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High-resolution patterns of palaeoenvironmental changes during the Little Ice Age and the Medieval Climate Anomaly in the northwestern Iberian Peninsula

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Geoscience Frontiers 2020年第5期11卷 1461-1475页

作者： Daniel Castro Martin Souto Maria Isabel Fraga Eduardo Garcia-Rodeja Sebastian Perez-Diaz Jose Antonio Lopez Saez xabier pontevedra-pombal Dpto.Botanica Fac.BioloxiaUniversidade de Santiago de CompostelaGaliciaSpain Dpto.Edafoloxia e Quimica Agricola Fac.BioloxiaUniversidade de Santiago de CompostelaGaliciaSpain Dpto.Geografia Urbanismo y Ordenacion Del TerritorioETS CaminosCanales y PuertosUniversidad de CantabriaSpain GI Arqueobiologia Instituto de HistoriaCCHS–CSICMadridSpain

to identify plant macrofossils,estimate peat humification and calculate hydroclimatic indices based on current bog species,with the overall aim of determining the climate conditions associated with evolution of the bog during the Medieval Climate Anomaly and the Little Ice *** proxies,together with historical and climate data,proved to be good indicators of the changes in bog surface ***:of the core led to identification of 9 different periods:two corresponding to the so-called Medieval Climate Anomaly(930 to 1345 AD,1075–665 calibrated years before present[*** BP]);four corresponding to the Little Ice Age(1345 to 1905 AD;665–105 cal yr BP);and three corresponding to the last century(1905 to 2000 AD).The findings revealed a generally dry climate that lasted until the 14th century,followed by a transition to a long period with a more humid,but characteristically very variable climate,which ended at the beginning of the 20th century and was followed by a rapid transition to more humid conditions and finally,a change to drier *** Medieval Climate Anomaly was indicated by the abundance of dry-adapted mosses(Leucobryum glaucum,Hypnum cupressiforme)and characterized by warm dry conditions and high levels of peat humification,with alternating wet *** LIA period was dated by a large abundance of Sphagnum species(an indicator of wetness)and a gradual increase in the humification ***,four different climate phases were differentiated in this ***-resolution reconstruction of the evolution of the CVM bog and the multiproxy approach have together enabled a more detailed identification of climatic variations in this area,which are generally consistent with the global models,as well as better definition of the elusive climatic oscillations in the last millennium and confirmation of the importance of local modulation of global *** study provides new information and a detailed chronology of climatic events that will hel

关键词： Last millennium Raised bog Plant macrofossil Humification analysis Southwest Europe Climate change

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10,000 years of climate control over carbon accumulation in an Iberian bog(southwestern Europe)

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Geoscience Frontiers 2019年第4期10卷 1521-1533页

作者： xabier pontevedra-pombal Daniel Castro Martín Souto Isabel Fraga William H. Blake Maarten Blaauw José A. López-Sáez Sebastián Pérez-Díaz Marcos Valcárcel Eduardo García-Rodeja Dpto.Edafoloxía e Química Agrícola Fac.BioloxíaUniversidade de Santiago de CompostelaGaliciaSpain Dpto.Botánica Fac.BioloxíaUniversidade de Santiago de CompostelaGaliciaSpain School of Geography Earth and Environmental SciencesUniversity of PlymouthUK School of Natural and Built Environment Queen’s University BelfastNorthern IrelandUK GI Arqueobiología Instituto de HistoriaCCHS - CSICMadridSpain Dpto.Xeografía Fac.Xeografía e HistoriaUniversidade de Santiago de CompostelaGaliciaSpain

The northwest region of the Iberian Peninsula is home to a unique ecosystem of bogs,which are particularly sensitive to projected climate cha *** this context,the rate of carbon(C)accumulation in Chao de Veiga *** intact raised bog,was *** in the accumulation rate over the past10 millennia were determined in a peat core of 847 cm in depth,with a high mean rate of peat growth(11 yr cm^-1,0.09 cm yr^-1).An age-depth model was generated from 22 14C dates and fallout ***,stratigraphical and physico-chemical data confirmed the existence of a single cycle of peat formation throughout the Holocene and the formation of ombrotrophic peat 9500 years *** total mean C content was 50.2%,and over 10 millennia 583 kg C m^-2 accumulated at a mean rate of 35.3 g C m^-2 yr^-1,with a long-term(apparent)rate of carbon accumulation in the catotelm of59.9 g C m^-2 yr^-*** values are much higher than reported for other Iberian peatlands and are amongst the highest documented for peatlands in the northern *** dynamics of C accumulation and other measured parameters reveals important variations throughout the *** could be associated with the main climatic events described in the northern hemisphere and are highly consistent with models established for northern *** Chao de Veiga Mol raised bog is unique and of great potential value for carrying out high resolution palaeoenvironmental studies,especially in relation to regional and Iocal modulations in southern Europe.

关键词： Peatland Geochemistry Holocene Climate change Palaeoenvironmental reconstruction

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Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala Sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

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Obstructive uropathy: Overview of the pathogenesis, etiology and management of a prevalent cause of acute kidney injury

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World Journal of Nephrology 2024年第2期13卷 5-15页

作者： xabier Pérez-Aizpurua Ramiro Cabello Benavente Gonzalo Bueno Serrano JoséMaría Alcázar Peral Blanca Gómez-Jordana Mañas Jaime Tufet i Jaumot Joaquín Ruiz de Castroviejo Blanco Felipe Osorio Ospina Carmen Gonzalez-Enguita Department of Urology Hospital Universitario Fundación Jiménez DíazMadrid 28015MadridSpain

Obstructive uropathy is defined as the structural or functional interruption of urinary outflow at any level in the urinary *** is regarded as one of the most prevalent causes of acute kidney injury(AKI),accounting for 5%–10%of *** severe obstruction of the urinary tract is a potentially threatening situation for the kidneys and therefore requires prompt identification and management to relieve *** aim of the present article is to review and synthesize available evidence on obstructive uropathy,providing a clinical guideline for clinicians.A literature review on obstructive uropathy in the context of AKI was performed,focusing on the least clarified aspects regarding diagnosis and *** literature searching was conducted in English and top-level evidence articles including systematic reviews,metanalyses and large series were *** obstruction of the urinary tract is a diagnostic and therapeutical challenge that may lead to important clinical complications together with direct structural and hemodynamic damage to the *** recognition of the leading cause and its exact location is essential to ensure prompt urinary drainage together with the most suitable drainage technique selection.A multidisciplinary approach,including urologists,nephrologists,and other medical specialties,is best suited to correctly manage concomitant hemodynamic changes,fluid and electrolyte imbalances,and other related *** uropathy is one of the leading causes of *** of patients suitable for early diversion and feasibility or adequate selection of the indicated technique is sometimes challeng-ing.A thorough understanding of the physiopathology behind the development of urinary obstruction is vital for correct diagnosis and management.

关键词： Obstructive uropathy Urinary tract obstruction Obstruction of the urinary tract Acute kidney injury Urinary diversion Renal recovery

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Simultaneous analysis of the intestinal parasites and diet through eDNA metabarcoding

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Integrative Zoology 2023年第3期18卷 399-413页

作者： xabier CABODEVILLA Benjamín Juan GÓMEZ-MOLINER Naiara ABAD María JoséMADEIRA Department of Zoology and Animal Cell Biology Faculty of PharmacyUniversity of the Basque Country(UPV/EHU)AlavaSpain Instituto de Investigación en Recursos Cinegéticos(IREC)(CSIC-UCLM-JCCM) Ciudad RealSpain

Agricultural expansion and intensiﬁcation are having a huge impact on plant and arthropod diversity and abun-dance,affecting food availability for farmland ***ﬁcult food access,in turn,can lead to immunosuppression and a higher incidence of *** the studies designed to examine changes in the diet of birds and their par-asites,metabarcoding is proving particularly *** technique requires mini-barcodes capable of amplifying the DNA of target organisms from fecal environmental *** help to understand the impact of agricultural expansion on biodiversity,this study sought to design and identify mini-barcodes that might simultaneously as-sess diet and intestinal parasites from the feces of farmland *** capacity to identify diet and parasites of 2 existing and 3 newly developed mini-barcodes was tested“in silico”in relation to the behavior of a reference eukaryotic *** the newly designed mini-barcodes,MiniB18S_81 showed the higher taxonomic cover-age of eukaryotic taxa and a greater ampliﬁcation and identiﬁcation capacity for diet and parasite ***,when it was tested on fecal samples from 5 different steppe bird species,MiniB18S_81 showed high taxonomic resolution of the most relevant diet and parasite phyla,Arthropoda,Nematoda,Platyhelminthes,and Apicomplexa at the order ***,the mini-barcode developed emerges as an excellent tool to simultaneously provide detailed information regarding the diet and parasites of birds,essential for conservation and management.

关键词： biomonitoring broad-spectrum primers eukaryotic mini-barcodes fecal eDNA farmland birds parasitology

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Master of one trade:Arbutus unedo relies on plasticity to persist under habitats differing in water availability

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Journal of Plant Ecology 2017年第5期10卷 869-881页

作者： xabier Santiso Rubén Retuerto Área de Ecología Facultad de BiologíaCampus VidaUniversidade de Santiago de Compostela15782 Santiago de CompostelaSpain

Aims the limited water supply in the Mediterranean Basin will be exacerbated in the immediate future as result of severe drought ***,the study of the intraspecific variability in functional traits of plant species is important,because such variability modulates species’***,we aimed to analyse the variability in plasticity of physiological and structural traits of Arbutus unedo *** response to water availability and to determine whether the levels of phenotypic plasticity varied in plants of different *** We kept two sets of plants under contrasted water regimes(high water and low water)and calculated a phenotypic plasticity index to determine the plastic response to water *** compared the response among kind of traits and *** also per-formed analysis of variance to assess the trait and provenance *** Findings We found that biomass and key physiological traits decrease under drought conditions,while the water use efficiency *** differed between groups of traits,being higher in structural and gas exchange parameters,but the provenance did not account for signifi-cant variation in *** has evolved a‘good saver’strat-egy,involving decreasing growth and water use-when this resource is unavailable-together with the dissipation of excess of radiation that it cannot *** homogeneous response between provenances may be the result of a canalization *** strategy,based on a high degree of plasticity,is a probable determining factor in the success of the species over its wide range of environmental conditions and will be critical to withstand the ongoing environmental changes.

关键词： adaptation canalization contrasted provenances drought global change phenotypic plasticity

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Biliary spillage a new prognostic factor in gallbladder cancer?

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 537-538页

作者： xabier de Aretxabala Department of Surgery Clínica Alemana de SantiagoSantiagoChile

Gallbladder cancer is considered a rare disease associatedwith a dismal prognosis(1-3).However,since the irruptionof laparoscopic cholecystectomy,incidental cases haveincreased and prognosis *** main reason forthis im... 详细信息

关键词： prognosis cancer gallbladder

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LIBRA:an adaptative integrative tool for paired single-cell multi-omics data

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Quantitative Biology 2023年第3期11卷 246-259页

作者： xabier Martinez-de-Morentin Sumeer AKhan Robert Lehmann Sisi Qu Alberto Maillo Narsis AKiani Felipe Prosper Jesper Tegner David Gomez-Cabrero Navarrabiomed Complejo Hospitalario de Navarra(CHN)Universidad Pública de Navarra(UPNA)IdiSNAPamplona 31001Spain Biological and Environmental Sciences and Engineering Division King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia Algorithmic Dynamic Lab Department of Oncology and PathologyCenter for Molecular MedicineKarolinska InstituteStockholm 17177Sweden Division of Hemato-Oncology Center for Applied Medical Research CIMACancer Center University of Navarra(CCUN)Navarra Institute for Health Research(IDISNA)CIBERONCPamplona 31008Spain Department of Hematology Clinica Universidad de NavarraCIBERONC Pamplona 31008Spain Computer Electrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia

Background:Single-cell multi-omics technologies allow a profound system-level biology understanding of cells and ***,an integrative and possibly systems-based analysis capturing the different modalities is *** response,bioinformatics and machine learning methodologies are being developed for multi-omics single-cell *** is unclear whether current tools can address the dual aspect of modality integration and prediction across modalities without requiring extensive parameter ***:We designed LIBRA,a neural network based framework,to learn translation between paired multi-omics profiles so that a shared latent space is ***,we implemented a variation,aLIBRA,that allows automatic fine-tuning by identifying parameter combinations that optimize both the integrative and predictive *** model parameters and evaluation metrics are made available to users with minimal user ***,aLIBRA allows experienced users to implement custom *** LIBRA toolbox is freely available as R and Python libraries at GitHub(TranslationalBioinformaticsUnit/LIBRA).Results:LIBRA was evaluated in eight multi-omic single-cell data-sets,including three combinations of *** observed that LIBRA is a state-of-the-art tool when evaluating the ability to increase cell-type(clustering)resolution in the integrated latent ***,when assessing the predictive power across data modalities,such as predictive chromatin accessibility from gene expression,LIBRA outperforms existing *** expected,adaptive parameter optimization(aLIBRA)significantly boosted the performance of learning predictive models from paired ***:LIBRA is a versatile tool that performs competitively in both“integration”and“prediction”tasks based on single-cell multi-omics *** is a data-driven robust platform that includes an adaptive learning scheme.

关键词： single-cell multi-omic Autoencoder auto-finetuning

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Neoadjuvant immunotherapy in non-small-cell lung cancer:Times are changing—and fast

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World Journal of Clinical Oncology 2022年第9期13卷 758-761页

作者： Carlos Aguado Unai Jiménez Maestre xabier Mielgo-Rubio Department of Medical Oncology Hospital Universitario Clínico San CarlosMadrid 28040Spain Department of Thoracic Surgery Hospital Universitario CrucesBarakaldo 48903BizkaiaSpain Department of Medical Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain

Recent data from a phase 3 trial have shown that the addition of immunotherapy to neoadjuvant chemotherapy improves event-free survival in patients with nonsmall-cell lung cancer(NSCLC).This is the first positive phase 3 trial in this setting,although several phase 3 trials are currently investigating the efficacy of neoadjuvant and adjuvant immunotherapy in resectable NSCLC.

关键词： Neoadjuvant Immunotherapy NSCLC Perioperative Checkmate-816 nivolumab Chemo-immunotherapy

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Electro-tribological properties of diamond like carbon coatings

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Friction 2020年第2期8卷 451-461页

作者： Iñigo BRACERAS Iñigo IBÁNEZ Santiago DOMINGUEZ-MEISTER xabier VELASCO Marta BRIZUELA Iñaki GARMENDIA Tecnalia Research&Innovation Mikeletegi Pasealekua 2Donostia-San Sebastian 20009Spain Mechanical Engineering Department University of the Basque Country UPV/EHUPlaza de Europa1Donostia-San Sebastian 20018Spain

Diamond like carbon(DLC)coatings typically present good self-lubricating tribological properties that could be of interest in sliding dielectric contacts in multiple electrical *** this work electro-tribological studies have been performed on several DLC coatings against aluminum in different humidity conditions,in which the coefficients of friction(CoFs)and electrical contact resistance(ECR)were continuously *** show that CoF and ECR data can be linked to the properties of the coatings(thickness,finishing,microstructure,residual stresses,and wettability)and the degradation modes of their tribological and electrical ***,electro-tribological data can provide valuable information about the performance of dielectric coatings,the reasons behind it,and assist in the development of the *** also shows potential for on-line monitoring of coated parts in operation.

关键词： DLC electro-tribology ECR-electrical contact resistance coefficient of friction

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