable concrete components is *** the sustainability and greenness of concrete is the focus of this *** this regard,899 data points were collected from existing studies where cement,slag,fly ash,superplasticizer,coarse aggregate,and fine aggregate were considered potential influential *** complex relationship between influential factors and concrete compressive strength makes the prediction and estimation of compressive strength *** of the traditional compressive strength test,this study combines five novel metaheuristic algorithms with extreme gradient boosting(XGB)to predict the compressive strength of green concrete based on fly ash and blast furnace *** intelligent prediction models were assessed using the root mean square error(RMSE),coefficient of determination(R^(2)),mean absolute error(MAE),and variance accounted for(VAF).The results indicated that the squirrel search algorithm-extreme gradient boosting(SSA-XGB)yielded the best overall prediction performance with R^(2) values of 0.9930 and 0.9576,VAF values of 99.30 and 95.79,MAE values of 0.52 and 2.50,RMSE of 1.34 and 3.31 for the training and testing sets,*** remaining five prediction methods yield promising ***,the developed hybrid XGB model can be introduced as an accurate and fast technique for the performance prediction of green ***,the developed SSA-XGB considered the effects of all the input factors on the compressive *** ability of the model to predict the performance of concrete with unknown proportions can play a significant role in accelerating the development and application of sustainable concrete and furthering a sustainable economy.

关键词： sustainable concrete fly ash slay extreme gradient boosting technique squirrel search algorithm parametric analysis

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Sublethal Effects of Metaflumizone on Plutella xylostella (Lepidoptera: Plutellidae)

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Journal of Integrative Agriculture 2012年第7期11卷 1145-1150页

作者： ZHANG Zhe LI jian-hong gao xi-wu College of Plant Science & Technology Huazhong Agricultural University Wuhan 430070 P.R.China Department of Entomology China Agricultural University Beijing 100193 P.R. China

Metaflumizone is a novel sodium channel blocker insecticide, which has been registered for controling the diamondback moth （DBM）, Plutella xylostella （Lepidoptera： Plutellidae） in China. It is unavoidable for DBMs to be exposed to sublethal dose of metaflumizone in brassicaceous vegetable field. Sublethal effects of metaflumizone at LC15 （1.06 mg L-1） and LCz5 （2.03 mg L-1） on the biological characteristics were investigated. Pupation rate, pupal period and pupal weight were significantly declined comparing with the control （P=0.05） when third instar larvae were exposed to LC15 and LC25 of metaflumizone. Comparing the control group to LC15 and LC25 treatment groups, there were significant differences in the development periods of eggs, first instar larvae, pupae and total preoviposition period. The peak of age-specific fecundity in LC15 and LC25 treatment groups was lagged behind control group. Mean values of intrinsic rate of increase （rm）, net reproductive rate （R0） and finite rate of increase （λ） observed from the LCl5 and LC25 treatment groups were lower than those from the control group. But mean values of gross reproduction rate （GRR） was not different. The mean generation time （T） of the treatment groups was prolonged. Whether sublethal doses of metaflumizone could stimulate reproduction in the long term needs further investigation on continuous generations.

关键词： Plutella xylostella metaflumizone sublethal dose life table parameters

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