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LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2942-2958页

作者： Shishi He Guowei Huang Rong Lei Rurong Jia Zhanghai He Jiewen Chen Hongyan Huang Zixian Huang Ailifeire Yilihamu xun li Zilin Zhuang Mengjia Han Xueman Chen Di Huang Yan Nie Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Pathology Shantou University Medical CollegeShantou 515041China School of Basic Medical Science Southern Medical UniversityGuangzhou 510515China Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Breast Medicine Affiliated Foshan Maternity and Child Healthcare HospitalSouthern Medical UniversityFoshan 528000China Department of Breast Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Oral and Maxillofacial Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Breast phyllodes tumor(PT)is a rare fibroepithelial neoplasm with potential malignant *** non-coding RNAs(lncRNAs)play multifaceted roles in various cancers,but their involvement in breast PT remains largely *** this study,microarray was leveraged for the first time to investigate the role of lncRNA in *** identified lncRNA ZFPM2-AS1 was significantly upregulated in malignant PT,and its overexpression endowed PT with high tumor grade and adverse ***,we elucidated that ZFPM2-AS1 promotes the proliferation,migration,and invasion of malignant PT in *** ZFPM2-AS1 through nanomaterial-mediated siRNA delivery in patient-derived xenograft(PDX)model could effectively inhibit tumor progression in ***,our findings showed that ZFPM2-AS1 is competitively bound to CDC42,inhibiting ACK1 and STAT1 activation,thereby launching the transcription of *** conclusion,our study provides evidence that ZFPM2-AS1 plays a pivotal role in the pathogenesis of breast PT,and suggests that ZFPM2-AS1 could serve as a prognostic indicator for patients with PT as well as a promising novel therapeutic target.

关键词： LncRNA Phyllodes tumor ZFPM2-AS1 Cell division cycle 42 Activated cdc42 kinase 1 Signal transducer and activator of transcription 1 TNF receptor superfamily member 19 Nano particles

Robust Composite Separator Randomly Interwoven by PI and Pre-oxidized PAN Nanofibers for High Performance lithium-ion Batteries

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Chinese Journal of Polymer Science 2024年第11期 1768-1779页

作者： Ying li Chen Pan Feng Gan Zhi-xun lin Jin-Chao Yu Zhen-Zhen Wei Yan Zhao College of Textile and Clothing Engineering National Engineering Laboratory for Modern SilkSoochow University College of Textile Science and Engineering Wuyi University

Electrospun nanofibrous separators, despite lacking superior mechanical strength, have gained widespread attention with high porosity and facile processing. Herein, utilizing the fact that thermal imidization temperature of poly(amic acid)(PAA) into polyimide(PI) coincides with the pre-oxidation temperature of polyacrylonitrile(PAN) into carbon fiber, we proposed a new cross-electrospinning strategy to obtain a composite nanofibrous separator(PI/oPAN) randomly interwoven by PI and pre-oxidized PAN(oPAN) nanofibers, via synchronously electrospinning the PAA and PAN onto the same collector and then heat-treating for 2 h at 300 ℃. The resultant PI/oPAN separator was able to preserve high porosity(71.7%), electrolyte wettability and thermal stability of PI nanofibrous membrane, and surprisingly exhibited high mechanical strength,being 3 times of PI, which mainly because of the numerous adhesion points generated by the melting of PAN in the pre-oxidation process. Meanwhile, the polar groups of oPAN and 3D fibrous network enhanced the PI/oPAN separator's ionic conductivity and li+ transference number, rendering the corresponding cell with more stable cycling performance than cells assembled with pure PI, PAN or commercial PP separator. Therefore, this work might provide a new avenue for the ongoing design and further development of liB separators capable of high safety and high performance.

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Stay in touch with the endoplasmic reticulum

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Science China(life Sciences) 2024年第2期67卷 230-257页

作者： Sha Sun Gan Zhao Mingkang Jia Qing Jiang Shulin li Haibin Wang Wenjing li Yunyun Wang Xin Bian Yan G.Zhao xun Huang Ge Yang Huaqing Cai Jose C.Pastor-Pareja liang Ge Chuanmao Zhang Junjie Hu National Laboratory of Biomacromolecules Institute of BiophysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China The Ministry of Education Key Laboratory of Cell Proliferation and Differentiation College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory of Computational Biology&Machine Intelligence School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Brain Research Center Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Neurosciences Consejo Superior de Investigaciones Científicas-Universidad Miguel HernándezSan Juan de Alicante 03550Spain

The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic *** a result,it engages a variety of organelles by establishing membrane contact sites(MCSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling ***,we systematically review recent advances and converging themes on ER-involved organellar *** molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,Golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关键词： endoplasmic reticulum nuclear envelope mitochondria Golgi apparatus endosome lysosome lipid droplets autophagosome plasma membrane membrane contact site

基于混合自适应扩展卡尔曼滤波的永磁同步直线电机等效机械参数辨识策略

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中国电机工程学报 2024年第3期44卷 1162-1172,I0026页

作者：张毅伟黄旭珍徐济安南京航空航天大学自动化学院江苏省南京市211100

针对机械参数辨识精度受推力系数波动影响而降低的问题,提出等效机械参数模型,将推力系数与待辨识参数相结合,并推导该模型在控制器调谐和前馈补偿上与传统模型的等效性。为了进一步实现等效机械参数在线辨识,构建基于混合自适应扩展卡... 详细信息

针对机械参数辨识精度受推力系数波动影响而降低的问题,提出等效机械参数模型,将推力系数与待辨识参数相结合,并推导该模型在控制器调谐和前馈补偿上与传统模型的等效性。为了进一步实现等效机械参数在线辨识,构建基于混合自适应扩展卡尔曼滤波的辨识器。混合自适应扩展卡尔曼滤波在系统噪声矩阵和渐消因子中加入自适应机制,能够估计系统噪声,并在负载突变时快速收敛。通过对系统可观性和矩阵正定性的推导,证明算法的稳定性。最后,在一台永磁同步直线电机上进行实验,验证所提算法的有效性及其在PWM周期为32 kHz和10 kHz时在线运行的可行性。

关键词：自适应扩展卡尔曼滤波机械参数辨识永磁同步直线电机位置伺服系统

Occurrence of Mafic Rocks within Ediacaran Strata in the Aksu Region, NW Tarim Craton, and its Geological Implications

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Acta Geologica Sinica(English Edition) 2024年第5期98卷 1244-1254页

作者： XIE Hongzhe ZHU Xiangkun WANG xun HE Yuan SHEN Weibing MNR Key Laboratory of Isotope Geology Sino Probe Laboratory Institute of Geology Chinese Academy of Geological Sciences

The Tarim Craton is an ancient Precambrian continental block, and detailed knowledge of its thermo-tectonic history is crucial for understanding the early history of continental evolution. Abundant layered mafic rocks, which have commonly been regarded as basalts, occur within the Ediacaran Sugetbrak Formation(Fm.) in the Aksu region of the northwestern Tarim Craton. Clear intrusive features have now been discovered, including mafic rocks truncating Ediacaran sedimentary layers, exhibiting an intrusion-baked margin where they interact with both the overlying and bottom wall rocks, and displaying a fine-grained transition zone from their interior to their margins. The new findings demonstrate that these mafic rocks within the Aksu Ediacaran strata were not erupted basalts but instead are intrusive diabase dykes. Therefore, these mafic rocks cannot be used to constrain the timing of the Sugetbrak Fm. in the Aksu area, nor as marker layers for regional stratigraphic correlation. Furthermore, the Ediacaran thermo-tectonic evolution in this region, deduced from the assumption that the mafic rocks are lavas, needs to be revised.

关键词： mafic rocks Neoproterozoic stratigraphy Tarim Craton tectonics

lithium isotopic fractionation in minerals from pegmatites: Perspective of crystal chemistry

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Journal of Earth Science 2024年

作者： Shan-Ke liu Ben-xun Su Key Laboratory of Mineral Resources， Institute of Geology and Geophysics， Chinese Academy of Sciences

Lack of information regarding lithium (li) crystal chemistry in numerous minerals， especially those containing trace amounts of li (ranging from few to tens of ppm)， limits our understanding of li isotopic fractionation in pegmatites. In this study， we examined the li isotopic composition and li content in various li-poor (e.g.， quartz or feldspar) together with li-rich (sopdumene or lepidolite) mineral phases within granitic pegmatites. We compiled a comprehensive dataset， encompassing a broad spectrum of li contents (ranging from a few to tens of thousands of ppm) and li isotopic values (-8‰ to 41‰). The minerals exhibited distinct li isotopic signatures. Specifically， elbaite and beryl showed the highest values， while biotite displayed a negative average. Compared to individual minerals， whole rocks demonstrated lower li isotopic values， with pegmatites exhibiting the highest and non-granitic pegmatite wall rocks showing the lowest. Our study also uncovered a clear "V" shape relationship between li isotopic values and logarithm of li content， with different mineral groups occupying specific regions within this shape. Furthermore， a significant correlation was observed between average li isotopic values and li-O(OH， F) bond lengths in various minerals. These discoveries underscore the crucial role of crystal chemistry in shaping the li isotopic behavior in pegmatites from a statistical perspective.

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Reducing Energy Costs during Hydrogen Production from Water Electrolysis by Coupling Small Molecule Oxidation: From Molecular Catalysis to Industrial Exploration

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Precision Chemistry 2024年第9期2卷 447-470页

作者： Jia Cheng Yang Xiang xun Huang Zidong Wei School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331P.R.China

Hydrogen energy has garnered significant attention in recent years as a solution to address the global energy crisis and environmental *** water electrolysis stands out as the most promising method to produce green hydrogen,the sluggish reaction kinetics of the oxygen evolution reaction(OER)on the anode increases the cost of hydrogen *** potential solution to this challenge is replace OER with the thermodynamically more favorable oxidation of small molecules,which can efficiently reduce the energy cost while simultaneously yielding high-value *** to now,various organic oxidation reactions have been reported to couple with hydrogen evolution,including alcohol oxidation,biomass platform molecule upgrading,and sacrificial reagents oxidation associated with wastewater *** review concentrates on the recent advancements in the mechanism,catalyst,reactor,and process in this field,with a discussion on its prospects for commercialization.

关键词： Hydrogen evolution reaction Biomass oxidation Pollutant degradation Hybrid water electrolysis Reactor

Design and test of a double compression seeder for pre-sowing and seed furrow of wheat in wide-seedling belts

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 136-145页

作者： xun He Run Zhang Jingfeng Zhang Yinghao Zhu Wanzhang Wang Hongmei Zhang College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China

To solve the problem of poor sowing quality due to loose soil in wheat seedbed after land preparation in the Huang-Huaihai region of China,a double compression seeder for pre-sowing and seed furrow of wheat in wide-seedling belts was *** machine sowing operation was divided into two processes:pre-sowing compression and seed ditch compression,pre-sowing compression was carried out homogenization of the pre-sowing seed bed that the tractor wheel has crushed,and the seed ditch compression compresses the seeds and soil in the seed ditch,so that the seeds were embedded in the seed ditch *** analyzing the kinematics of the pre-planting compression device and the spiral blade in the process of soil levelling and compression,the structure of the equal-difference variable-diameter equal-pitch spiral conveying winch was designed,and the key parameters of the drum spiral blade were determined,and then the height of the spiral blades,the rutting distance and the speed of the compression roller were taken as the test factors,and the soil flatness was used as the index to carry out the discrete element simulation *** simulation results show that when the spiral blade was 4.85 cm,the rut distance was 37.4 cm,and the rotation speed was 327.16 r/min,the optimal land flatness was ***,field experiments were carried out on the seeder,and the results showed that:the soil bulk density after operation was 22.7%greater than that before sowing(p<0.01),and the soil flatness was 1.9 cm,which was consistent with the simulated *** use of pre-sowing compression and seed furrow compression methods improved the soil environment of the seed bed,increased the uniformity of the seeding depth,and promoted the root growth of *** study provides equipment support and technical reference for agricultural production in wheat-corn rotation areas in the Huang-Huaihai region of China.

关键词： wheat seeding quality pre-sowing compression seed furrow compression field experiment

Probing the Affinity of Coronavirus with Contact Surfaces in Simulated Body Fluids

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Environment & Health 2024年第5期2卷 269-277页

作者： Yarong Qi xun Guan Yun Shen Xitong liu Department of Civil&Environmental Engineering The George Washington UniversityWashingtonD.C.20052United States Department of Environmental Science Policyand ManagementUniversity of CaliforniaBerkeleyCalifornia 94720United States

Transmission of viral pathogens has raised serious public health concerns,but the affinity and strength of viruses adhering to hightouch surfaces are not *** systematically investigated the propensities of a coronavirus,Murine hepatitis virus A59(MHV),adhering onto and releasing from four representative contact surfaces,silica,stainless steel,cellulose,and polystyrene,in simulated saliva and urine using quartz crystal microbalance with dissipation monitoring(QCM-D).We also quantified the interactions between MHV and contact surfaces using atomic force microscopy(AFM).Both initial adhesion rates and saturated adhesion mass of MHV were higher in urine buffer than in saliva buffer,which is attributed to the higher repulsions between the virus and surfaces in the presence of *** maximum adhesion mass of MHV follows the order of stainless steel>silica>cellulose≈polystyrene in both urine and saliva *** steel and silica are surfaces with likely higher risks of virus contamination due to their highest maximum adhesion mass in both urine and saliva buffers and lower virus release percentages upon water *** results of this study will provide insights into risk assessment and control of pathogens associated with contact surfaces.

关键词： Coronavirus Contact surfaces Silica Stainless steel Cellulose Polystyrene Fomite transmission