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hVOF-sprayed hAp/S53P4 BG composite coatings on an AZ31 alloy for potential applications in temporary implants

Journal of Magnesium and Alloys 2024年第1期12卷 345-360页

作者： Carlos A.Poblano-Salas John henao Astrid L.Giraldo-Betancur Paola Forero-Sossa Diego German Espinosa-Arbelaez Jorge A.González-Sánchez Luis R.Dzib-Pérez Susana t.Estrada-Moo Idelfonso E.Pech-Pech CIAtEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAhCYt-CIAtEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAhCYt-Cinvestav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Universidad tecnológica de Querétaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDESI Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Center for Corrosion Research Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive thermal spray coatings produced via high-velocity oxygen fuel spray(hVOF)from hydroxyapatite(hAp)and bioactive glasses(BG)have the potential to be employed on temporary implants due to the ability of both hAp and BG to dissolve and promote osseointegration,considering that both phases have different reaction and dissolution rates under in-vitro *** the present work,75%***-25%wt.S53P4 bioactive glass powders were hVOF-sprayed to obtain hAp/S53P4 BG composite coatings on a bioresorbable AZ31 *** study is focused on exploring the effect of the stand-off distance and fuel/oxygen ratio variation as hVOF parameters to obtain stable structural coatings and to establish their effect on the phases and microstructure produced in those *** characterization techniques,such as scanning electron microscopy,X-ray diffraction,and Fourier transform infrared spectroscopy,were employed to characterize relevant structural and microstructural properties of the composite *** results showed that thermal gradients during coating deposition must be managed to avoid delamination due to the high temperature achieved(max 550℃)and the differences in coefficients of thermal *** was also found that both spraying distance and oxygen/fuel ratio allowed to keep the hydroxyapatite as the main phase in the *** addition,in-vitro electrochemical studies were performed on the obtained hAp/S53P4 BG composite coatings and compared against the uncoated AZ31 *** results showed a significant decrease in hydrogen evolution(at least 98%)when the bioactive coating was applied on the Mg alloy during evaluation in simulated body fluid(SBF).

关键词： Coatings Composites thermal spray temporary implants hydrogen evolution

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Is Being Funny a Useful Policy?how Local Governments' humorous Crisis Response Strategies and Crisis Responsibilities Influence trust,Emotions,and Behavioral Intentions

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International Journal of Disaster Risk Science 2022年第5期13卷 676-690页

作者： Janna hämpke Stefan Röseler Meinald t.thielsch Department of Psychology University of Münster48149 MünsterGermany

this study is the first to investigate how a local government’s humorously framed response strategy on social media to a low-severity crisis influences people ’s trust in the local government and their crisis-related behavioral intentions,specific ally when considering the government’s responsibility for the *** on the situational crisis communication theory,we examined the mediating role of experienced positive or negative affect on people’ s responses to a local government’s crisis communication ***,we exploratorily examined the predictive power and moderating role of demographics,sense of humor,disposition to trust,and the respective crisis scenarios.A total of517 people participated in an online experiment in which they were confronted with three randomly presented fictive crisis scenarios where the local government’s crisis responsibility(high versus low) and the framing of their crisis response strategy(in form of humorous versus rational twitter posts) were systematically varied between ***,the results mostly corroborate earlier findings about the degree of crisis responsibility(that is,when a government’s crisis responsibility is high,people have less trust and behavioral intentions) and about the mediating role of experienced ***,we found that humorously framed strategies negatively influence trust and positive affect(but not behavioral intentions).In contrast to earlier findings,the crisis responsibility × framing interaction was not ***,the results advise against using humor in crisis communications on social media,even in lowseverity *** analyses indicate that further investigations should focus on specific crisis characteristics and potential moderators.

关键词： Afect Crisis communication Crisis responsibility humor Situational crisis communication theory Social media

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Ultrafast probing of plasma ion temperature in proton–boron fusion by nuclear resonance fluorescence emission spectroscopy

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Matter and Radiation at Extremes 2022年第3期7卷 1-9页

作者： t.-t.Qin W.Luo h.-Y.Lan W.-M.Wang School of Nuclear Science and technology University of South ChinaHengyang 421001China Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices and Department of Physics Renmin University of ChinaBeijing 100872China

ABStRACt Aneutronic fusion reactions such as proton-boron fusion could efficiently produce clean energy with quite low neutron ***,as a consequence,conventional neutron spectral methods for diagnosing plasma ion temperature would no longer ***,finding a way to probe the ion temperature in aneutronic fusion plasmas is a crucial ***,we present a method to realize ultrafast in situ probing of^(11)B ion temperature for proton-boron fusion by Doppler broadening of the nuclear resonance fluorescence(NRF)emission *** NRF emission is excited by a collimated,intenseγ-ray beam generated from submicrometer wires irradiated by a recently available petawatt(PW)laser pulse,where theγ-ray beam generation is calculated by three-dimensional particle-in-cell *** the laser power is higher than 1 PW,five NRF signatures of a^(11)B plasma can be clearly identified with high-resolutionγ-ray detectors,as shown by our Geant4 *** correlation between the NRF peak width and^(11)B ion temperature is discussed,and it is found that NRF emission spectroscopy should be sensitive to 11B ion temperatures t_(i)>2.4 *** probing method can also be extended to other neutron-free-fusion isotopes,such as^(6)Li and^(15)N.

关键词： spectrum boron spectroscopy

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Enhancing strength and ductility of AlSi10Mg fabricated by selective laser melting by tiB_(2)nanoparticles

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Journal of Materials Science & technology 2022年第14期109卷 254-266页

作者： Y.K.Xiao h.Chen Z.Y.Bian t.t.Sun h.Ding Q.Yang Y.Wu Q.Lian Z.Chen h.W.Wang State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China School of Materials Science&Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In the metallic components fabricated by the emerging selective laser melting(SLM)technology,most strategies used for strengthening the materials sacrifice the ductility,leading to the so-called strengthductility *** the present study,we report that the strength and ductility of materials can be enhanced simultaneously by introducing nanoparticles,which can break the trade-off of the metallic *** the case of in-situ nano-tiB_(2)decorated AlSi10Mg composites,the introduced nanoparticles lead to columnar-to-equiaxed transition,grain refinement and texture *** increasing content of nanoparticles,the strength increases ***,the ductility first increases and then *** results show that the ductility is controlled by the competition between the crack-induced catastrophic fracture and ductile fracture associated with dislocation *** first increase of ductility is mainly attributed to the suppression of crack-induced catastrophic fracture when tiB_(2)nanoparticles *** the further increase of tiB_(2)nanoparticles,the subsequent decrease of ductility is mainly controlled by dislocation ***,the materials will exhibit the optimum strength and ductility combination in a certain range of tiB_(2)*** study clarifies the physical mechanism controlling ductility for nano-tiB_(2)decorated Al Si10Mg composites,which provides the insights for the design of structural materials.

关键词： Selective laser melting Aluminium matrix composites Ductility Mechanical behavior Dislocations Cracks

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ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2026-2038页

作者： Shiqiang Xu Qilian Ma Junwen Shen Ningning Li Shan Sun Nana Wang Yang Chen Chunsheng Dong Kin Yip tam Jochen h.M.Prehn hongfeng Wang Zheng Ying Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric Diseases and Immunology College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and therapeutics Development Soochow UniversitySuzhou 215123China Dept.of Physiology&Medical Physics and FUtURE-NEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of health Sciences University of MacaoTaipaMacao 999078China Insititutes of Biology and Medical Science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FtD),two neurodegenerative *** GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both ALS and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional repeat-associated non-AtG translation,which produces dipeptide repeat(DPR)*** there is a growing understanding that C9orf72 DPRs have a strong ability to harm neurons and induce C9orf72-linked ALS/FtD,whether these DPRs can affect autophagy remains *** the present study,we find that poly-GR and poly-PR,two arginine-containing DPRs which display the most cytotoxic properties according to the previous studies,strongly inhibit starvation-induced ***,our data indicate that arginine-rich DPRs enhance the interaction between BCL2 and BECN1/Beclin 1 by inhibiting BCL2 phosphorylation,therefore they can impair autophagic clearance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not only highlights the role of C9orf72 DPR in autophagy dysfunction,but also provides novel insight that pharmacological intervention of autophagy using SW063058,a small molecule compound that can disrupt the interaction between BECN1 and BCL2,may reduce C9orf72 DPR-induced neurotoxicity.

关键词： Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 Autophagy BCL2 BECN1/Beclin 1 Dipeptide repeat Neurodegeneration

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全球日晒行为调查研究

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中华皮肤科杂志 2024年第7期57卷 672-673页

作者： thierry Passeron henry W. Lim Chee Leok Goh hee Young Kang Fatimata Ly Akimichi Morita Jorge Ocampo-Candiani Susana Puig Sergio Schalka Wei Liu Anne-Laure Demessant-Flavigny Caroline Le Floc’h Delphine Kerob Brigitte Dreno Jean Krutmann Department of Dermatology Côte d'Azur University Nice University Hospital Center Nice France INSERM U1065 C3M Côte d'Azur University Nice France Department of Dermatology Henry Ford Health Detroit Michigan USA National Skin Centre Singapore City Singapore Department of Dermatology Ajou University School of Medicine Suwon South Korea Department of Dermatology Cheikh Anta Diop Dakar University EPS Institute of Social Hygiene Dakar Senegal Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences Nagoya Japan Universidad Autonoma de Nuevo León Facultad de Medicina University Hospital “Dr. Jose E. González” Monterrey Mexico Dermatology Department Hospital Clinic de Barcelona Barcelona University Barcelona Spain Medcin Skin Research Center and Biochemistry Department Chemistry Institute of Sao Paulo University Sao Paulo Brazil Department of Dermatology The General Hospital of Air Force PLA Beijing China La Roche-Posay International Levallois-Perret France Nantes University Univ Angers INSERM Immunology and New Concepts in ImmunoTherapy INCIT UMR 1302 Nantes France IUF Leibniz Research Institute for Environmental Medicine Duesseldorf Germany Medical Faculty Heinrich-Heine-University Duesseldorf Germany

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,40... 详细信息

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,400~700nm)和红外线(700nm~1mm)也是皮肤光老化和光损伤的影响因素,可见光会导致黄褐斑等色素性疾病加重。

关键词：色素性疾病皮肤光老化光变态反应慢性损伤日光照射黄褐斑机体损伤维生素D

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Inhomogeneous dealloying kinetics along grain boundaries during liquid metal dealloying

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Journal of Materials Science & technology 2022年第11期106卷 41-48页

作者： S.-h.Joo Y.B.Jeong t.Wada I.V.Okulov h.Kato Department of Materials Science and Engineering Dankook University119 Dandae-roCheonan 31116Korea Institute for Materials Research Tohoku UniversityKatahira 2-1-1Sendai 980-8577Japan Institute of Natural Sciences and Mathematics Ural Federal University620000 EkaterinburgRussia Faculty of Production Engineering University of BremenBadgasteiner Str.128359 BremenGermany Leibniz Institute for Materials Engineering-IWt Badgasteiner Str.328359 BremenGermany

In this study, the inhomogeneous dealloying phenomenon during the liquid metal dealloying(LMD) was investigated using FeNi+Mg and(FeCo)Ni+Mg systems. For the FeNi+Mg system, the inhomogeneous dealloying and wetting of Mg melt occurred along triple junction(tJ) and grain boundary(GB).temperature increase enhances the inhomogeneous dealloying kinetics and leads to the formation of the plate-shaped abnormal ligaments at the GB region. the energy banlance between a GB energy(γGB)and solid-liquid interface energies(γsl) is the key factor governing the inhomogeneous dealloying and wetting. Particularly, the low-energy twin boundaries were unaffected by the inhomogeneous ***, precursor microstructure is an important factor determining the final morphology of dealloyed material as well as its physical properties. In the case of the(FeCo)Niprecursor, all tJ and GB were stable against the preferred penetration of Mg melt from 600 ℃ to 800 ℃. It was concluded that a minor addition of alloying elements(VorCr) changes GB characteristics as well as γslof the precursor ***, this significantly influences dealloying mechanisms and final morphology of the dealloyed material. the current findings demonstrate the importance of GB engineering in the precursor materials for the technological application of liquid metal dealloying for the synthesis of advanced structural and functional materials.

关键词： Liquid metal dealloying Inhomogeneous dealloying Dealloying mechanism Abnormal ligament Porous material

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Ct thresholds for Spinal Bone Mineral Attenuation to Prioritize Eligible Older Women for Osteoporosis Screening

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Open Journal of Radiology 2024年第2期14卷 92-101页

作者： Seo Yeon K. Orite Bryn higuchi hyo-Chun Yoon Lana h. Gimber St. Elizabeths Medical Center Brighton MA USA University of California Irvine CA USA Kaiser Permanente Division of Research Oakland CA USA Department of Diagnostic Imaging Hawaii Permanente Medical Group Honolulu HI USA

Introduction: Computed tomography (Ct) measurements of bone mineral attenuation may be a useful means to identify older women who should be prioritized for bone mineral density screening. Methods: We compared bone mineral attenuation as measured in the L1 vertebra of Ct studies to the results of dual-energy x-ray absorptiometry (DEXA) studies to determine what Ct attenuation thresholds might yield a reasonable combination of sensitivity and specificity for the detection of osteoporosis. the study was limited to women between the ages of 65 and 75 years who had a DEXA study and a Ct that included the L1 or adjacent vertebra performed within 3 years of the DEXA study. Results: there were 1226 women in this study, of whom 452 (38%) had osteoporosis based on a t-score ≤ −2.5 by DEXA. there were 830 Ct studies performed with contrast and 396 studies which were performed without contrast. there was a statistically significant difference in the mean hU of those studies performed without contrast compared to those with contrast (unenhanced mean 103 hU versus 125 hU, p t Ct attenuation thresholds provided the most appropriate combination of sensitivity and specificity for the detection of osteoporosis when comparing Ct studies performed without or with IV contrast and when all the Ct data were used in aggregate. Conclusion: Different thresholds appear necessary when using the mean Ct vertebral attenuation to identify older women for preferential referral for DEXA studies.

关键词： Osteoporosis Bone Mineral Attenuation Ct threshold

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三轴形变核^(131)Ba中的奇异集体激发模式

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物理学报 2024年第11期73卷 89-100页

作者：韦锐周厚兵王思成丁兵强赟华贾晨旭陈红星郭松 C.M.Petrache D.Mengoni A.Astier E.Dupont 吕冰锋 D.Bazzacco A.Boso A.Goasduff F.Recchia D.testov F.Galtarossa G.Jaworski D.R.Napoli S.Riccetto M.Siciliano J.J.Valiente-Dobon C.Andreoiu F.h.Garcia K.Ortner K.Whitmore A.Ataç-Nyberg t.Bäck B.Cederwall E.A.Lawrie I.Kuti D.Sohler t.Marchlewski J.Srebrny A.tucholski 广西师范大学物理科学与技术学院桂林541004 广西核物理与核技术重点实验室桂林541004 中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 巴黎萨克雷大学 CNRS/IN2P3IJCLab奥赛91405 帕多瓦大学物理和天文学系帕多瓦I-35131 意大利国家核物理研究所帕多瓦分部帕多瓦I-35131 意大利国家核物理研究所莱尼亚罗国家实验室莱尼亚罗(帕多瓦)I-35020 费拉拉大学理学与自然科学院费拉拉西蒙菲莎大学化学系本拿比BC V5A 1S6 皇家理工学院物理系斯德哥摩尔S-10691 国家研究基金会ithemba加速器科学实验室西萨默塞特7123 西开普大学物理与天文系贝尔维尔ZA-7535 hUN-REN原子核研究所德布勒森4001 华沙巴斯德拉大学重离子实验室华沙02-093

利用意大利Legnaro实验室串列静电加速器提供的65 MeV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)Ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.... 详细信息

利用意大利Legnaro实验室串列静电加速器提供的65 MeV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)Ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.正负宇称手征带通过一系列增强的E1跃迁连接,表明它们之间存在八极关联.在低自旋区域搭建了一条新的转动带,通过一系列γ跃迁向νh1_(1/2)晕带退激.这种能级结构与摇摆带相似,但基于现有的实验证据还难以将它确认为摇摆带,不能排除其他集体激发机制,如γ振动的影响.

关键词：高自旋态手征带赝自旋八极关联摇摆运动

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Iron oxide nanoparticles in magnetic drug targeting and ferroptosis-based cancer therapy

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Medical Review 2023年第5期3卷 444-447页

作者： Quazi t.h.Shubhra Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Institute of Chemistry University of Silesia in Katowice41-500 ChorzówPoland

Iron oxide(IO)nanoparticles(NPs)have gained significant attention in the field of biomedicine,particularly in drug targeting and cancer *** potential in magnetic drug targeting(MDt)and ferroptosis-based cancer therapy is highly *** NPs serve as an effective drug delivery system(DDS),utilizing external magnetic fields(EMFs)to target cancer cells while minimizing damage to healthy ***,IO NPs can generate reactive oxygen species(ROS)and induce ferroptosis,resulting in cytotoxic effects on cancer *** article explores how IO NPs can potentially revolutionize cancer research,focusing on their applications in MDt and ferroptosis-based therapy.

关键词： magnetic nanoparticles ferroptosis drug targeting cancer

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