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Long noncoding RNAs HAND2-AS1 ultrasound microbubbles suppress hepatocellular carcinoma progression by regulating the miR-873-5p/tissue inhibitor of matrix metalloproteinase-2 axis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1547-1563页

作者： Qiang Zou Hao-Wen Wang xi-Liang di Yuan Li Hui Gao Department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalTianjin 300060China National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030Heilongjiang ProvinceChina Department of Hematology and Oncology Linyi People’s HospitalLinyi 251500Shandong ProvinceChina Department of Comprehensive Oncology Baotou Cancer HospitalBaotou 014030Inner Mongolia Autonomous RegionChina

BACKGROUND Increasing data indicated that long noncoding RNAs(lncRNAs)were directly or indirectly involved in the occurrence and development of tumors,including hepatocellular carcinoma(HCC).Recent studies had found that the expression of lncRNA HAND2-AS1 was downregulated in HCC tissues,but its role in HCC progression is *** targeted microbubble destruction mediated gene transfection is a new method to overexpress *** To study the role of ultrasound microbubbles(UTMBs)mediated HAND2-AS1 in the progression of HCC,in order to provide a new reference for the treatment of *** In vitro,we transfected HAND2-AS1 siRNA into HepG2 cells by UTMBs,and detected cell proliferation,apoptosis,invasion and epithelial-mesenchymal transition(EMT)by cell counting kit-8 assay,flow cytometry,Transwell invasion assay and Western blotting,*** addition,we transfected miR-837-5p mimic into UTMBs treated cells and observed the changes of cell ***,the UTMBs treated HepG2 cells were transfected together with miR-837-5p mimic and tissue inhibitor of matrix metalloproteinase-2(TIMP2)overexpression vector,and we detected cell proliferation,apoptosis,invasion and *** vivo,we established a mouse model of subcutaneous transplantation of HepG2 cells and observed the effect of HAND2-AS1 silencing on tumor formation *** We found that UTMBs carrying HAND2-AS1 restricted cell proliferation,invasion,and EMT,encouraged apoptosis,and HAND2-AS1 silencing eliminated the effect of ***,miR-873-5p targets the gene HAND2-AS1,which also targets the 3’UTR of *** miR-873-5p mimic counteracted the impact of ***,miR-873-5p mimic solely or in combination with pcDNA-TIMP2 had been transformed into HepG2 cells exposed to *** discovered that TIMP2 reversed the effect of miR-873-5p mimic caused by the blocked signalling cascade for matrix metalloproteinase(MMP)2/*** vivo results showed that HAND2-AS1 silencing sig

关键词： Hepatocellular carcinoma Ultrasound microbubbles Long noncoding RNA HAND2-AS1 miR-873-5p Tissue inhibitor of matrix metalloproteinase-2

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Liquid-metal microgrid stretchable electronics based on bionic leaf veins with ultra-stretchability and high conductivity

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Rare Metals 2024年第6期43卷 2747-2757页

作者： xi-di Sun Jun-Yang An Yi-Qi Sun xin Guo Jing Wu Jiang-Bo Hua Meng-Rui Su Yi Shi Li-Jia Pan Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China

Stretchable electronics that monitor joint activity and treat diseases based on liquid metal could be used in the development of healthcare *** devices can be seamlessly integrated with human ***,most high-precision microstructures and complex patterns are difficult to fabricate due to the limitations of conventional fabrication solutions,resulting in suboptimal performance under practical ***,a liquid-metal stretchable system utilizing natural leaf veins was reported as microstructures,which was based on a biomimetic concept and utilized an all-solution process for the preparation of complex *** systems are ultra-high tensile(800%tensile strain),environmentally stable(20 days)and mechanically durable(300-cycle).The system can accurately recognize the wearer's finger bending level as well as simple gesture *** the same time,the system acts as a wearable heater,which can realize the fast heating behavior of heating up to 50℃in 3 min under the human body-safe voltage(1.5 V).The tensile stability is demonstrated by the heterogeneous integration of lasers(405 nm)with the system interconnects for a stretchable and wearable light source.

关键词： Stretchable electronics Liquid metal Stretchable conductor Vein Bionicist electronics

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Effect of care intervention with a health education form for breastfeeding on breast distension,pain,and lactation in postpartum mothers

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World Journal of Clinical Cases 2024年第22期12卷 5059-5066页

作者： xi di Xu-Ling Ge Dan Wang Postpartum Ward Liyang People's Hospital of Jiangsu ProvinceLiyang 213300Jiangsu ProvinceChina Health Management Center Liyang People's Hospital of Jiangsu ProvinceLiyang 213300Jiangsu ProvinceChina Department of Obstetrics Liyang People's HospitalLiyang 213300Jiangsu ProvinceChina

BACKGROUND Breastfeeding not only meets the nutritional needs of newborn growth and development but also promotes uterine contraction and discharge of lochia,which helps in maternal ***,some mothers experience abnormal lactation and breast swelling due to a lack of breastfeeding knowledge,painful cesarean incisions,anesthesia,negative emotions,and other factors,resulting in a reduced breastfeeding rate,which adversely affects neonatal and maternal *** To explore the effects of care intervention with a health education form for breastfeeding on breastfeeding-related *** In this study,207 mothers with postpartum breast pain and difficulty lactating were selected and divided into intervention and control groups using a random number *** groups of mothers were provided with basic nursing and related treatment measures after *** intervention group additionally received care intervention with a health education form for *** scores of lactation volume,breast distension and pain,breastfeeding rate,breastfeeding self-efficacy,treatment effect,and complication rate of the two groups were *** After treatment,the breast pain score of the intervention group was significantly lower than that of the control group,while the lactation score,score of Breastfeeding Self-Efficacy Scale Short Form scale,parent-child communication score,maternal-infant interaction score,total score of maternal-infant communication,and breastfeeding rate of the intervention group were significantly higher than those of the control *** intervention,the overall therapeutic effect of the intervention group was better than that of the control group,and the complication rate of the intervention group was lower than that of the control *** Breastfeeding health education and nursing intervention combined with basic clinical treatment have good clinical effects in managing postpartum breast distension and pain and i

关键词： Breastfeeding Health education Nursing intervention Breast distension and pain Lactation

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基于编码分析的生态产品价值实现机制研究

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中国环保产业 2024年第7期 2463-2467页

作者：杨茜迪陈红敏复旦大学

本研究利用质性分析法对自然资源部发布的四批生态产品价值实现典型案例进行编码分析，揭示在生态产品价值实现中的各类要素投入、产出和分配过程，构建基于价值形成和价值分配分析的生态产品市场价值实现的理论研究框架，旨在完善可持... 详细信息

本研究利用质性分析法对自然资源部发布的四批生态产品价值实现典型案例进行编码分析，揭示在生态产品价值实现中的各类要素投入、产出和分配过程，构建基于价值形成和价值分配分析的生态产品市场价值实现的理论研究框架，旨在完善可持续的生态产品市场价值实现机制，更好地维护生态系统健康、促进生态系统功能提升、实现生态产品价值。

关键词：生态产品生态产品价值生态产品价值实现

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景区环保规则推行面临的困境与应对

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中国环保产业 2024年第7期 2468-2473页

作者：李古月杨茜迪陈红敏复旦大学

旅游业的可持续发展离不开旅游者的积极响应，景区环保规则是引导和规范旅游者环保行为的重要依据。但景区环保规则在落实过程中也面临多方面的质疑，从而导致推行困难，其中包括对规则的出发点、成效和灵活性的质疑等。为提升景区环保... 详细信息

旅游业的可持续发展离不开旅游者的积极响应，景区环保规则是引导和规范旅游者环保行为的重要依据。但景区环保规则在落实过程中也面临多方面的质疑，从而导致推行困难，其中包括对规则的出发点、成效和灵活性的质疑等。为提升景区环保规则推行的有效性，相关部门首先应当促进环保规则的信息透传，引导游客的积极响应；其次，树立并维护景区的生态环保形象，形成景区生态共建共享的氛围；最后，完善景区设施和服务水平，降低游客践行环境责任行为的门槛。

关键词：环保规则低碳旅游环保行为信息透传

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细菌感染患者发生脓毒症的临床特点及危险因素分析

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广东医学 2024年第5期45卷 571-576页

作者：黄迪希欧阳慧罗玉婷纪宇欣刘曦中山大学附属第五医院感染病防治中心广东珠海519000 南华大学附属第二医院重症监护室湖南衡阳421200

目的分析细菌感染患者发生脓毒症的临床特点及危险因素。方法收集2019年10月1日至2020年9月30日细菌培养阳性患者2158例,其中脓毒症组229例,非脓毒症组1929例,收集患者一般资料、实验室检查结果、基础疾病史、临床表现等,比较两组患者... 详细信息

目的分析细菌感染患者发生脓毒症的临床特点及危险因素。方法收集2019年10月1日至2020年9月30日细菌培养阳性患者2158例,其中脓毒症组229例,非脓毒症组1929例,收集患者一般资料、实验室检查结果、基础疾病史、临床表现等,比较两组患者的临床特点并筛选出相关危险因素。采用非条件logistic回归模型分析筛选独立危险因素。结果两组相比,性别、年龄、吸烟、嗜酒、存在充血性心力衰竭、CKD、慢性乙型肝炎、肝硬化、恶性肿瘤差异具有统计学意义(P均<0.05)。男性(OR=2.17,P<0.01)、年龄(OR=1.01,P<0.05)、慢性乙型肝炎(OR=1.86,P<0.05)是脓毒症发生的独立危险因素。结论脓毒症与男性、高龄、吸烟、嗜酒显著相关;存在充血性心力衰竭、CKD、慢性乙型肝炎、肝硬化、恶性肿瘤等基础疾病的患者,更容易发生脓毒症。男性、高龄、慢性乙型肝炎是脓毒症发生的独立危险因素。

关键词：细菌感染脓毒症危险因素

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基于模糊数学评价法优化新疆干辣椒炒牛肉预制菜配方工艺

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中国调味品 2024年第3期49卷 105-111页

作者：顾雪敏王梓棚李喜弟常梅马慧梅洁孔令明新疆农业大学食品科学与药学学院乌鲁木齐830052 新疆西尔丹食品有限公司乌鲁木齐830023

为充分利用新疆四平头干辣椒,拓宽辣椒产业,开发新产品,以新疆四平头干辣椒为主要原料,以色泽和感官评分为指标,在单因素试验的基础上,采用模糊数学综合评价法结合正交试验对新疆干辣椒炒牛肉预制菜的配方工艺参数进行优化。新疆干辣椒... 详细信息

为充分利用新疆四平头干辣椒,拓宽辣椒产业,开发新产品,以新疆四平头干辣椒为主要原料,以色泽和感官评分为指标,在单因素试验的基础上,采用模糊数学综合评价法结合正交试验对新疆干辣椒炒牛肉预制菜的配方工艺参数进行优化。新疆干辣椒炒牛肉预制菜的最佳配方参数为食盐添加量4%、姜粉添加量1.5%、味精添加量5%、淀粉添加量4%。在此配方条件下新疆干辣椒炒牛肉预制菜产品的感官评分最佳,颜色红润,外观光泽鲜亮,风味独特,具有协调浓郁的辣椒香气,辣椒和牛肉的口感鲜明。

关键词：四平头干辣椒预制菜模糊数学评价法配方优化

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Prescribed Performance Tracking Control of Time-Delay Nonlinear Systems With Output Constraints

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1557-1565页

作者： Jin-xi Zhang Kai-di Xu Qing-Guo Wang IEEE the State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110819China Institute of Artificial Intelligence and Future Networks Beijing Normal UniversityZhuhai 519087 Guangdong Key Laboratory of Artificial Intelligence and Multi-Modal Data Processing Beijing Normal University-Hong Kong Baptist University United International CollegeZhuhai 519087

The problem of prescribed performance tracking control for unknown time-delay nonlinear systems subject to output constraints is dealt with in this paper. In contrast with related works, only the most fundamental requirements, i.e., boundedness and the local Lipschitz condition, are assumed for the allowable time delays. Moreover, we focus on the case where the reference is unknown beforehand, which renders the standard prescribed performance control designs under output constraints infeasible. To conquer these challenges, a novel robust prescribed performance control approach is put forward in this ***, a reverse tuning function is skillfully constructed and automatically generates a performance envelop for the tracking error. In addition, a unified performance analysis framework based on proof by contradiction and the barrier function is established to reveal the inherent robustness of the control system against the time delays. It turns out that the system output tracks the reference with a preassigned settling time and good accuracy,without constraint violations. A comparative simulation on a two-stage chemical reactor is carried out to illustrate the above theoretical findings.

关键词： Nonlinear systems output constraints prescribed performance reference tracking time delays

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Tunable structural coloration of ultrathin zirconia nanotubes film

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Rare Metals 2023年第10期42卷 3304-3310页

作者： xi-di Sun Hui-Wen Yu Cheng-Yan Zhao Jing Zhang Yi Shi Li-Jia Pan Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing210093China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China

Zirconium(Zr) is a rare metal widely used in aero space and military ***,its single color does not meet the requirements of camouflage and ***,a series of ultrathin structural colorations of Zr by coating it with a on... 详细信息

关键词： structural film coating

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CToMP: a cycle-task-oriented memory protection scheme for unmanned systems

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Science China(Information Sciences) 2024年第6期67卷 399-417页

作者： Chengyan MA Ning xi di LU Yebo FENG Jianfeng MA School of Cyber Engineering Xidian University School of Computer Science and Technology Xidian University Department of Computer and Information Science University of Oregon

Memory corruption attacks(MCAs) refer to malicious behaviors of system intruders that modify the contents of a memory location to disrupt the normal operation of computing systems, causing leakage of sensitive data or perturbations to ongoing processes. Unlike general-purpose systems, unmanned systems cannot deploy complete security protection schemes, due to their limitations in size, cost and *** in unmanned systems are particularly difficult to defend against. Furthermore, MCAs have diverse and unpredictable attack interfaces in unmanned systems, severely impacting digital and physical sectors. In this paper, we first generalize, model and taxonomize MCAs found in unmanned systems currently, laying the foundation for designing a portable and general defense approach. According to different attack mechanisms,we found that MCAs are mainly categorized into two types — return2libc and return2shellcode. To tackle return2libc attacks, we model the erratic operation of unmanned systems with cycles and then propose a cycle-task-oriented memory protection(CToMP) approach to protect control flows from tampering. To defend against return2shellcode attacks, we introduce a secure process stack with a randomized memory address by leveraging the memory pool to prevent Shellcode from being executed. Moreover, we discuss the mechanism by which CTo MP resists the return-oriented programming(ROP) attack, a novel variant of return2libc attacks. Finally, we implement CTo MP on CUAV V5+ with Ardupilot and Crazyflie. The evaluation and security analysis results demonstrate that the proposed approach CTo MP is resilient to various MCAs in unmanned systems with low footprints and system overhead.

关键词： unmanned system memory corruption attack memory protection system security randomized memory address

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