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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin xi shi Wei Chen shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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A kind of noise-induced transition to noisy chaos in stochastically perturbed dynamical system

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Acta Mechanica Sinica 2012年第5期28卷 1416-1423页

作者： Chun-Biao Gan shi-xi Yang Hua Lei Department of Mechanical Engineering Zhejiang University Department of Engineering Mechanics Zhejiang University

We investigate a kind of noise-induced transition to noisy chaos in dynamical systems. Due to similar phenomenological structures of stable hyperbolic attractors excited by various physical realizations from a given stationary random process, a specific Poincar6 map is established for stochastically perturbed quasi-Hamiltonian system. Based on this kind of map, various point sets in the Poincar6＇s cross-section and dynamical transitions can be analyzed. Results from the customary Duffing oscillator show that, the point sets in the Poincare＇s global cross-section will be highly compressed in one direction, and extend slowly along the deterministic period-doubling bifurcation trail in another direction when the strength of the harmonic excitation is fixed while the strength of the stochastic excitation is slowly increased. This kind of transition is called the noise-induced point-overspreading route to noisy chaos.

关键词： Stochastic excitation - Dynamical system - Specific Poincare map Noise-induced transition to chaos

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Electrochemical performance of LiNi_(0.5)Mn_(0.5)O_2 with different synthesis methods

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Rare Metals 2015年第8期34卷 580-585页

作者： Hong Li Qiang Xu xi-xi shi Da-Wei Song Lian-Qi Zhang Department of Applied Chemistry School of Chemical and Engineering Tianjin University School of Materials Science and Engineering Tianjin University of Technology

Li Ni0.5Mn0.5O2 as a cathode material for Li-ion battery was prepared by the metal acetate decomposition method, sol–gel method, and carbonate co-precipitation method, respectively. The influences of synthesis methods on the physical and electrochemical behaviors of Li Ni0.5Mn0.5O2 were characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM) and electrochemical tests. XRD patterns show that both the sol–gel and carbonate co-precipitation methods can form single phase of layered structure, while a trace of Ni O impurity is observed via the metal acetate decomposition method. SEM results show the as-prepared carbonate particle has a spherical morphology with an average diameter of 10 lm, consisted of primary nano-sized particles with particle diameter of200 nm. The sample prepared by the carbonate co-precipitation method exhibits the highest discharge specific capacity and the best cycling stability, which results from the steady homogeneity of precursor constant by the fixation of CO2-3group. It can deliver an initial discharge specific capacity of 186.3 m Ahág-1, and retain 170 m Ahág-1after100 cycles at a current rate of 20 m Aág-1in the voltage range of 2.5–4.7 V at 25 °C. Moreover, even at the high temperature of 55 °C, it still delivers a reversible specific capacity of 222.6 m Ahág-1with little capacity loss after 30 cycles.

关键词： Sol–gel Carbonate co-precipitation LiNi0.5Mn0.5O2

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A new benzophenone C-glycoside from Polygala telephioides Willd

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Chinese Chemical Letters 2010年第5期21卷 584-586页

作者： Ting Jun Ma[a], xi Cheng shi[b] Chang xi Jia[a] [a] Department of Food Science Beijing Agricultural College Beijing 102206 China [b] Research Insitute of Chemical Defense Beijing 100083 China

A new benzophenone C-glucoside,3’-C-[4-O-(5-hydroxyferuloyl)-β-D-glucopyranosyl]-2′,4′,6′-trihydroxy-3,4-dimethoxy-benzophenone, named telephenone D,was isolated from the whole plants of Polygala telephioides,and... 详细信息

关键词： Polygala telephioides Benzophenone C-glucoside Telephenone D

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Dynamical analysis and performance evaluation of a biped robot under multi-source random disturbances

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Acta Mechanica Sinica 2014年第6期30卷 983-994页

作者： Chun-Biao Gan Chang-Tao Ding shi-xi Yang The State Key Laboratory of Fluid Power Transmission and Control Department of Mechanical EngineeringZhejiang University

During bipedal walking,it is critical to detect and adjust the robot postures by feedback control to maintain its normal state amidst multi-source random disturbances arising from some unavoidable uncertain *** radical basis function（RBF）neural network model of a five-link biped robot is established,and two certain disturbances and a randomly uncertain disturbance are then mixed with the optimal torques in the network model to study the performance of the biped robot by several evaluation indices and a specific Poincar′e *** contrast with the simulations,the response varies as desired under optimal inputting while the output is fluctuating in the situation of disturbance *** results from noise inputting also show that the dynamics of the robot is less sensitive to the disturbance of knee joint input of the swing leg than those of the other three joints,the response errors of the biped will be increasing with higher disturbance levels,and especially there are larger output fluctuations in the knee and hip joints of the swing leg.

关键词： Biped robot Multi-source random disturbances Sensitive parameters RBF neural network Taguchi method Performance evaluation

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Input torque sensitivity to uncertain parameters in biped robot

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Acta Mechanica Sinica 2013年第3期29卷 452-461页

作者： Chang-Tao Ding shi-xi Yang Chun-Biao Gan Department of Mechanical Engineering Zhejiang University

Input torque is the main power to maintain bipedal walking of robot, and can be calculated from trajectory planning and dynamic modeling on biped robot. During bipedal walking, the input torque is usually required to be adjusted due to some uncertain parameters arising from objective or subjective factors in the dynamical model to maintain the pre-planned stable trajectory. Here, a planar 5-link biped robot is used as an illustrating example to investigate the effects of uncertain parameters on the input torques. Kine-matic equations of the biped robot are firstly established by the third-order spline curves based on the trajectory planning method, and the dynamic modeling is accomplished by taking both the certain and uncertain parameters into account. Next, several evaluation indices on input torques are intro-duced to perform sensitivity analysis of the input torque with respect to the uncertain parameters. Finally, based on the Monte Carlo simulation, the values of evaluation indices on input torques are presented, from which all the robot param-eters are classified into three categories, i.e., strongly sensi-tive, sensitive and almost insensitive parameters.

关键词： Biped robot · Uncertain parameter · Trajectory planning · Input torque · Sensitivity

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Global track extraction for probability hypothesis density filter

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Journal of Systems Engineering and Electronics 2016年第6期27卷 1151-1157页

作者： Feng Yang xi shi Keli Liu Yan Liang Hao Chen School of Automation Northwestern Polytechnical UniversityXi’an 710072China

The probability hypothesis density (PHD), a well-known scheme for multi-target tracking in clutters, can obtain peaks of possible tracks, and its cluster-indexed method is widely accepted in further track extraction. However, the track extraction may face high risk in the case that the targets are so approached that it is hardly to discern their measurements. The concept of the distance between track sets in two adjacent times is defined and a consistency measure metric between any two peaks in two adjacent times is further proposed based on 'global information', containing spatial information (topology feature) among tracks, along with the temporal information of each track. Then, a global track extraction method is proposed based on the consistency belief and four decision rules. Via the simulation comparison with the cluster-indexed method, the proposed method can avoid the track break and mistake association. © 2016 Beijing Institute of Aerospace Information.

关键词： Bandpass filters Clutter (information theory) Probability Target tracking Tracking (position)

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Stable carbon isotope composition and intrinsic water use efficiency in plants along an altitudinal gradient on the eastern slope of Yulong Snow Mountain, China

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Ecological Processes 2024年第2期13卷 218-230页

作者： Feng Jiang Tao Pu Zi-Jing Xue Yan-Wei Ma xiao-Yi shi Fu-xi shi College of Geography and Environmental Sciences Zhejiang Normal University Yulong Snow Mountain Glacier and Environment Observation and Research Station/State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of Forestry Jiangxi Agricultural University

Background Stable carbon isotope composition(δ13Cp) can be used to estimate the changes in intrinsic water use efficiency（iWUE） in plants,which helps us to better understand plants' response strategies to climate *** study focused on the variations in δ13Cpand iWUE for the different life-form plants（i.e.,herbs,shrubs,and trees）along an altitudinal gradient（3300,3600,3900,4100,4300,and 4500 m） on the eastern slope of Yulong Snow Mountain,southeastern margin of the Qinghai-Tibet *** response mechanisms of δ13Cpand iWUE for different life-form plants to altitude were thoroughly analyzed in this mountain *** The δ13Cpvalues of plants on the eastern slopes of Yulong Snow Mountain ranged from-30.4‰to-26.55‰,with a mean of-28.02‰,indicating a dominance of *** δ13Cpand iWUE values varied among different life-form plants in the order of herbs> shrubs> trees,particularly in 3600,3900,and 4300 ***δ13Cpand iWUE values for herbs and shrubs increased with altitude and were mainly controlled by air *** two parameters for trees exhibited a trend of initial decrease followed by an increase with *** 3900 m,the δ13Cpand iWUE values decreased with altitude,influenced by soil ***,above 3900 m,the two parameters increased with altitude,mainly regulated by air *** addition,iWUE was positively correlated with leaf P content but negatively correlated with leaf N:P ratio,especially for herbs and trees,suggesting that P plays a key role in modulating iWUE in this *** The diffe rentiated responses of water availability for different life-form plants to a higher altitudinal gradient are regulated by air temperature,soil moisture,and leaf P content in the Yulong Snow *** results provide valuable insights into understanding the wate r-carbon relationships in high-altitude ecosystems.

关键词： Stable carbon isotope Water use efficiency Altitude Life form Yulong Snow Mountain

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Microstructure and Mechanical Properties of High Manganese TRIP Steel

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Journal of Iron and Steel Research International 2012年第4期19卷 57-62页

作者： ZHAO Jin-long xi Yan shi Wen LI Lin College of Material Science and Engineering Shanghai University Shanghai 200072 China

Microstructure evolution and mechanical properties of newly designed 0.1C-6Mn-0.5Si-1Al TRIP-aided steels under different annealing conditions and the effects of matrix microstructure before intercritical annealing on the final microstructure were studied by means of X-ray diffraction（XRD）,scanning electron microcopy（SEM）,dilatometric simulation,optical microstructure（OM） and tensile testing in this *** experimental results indicate that the TRIP steel with Mn of 6% could form a considerable amount of retained austenite with good TRIP effect after a simple intercritical annealing treatment,and the matrix microstructure before intercritical annealing treatment can greatly affect the final *** original microstructure of the ferritic matrix steel was eliminated,while annealed martensite was remained from the martensite matrix steel under the same intercritical annealing conditions

关键词： high manganese TRIP steel intercritical annealing microstructure mechanical properties

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Impact of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis

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World Journal of Gastroenterology 2009年第8期15卷 996-1003页

作者： Li-Ping Deng xi-En Gui Yong-xi Zhang shi-Cheng Gao Rong-Rong Yang Department of Infectious Diseases Zhongnan Hospital Wuhan University Wuhan 430071 Hubei Province China

AIM: To analyze the influence of human immunodeficiency virus (HIV) infection on the course of hepatitis C virus (HCV) infection. METHODS: We performed a meta-analysis to quantify the effect of HIV co-infection on progressive liver disease in patients with HCV infection. Published studies in the English or Chinese-language medical literature involving cohorts of HIV-negative and -positive patients coinfected with HCV were obtained by searching the PUBMED, EMBASE and CBM. Data were extracted independently from relevant studies by 2 investigators and used in a fixed-effect meta analysis to determine the difference in the course of HCV infection in the 2 groups. RESULTS: Twenty-nine trails involving 16 750 patients were identified including the outcome of histological fibrosis or cirrhosis or de-compensated liver disease or hepatocellular carcinoma or death. These studies yielded a combined adjusted odds ratio (OR) of 3.40 [95% confidence interval (CI) = 2.45 and 4.73]. Of note, studies that examined histological fibrosis/ cirrhosis, decompensated liver disease, hepatocellular carcinoma or death had a pooled OR of 1.47 (95% CI = 1.27 and 1.70), 5.45 (95% CI = 2.54 and 11.71), 0.76 (95% CI = 0.50 and 1.14), and 3.60 (95% CI = 3.12 and 4.15), respectively. CONCLUSION: Without highly active antiretroviral therapies (HAART), HIV accelerates HCV diseaseprogression, including death, histological fibrosis/ cirrhosis and decompensated liver disease. However, the rate of hepatocellular carcinoma is similar in persons who had HCV infection and were positive for HIV or negative for HIV.

关键词： Human immunodeficiency virus Hepatitis C virus Coinfection Disease progression Meta-analysis

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