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evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification

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World Journal of Gastrointestinal Pathophysiology 2020年第3期11卷 64-77页

作者： Mireia Lopez-Siles xavier Aldeguer Miriam Sabat-Mir Mariona Serra-Pagès Sylvia H Duncan Harry J Flint L Jesús Garcia-Gil Margarita Martinez-Medina Laboratory of Molecular Microbiology Biology DepartmentUniversitat de GironaGirona 17003Spain Department of Gastroenterology Hospital Universitari Dr.Josep TruetaGirona 17007Spain Department of Gastroenterology Hospital Santa CaterinaSalt 17190Spain GoodGut SL Girona 17003Spain Microbiology Group Rowett Institute of Nutrition and HealthUniversity of AberdeenAberdeen AB252ZDUnited Kingdom

BACKGROUND The challenges for inflammatory bowel disease(IBD)diagnostics are to discriminate it from gut conditions with similar symptoms such as irritable bowel syndrome(IBS),to distinguish IBD subtypes,to predict disease progression,and to establish the risk to develop colorectal cancer(CRC).Alterations in gut microbiota have been proposed as a source of information to assist in IBD *** prausnitzii(***),its phylogroups,and escherichia coli(***)have been reported as potential biomarkers,but their performance in challenging IBD diagnostic situations remains *** hypothesize that bacterial biomarkers based in these species may help to discriminate these conditions of complex *** To evaluate the usefulness of indices calculated from the quantification of these species as biomarkers to aid in IBD *** A retrospective study of 131 subjects(31 controls(H);45 Crohn’s disease(CD),25 ulcerative colitis(UC),10 IBS,and 20 CRC patients)was performed to assess the usefulness of bacterial biomarkers in ***,the performance of biomarkers in faeces was studied in 29 stool samples(19 CD,10 UC).Relative abundances of total ***(FP),its phylogroups(PHGI and PHGII),and ***(e)quantification were determined by *** were combined to calculate the FP-e index,the PHGI–e index and the PHGII-e *** accuracy to discriminate among conditions was measured by the area under the receiver operating characteristic curve(AUC).ReSULTS In biopsies,FP-e index was good for discriminating IBS from CD(AUC=0.752)while PHGII-e index was suitable for discriminating IBS from UC(AUC=0.632).The FP-e index would be the choice to discriminate IBD from CRC,especially from all UC subtypes(AUC≥0.875),regardless of the activity status of the *** between UC patients that had the longest disease duration and those with CRC featured slightly lower AUC *** differentiation in IB

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Diagnostic tests Faecalibacterium prausnitzii escherichia coli Irritable bowel syndrome Colorectal cancer

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Anomalous transport of light at the phase transition to localization:strong dependence with incident angle

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Photonics Research 2018年第10期6卷 929-942页

作者： eRNeSTO JIMeNeZ-VILLAR M.C.S.xavier NIKLAUS U.WeTTeR VALDeCI MeSTRe WeLITON S.MARTINS GABRIeL F.BASSO V.A.eRMAKOV F.C.MARQUeS GILBeRTO F.De SA Instituto de Pesquisas energeticas e Nucleares CNEN_IPENSao PauloSP 05508-000Brazil Departamento de Ffsica Universidade Federal da ParaibaJoao PessoaPB 58051-970Brazil Departamento de Fisica Universidade Estadual da ParaibaArarunaPB 58233-000Brazil CCeA Universidade Estadual da ParaibaPatosPB 58706-560Brazil Departamento de Fisica Universidade Federal Rural de PernambucoRecifePE 52171-900Brazil Departamento de Informatica Universidade Federal da ParaibaJoao PessoaPB 58055-000Brazil Departamento de Fisica Aplicada Universidade Estadual de CampinasCampinasSP 13083-859Brazil Quimica Fundamental Universidade Federal de PernambucoRecifePE 50670-901Brazil

There has been a growing interest in disordered optical media in recent years due to their potential applications in solar collectors, random lasers, light confinement, and other advanced photonic functions. This paper studies the transport of light for different incidence angles in a strongly disordered optical medium composed of core-shell TiO_2@Silica nanoparticles suspended in an ethanol solution. A decrease of optical conductance and an increase of absorption near the input border are reported when the incidence angle increases. The specular reflection, measured for the photons that enter the sample, is lower than the effective internal reflection undergone by the coherently backscattered photons in the exact opposite direction, indicating a nonreciprocal propagation of *** study represents a novel approach in order to understand the complex physics involved at the phase transition to localization.

关键词：光学介质太阳能通讯技术发展现状

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AVirtual Cloud Storage Architecture for enhanced Data Security

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Computer Systems Science & engineering 2023年第2期44卷 1735-1747页

作者： M.Antony Joans Kumar C.Christopher Columbus e.Ben George T.Ajith Bosco Raj Department of Information Technology St.Xavier’s Catholic College of EngineeringNagercoil629003Tamil NaduIndia Department of Computer Science engineering PSN College of Engineering and TechnologyTirunelveli627152India Department of Computer Science engineering University of Technology and Applied SciencesMuscat112Oman Department of electronics and Communications engineering PSN College of Engineering and TechnologyTirunelveli627152India

The sensitive data stored in the public cloud by privileged users,such as corporate companies and government agencies are highly vulnerable in the hands of cloud providers and *** proposed Virtual Cloud Storage Archi-tecture is primarily concerned with data integrity and conﬁdentiality,as well as *** provide conﬁdentiality and availability,theﬁle to be stored in cloud storage should be encrypted using an auto-generated key and then encoded into distinct *** the encoded chunks ensured theﬁle integrity,and a newly proposed Circular Shift Chunk Allocation technique was used to determine the order of chunk ***ﬁle could be retrieved by performing the opera-tions in *** the regenerating code,the model could regenerate the missing and corrupted chunks from the *** proposed architecture adds an extra layer of security while maintaining a reasonable response time and sto-rage *** results analysis show that the proposed model has been tested with storage space and response time for storage and *** VCSA model consumes 1.5x(150%)storage *** was found that total storage required for the VCSA model is very low when compared with 2x Replication and completely satisﬁes the CIA *** response time VCSA model was tested with different sizedﬁles starting from 2 to 16 *** response time for storing and retrieving a 2 MBﬁle is 4.96 and 3.77 s respectively,and for a 16 MBﬁle,the response times are 11.06 s for storage and 5.6 s for retrieval.

关键词： erasure code regenerating code cryptography virtual cloud storage architecture circular shift chunk allocation algorithm

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Anomalous transport of light at the phase transition to localization:strong dependence with incident angle

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Photonics Research 2018年第10期 55-68页

作者： IPeN M.C.S.xavier IPeN VALDeCI MeSTRe WeLITON S.MARTINS GABRIeL F.BASSO V.A.eRMAKOV F.C.MARQUeS GILBeRTO F.De S Instituto de Pesquisas energéticas e Nucleares CNeN Departamento de F?′sica Universidade Federal da Para?′ba Departamento de F?′sica Universidade Estadual da Para?′ba 4. Instituto de Pesquisas Energéticas e Nucleares CNEN 5. CCEA Universidade Estadual da Para?′ba 6. Departamento de F?′sica Universidade Federal Rural de Pernambuco 7. Departamento de Informática Universidade Federal da Para?′ba 8. Departamento de F?′sica Aplicada Universidade Estadual de Campinas 9. Qu?′mica Fundamental Universidade Federal de Pernambuco

There has been a growing interest in disordered optical media in recent years due to their potential applications in solar collectors, random lasers, light confinement, and other advanced photonic functions. This paper studies the transport of light for different incidence angles in a strongly disordered optical medium composed of core-shell TiO@Silica nanoparticles suspended in an ethanol solution. A decrease of optical conductance and an increase of absorption near the input border are reported when the incidence angle increases. The specular reflection, measured for the photons that enter the sample, is lower than the effective internal reflection undergone by the coherently backscattered photons in the exact opposite direction, indicating a nonreciprocal propagation of *** study represents a novel approach in order to understand the complex physics involved at the phase transition to localization.

关键词： der exp Anomalous transport of light at the phase transition to localization:strong dependence with incident angle

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外周阻滞对炎症导致的大鼠前列腺素e2和环氧合酶表达的影响

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麻醉与镇痛 2011年第1期7卷 49-57页

作者： Helene Beloeil Marc Gentili Dan Benhamou Jean-xavier Mazoit 罗小会(译) 杜金(校) Univ Paris-Sub laboratoire d'Anesthesie UPRES EA3540 F-94276 Le Kremlin Bicatre France 不详

背景外周炎性疼痛与脊髓COX-2（环氧合酶-2）上调及随之而来的中枢前列腺素e2（PGe2）水平升高和痛觉超敏的发生有关。本研究中，我们评估了布比卡因经神经阻滞和全身应用对PGe2和COX在外周炎症大鼠模型脊髓表达的影响。方法所有大鼠随... 详细信息

背景外周炎性疼痛与脊髓COX-2（环氧合酶-2）上调及随之而来的中枢前列腺素e2（PGe2）水平升高和痛觉超敏的发生有关。本研究中，我们评估了布比卡因经神经阻滞和全身应用对PGe2和COX在外周炎症大鼠模型脊髓表达的影响。方法所有大鼠随机接受3种注射：①左后爪皮下注射（0．2ml2％w／v角又聚糖或盐水），②左坐骨神经阻滞（0．2ml0．5％布比卡因或盐水），③全身注射（肩胛间皮下0．2ml0．5％布比卡因或盐水）。测量局部水肿、发热、机械性痛觉超敏、脑脊液PGe2浓度和脊髓背根神经节COX-1、COX-2表达。结果证实布比卡因阻滞可以自0弱炎性疼痛模型的痛觉超敏和局部炎症，这一效果可能与抑制外周炎症导致脊髓和背根神经节的COX-2表达增强有关。脑脊液PGe2的生成也被削弱。全身应用布比卡因没有减轻痛觉超敏和局部炎症或COX表达。结论本研究结果强烈提示，局部麻醉药全身用药或神经阻滞，是在不同水平起作用的。

关键词：坐骨神经阻滞前列腺素e2 大鼠模型外周炎症环氧合酶脊髓背根神经节 COX-2表达酶表达

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Biomonitoring the <i>Vitex gardneriana</i>Shauer (Lamiaceae) Toxic effects to Shed Light on Bioactive Compounds against a Major Coconut Pest Mite

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American Journal of Plant Sciences 2021年第11期12卷 1601-1612页

作者： Anderson Soares de Almeida Caroline Rabelo Coelho Mirele Santana de Sá edson de Souza Bento Alberto Wisniewski Junior Adenir Vieira Teodoro Haroudo Sátiro xavier Jose Guedes de Sena Filho Departamento de Farmácia Universidade Federal de Sergipe Cidade Universitária Professor José Aloísio de Campos Avenida Mare-chal Rondon s/n Bairro Jardim Rosa Elze S&#227 o Cristóvã o Brazil Universidade estadual do Maranhã o Cidade Universitária Paulo VI s/n Bairro Tirirical S&#227 o Luís Brazil Petroleum and energy from Biomass Research Group (PeB) Department of Chemistry Federal University of Sergipe S&#227 o Cristóvã o Brazil Instituto de Química e Biotecnologia Universidade Federal de Alagoas Cidade Universitária Campus Aristóteles Calazans Sim&#245 es Avenida Lourival Melo Mota s/n Bairro Tabuleiro do Martins Maceió Brazil embrapa Tabuleiros Costeiros Bairro Jardins Aracaju Brazil Departamento de Ciências Farmacêuticas Universidade Federal de Pernambuco Cidade universitária Recife Brazil

The coconut mite, Aceria guerreronis Keifer (Acari: eriophyidae), is a major pest of coconut plantations (Cocos nucifera L.) worldwide. Here, we conducted a bioguided phytochemical approach using toxicity and repellency bioassays of nonpolar extract and its fractions of Vitex gardneriana Schauer (Lamiaceae) leaves to this pest. Nonpolar crude extract was fractionated by column chromatography using solvents with increased polarity and binary mixtures, resulting in five semipurified groups. The biomonitoring bioassay provided active fractions and led to the isolation and characterization of the bioactive compound squalene, a biosynthetic precursor of 20-hydroxyecdysone, which plays an important role in plant defense against arthropods. The LC50 of the crude extract of V. gardneriana for A. guerreronis was estimated to be 0.185 mg·mL-1 and LC80 = 4.123 mg·mL-1. Also, the extract was highly repellent to this pest for up to 24 h. The fractions of V. gardneriana, and also squalene, caused mortality to A. guerreronis. The potential of V. gardneriana fractions/squalene as biopesticides for controlling A. guerreronis in coconut plantations is discussed herein.

关键词： Bioassay Toxicity Phytochemistry Terpene Biopesticides Biorational Control

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Changes in aminoacidergic and monoaminergic neurotransmission in the hippocampus and amygdala of rats after ayahuasca ingestion

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World Journal of Biological Chemistry 2013年第4期4卷 141-147页

作者： eduardo Ferreira de Castro-Neto Rafael Henrique da Cunha Dartiu xavier da Silveira Mauricio Yonamine Telma Luciana Furtado Gouveia esper Abr o Cavalheiro Débora Amado Maria da Gra a Naffah-Mazzacoratti Departamento Neurologia/Neurocirurgia Universidade Federal de S o Paulo Departamento de Psiquiatria Universidade Federal de S o Paulo Faculdade de Ciências Farmacêuticas Universidade de S o Paulo Departamento de Bioquímica Universidade Federal de S o Paulo

AIM: To evaluate changes in neurotransmission induced by a psychoactive beverage ayahuasca in the hippocampus and amygdala of naive rats. MeTHODS: The level of monoamines, their main metabolites and amino acid neurotransmitters concentrations were quantified using high performance liquid chromatography(HPLC). Four groups of rats were employed: saline-treated and rats receiving 250, 500 and 800 mg/kg of ayahuasca infusion(gavage). Animals were killed 40 min after drug ingestion and the structures stored at-80 ℃ until HPLC assay. The data from all groups were compared using Analysis of variance and Scheffé as post test and P epted as significant. ReSULTS: The results showed decreased concentrations of glycine(GLY)(0.13 ± 0.03 vs 0.29 ± 0.07, P e amygdala of rats that received 500 of ayahuasca. Animals that ingested 800 mg/kg of ayahuasca also showed a reduction of GLY level(0.11 ± 0.01 vs 0.29 ± 0.07, P e hippocampus, increased GABA levels were found in rats that received all ayahuasca doses: 250 mg/kg(1.29 ± 0.19 vs 0.84 ± 0.21, P eased utilization rate of all monoamines was found in the amygdala after ayahuasca administration in doses: 250 mg/kg(noradrenaline: 0.16 ± 0.02 vs 0.36 ± 0.06, P e: 0.39 ± 0.012 vs 2.39 ± 0.84, P erotonin: 1.02 ± 0.22 vs 4.04 ± 0.91, P enaline: 0.08 ± 0.02 vs 0.36 ± 0.06, P e: 0.33 ± 0.19 vs 2.39 ± 0.84, P erotonin: 0.59 ± 0.08 vs 4.04 ± 0.91, P enaline: 0.16 ± 0.04 vs 0.36 ± 0.06, P e: 0.84 ± 0.65 vs2.39 ± 0.84, P erotonin: 0.36 ± 0.02 vs 4.04 ± 0.91, P est increased release of inhibitory amin

关键词： Ayahuasca Amino Acids Monoamines Hippocampus Amygdala

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Membrane and Subcellular Muscle Injury Are Induced by Single or Multiple exposure to Cigarette Smoke

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Open Journal of Pathology 2014年第3期4卷 125-137页

作者： Ana Maria Fleig-Mayer Alba Ramirez-Sarmiento Amanda Iglesias Montserrat Morla Carlos Coronell Diego Rodríguez Simona Pichinni Josep Lloreta Piergiorgio Zuccaro xavier Busquets Joaquim Gea Jose R.Jardim Mauricio Orozco-Levi Centro Universitario do Triangulo(UNITRI) Avenida nicomedes Alves Dos Santos4545-GaveaUberlandiaPulmonary Rehabilitation CenterRespiratory DivisionFederal University of Sao PauloSao PauloBrazil Group of Research in Injury Immune Response and Function(LIF)Municipal Institute of Medical Research(IMIM)Carrer Dr.Aiguader 88BarcelonaE-08003Spain Servei de Pneumologia Hospital del MarPasseig Maritim 25BarcelonaE-08003Spain Centro en Red de Investigacion de enfermedades Respiratorias(CIBeReS) Recinto Hospital Joan March Carretera Soller Km.1207110BunyolaMallorcaIlles BalearsSpain Institut Universitari d’Investigacio en Ciencies de la Salut(IUNICS)and Department de Biologia Universitat Illes Balears(UIB)Cra de ValldemossaKm 7.5PalmaIlles BalearsSpain Laboratorio Di Biochimica Clinica Istituto Superiore Di Sanita.Viale Regina Elena 29900161RomaItaly Respiratory Department Fundacion Cardiovascular de ColombiaCalle 155A 23-58FloridablancaSantanderColombia Servei d’Anatomia Patologica Hospital del MarPasseig Maritim 25BarcelonaE-08003Spain

Cigarette smoking is the main cause of chronic obstructive pulmonary disease (COPD). Diaphragm injury is observed in patients with COPD. However, the potential role of smoking in triggering or perpetuating muscle injury is unknown. The present study was aimed at evaluating the potential role of commercial tobacco smoke as a direct cause of skeletal muscle injury in experimental conditions. Seventy Wistar rats (170 - 250 g) were assigned to smoking (n = 49) or non-smoking (n = 21) groups. The smoking groups were submitted to a single or multiple (i.e., five or thirty) daily sessions of cigarette smoking in an inhalatory chamber (time length: 2 h each session). The level of exposure was constant and assessed by CO concentrations (50 ppm) and serum cotinine analysis. Animals submitted to a single smoke exposure and the corresponding controls were euthanized in groups at 0 h, 2 h, 4 h, 24 h or 48 h after completing the exposure. Animals submitted to multiple exposures were euthanized at 0 h after smoking. Samples from vastus lateralis muscle were obtained and processed for assessing cell injury and selected protein expression. Monoclonal anti-albumin antibodies were used to identify muscle fibers with sarcolemmal (membrane) injury. Subcellular muscle injury was assessed using transmission electron microscopy (eM). MyoD, myogenin and α-tubulin were immunodetected using western blot techniques. exposure to cigarette smoke associated with significant membrane damage (mean relative difference (MRD) with controls: +181%, p = 0.004) and sarcomere disruptions (MRD: +226%, p = 0.001). expression of MyoD and myogenin (normalized to α-tubulin) were significantly increased at 4 h and remained increased at 48 h post-exposure. We conclude that not only a single but also consecutive exposure to tobacco smoke have acute deleterious effects on peripheral muscle structure. A rapid induction of subrogate markers of skeletal muscle stress and repair processes associates to sarcolemmal and

关键词： Skeletal Muscle Muscle Injury Muscle Regeneration Quadriceps Cigarette Smoking

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The effect of a<i>Lactobacillus</i>-Based Probiotic for the Control of Necrotic enteritis in Broilers

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Food and Nutrition Sciences 2013年第11期4卷 1-7页

作者： Sherryll Lynn Layton Xochitl Hernandez-Velasco Shivaramaiah Chaitanya Jorge xavier Anita Menconi Juan David Latorre Gopala Kallapura Vivek Ayamchirakkunnel Kuttappan Ross elderon Wolfenden Raphael Lucio Andreatti Filho Billy Marshal Hargis Guillermo Téllez Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México México City México Department of Poultry Science University of Arkansas Fayetteville USA Department of Poultry Science University of Arkansas Fayetteville USA Vetanco Argentina S.A. Chile 33 (B1603CMA) Vicente López Buenos Aires Argentina Department of Veterinary Clinics FMVZ UNESP Campus Botucatu Brazil. Pacific Vet Group-USA Inc. Creek View Drive Fayetteville USA Vetanco Argentina S.A. Chile 33 (B1603CMA) Vicente López Buenos Aires Argentina

Necrotic enteritis (Ne) caused by Clostridium perfringens (CP) in poultry is probably the most important bacterial disease in terms of economic implications. The disease is multi-factorial and is invariably associated with predisposing factors. The present study investigated the effect of a commercially available Lactobacillus-based probiotic (FM-B11) for the control of necrotic enteritis in broiler chickens. In experiment 1, one-day-of-hatch broiler chicks were randomly allocated to the following treatment groups: 1) Non-challenged (NC);2) Challenged (C);3) Challenged + probiotic (C+ FM-B11). Prior to placement, chicks in groups 2 and 3 received 0.25 mL of Salmonella typhimurium (ST) containing 105 cfu of viable cells by oral gavage. At 14, 15 and 16 days of age, all chicks in group 3 were treated with FM-B11 in the drinking water at a concentration of 106 cfu/ml. At 21d of age, all chicks in groups 2 and 3, were individually challenged with 5 × 104 sporulated oocysts of e. maxima by oral gavage. At 26d of age, all chicks in groups 2 and 3, were individually challenged with 108 cfu CP;body weight (BW) was recorded prior to challenge. The experiment was terminated at 29 days of age and the following parameters were evaluated: Ne-associated mortality, CP lesion scores, CP concentrations in ileum, BW, and body weight gain (BWG). Chicks treated with FM-B11 had significantly (P er body weight gain after challenge when compared to control challenge chickens. Total mortality was higher in the C group (48.8%) when compared to the C + FM-B11 (12.7%). even though there was no significant (P > 0.05) difference in lesion score between C and C + FM-B11, group C + FM-B11 had significantly (P er total number of cfu of CP recovered from the ileal mucosa and content samples when compared to group C. experiment 2 was a unique and remarkable case report of a field outbreak of Ne in a commercial broiler farm in Argentina. A reduction and control of the mortality

关键词： Lactobacillus Necrotic enteritis Salmonella Coccidiosis Probiotic

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erratum to“The power of many brains:Catalyzing neuropsychiatric discovery through open neuroimaging data and large-scale collaboration”[Sci Bull 2024;69:1536-1555]

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Science Bulletin 2024年第17期69卷 2793-2793页

作者： Bin Lu Xiao Chen Francisco xavier Castellanos Paul MThompson Xi-Nian Zuo Yu-Feng Zang Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100101China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew York 10016USA Nathan Kline Institute for Psychiatric Research Orangeburg 10962USA Imaging Genetics Center Mark&Mary Stevens Institute for Neuroimaging&InformaticsKeck School of MedicineUniversity of Southern CaliforniaLos Angeles 90033USA Developmental Population Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China National Basic Science Data Center Beijing 100190China Centre for Cognition and Brain Disorders The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310004China Institute of Psychological Science Hangzhou Normal UniversityHangzhou 310030China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairment Hangzhou 311121China International Big-Data Center for Depression Research Institute of PsychologyChinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China

The publisher regrets to note that reference citation errors have occurred in panels b,c,e-l in Fig 2 and the sentence“However,the literature reports both decreased and increased intra-network functional connections among patients with depression[115,116].”The publisher would like to apologise for any inconvenience *** neuroimaging findings in major depressive disorder.(a)Decreased intra-DMN FC is observed in recurrent MDD patients[35].(b)eight-week antidepressant treatment reduce extensive large-scale functional networks[107].(c)Reduced global and local efficiency(eglob/eloc)are revealed in MDD patients[108].(d)Structural variations of the cortex and subcortical nuclei are found in eNIGMA-MDD studies[82].(e)Accelerated brain aging based on functional MRI is observed in MDD patients[114].(f)Accelerated brain aging based on structural MRI is observed in MDD patients[115].(g)Two subtypes of MDD can be identified through DMN FC[127].(h)A significant schizophrenia PRS by MDD interaction for rostral anterior cingulate cortex thickness is found in the UK Biobank dataset[215].(i)Stability of the four MDD subtypes based on FC[126].(j)The two subtypes of MDD exhibit distinct patterns of FC within and between SMS,DMN,and subcortical structures[130].(k)Performance of the functional connectivity-based classifiers across two multicenter datasets[135].(l)Salient brain regions that serve as important classification features for the graph convolutional network-based classifier[136].Brain-PAD:brain-predicted age difference;DAN:dorsal attention network;DMN:default mode network;FC:functional connectivity;FeDN:first-episode and drug-naïve;FPN:frontoparietal network;GCN:graph convolutional neural network;HC:healthy control;linear-SVM:linear support vector machine;MDD:major depressive disorder;mddrest:ReST-meta-MDD dataset;NC:normal control;RACC:rostral anterior cingulate cortex;PRS:polygenic risk score;psymri:PsyMRI dataset;rbf-SVM:radial basis function support vector

关键词： cortex network scale

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