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The 2<sup>nd</sup>Step by Step International Spinal Cord Repair—Combining research Step by Step into multi-pronged approaches for spinal cord repair

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Journal of Biomedical Science and Engineering 2013年第7期6卷 21-32页

作者： Maria Teresa Moreno-Flores Francois Ferón Victor Arvanian Armin Blesch Armin Curt David J. Fink Marina Mata Kinichi Nakashima xavier navarro Francisco Javier Rodríguez Michal Schwartz Mikael Svensson Erik Sundstrom Joan Romero Filip Lim Department of Biotechnology University Francisco de Vitoria Pozuelo de Alarcón Spain Department of Cell Biology Physiology and Immunology University Autonoma de Barcelona Barcelona Spain Department of Medicine University Hospital Balgrist Zurich Switzerland Department of Molecular Biology University Autónoma de Madrid Madrid Spain Department of Neurobiology Care Sciences and Society Karolinska Institute Stockholm Sweden Department of Neurobiology Weizmann Institute of Science Rehovot Israel Department of Neurology University of Michigan Ann Arbor USA Department of Stem Cell Biology and Medicine Kyushu University Fukuoka Japan Faculty of Medicine Aix Marseille University Marseille France National Paraplegics Hospital Toledo Spain Northport Veterans Affairs Medical Center Northport USA Spinal Cord Injury Center University Hospital Heidelberg Germany Step by Step Foundation Barcelona Spain

On April 26-27, 2013, the Step by Step Foundation hosted the Second International Spinal Cord Repair Meeting at the Fira Barcelona Convention Center in Hospitalet de Llobregat, Spain, highlighting some of the exciting research including clinical trials which show promise for treatments for this devastating disorder. This meeting brought together clinicians, clinical scientists and molecular biologists from more than 10 countries to evaluate current knowledge on clinical, cellular, and biomolecular aspects of spinal cord injury. A major goal of the conference in advancing the translation of research data to the clinic was to promote multi-pronged approaches for therapy of this complex problem.

关键词： Spinal Cord Injury Immunomodulation Glial Scar Nerve Grafts Neurotrophins Neural Stem Cells Electromagnetic Stimulation HSV-1 Vectors Cholecalciferol Vitamin D3 Wnt Proteins Neuroregeneration

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Transanal endoscopic surgery in rectal cancer

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World Journal of Gastroenterology 2014年第33期20卷 11538-11545页

作者： xavier Serra-Aracil Laura Mora-Lopez Manel Alcantara-Moral Aleidis Caro-Tarrago Carlos Javier Gomez-Diaz Salvador navarro-Soto Coloproctology Unit General and Digestive Surgery Service Parc Tauli University Hospital Universitat Autònoma de Barcelona 08208 Sabadell (Barcelona) Spain

Total mesorectal excision(TME) is the standard treatment for rectal cancer, but complications are frequent and rates of morbidity, mortality and genitourinary alterations are high. Transanal endoscopic microsurgery(TEM) allows preservation of the anal sphincters and, via its vision system through a rectoscope, allows access to rectal tumors located as far as 20 cm from the anal verge. The capacity of local surgery to cure rectal cancer depends on the risk of lymph node invasion. This means that correct preoperative staging of the rectal tumor is necessary. Currently, local surgery is indicated for rectal adenomas and adenocarcinomas invading the submucosa, but not beyond(T1). Here we describe the standard technique for TEM, the different types of equipment used, and the technical limitations of this approach. TEM to remove rectal adenoma should be performed in the same way as if the lesion were an adenocarcinoma, due to the high percentageof infiltrating adenocarcinomas in these lesions. In spite of the generally good results with T1, some authors have published surprisingly high recurrence rates; this is due to the existence of two types of lesions, tumors with good and poor prognosis, divided according to histological and surgical factors. The standard treatment for rectal adenocarcinoma T2N0M0 is TME without adjuvant therapy. In this type of adenocarcinoma, local surgery obtains the best results when complete pathological response has been achieved with previous chemoradiotherapy. The results with chemoradiotherapy and TEM are encouraging, but the scientific evidence remains limited at present.

关键词： Rectal cancer Rectal adenocarcinoma Transanal endoscopic microsurgery Transanal endo-scopic surgery Colorectal cancer

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Sphincter lesions observed on ultrasound after transanal endoscopic surgery

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World Journal of Gastroenterology 2015年第46期21卷 13160-13165页

作者： Laura Mora López xavier Serra-Aracil Salvador navarro Soto General and Digestive Surgery Service Parc Tauli University HospitalUniversidad Autonoma Barcelona

AIM: To assess the morphological impact of transanal endoscopic surgery on the sphincter apparatus using the modified Starck classification. METHODS: A prospective,observational study of 118 consecutive patients undergoing Transanal Endoscopic Operation/Transanal Endoscopic Microsurgery(TEO/TEM) from March 2013 to May 2014 was performed. All the patients underwent an endoanal ultrasound prior to surgery and one and four months postoperatively in order to measure sphincter width,identify sphincter defects and to quantify them in terms of the level,depth and size of the affected anal canal. To assess the lesions,we used the "modified" Starck classifi-cation,which incorporates the variable "sphincter fragmentation". The results were correlated with the Wexner incontinence ***: Of the 118 patients,twelve(sphincter lesions) were excluded. The results of the 106 patients were as follows after one month: 31(29.2%) lesions found on ultrasound after one month,median overall Starck score of 4(range 3-6); 10(9.4%) defects in the internal anal sphincter(IAS) and 3(2.8%) in the external anal sphincter(EAS); 17 patients(16%) had fragmentation of the sphincter apparatus with both sphincters affected in one case. At four months: 7(6.6%) defects,all in the IAS,overall median Starck score of 4(range 3-6). Mean IAS widths were 3.5 mm(SD 1.14) preoperatively,4.38 mm(SD 2.1) one month postoperatively and 4.03 mm(SD 1.46) four months postoperatively. The only statistically significant difference in sphincter width in the IAS measurements was between preoperatively and one month postoperatively. No incontinence was reported,even in cases of ultrasound ***: TEO/TEM may produce ultrasounda b n o r m a l i t i e s b u t t h i s i s n o t a c c o m p a n i e d b y clinical changes in continence. The modified Starck classification is useful for describing and managing these disorders.

关键词： Transanal endoscopic surgery Endoscopic ultrasound

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软组织封闭术在美学区域单颗牙缺失种植修复和引导骨组织再生中的应用

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中国口腔医学继续教育杂志 2018年第5期21卷 257-268页

作者： Bruno Negri Otto Zuhr Stefan Fickl xavier Rodriguez Ciurana Jose Manuel navarro Martinez Victor Mendez Blanco 黎艳珊(译) 滕伟(审) 不详中山大学光华口腔医学院·附属口腔医院 510000

目的:即便是对牙拔除术后的生物学效应有全面的了解,前牙的种植修复仍被认为是十分复杂的。前牙美学种植修复的目标是唇侧的软组织和龈乳头保持稳定。如何处理新鲜拔牙创以最大限度保存牙槽嵴是临床医师在每天的临床实践中都要面对的一... 详细信息

目的:即便是对牙拔除术后的生物学效应有全面的了解,前牙的种植修复仍被认为是十分复杂的。前牙美学种植修复的目标是唇侧的软组织和龈乳头保持稳定。如何处理新鲜拔牙创以最大限度保存牙槽嵴是临床医师在每天的临床实践中都要面对的一个问题。保存牙槽嵴轮廓往往益于后续治疗的实施。材料与方法:本文将通过3个病例来进行讲述这些技术的应用。结果:软组织封闭术和位点保存技术结合即刻种植、早期种植、延期种植对于单颗牙的修复有重要意义。然而,在不同条件下选择牙槽嵴保存技术的效应仍需进一步明确。

关键词：种植修复前牙美学引导骨组织再生牙缺失软组织封闭术保存技术生物学效应

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Research and development of the back-end electronics for the two-dimensional improved resistive plate chambers in CMS upgrade

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Radiation Detection Technology and Methods 2021年第2期5卷 181-191页

作者： P.Cao Z-A.Liu J.Zhao H.Kou J.Tao J.Song W.Gong N.Wang A.Samalan M.Tytgat N.Zaganidis G.A.Alves F.Marujo F.Torres.Da.S.ilva.De.Araujo E.M.Da Costa D.De Jesus Damiao H.Nogima A.Santoro S.Fonseca De Souza A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.Shopova G.Sultanov M.Bonchev A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov S.J.Qian C.Bernal A.Cabrera J.Fraga A.Sarkar S.Elsayed Y.Assran M.El Sawy M.A.Mahmoud Y.Mohammed X.Chen C.Combaret M.Gouzevitch G.Grenier I.Laktineh L.Mirabito K.Shchablo I.Bagaturia D.Lomidze I.Lomidze V.Bhatnagar R.Gupta P.Kumari J.Singh V.Amoozegar B.Boghrati M.Ebraimi R.Ghasemi M.Mohammadi Najafabadi E.Zareian M.Abbrescia R.Aly W.Elmetenawee N.De Filippis A.Gelmi G.Iaselli S.Leszki F.Loddo I.Margjeka G.Pugliese D.Ramos L.Benussi S.Bianco D.Piccolo S.Buontempo A.Di Crescenzo F.Fienga G.De Lellis L.Lista S.Meola P.Paolucci A.Braghieri P.Salvini P.Montagna C.Riccardi P.Vitulo B.Francois T.J.Kim J.Park S.Y.Choi B.Hong K.S.Lee J.Goh H.Lee J.Eysermans C.Uribe Estrada I.Pedraza H.Castilla-Valdez A.Sanchez-Hernandez C.A.Mondragon Herrera D.A.Perez navarro G.A.Ayala Sanchez S.Carrillo E.Vazquez A.Radi A.Ahmad I.Asghar H.Hoorani S.Muhammad M.A.Shah I.Crotty Department of Physics and Astronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium Centro Brasileiro Pesquisas Fisicas R.Dr.Xavier Sigaud150-UrcaRio de JaneiroRJ 22290-180Brazil Dep.de Fisica Nuclear e Altas Energias Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524BR-Rio de Janeiro 20559-900RJBrazil Bulgarian Academy of Sciences Inst.for Nucl.Res.and Nucl.EnergyTzarigradsko shaussee Boulevard 721784 SofiaBulgaria Faculty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria School of Physics Peking UniversityBeijing 100871China Institute of High Energy Physics UCAS/CAS19(B)Yuquan RoadShijingshan DistrictBeijing 100049China Universidad de Los Andes Apartado Aereo 4976Carrera 1Eno.18A 10BogotaCOColombia Egyptian Network for High Energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt The British University in Egypt(BUE) P.O.Box 43Elsherouk CitySuez Desert RoadCairo 11837Egypt Suez University Elsalam CitySuez-Cairo RoadSuez 43522Egypt Department of Physics Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Center for High Energy Physics Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgian Technical University 77 Kostava Str.Tbilisi 0175Georgia Department of Physics Panjab UniversityChandigarh 160014India School of Particles and Accelerators Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531TehranIran School of Engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso Univ.Monte S.AngeloVia Cintia80126 NaplesItaly INFN Sezione di PaviaVia Bassi 6PaviaItaly INFN Sezione di Pavia and University of PaviaVia Bassi 6PaviaItaly Hanyang University 222 Wangsimni-roSageun-dongSeongdong

Purpose To complement and ensure redundancy in the endcap muon system of the Compact Muon Solenoid(CMS)detector and to extend the Resistive Plate Chamber(RPC)system coverage,improved RPCs(iRPCs)with either orthogonal layer strips with one-end electronics or single layer strips with two-end electronics providing more precise time measurement will be installed in the very forward pseudorapidity region of|η|<*** iRPC readout system needs to support twodimensional(2D)or two-end *** addition,it must combine detector data with Timing,Trigger and fast Control(TTC)and Slow Control(SC)into one data stream over a bi-directional optical link with a line rate of 4.8 Gb/s between the Front-End Electronics(FEE)and the Back-End Electronics(BEE).To fulfill these requirements,a prototype BEE for the iRPC 2D chamber has been researched and *** A Micro-Telecommunication and Computing Architecture(μTCA)-based processing card was designed in this study to establish a prototype system together with aμTCA *** Giga-Bit Transceiver(GBT)protocol is integrated to provide bi-directional communication between the FEE and BEE.A server is connected with the BEE by a Gigabit Ethernet(GbE)link for SC and a 10-GbE link for Data AcQuisition(DAQ).Results The Bit Error Rate(BER)test of the back-end board and a joint test with the iRPC 2D prototype chamber were *** less than 1.331×10−16 was *** timemeasurement with a resolution of 3.05 nswas successfully realized,and detector efficiencies of 97.7%for longitudinal strips and 96.0%for orthogonal strips were *** results demonstrate the correctness and reliability of the prototype *** The BEE prototype satisfies the requirements for the iRPC 2D chamber,and it worked stably and reliably during a long-term joint test run.

关键词： CMS iRPC TTC SC BEE μTCA GBT DAQ

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