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ACEI attenuates the progression of CCl_4-induced rat hepatic fibrogenesis by inhibiting TGF-β1, PDGF-BB, NF-κB and MMP-2,9

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World Journal of Gastroenterology 2005年第31期11卷 4807-4811页

作者： Xu Li Ying Meng xi-shan yang Ling-Fei Mi Shao-xi Cai Department of Emergency Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong ProvinceChina Department of Respiratory Diseases Nanfang HospitalSouthern Medical University Guangzhou 510515 Guangdong Province China Department of Digestive Disease Nanfang HospitalSouthern Medical University Guangzhou 510515 Guangdong Province China Department of Emergency the First People's Hospital of Huaihua 418000 Hunan Province China Department of Respiratory Diseases Nanfang Hospital Southern Medical University Guangzhou 510515Guangdong Province China

AIM： Angiotensin II has pro-fibrotic function in the liver. Blockade of the renin-angiotensin-aldosterone-system （RAAS） attenuates hepatic fibrosis. The aim of the present study was to determine the mechanism of angiotensin-converting enzyme inhibitor （ACEI） on the progression of rat hepatic fibrosis. METHODS： Forty male Wistar rats were divided into three groups. Model group （Mo）： The rats were injected subcutaneously with 40% of CCl4 0.25 mL/100 g. Perindopril group （Pe）： The rats were injected subcutaneously with 40% of CCl4. Perindopril, equivalent to 2 mg/（kg·d）, was administrated. Control group （Nc）： the rats were treated with olive oil only. After 4 and 6 wk, the rats were killed. The liver sections were stained with Masson. The protein expressions of ATIR, TGF-β1 and PDGF-BB were examined by Western blot. Nuclear factor κB （NF-κB） DNA binding activity was examined by EMSA （Electrophoretic gel mobility shift assay）. Matrix metalloproteinase-2,9 （MMP-2,9） activity was assessed by zymography. Serum laminin （LN） and hyaluronic acid （HA） were measured using radioimmunoassays. RESULTS： Using Western blot, we clearly provided direct evidence for the expression of ATIR in liver. The expression was up-regulated when fibrogenesis occurred. Perindopril treatment significantly reduced mean fibrosis score, protein levels of ATIR, TGF-β1 and PDGF-BB, serum levels of HA and LN, and the activity of MMP-2,9. NF-κB DNA bindingactivity markedly increased in model group, perindopril treatment considerably reduced NF-κB DNA binding ***： Perindopril attenuates CCl4-induced hepatic fibrogenesis of rat by inhibiting TGF-β1, PDGF-BB, NF-BB and MMP-2,9.

关键词： Renin-angiotensin-aldosterone system Angiotensin-converting enzyme inhibitor Hepatic fibrosis

Extended hopanes and 8,14-secohopanes up to C_(40)in unbiodegraded marine oils from the Tarim Basin,NW China

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Petroleum Science 2022年第2期19卷 498-508页

作者： Jian-Ping Bao Cui-shan Zhu xi yang Hubei Key Laboratory of Petroleum Geochemistry and Environment Key Lab.of Exploration Technologies for Oil&Gas ResourcesMinistry of EducationGeochemistry DepartmentYangtze UniversityWuhan430100HubeiChina

Extended 17α(H),21β(H)-hopanes and three series of 8,14-secohopanes up to C_(40),including 8α(H),14α(H),17α(H),21β(H)-,8α(H),14α(H),17β(H),21α(H)-and 8α(H),14β(H),17β(H),21α(H)-,were detected by GC-MS-MS method in the branched/cyclic hydrocarbon fractions of some unbiodegraded marine oils from the Tazhong uplift in the Tarim Basin,NW *** coexistence of extended hopanes and 8,14-secohopanes up to C_(40)in unbiodegraded oils suggests that they are primary and independent on *** similarity of distribution and composition for extended hopanes and 8,14-secohopanes up to C_(40)in unbiodegraded oils proposes that they could be derived from a similar biological ***,an abrupt decrease up to 3-5 times in the relative abundance from C_(35)to C_(36)in C_(31-40)extended hopanes and extended 8,14-secohopanes suggests that C_(31-35)and C_(36-40)extended hopanes and extended 8,14-secohopanes should have their own biological *** known C35bacteriohopanetetrol should be biological precursor of C_(31-35)extended hopanes and 8,14-secohopanes,but an unknown C_(40)functionalized hopanoid could be biological precursor of C_(36-40)extended hopanes and 8,*** attention should be paid to their potential roles in oil-source correlation for severely biodegraded oils based on their widespread occurrence in various source rocks,unbiodegraded and severely biodegraded oils.

关键词： Extended hopanes Extended 8,14-secohopanes Biomarkers Bacteriohopanetetrol Unbiodegraded marine oils Tazhong Uplift Tarim Basin

Multiobjective economic model predictive control using utopia-tracking for the wet flue gas desulphurization system

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Chinese Journal of Chemical Engineering 2023年第2期54卷 343-352页

作者： shan Liu Wenqi Zhong xi Chen Li Sun Lukuan yang Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Efficient control of the desulphurization system is challenging in maximizing the economic objective while reducing the SO_(2) emission concentration. The conventional optimization method is generally based on a hierarchical structure in which the upper optimization layer calculates the steady-state results and the lower control layer is responsible to drive the process to the target point. However, the conventional hierarchical structure does not take the economic performance of the dynamic tracking process into account. To this end, multi-objective economic model predictive control(MOEMPC) is introduced in this paper, which unifies the optimization and control layers in a single stage. The objective functions are formulated in terms of a dynamic horizon and to balance the stability and economic performance. In the MOEMPC scheme, economic performance and SO_(2) emission performance are guaranteed by tracking a set of utopia points during dynamic transitions. The terminal penalty function and stabilizing constraint conditions are designed to ensure the stability of the system. Finally, an optimized control method for the stable operation of the complex desulfurization system has been established. Simulation results demonstrate that MOEMPC is superior over another control strategy in terms of economic performance and emission reduction, especially when the desulphurization system suffers from frequent flue gas disturbances.

关键词： Desulphurization system Economics Economic model predictive control Flue gas Optimization Utopia point

Experimental Study on Flow past A Rotationally Oscillating Cylinder

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China Ocean Engineering 2017年第4期31卷 495-503页

作者： GAO yang-yang YIN Chang-shan yang Kang ZHAO xi-zeng TAN Soon Keat Ocean College Zhejiang University Nanyang Environment and Water Research Institute and School of Civil and Environmental Engineering Nanyang Technological University

A series of experiments was carried out to study the flow behaviour behind a rotationally oscillating cylinder at a low Reynolds number （Re=300） placed in a recirculation water channel. A stepper motor was used to rotate the cylinder clockwise- and- counterclockwise about its longitudinal axis at selected frequencies. The particle image velocimetry （PIV） technique was used to capture the flow field behind a rotationally oscillating cylinder. Instantaneous and time-averaged flow fields such as the vorticity contours, streamline topologies and velocity distributions were analyzed. The effects of four rotation angle and frequency ratios Fr （Fr=fn/fv, the ratio of the forcing frequency fn to the natural vortex shedding frequency fv） on the wake in the lee of a rotationally oscillating cylinder were also examined. The significant wake modification was observed when the cylinder undergoes clockwise-and-counterclockwise motion with amplitude of π, especially in the range of 0.6≤Fr≤1.0.

关键词： rotational oscillation cylinder PIV frequency ratio wake flow pattern time-averaged flow field

基于储能型智能软开关联合网络重构的配电网供电恢复策略

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湖南工业大学学报 2025年第1期39卷 35-42页

作者：喻希杨杉兰征高芷蓉湖南工业大学电气与信息工程学院湖南株洲412007

为应对自然灾害、网路攻击等极端事件导致的停电事故,并降低电网的失负荷率与经济损失,提出了一种极端事件下储能型智能软开关(energy storage integrated soft open point,E-SOP)联合网络重构的主动配电网供电恢复策略。首先,介绍了E-... 详细信息

为应对自然灾害、网路攻击等极端事件导致的停电事故,并降低电网的失负荷率与经济损失,提出了一种极端事件下储能型智能软开关(energy storage integrated soft open point,E-SOP)联合网络重构的主动配电网供电恢复策略。首先,介绍了E-SOP接入配网的拓扑结构示意图,并建立其在故障恢复下的数学模型。其次,考虑三级负荷的重要程度和网络损耗,以配网各节点损失程度和网络损失最小为目标函数,构建E-SOP和网络重构联合进行供电恢复的运行模型,实现极端事件下主动配电网的快速恢复。最后,以改进的IEEE33节点配电网为例分别研究了E-SOP安装容量、位置、数量等参数对电网恢复能力的影响,并对其供电恢复策略进行验证分析。研究结果表明:所提策略可减少配电网故障下的失负荷率,进一步提升供电恢复水平。

关键词：极端事件储能型智能软开关供电恢复策略网络重构

Segregation between the parietal memory network and the default mode network： effects of spatial smoothing and model order in ICA

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Science Bulletin 2016年第24期61卷 1844-1854页

作者： yang Hu Jijun Wang Chunbo Li Yin-shan Wang Zhi yang xi-Nian Zuo Key Laboratory of Behavioral Science Laboratory for HumanConnectome and Development Magnetic Resonance ResearchCenter Institute of Psychology Chinese Academy of SciencesBeijing 100101 China University of Chinese Academy of Sciences Beijing 100049China shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai 200030 China

Abstract A brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent fMRI studies. Though it is anatomically adjacent to and spatially overlaps with the default mode network （DMN）, its function has been associated with memory processing, and it has been referred to as the parietal memory network （PMN）. Independent component analysis （ICA） is the most common data-driven method used to extract PMN and DMN simultaneously. However, the effects of data preprocessing and parameter determi- nation in ICA on PMN-DMN segregation are completely unknown. Here, we employ three typical algorithms of group ICA to assess how spatial smoothing and model order influence the degree of PMN-DMN segregation. Our findings indicate that PMN and DMN can only be stably separated using a combination of low-level spatial smoothing and high model order across the three ICA algorithms. We thus argue for more considerations on parametric settings for interpreting DMN data.

关键词： Default mode network Parietal memory network Independent component analysis Model order Resting-state fMRI Spatial smoothing

Dynamic Analysis of A Subsea Suspended Manifold Going Through Splash Zone During Installation

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China Ocean Engineering 2022年第4期36卷 553-564页

作者： WANG Ying-ying yang Chao yang Zhong-shan ZHAO xiao-yu YIN Jian-xi HU yang-dong College of Safety and Ocean Engineering China University of Petroleum-BeijingBeijing 102249China Deepwater Drilling and Production Technology Company CNOOC Energy Technology&Service LimitedZhanjiang 524057China China Vessel Scientific Research Center Wuxi 214028China

The subsea suspended manifold designed to replace the traditional foundation structure with the buoys is a new generation subsea production system that can be suspended at a certain height from the seafloor and rapidly recycled by its own *** to complex environmental conditions,its hydrodynamic performance in the splash zone is extremely important for the safety of the whole installation *** this paper,the mathematical model for the dynamic analysis of the seawater ingress process of the single-layer pre-set horizontal cabin is proposed based on the different center of gravity positions of the ***,the theoretical analysis of fiber cable is divided into infinite differential units by the discretization method,and the formulae of the horizontal displacement of the subsea suspended manifold are *** addition,the simulations are carried out to verify the rules of the dynamic responses on the subsea suspended manifold system with the consideration of the environmental conditions in the South China *** with the calculated value of the mathematical model of the cabin water ingress,the error of the simulation result by use of FLUENT is about 5.47%.Furthermore,the wave height is greater than the current impact on the lowering manifold system and the azimuth angle of the installation vessel is aligned with the direction of the environmental load.

关键词： subsea suspended manifold lowering installation seawater ingress splash zone dynamic response

One-dimensional sp carbon:Synthesis,properties,and modifications

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Chinese Physics B 2022年第12期31卷 567-589页

作者： Chao-Fan Lv xi-Gui yang Chong-xin shan State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China University of Chinese Academy of Sciences Beijing 100049China Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China

Carbyne,as the truly one-dimensional carbon allotrope with sp-hybridization,has attracted significant interest in recent years,showing potential applications in next-generation molecular devices due to its ultimate one-atom *** excellent properties of carbyne have been predicted,however,free-standing carbyne sample is extremely unstable and the corresponding experimental researches and modifications are under-developed compared to other known carbon *** synthesis of carbyne has been slowly developed for the past ***,there have been several breakthroughs in in-situ synthesis and measurement of carbyne related materials,as well as the preparation of ultra-long carbon chains toward infinite *** progresses have aroused widespread discussion in the academic *** this review,the latest approaches in the synthesis of sp carbon are *** then discuss its extraordinary properties,including mechanical,electronic,magnetic,and optical properties,especially focusing on the regulations of these ***,we provide a perspective on the development of carbyne.

关键词： carbyne polyyne linear carbon chains

Selective CO_(2)Electroreduction to Multi-Carbon Products on Organic-Functionalized CuO Nanoparticles by Local Micro-Environment Modulation

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Nano-Micro Letters 2024年第12期16卷 120-132页

作者： shan Ren xi Cao Qikui Fan Zhimao yang Fei Wang xin Wang Licheng Bai Jian yang Materials Interfaces Center Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongPeople’s Republic of China Key Laboratory of Functional Molecular Solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002AnhuiPeople’s Republic of China School of Physics Xi’an Jiaotong UniversityXi’an 710049ShaanxiPeople’s Republic of China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongPeople’s Republic of China

Surface functionalization of Cu-based catalysts has demonstrated promising potential for enhancing the electrochemical CO_(2)reduction reaction(CO_(2)RR)toward multi-carbon(C2+)products,primarily by suppressing the parasitic hydrogen evolution reaction and facilitating a localized CO_(2)/CO concentration at the *** upon this approach,we developed surface-functionalized catalysts with exceptional activity and selectivity for electrocatalytic CO_(2)RR to C_(2+)in a neutral *** CuO nanoparticles coated with hexaethynylbenzene organic molecules(HEB-CuO NPs),a remarkable C_(2+)Faradaic efficiency of nearly 90%was achieved at an unprecedented current density of 300 mA cm^(-2),and a high FE(>80%)was maintained at a wide range of current densities(100-600 mA cm^(-2))in neutral environments using a flow ***,in a membrane electrode assembly(MEA)electrolyzer,86.14%FEC2+was achieved at a partial current density of 387.6 mA cm^(-2)while maintaining continuous operation for over 50 h at a current density of 200 mA cm^(-2).In-situ spectroscopy studies and molecular dynamics simulations reveal that reducing the coverage of coordinated K⋅H2O water increased the probability of intermediate reactants(CO)interacting with the surface,thereby promoting efficient C-C coupling and enhancing the yield of C_(2+)*** advancement offers significant potential for optimizing local micro-environments for sustainable and highly efficient C_(2+)production.

关键词： CO_(2)electroreduction to C_(2+) Neutral electrolyte Organic-functionalized CuO nanoparticles Local micro-environment