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Expression of Wnt and NCX1 and its correlation with cardiomyocyte apoptosis in mouse with myocardial hypertrophy

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Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 909-914页

作者： jing He Yi Cai Leiming Luo Rong Wang Department of General Surgery PLA General Hospital

Objective:To study the correlation between expression of Wnt and NCXl and cardiomyocyte apoptosis in mouse with myocardial ***:C57B/16 male mice were given the subcutaneous injection of 1 mg/kg isoprenaline to build the myocardial hypertrophy *** 14 d of model building,mice were executed by cervical vertebra *** ratio of heart weight/body weight(HW/BW) and heart weight/tibia length(HW/TL) was observed and proved using HE staining mat detected the size of eaidiomyocytes.40 male C57B/16 mice were randomly divided into the sham group(normal saline) and model group(isoprenaline),with 20 mice in each *** terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling was applied to detect the cardiomyocyte apoptosis;while Western blot and immunohistochemistry were employed to detect the expression of Wnt and ***,the correlation between these two proteins and cardiomyocyte apoptosis was ***:Compared with the sham group,the ratio of HW/BW and HW/TL was increased in the model group,as well as the bigger and hypertrophied cardiomyocytes,decreased number and increased apoptosis of eaidiomyocytes,and increased positive expression of Wnt3 a,WntSa and NCXl in the cardiac muscle ***,there was positive correlation between the expression of Wnt and NCXl and the cardiomyocyte ***:The expression of Wnt3 a,Wnt5a and NCXl in mouse with myocardial hypertrophy is increased and positively correlated with the cardiomyocyte apoptosis.

关键词： Myocardial hypertrophy Wnt NCX1 Cardiomyocyte apop

Research on micr oseismic denoising method based on CBDNet

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Artificial Intelligence in Geosciences 2023年第1期4卷 28-38页

作者： Jianchao Lin jing Zheng Dewei Li Zhixiang Wu China University of Mining and Technology(Beijing) Beijing100083China State Key Laboratory of Coal Resources and Safe Mining Beijing100083China

Naise sppeaion s an important part of micrseimic momiloring *** and naise can be separated by denoisig and fihering to improve the subesequent *** this paper,we popoase a new denoising method besed on comvolutional blind denoising netwonk(CBDNet).The method is pnily modied for image denoising netwarck CBDNet to make it suitble for ome dimernsional data denoising At present,moast aof the existing ftering methods are proposed for the Gausian white nmoise denoising h comtrast the propesed method also leams the wind moise mnstruction noix trafc noie and mixed noise through the sategy of reidual *** full anvohution *** used to esimate the noise level,which significandy improves the *** nise mio and ibs perfommance of removing the comelated noises The model is trmined with dffent types of real naise and randoam noises The denoising esult is evaluated by comespanding indexes and compured with ofher denoing *** reuls show that the poposed method has better demoising performance than raditiomal methods,and it has a superior noise supession level for ail well construction noise and mixed *** proposed method can supress the inerference of time frequeney owedapped end to end and still he nmoise suppesion and event detection capability even if the sigmul is superimpased on other types of noie.

关键词： Denoising Microseismic Deep learning Surface monitoring

Modified subintimal plaque modification improving future recanalization of chronic total occlusion percutaneous coronary intervention

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Journal of Geriatric Cardiology 2020年第7期17卷 393-399页

作者： Ruo-Fei JIA Long LI Yong ZHU Cheng-Zhi YANG Shuai MENG Yang RUAN Xiao-jing CAO Hong-Yu HU Wei CHEN jing NAN Xiao-Wei XIONG jing-Jin LI Jia-Yu WANG Ze-Ning JIN Department of Cardiology and Macrovascular Disease Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

Background Subintimal plaque modification(SPM) is often performed to restore antegrade flow and facilitate subsequent lesion recanalization. This study aimed to compare the safety and efficacy of modified SPM with traditional SPM. Methods A total of 1454 consecutive patients who failed a chronic total occlusion percutaneous coronary intervention(CTO PCI) attempt and underwent SPM from January 2015 to December 2019 at our hospital were reviewed retrospectively. Fifty-four patients who underwent SPM finally were included in this study. We analyzed the outcomes of all the patients, and the primary endpoint was recanalization rate, which was defined as Thrombolysis in Myocardial Infarction(TIMI) grades 2-3 flow on angiography 30 to 90 days post-procedure. Results The baseline characteristics were similar between the two groups. In the follow-up, the recanalization rate was noticeably higher in the modified SPM group compared with the traditional SPM group(90.9% vs. 62.5%, P < 0.05). The proposed strategy in the modified group was more aggressive, including a larger balloon size(1.83 ± 0.30 vs. 2.48 ± 0.26 mm, P < 0.05) and longer subintimal angioplasty(0.59 ± 0.16 vs. 0.92 ± 0.12 mm, P < 0.05). Also, the common use of a Stingray balloon and guide catheter extension resulted in improvement of patients in the modified SMP group(12.5% vs. 100%, P < 0.05). Conclusion Modified SPM, which is associated with a high likelihood of successful recanalization, is an effective and safe CTO PCI bail out strategy.

关键词： Chronic total occlusion Recanalization Subintimal plaque modification

Robust H-infinity control for discrete-time T-S fuzzy systems with input delay

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控制理论与应用（英文版） 2011年第2期9卷 189-194页

作者： Liu, Jianchen Zhang, jing Zheng, Yufang He, Min College of Electrical and Information Engineering Hunan University Changsha Hunan 410082 China Institute of Information and Electrical Engineering Hunan University of Science and Technology Xiangtan Hunan 411201 China Department of Electronic and Electrical Engineering Taizhou Vocational and Technical College Taizhou Zhejiang 318000 China

Delay-dependent robust H-infinity control for discrete-time Takagi-Sugeno (T-S) fuzzy systems with interval time-varying input delay is *** constructing a new Lyapunov-Krasovskii functional and using convex combination method,a delay-dependent condition is established,under which the resulted closed-loop systems via a fuzzy state feedback are robust asymptotically stable with given H-infinity norm ***,an iterative algorithm based on the modified SLPMM algorithm is proposed to solve the fuzzy H-infinity ***,a numerical example is used to illustrate the effectiveness and feasibility of the approaches proposed.

关键词： T-S fuzzy system Input delay Discrete-time system H-infinity control

Bayesian Analysis of Complex Mutations in HBV, HCV,and HIV Studies

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Big Data Mining and Analytics 2019年第3期2卷 145-158页

作者： Bing Liu Shishi Feng Xuan Guo jing Zhang Department of Mathematics and Statistics Georgia State UniversityAtlantaGA 30303USA Department of Computer Science and Engineering University of North TexasDentonTX 76203USA

In this article,we aim to provide a thorough review of the Bayesian-inference-based methods applied to Hepatitis B Virus(HBV),Hepatitis C Virus(HCV),and Human Immunodeficiency Virus(HIV)studies with a focus on the detection of the viral mutations and various problems which are correlated to these *** is particularly difficult to detect and interpret these interacting mutation patterns,but by using Bayesian statistical modeling,it provides a groundbreaking opportunity to solve these *** we summarize Bayesian-based statistical approaches,including the Bayesian Variable Partition(BVP)model,Bayesian Network(BN),and the Recursive Model Selection(RMS)procedure,which are designed to detect the mutations and to make further inferences to the comprehensive dependence structure among the ***,BN,and RMS in which Markov Chain Monte Carlo(MCMC)methods are used have been widely applied in HBV,HCV,and HIV studies in the recent *** also provide a summary of the Bayesian methods’applications toward these viruses’studies,where several important and useful results have been *** envisage the applications of more modified Bayesian methods to other infectious diseases and cancer cells that will be following with critical medical results before long.

关键词： Bayesian analysis Hepatitis B Virus(HBV) Hepatitis C Virus(HCV) Human Immunodeficiency Virus(HIV) complex mutations Markov chain Monte Carlo

Controllable Synthesis of Mixed-Phase TiO_2 with Small Anatase and Rutile Particle and Its Enhanced Photocatalytic Activity

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China Petroleum Processing & Petrochemical Technology 2018年第1期20卷 37-43页

作者： Bai Yu Li Kuan Chen Xuebing Zhang jing School of Chemistry and Materials Science Liaoning Shihua University

Mixed-phase TiO_2 photocatalysts with small particle size of anatase and rutile(~5 nm) have been successfully synthesized using hydrothermal method. The effects of curing temperature and curing time before the hydrothermal treatment on the crystalline phase, the phase composition, and the particle size of TiO_2 were investigated by the X-ray diffraction spectroscopy(XRD) and the transmission electron microscopy(TEM), respectively. It was found that the anatase and rutile phase contents in the TiO_2 particles were successfully controlled by simply adjusting the curing temperature and the curing time. More importantly, the particle size of both anatase and rutile is small in the mixed-phase TiO_2 particles. The photocatalytic activity of TiO_2 was evaluated by the degradation of Rhodamine B(Rh B) in aqueous solution. The Ti O2 with phase junction formed by anatase and rutile exhibited higher separation rate between the photo-induced electrons and holes, which was confirmed by the surface photovoltage(SPV) spectra, and at the same time exhibited the higher photocatalytic degradation on Rh B than pure anatase-phase TiO_2. Moreover, it was found that TiO_2 with 83% of anatase and 17% of rutile showed a highest photocatalytic activity among the mixed-phase TiO_2 samples.

关键词： TiO2 phase juction hydrothermal method photocatalytic degradation

Efficacy, safety, predictability, aberrations and corneal biomechnical parameters after SMILE and FLEx: Metaanalysis

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 757-762页

作者： jing Ma Nan-Jue Cao Li-Kun Xia Department of Ophthalmology Shengjing Hospital of China Medical University

AIM： To identify possible differences of efficacy, safety predictability, higher-order aberrations and cornea biomechnical parameters after small-incision lenticule extraction（SMILE） and femtosecond lenticule extraction（FLEx）.· METHODS： A systematic literature retrieval was conducted in Medline,Embase and the Cochrane Library up to October, 2015. The included studies were subject to a Meta-analysis. Comparison between SMILE and FLEx was measured as pooled odds ratio（OR） or weighted mean differences（WMD）. Of 95% confidence intervals（CI） were used to analyze data.·RESULTS： A total of seven studies were included Firstly, there were no differences in uncorrected distance visual acuity（UDVA） 20/20 or better（OR, 1.37; 95% CI0.69 to 2.69; P =0.37） and log MAR UDVA（WMD,-0.02;95% CI,-0.05 to 0.01; P =0.17） after SMILE versus FLEx We found no differences in corrected distance visua acuity（CDVA） unchanged（OR, 0.98; 95% CI, 0.46 to 2.11;P =0.97） and log MAR CDVA（WMD,-0.00; 95% CI,-0.01 to 0.01; P =0.90） either. Secondly, we found no differences in refraction within ±1.00 D（OR, 0.98; 95% CI0.13 to 7.28; P =0.99） and ±0.50 D（OR, 1.62; 95% CI0.62 to 4.28; P =0.33） of target postoperatively. Thirdly for higher-order aberrations, we found no differences in the total higher-order aberrations（WMD,-0.04; 95%CI,-0.09 to 0.01;P =0.14）, coma（WMD,-0.04; 95% CI,-0.09 to 0.01; P =0.11）, spherical（WMD, 0.01; 95% CI,-0.02 to0.03; P =0.60） and trefoil（WMD,-0.00; 95% CI,-0.04 to0.03; P =0.76）. Furthermore, for corneal biomechanica parameters, we also found no differences（WMD, 0.08;95% CI,-0.17 to 0.33; P =0.54） after SMILE versus FLEx.·CONCLUSION： There are no statistically differences in efficacy, safety, predictability, higher-order aberrations and corneal biomechnical parameters postoperative between SMILE and FLEx.

关键词： visual quality aberrations corneal biomechnical parameters small-incision lenticule extraction femtosecond lenticule extraction

Effects of He-Ne laser irradiation on chronic atrophic gastritis in rats

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World Journal of Gastroenterology 2005年第25期11卷 3958-3961页

作者： Xue-HuiShao Yue-PingYang JieDa jing-FangWu Ai-HuaBo DepartmentofMedicalPhysics HebeiNorthUniversityZhangjiakou075000HebeiProvinceChina DepartmentofPathology HebeiNorthUniversityZhangjiakou075000HebeiProvinceChina DepartmentofHistologyandEmbryology HebeiNorthUniversityZhangjiakou075000HebeiProvinceChina

AIM: To study the effects of He-Ne laser irradiation on experimental chronic atrophic gastritis (CAG) in ***: Sixty-three male adult Wistar rats were randomly divided into five groups including normal control group, model control group and three different dosages He-Ne laser groups. The chronic atrophic gastritis (CAG)model in rats was made by pouring medicine which was a kind of mixed liquor including 2% sodium salicylate and 30% alcohol down the throat for 8 wk to stimulate rat gastric mucosa, combining with irregular fasting and compulsive sporting as pathogenic factors; 3.36, 4.80, and 6.24J/cm2doses of He-Ne laser were used, respectively for three different treatment groups, once a day for 20 d. The pH value of diluted gastric acid was determined by acidimeter,the histopathological changes such as the inflammatory degrees in gastric mucosa, the morphology and structure of parietal cells were observed, and the thickness of mucosa was measured by micrometer under optical ***: In model control group, the secretion of gastric acid was little, pathologic morphological changes in gastric mucosa such as thinner mucous, atrophic glands, notable inflammatory infiltration were found. After 3.36 J/cm2 dose of He-Ne laser treatment for 20 d, the secretion of gastric acid was increased (P＜0.05), the thickness of gastric mucosa was significantly thicker than that in model control group (P＜0.01), the gastric mucosal inflammation cells were decreased (P＜0.05). Morphology, structure and volume of the parietal cells all recuperated or were closed to ***: 3.36J/cm2 dose of He-Ne laser has a significant effect on CAG in rats.

关键词： Chronic atrophic gastritis Laser He-Ne Rat

Solvent-assisted polymer micro-molding

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Chinese Science Bulletin 2009年第13期54卷 2193-2204页

作者： HAN LuLu ZHOU jing GONG Xiao GAO ChangYou Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

The micro-molding technology has played an important role in fabrication of polymer micro-patterns and development of functional *** such a process,suitable solvent can swell or dissolve the polymer films to decrease their glass transition temperature(Tg) and viscosity and thereby improve flowing ***,it is easy to obtain the 2D and 3D patterns with high fidelity by the solvent-assisted *** with the high temperature molding,this technology overcomes some shortcomings such as shrinking after cooling,degradation at high temperature,difficulty in processing some functional materials having high Tg,*** can be applied to making patterns not only on polymer monolayers but also on polyelectrolyte ***,the compression-induced patterns on the multilayers are chemically homogenous but physically *** this review,the controlling factors on the pattern quality are also discussed,including materials of the mold,solvent,pressure,temperature and pattern density.

关键词：聚合物膜微成型溶剂玻璃化转变温度聚电解质多层膜成型技术功能材料功能器件