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f.ontiers of.Structural and Civil Engineering 2015年第2期9卷 107-113页

作者： xi f. xu School of.Civil Engineering Beo'ing Jiaotong University Beijing 100044 China

The Green-f.nction-based multiscale stochastic f.nite element method (MSf.M) has been f.rmulated based on the stochastic variational principle. In this study a f.st computing procedure based on the MSf.M is developed to solve random f.eld geotechnical problems with a typical coef.icient of.variance less than 1. A unique f.st computing advantage of.the procedure enables computation perf.rmed only on those locations of.interest, theref.re saving a lot of.computation. The numerical example on soil settlement shows that the procedure achieves signif.cant computing ef.iciency compared with Monte Carlo method.

关键词： multiscale f.nite element settlement perturbation random f.eld geotechnical

Special Column on Multiscale Stochastic f.nite Element Method

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f.ontiers of.Structural and Civil Engineering 2015年第2期9卷 105-106页

作者： xi f. xu (1) George Stef.nou (2) Carsten Proppe (3) Yu Ching Wu (4) 1.Beijing Jiaotong University Beijing China 2.Aristotle University of Thessaloniki Thessaloniki Greece 3.Karlsruhe Institute of Technology Karlsruhe Germany 4.Tongji University Shanghai China

In the past decade, multi-scale modelling in mathematical physics and engineering has been growing with vast advancement based on deterministic assumption. Because all inf.rmation across scales contains a certain level of.uncertainty due to incomplete knowledge and inherent chaos with respect to physical laws and parameters, a combination of.multi-scale and stochastic techniques becomes a new approach. Incorporation of.stochastic process into multi-scale modelling with accurate assessment of.uncertainty propagation across scales is highly challenging but essential f.r a rising number of.applications, and in certain areas such models can provide critical insights that deterministic approaches could never predict. In computational mechanics, research topics on discrete-to-continuum, stochastic-to-deterministic, and scale coupling are prioritized as the most signif.cant directions. In the past half.century, the f.nite element method has been a mature and widely-used numerical technique. When both multi-scale and stochastic phenomena are considered, cross-cutting multi-scale stochastic f.nite element modelling f.rms a novel research f.ontier. In this special issue,there are f.ve original research papers relevant to multi-scale stochastic f.nite element methods or their applications.

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Smart Cellulose‑Based Janus f.brics with Switchable Liquid Transportation f.r Personal Moisture and Thermal Management

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianf.ng xi Yanling Lou Liucheng Meng Chao Deng Youlu Chu Zhaoyang xu Huining xiao Weibing Wu Jiangsu Co‑Innovation Center of.Ef.icient Processing and Utilization of.f.rest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of.Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of.Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus f.brics designed f.r personal moisture/thermal regulation have garnered signif.cant attention f.r their potential to enhance human ***,the development of.smart and dynamic f.brics capable of.managing personal moisture/thermal comf.rt in response to changing external environments remains a ***,a smart cellulose-based Janus f.bric was designed to dynamically manage personal moisture/*** cotton f.bric was graf.ed with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanof.ber were sprayed on the bottom and top sides of.the f.bric to obtain wettability *** f.bric exhibits anti-gravity directional liquid transportation f.om hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of.3–66 s as the temperature increases f.om 10 to 40℃.This smart f.bric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human f.om becoming too *** addition,the f.bric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart f.bric of.ers an innovative approach to maximizing personal comf.rt in environments with signif.cant temperature variations.

关键词： Directional water transport Cotton f.bric Anti-gravity directional liquid transportation Janus wettability

EZH2-dependent myelination f.llowing sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu xi xu Tianyi Huang Ying Wang Siyuan xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin xue Research Center of.Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of.Nantong University NantongJiangsu ProvinceChina Department of.Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of.Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of.Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major f.cal points in the study of.peripheral nerve regeneration f.llowing peripheral nerve ***,the gene regulatory network of.regenerated myelin dif.ers f.om that of.native *** of.enhancer of.zeste homolog 2(EZH2)hinders the dif.erentiation,maturation,and myelination of.Schwann cells in *** f.rther determine the role of.EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(f./f.);Dhh-Cre and Ezh2^(f./f.);Mpz-Cre)were *** results show that a signif.cant proportion of.axons in the sciatic nerve of.Ezh2-depleted mice remain *** highlights the crucial role of.Ezh2 in initiating Schwann cell ***,we observed that 21 days af.er inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(f./f.);Mpz-Cre mice had signif.cantly f.wer remyelinated axons compared with their wild-type *** suggests that the absence of.Ezh2 in Schwann cells impairs myelin f.rmation and *** conclusion,EZH2 has emerged as a pivotal regulatory f.ctor in the process of.demyelination and myelin regeneration f.llowing peripheral nerve *** EZH2 activity during these processes may of.er a promising therapeutic target f.r the treatment of.peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

Development of.a nomogram f.r overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of.Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu xi Zheng xiao-Sheng Li Qian-Jie xu Wei Zhang Zhong-Li Liao Hai-Ke Lei Department of.Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of.Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a signif.cant public health issue in China,with its prognosis impacted by myriad *** creation of.a reliable prog-nostic model f.r the overall survival(OS)of.EC patients promises to greatly advance the customization of.treatment *** To create a more systematic and practical model that incorporates clinically signif.cant indicators to support decision-making in clinical *** This study utilized data f.om a prospective longitudinal cohort of.3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables f.r constructing the *** ef.icacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be signif.cant predictors of.OS in EC patients:Body mass index(BMI),Karnof.ky perf.rmance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of.0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs f.r 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verif.ed the model's predictive accuracy and net *** A novel prognostic model f.r determining the OS of.EC patients was successf.lly developed and validated to help clinicians in devising individualized treatment schemes f.r EC patients.

关键词： Esophageal carcinoma High-risk f.ctors Prognosis Overall survival Prediction model

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： xihang Chen Zhif.ng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei xu Chang Lin xi Shi Wei Chen Shiming Yang Senior Department of.Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of.Hearing and Balance Science BeijingChina National Clinical Research Center f.r Otolaryngologic Diseases BeijingChina Key Laboratory of.Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of.Hearing Impairment Prevention and Treatment BeijingChina Department of.Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of.Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of.Tropical Biological Resources of.Ministry of.Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of.Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic f.ctor contributing to auditory ***,there are currently no ef.ective pharmacological interventions f.r patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specif.c demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of.permanent threshold shif. hearing loss by exposing the mice to white broadband noise at a sound pressure level of.120 d B f.r 4 *** f.und that tranylcypromine treatment led to the upregulation of.Sestrin2(SESN2)and activation of.the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of.mice treated with *** noise exposure group treated with tranylcypromine showed signif.cantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz f.equencies compared with the noise exposure group treated with *** f.ndings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression af.er noise exposure,leading to a reduction in levels of.4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of.NOD-like receptor f.mily pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inf.ammation by promoting the expression of.SESN2,which induced autophagy,thereby restricting NLRP3-related inf.ammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** f.ndings suggest that inhibiting lysine-specif.c demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inf.ammation NOD-like receptor f.mily pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

Closed-f.rm solutions f.r f.ee vibration of.rectangular f.M thin plates resting on elastic f.undation

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Acta Mechanica Sinica 2016年第6期32卷 1088-1103页

作者： T. f. xu Y. f. xing Institute of.Solid Mechanics Beihang UniversityBeijing 100191 China China Academy of.Launch Vehicle Technology R&D Center Beijing 100076 China

This article presents closed-f.rm solutions f.r the f.equency analysis of.rectangular f.nctionally graded material (f.M) thin plates subjected to initially in-plane loads and with an elastic f.undation. Based on classical thin plate theory, the governing dif.erential equations are derived using Hamilton's principle. A neutral surf.ce is used to eliminate stretching-bending coupling in f.M plates on the basis of.the assumption of.constant Poisson's ratio. The resulting governing equation of.f.M thin plates has the same f.rm as homogeneous thin plates. The separation-of.variables method is adopted to obtain solutions f.r the f.ee vibration problems of.rectangular f.M thin plates with separable boundary conditions, including, f.r example, clamped plates. The obtained normal modes and f.equencies are in elegant closed f.rms, and present f.rmulations and solutions are validated by comparing present results with those in the literature and f.nite element method results obtained by the authors. A parameter study reveals the ef.ects of.the power law index n and aspect ratio a/b on f.equencies.

关键词： f.nctionally graded material f.ee vibration Rectangular plate Close f.rm solutions Neutral surf.ce

A high-entropy spinel ceramic oxide as the cathode f.r proton-conducting solid oxide f.el cells

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Journal of.Advanced Ceramics 2022年第5期11卷 794-804页

作者： Yangsen xu xi xu Lei BI School of.Resource Environment and Saf.ty Engineering University of South ChinaHengyang 421001China Department of.Materials Imperial College London SW72BPUK

A high-entropy ceramic oxide is used as the cathode f.r the f.rst time f.r proton-conducting solid oxide f.el cells(H-SOf.s).The f._(0.6)Mn_(0.6)Co_(0.6)Ni_(0.6)Cr_(0.6)O_(4)(f.CNC)high-entropy spinel oxide has been successf.lly prepared,and the in situ chemical stability test demonstrates that the f.CNC material has good stability against CO_(2).The f.rst-principles calculation indicates that the high-entropy structure enhances the properties of.the f.CNC material that surpasses their individual components,leading to lower O_(2)adsorption energy f.r f.CNC than that f.r the individual *** HSOf. using the f.CNC cathode reaches an encouraging peak power density(PPD)of.1052 mW·cm^(-2)at 700℃,which is higher than those of.the H-SOf.s reported *** comparison was made between the high-entropy f.CNC cathode and the traditional Mn_(1.6)Cu_(1.4)O_(4)(MCO)spinel cathode without the high-entropy structure,revealing that the f.rmation of.the high-entropy material allows the enhanced protonation ability as well as the movement of.the O p-band center closer to the f.rmi level,thus improving the cathode catalytic *** a result,the high-entropy f.CNC has a much-decreased polarization resistance of.0.057Ω·cm^(2)at 700℃,which is half.of.that f.r the traditional MCO spinel cathode without the high-entropy *** excellent perf.rmance of.the f.CNC cell indicates that the high-entropy design makes a new lif. f.r the spinel oxide as the cathode f.r HSOf.s,of.ering a novel and promising route f.r the development of.high-perf.rmance materials f.r H-SOf.s.

关键词： proton-conducting oxides high-entropy oxides cathode solid oxide f.el cells(SOf.s)

Rare nanoparticles shine colors with low-power STED

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Light(Science & Applications) 2022年第7期11卷 1324-1326页

作者： xinzhu xu Peng xi College of.f.ture Technology Peking UniversityBeijingChina

The ef.ect of.cascade amplif.ed depletion in lanthanide upconversion systems boosts their own emission bands inhibition,which f.cilitates multi-color nanoscopy with only one pair of.low-power NIR CW lasers.

关键词： Rare lanthanide bands

Prospects f.r the application of.transcranial magnetic stimulation in diabetic neuropathy

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Neural Regeneration Research 2021年第5期16卷 955-962页

作者： xi xu Dong-Sheng xu Department of.Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of.Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina School of.Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina

Encouraging results have been reported f.r the use of.transcranial magnetic stimulationbased nerve stimulation in studies of.the mechanisms of.neurological regulation,nerve injury repair,and nerve ***,to date,there are only a f.w reviews on the use of.transcranial magnetic stimulation f.r diabetic *** with diabetic neuropathy vary in disease progression and show neuropathy in the early stage of.the disease with mild symptoms,making it dif.icult to screen and *** the later stage of.the disease,irreversible neurological damage occurs,resulting in treatment *** this review,we summarize the current state of.diabetic neuropathy research and the prospects f.r the application of.transcranial magnetic stimulation in diabetic *** review signif.cant studies on the benef.cial ef.ects of.transcranial magnetic stimulation in diabetic neuropathy treatment,based on the outcomes of.its use to treat neurodegeneration,pain,blood f.ow change,autonomic nervous disorders,vascular endothelial injury,and ***,the studies suggest that transcranial magnetic stimulation can produce excitatory/inhibitory stimulation of.the cerebral cortex or local areas,promote the remodeling of.the nervous system,and that it has good application prospects f.r the localization of.the injury,neuroprotection,and the promotion of.nerve ***,transcranial magnetic stimulation is usef.l f.r the screening and early treatment of.diabetic *** magnetic stimulation can also alleviate pain symptoms by changing the cortical threshold and inhibiting the conduction of.sensory inf.rmation in the thalamo-spinal pathway,and theref.re it has therapeutic potential f.r the treatment of.pain and pain-related depressive symptoms in patients with diabetic ***,based on the ef.ect of.transcranial magnetic stimulation on local blood f.ow and its ability to change heart rate and urine protein conten

关键词： autonomic neuropathy central nervous system depression inf.ammation oxidative stress pain peripheral nerve plasticity recovery regeneration vascular