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神经损伤与功能重建 2021年第2期16卷 F0003-F0003页

作者： Martine Cohen-Salmon Leila Slaoui Noémie Mazaré Alice Gilbert Marc Oudart Rodrigo Alvear-Perez xabier elorza-vidal Oana Chever Anne-Cécile Boulay 杜一星(编译) Physiology and Physiopathology of the Gliovascular Unit Research Group Center for Interdisciplinary Research in Biology(CIRB)College de FranceCNRS UnitéMixte de Recherche 724INSERM Unité1050Labex MemolifePSL Research UniversityParisFrance Normandie University UNIROUENINSERMDC2NIRIBRouenFrance 不详

星形胶质细胞是脑内神经胶质细胞中数量最多的一种类型,对脑血管系统具有重要的影响。它们参与调控血管周围内稳态、血脑屏障的完整性、与外周免疫系统的交流、血液中代谢物的转移以及与神经元活动相应的血管收缩。这些调控过程发生在... 详细信息

星形胶质细胞是脑内神经胶质细胞中数量最多的一种类型,对脑血管系统具有重要的影响。它们参与调控血管周围内稳态、血脑屏障的完整性、与外周免疫系统的交流、血液中代谢物的转移以及与神经元活动相应的血管收缩。这些调控过程发生在由血管周围星形胶质细胞突起组成的几乎完全覆盖了脑血管特殊界面中。科学家直到最近才开始研究这种界面的形成方式及其如何影响脑血管功能。本文综述了有关星形胶质细胞在调节脑血管系统中作用的文献。涵盖了胶质血管界面的解剖结构和发育、已知的胶质血管功能和分子因素、后者在某些病理生理情况下的作用以及最近开发的用于检验星形胶质细胞在血管界面作用的尖端实验工具。最后,本综述重点介绍了该研究领域中的一些尚未解决的问题。

关键词：星形胶质细胞脑血管系统胶质血管界面

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Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala Sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

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Current treatment landscape for oligometastatic non-small cell lung cancer

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World Journal of Clinical Oncology 2022年第6期13卷 485-495页

作者： Javier Garde-Noguera Margarita Martín-Martín Andres Obeso Miriam López-Mata Inigo Royo Crespo Lira Pelari-Mici O Juan vidal xabier Mielgo-Rubio Juan Carlos Trujillo-Reyes Felipe Couñago Department of Medical Oncology Hospital Arnau de VilanovaValencia 46015Spain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Thoracic Surgery Hospital Clínico Universitario de Santiago de CompostelaVigo 15706Spain Department of Radiation Oncology Hospital Clínico Universitario Lozano BlesaZaragoza 50009Spain Department of Thoracic Surgery Hospital Universitari Vall d’HebronBarcelona 08035Spain Department of Medical Oncology Hospital Universitario y Politécnico La FeValencia 46026Spain Department of Medical Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029Spain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

The management of patients with advanced non-small cell lung carcinoma(NSCLC)has undergone major changes in recent *** the one hand,improved sensitivity of diagnostic tests,both radiological and endoscopic,has altered the way patients are *** the other hand,the arrival of new drugs with antitumoral activity,such as targeted therapies or immunotherapy,has changed the prognosis of patients,improving disease control and prolonging ***,the development of radiotherapy and surgical and interventional radiology techniques means that radical ablative treatments can be performed on metastases in any location in the *** of these advances have impacted the treatment of patients with advanced lung cancer,especially in a subgroup of these patients in which all of these treatment modalities *** poses a challenge for physicians who must decide upon the best treatment strategy for each patient,without solid evidence for one optimal mode of treatment in this patient *** aim of this article is to review,from a practical and multidisciplinary perspective,published evidence on the management of oligometastatic NSCLC *** evaluate the different alternatives for radical ablative treatments,the role of primary tumor resection or radiation,the impact of systemic treatments,and the therapeutic *** short,the present document aims to provide clinicians with a practical guide for the treatment of oligometastatic patients in routine clinical practice.

关键词： Oligometastatic Non-small cell lung carcinoma Non-small cell lung cancer Oligometastasis

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