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Photoionisation detection of a single Er3+ ion with sub-100-ns time resolution

National Science Review 2024年第4期11卷 38-45页

作者： Yangbo Zhang Wenda Fan Jiliang Yang Hao Guan Qi Zhang xi qin Changkui Duan Gabriele G.de Boo Brett C.Johnson Jeffrey C.Mc Callum Matthew J.Sellars Sven Rogge Chunming Yin Jiangfeng Du CAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of New South Wales Centre of Excellence for Quantum Computation and Communication Technology School of Engineering RMIT University Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of Melbourne Centre of Excellence for Quantum Computation and Communication Technology Research School of Physics and Engineering Australian National University

Efficient detection of single optical centres in solids is essential for quantum information processing, sensing and single-photon generation applications.In this work,we use radio-frequency（RF） reflectometry to electrically detect the photoionisation induced by a single Er3+ion in Si.The high bandwidth and sensitivity of the RF reflectometry provide sub-100-ns time resolution for the photoionisation detection.With this technique,the optically excited state lifetime of a single Er3+ion in a Si nano-transistor is measured for the first time to be 0.49±0.04μs.Our results demonstrate an efficient approach for detecting a charge state change induced by Er excitation and relaxation.This approach could be used for fast readout of other single optical centres in solids and is attractive for large-scale integrated optical quantum systems thanks to the multi-channel RF reflectometry demonstrated with frequency multiplexing techniques.

关键词： single optical centres erbium ions RF reflectometry photoionisation detection

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RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su Brandon Tan Chao Shen Wei Li Zhicong Zhao Ying qing xi qin Kitty Wang Keith Leung Mark Boldin Chun-Wei Chen David Ann Zhijian Qian xiaolan Deng Jianjun Chen Zhenhua Chen Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia Research City of HopeDuarteCA 91010USA Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China School of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including tumorigenesis.It was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to tumorigenesis.Here,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in AML.Moreover,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature miR-126.Mechanistically,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of pre-miR-126.YTHDF2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in AML.Overall,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

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用回归模型分析混合所有制类型对企业绩效的影响

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四川大学学报（自然科学版） 2024年第3期61卷 346-351页

作者：邢璇甄佳秦茜茜中共四川省委组织部成都610012 四川省能源投资有限责任公司成都610000 成都理工大学数理学院数学地质四川省重点实验室成都610059

在混合所有制改革中,国有企业通过引入非国有资本来实现股权结构的多元化、提高企业的经济效益.基于不同的所有制形式,除了控股股东之外,股权制衡也可能显著影响企业的绩效.为研究股权制衡与集中对公司绩效的影响,本文将控股股东和股权... 详细信息

在混合所有制改革中,国有企业通过引入非国有资本来实现股权结构的多元化、提高企业的经济效益.基于不同的所有制形式,除了控股股东之外,股权制衡也可能显著影响企业的绩效.为研究股权制衡与集中对公司绩效的影响,本文将控股股东和股权制衡的类型分为三种,并选取2006—2017年间相关上市公司的面板数据作为研究对象,对数据进行分类并利用回归模型对其进行了分析.结果显示,混合Ⅱ型股权制衡与企业绩效在1%置信水平下显著正相关,且在三种混合类型中具有最大的回归系数,说明在国有股东控股的同时引入大宗股份及积极股东等非国有股东进行制衡的混合股权结构可能产生更优的企业绩效.

关键词：回归分析混合所有制绩效

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Simultaneous Dehalogenation and Hydrogenation in Sonogashira Coupling

Precision Chemistry

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Precision Chemistry 2023年第10期1卷 602-607页

作者： Huafeng Chen Lei Zhai Yulan Zuo xi qin Jinling Zhang Kui Tian Peng Xu Department of Chemistry and Chemical Engineering Chongqing University of Science and TechnologyChongqing 401331P.R.China

We herein report a simultaneous dehalogenation and hydrogenation(DHH)reaction in Sonogashira coupling involving hexahalogenobenzene C6X6(X=I,Br),in which a halogen on the aryl polyhalide substrate was substituted by a hydrogen atom.First,a steric bulky terminal alkyne 5 was designed and synthesized to study the influence of the reaction conditions(e.g.,catalyst,solvent,temperature)and the halogens on the substrates C6X6 on the DHH reaction.Moreover,based on the optimized conditions,a terminal alkyne 6 with less steric hindrance was further synthesized to investigate the influence of alkyne on the DHH reaction.As a result,two aromatic polyynes 7 and 8 were were further studied and compared.The influence produced by the alkynes and aryl polyhalides substrate provide insights into Sonogashira coupling involving terminal alkyne with huge steric hindrance and polyhalogenated aromatic hydrocarbons.

关键词： Sonogashira coupling Dehalogenation Hydrogenation Mechanism Photophysical properties

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经济社会与生态用水平衡计算规则与方法

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水资源保护 2024年第3期40卷 1-10页

作者：左其亭全志淼吴青松邱曦秦西张羽郑州大学水利与交通学院河南郑州450001 河南省水循环模拟与水环境保护国际联合实验室河南郑州450001

从平衡的概念出发,针对经济社会与生态用水竞争问题,提出了经济社会与生态用水平衡的概念,并论述了其内涵及特性;构建了经济社会与生态用水平衡计算规则框架,包括遵循四大规律、基于六大理论、考虑六大因素、符合三大准则;提出了经济社... 详细信息

从平衡的概念出发,针对经济社会与生态用水竞争问题,提出了经济社会与生态用水平衡的概念,并论述了其内涵及特性;构建了经济社会与生态用水平衡计算规则框架,包括遵循四大规律、基于六大理论、考虑六大因素、符合三大准则;提出了经济社会与生态用水平衡的计算思路,包括资料处理、量化计算、结果检验3个步骤,并给出了其计算方法和计算结果表征方式。以2019年沁河流域为例,量化了流域经济社会与生态用水平衡;在求解一次平衡点以及经济社会用水刚性约束、生态用水刚性约束、综合效益刚性约束条件下平衡结果的基础上,综合考虑六大因素以及总需水量与水资源总量关系,确定了沁河流域经济社会与生态用水平衡点,即经济社会用水与生态用水的比例为0.71∶0.29。

关键词：经济社会与生态用水平衡区域水平衡计算规则人水关系沁河流域

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Development of novel-nanobody-based lateral-flow immunochromatographic strip test for rapid detection of recombinant human interferon a2b

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Journal of Pharmaceutical Analysis 2022年第2期12卷 308-316页

作者： xi qin Maoqin Duan Dening Pei Jian Lin Lan Wang Peng Zhou Wenrong Yao Ying Guo xiang Li Lei Tao Youxue Ding Lan Liu Yong Zhou Chuncui Jia Chunming Rao Junzhi Wang National Institutes for Food and Drug Control Beijing100050China Synthetic and Functional Biomolecules Center Peking UniversityBeijing100871China WHO Collaboration Centre for Biologicals Standardization and Evaluation Beijing100050China

Recombinant human interferon a2b(rhIFNa2b)is widely used as an antiviral therapy agent for the treatment of hepatitis B and hepatitis C.The current identification test for rhIFNa2b is complex.In this study,an anti-rhIFNa2b nanobody was discovered and used for the development of a rapid lateral flow strip for the identification of rhIFNa2b.RhIFNa2b was used to immunize an alpaca,which established a phage nanobody library.After five steps of enrichment,the nanobody I22,which specifically bound rhIFNa2b,was isolated and inserted into the prokaryotic expression vector pET28a.After subsequent purification,the physicochemical properties of the nanobody were determined.A semiquantitative detection and rapid identification assay of rhIFNa2b was developed using this novel nanobody.To develop a rapid test,the nanobody I22 was coupled with a colloidal gold to produce lateral-flow test strips.The developed rhIFNa2b detection assay had a limit of detection of 1 mg/mL.The isolation of I22 and successful construction of a lateral-flow immunochromatographic test strip demonstrated the feasibility of performing ligand-binding assays on a lateral-flow test strip using recombinant protein products.The principle of this novel assay is generally applicable for the rapid testing of other commercial products,with a great potential for routine use in detecting counterfeit recombinant protein products.

关键词： Recombinant human interferon a2b Nanobody Phage display Screening Rapid test

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现代学徒制视域下高职生工匠精神培养研究

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职业技术 2024年第2期23卷 30-36页

作者：秦希浙江交通职业技术学院杭州311100

学徒制与工匠精神的起源和发展有着密切的联系,这为职业教育人才培养研究提供了独到的视角。本研究旨在从两者的交汇点切入,深入探讨和分析基于现代学徒制如何有效地培养学生的工匠精神,以期丰富工匠精神的培养理论。文章在现代学徒制... 详细信息

学徒制与工匠精神的起源和发展有着密切的联系,这为职业教育人才培养研究提供了独到的视角。本研究旨在从两者的交汇点切入,深入探讨和分析基于现代学徒制如何有效地培养学生的工匠精神,以期丰富工匠精神的培养理论。文章在现代学徒制背景下,对高职生工匠精神培养存在的问题进行了深入、系统的研究,并结合高职教育的当前状况以及技能人才的成长模式,提出了有针对性的培养策略。

关键词：现代学徒制工匠精神高职生职业教育人才培养模式

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计算机信息处理技术在办公自动化中的应用分析

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科学与信息化 2024年第7期 56-58页

作者：秦曦河南省新闻出版学校河南郑州 450000

随着计算机科技的不断发展与进步,计算机信息处理技术在办公自动化中的应用也得到了长足的发展.文章从计算机信息技术应用于办公自动化的优势以及计算机信息处理技术在办公自动化中的具体应用进行分析和阐述,同时,对未来计算机信息处理... 详细信息

随着计算机科技的不断发展与进步,计算机信息处理技术在办公自动化中的应用也得到了长足的发展.文章从计算机信息技术应用于办公自动化的优势以及计算机信息处理技术在办公自动化中的具体应用进行分析和阐述,同时,对未来计算机信息处理技术在办公自动化中的发展方向进行展望.

关键词：信息处理技术计算机办公自动化应用发展

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铜鼓资源组织中的史料文献细粒度知识元研究

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四川图书馆学报 2024年第4期 23-31页

作者：覃熙广西民族大学图书馆南宁530006

铜鼓作为古代文化遗产的重要组成部分,其资源的语义表达形式需要向知识细粒度化、知识集成、知识可视化方向拓展,并充分利用强大的文献资源作为其知识体系的重要支撑。本研究以铜鼓史料文献为研究对象,利用知识元提取和可视化图谱技术,... 详细信息

铜鼓作为古代文化遗产的重要组成部分,其资源的语义表达形式需要向知识细粒度化、知识集成、知识可视化方向拓展,并充分利用强大的文献资源作为其知识体系的重要支撑。本研究以铜鼓史料文献为研究对象,利用知识元提取和可视化图谱技术,探索表层视觉元素与内在知识的关联、铜鼓文献知识元组织模型的构建,以及时空属性向量可视化等问题,提出数据融合的铜鼓知识平台应由至少4个基础数据库组合而成,并展望其下一步探索路径。

关键词：铜鼓知识元细粒度时空向量数据融合

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Positional Isomeric Thiophene-Based π-Conjugated Chromophores:Synthesis,Structure,and Optical Properties

Precision Chemistry

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Precision Chemistry 2023年第9期1卷 548-554页

作者： Huan Yi xi qin Lei Zhai Huiyuan Duan Huafeng Chen Yulan Zuo xin Lian Kui Tian Jinling Zhang Zhengli Liu Peng Xu Department of Chemistry and Chemical Engineering Chongqing University of Science and TechnologyChongqing 401331P.R.China School of Pharmaceutical Sciences Chongqing UniversityChongqing 401331P.R.China

A series of positional isomeric chromophores o-TC,m-TC,and p-TC,in which electron-rich thiophene moieties were connected byπ-conjugated bridges,were divergently synthesized and characterized.Single-crystal X-ray diffraction analysis revealed an intriguing zipper-like packing mode which was adopted by m-TC in the solid state.Subsequently,UV−vis absorption spectra and fluorescence spectra in a series of solvents were investigated.The nearly coplanar para isomer p-TC was found to have the most intense UV−vis absorption,fluorescence emission,and the highest photoluminescence quantum yield.The molecule structure,electronic nature,and origination of the absorption of p-TC were revealed through density functional theory calculations.Interestingly,all three positional isomers exhibited strong and stable electrochemiluminescence emission,which enriched the existing knowledge on the optical properties of thiophene-based oligomers.

关键词： Positional isomers Single-crystal structure UV−vis absorption Fluorescence emission ECL properties DFT simulations

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