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T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo wang Changxiang Li xueqian wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

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Bioinspired Spiral Soft Pneumatic Actuator and Its Characterization

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Journal of Bionic Engineering 2021年第5期18卷 1101-1116页

作者： Zhiyuan Zhang xueqian wang Deshan Meng Bin Liang Shenzhen Key Laboratory of Intelligent Robotics Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Robotics and Intelligent Systems ETH Zurich8801 ZurichSwitzerland Research Institute of Tsinghua University at Shenzhen Shenzhen 518057China School of Aeronautics and Astronautics Sun Yat-Sen UniversityShenzhen 518107China

Soft robots have unique advantages over traditional rigid robots and have broad application prospects in many *** expand their bioinspired applications,we propose a novel Soft Pneumatic Actuator(SPA)associated with spiral configuration inspired by the structure and unwinding motion of the seahorse *** erent from bending motion of common soft actuators,the spiral SPA can generate unwinding motion as input air pressure ***,to explore the eff ect of diff erent initial spiral types on unwinding performance,three typical spiral SPAs are designed and simulated while keeping the outside arc of actuator body ***,a static model of the spiral SPA is established by combining the hyperelastic material model,geometric relationships,and virtual work *** improve model accuracy,two geometric correction parameters are employed and their physical significance is analyzed by finite element ***,a prototype of the logarithmic spiral SPA(Log_spiral SPA)is fabricated and a Fiber Bragg Grating(FBG)sensor array is designed to detect and reconstruct unwinding shapes of the ***,the unwinding performance,static model and output force capability of the prototype are tested and ***,we discuss prospects for this novel spiral SPA and test its practical applications in inchworm-like motion,assisting finger rehabilitation and object capture.

关键词： Soft robotics Spiral Soft actuator Virtual work principle Fiber Bragg grating

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Density-based ship detection in SAR images:Extension to a self-similarity perspective

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Chinese Journal of Aeronautics 2024年第3期37卷 168-180页

作者： xueqian wang Gang LI Zhizhuo JIANG Yu LIU You HE Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China

Nonlocal self-similarity is an important property of Synthetic Aperture Radar(SAR)images to characterize the repetitiveness of features embodied by SAR images within nonlocal areas and has been used for enhancement of SAR *** SAR ship detectors often independently handle small sub-images cropped from a large marine SAR image and do not exploit the nonlocal self-similarity *** this paper,we propose a new ship detector from the perspective of nonlocal self-similarity in SAR images to improve the ship detection performance,basically including three stages:prescreening,intra-cue calculation,and inter-cue *** the prescreening stage,we design a new Histogram-based Density(HD)feature to rapidly select candidate sub-images potentially containing ship targets from a large SAR *** the intra-cue calculation stage,target cues within a single candidate sub-image are *** the inter-cue calculation stage,thanks to the nonlocal self-similarity among different candidate sub-images in terms of density features,we innovatively extract a weighted superpixel-HD map to obtain accumulated intracues across all the candidate ***,for each candidate sub-image,we fuse its inter-cue and intra-cue to obtain final detection *** results based on real SAR images show that our newly proposed method provides a better target-to-clutter contrast and ship detection performance than those of other state-of-the-art detection approaches.

关键词： Ship detection Synthetic aperture radar(SAR) Density Self-similarity Histogram

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Nonreciprocal thermal metamaterials:Methods and applications

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1678-1693页

作者： Zhengjiao Xu Chuanbao Liu xueqian wang Yongliang Li Yang Bai Institute for Advanced Material and Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

Nonreciprocity of thermal metamaterials has significant application prospects in isolation protection,unidirectional transmission,and energy ***,due to the inherent isotropic diffusion law of heat flow,it is extremely difficult to achieve nonreciprocity of heat *** review presents the recent developments in thermal nonreciprocity and explores the fundamental theories,which underpin the design of nonreciprocal thermal metamaterials,i.e.,the Onsager reciprocity ***,three methods for achieving nonreciprocal metamaterials in the thermal field are elucidated,namely,nonlinearity,spatiotemporal modulation,and angular momentum bias,and the applications of nonreciprocal thermal metamaterials are *** also discuss nonreciprocal thermal ***,the potential applications of nonreciprocity to other Laplacian physical fields are ***,the prospects for advancing nonreciprocal thermal metamaterials are highlighted,including developments in device design and manufacturing techniques and machine learning-assisted material design.

关键词： thermal metamaterials nonreciprocity nonlinearity spatiotemporal modulation

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Human stochastic closed-loop behavior for master-slave teleoperation using multi-leap-motion sensor

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Science China(Technological Sciences) 2017年第3期60卷 374-384页

作者： HU TianJian ZHU XiaoJun wang xueqian wang TianShu LI JunFeng QIAN WeiPing Beijing Institute of Tracking and Telecommunication Technology Beijing 100094 China School of Aerospace Engineering Tsinghua University Beijing 100084 China Shenzhen Laboratory of Space Robotics and Telescience Shenzhen 518055 China The Graduate School of Shenzhen Tsinghua University Shenzhen 518055 China

abstracting human control strategy in controlling dynamically stable robots.J Intell Robot Syst,2009,55：39-54

关键词： human behavior teleoperation statistical learning leap motion

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Feedback Attitude Sliding Mode Regulation Control of Spacecraft Using Arm Motion

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Chinese Journal of Mechanical Engineering 2013年第5期26卷 873-880页

作者： SHI Ye LIANG Bin XU Dong wang xueqian XU Wenfu Qian Xuesen Laboratory of Space Technology Dongfanghong Development Ltd Shenzhen Beijing Military Command Area 66240 Troops Shenzhen Graduate School Harbin Institute of Technology

The problem of spacecraft attitude regulation based on the reaction of arm motion has attracted extensive attentions from both engineering and academic *** of the solutions of the manipulator’s motion tracking problem just achieve asymptotical stabilization performance,so that these controllers cannot realize precise attitude regulation because of the existence of non-holonomic ***,sliding mode control algorithms are adopted to stabilize the tracking error with zero transient *** to the switching effects of the variable structure controller,once the tracking error reaches the designed hyper-plane,it will be restricted to this plane permanently even with the existence of external ***,precise attitude regulation can be ***,taking the non-zero initial tracking errors and chattering phenomenon into consideration,saturation functions are used to replace sign functions to smooth the control *** relations between the upper bounds of tracking errors and the controller parameters are derived to reveal physical characteristic of the *** models of free-floating space manipulator are established and simulations are conducted in the *** results show that the spacecraft’s attitude can be regulated to the position as desired by using the proposed algorithm,the steady state error is 0.000 2 *** addition,the joint tracking trajectory is smooth,the joint tracking errors converges to zero quickly with a satisfactory continuous joint control *** proposed research provides a feasible solution for spacecraft attitude regulation by using arm motion,and improves the precision of the spacecraft attitude regulation.

关键词： attitude regulation space robot trajectory tracking sliding mode control

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Autophagy,ferroptosis,pyroptosis,and necroptosis in tumor immunotherapy

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2311-2336页

作者： Weitong Gao Xueying wang Yang Zhou xueqian wang Yan Yu Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China Department of Otolaryngology Head and Neck Surgery Xiangya HospitalCentral South Universitychangsha 410008China Department of Head and Neck Surgery Harbin Medical University Cancer HospitalHarbin 150081China

In recent years,immunotherapy represented by immune checkpoint inhibitors(ICIs)has led to unprecedented breakthroughs in cancer ***,the fact that many tumors respond poorly or even not to ICIs,partly caused by the absence of tumorinfiltrating lymphocytes(TILs),significantly limits the application of *** these immune“cold”tumors into“hot”tumors that may respond to ICIs is an unsolved question in cancer *** it is a general characteristic of cancers to resist apoptosis,induction of non-apoptotic regulated cell death(RCD)is emerging as a new cancer treatment ***,several studies have revealed the interaction between non-apoptotic RCD and antitumor ***,autophagy,ferroptosis,pyroptosis,and necroptosis exhibit synergistic antitumor immune responses while possibly exerting inhibitory effects on antitumor immune ***,targeted therapies(inducers or inhibitors)against autophagy,ferroptosis,pyroptosis,and necroptosis in combination with immunotherapy may exert potent antitumor activity,even in tumors resistant to *** review summarizes the multilevel relationship between antitumor immunity and non-apoptotic RCD,including autophagy,ferroptosis,pyroptosis,and necroptosis,and the potential targeting application of non-apoptotic RCD to improve the efficacy of immunotherapy in malignancy.

关键词： immunotherapy immunity breakthrough

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Metal loaded zeolite adsorbents for hydrogen cyanide removal

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Journal of Environmental Sciences 2013年第4期25卷 808-814页

作者： Ping Ning Juan Qiu xueqian wang Wei Liu Wei Chen Faculty of Environmental Science and Engineering Kunming University of Science and Technology

Metal （Cu, Co, or Zn） loaded ZSM-5 and Y zeolite adsorbents were prepared for the adsorption of hydrogen cyanide （HCN） toxic gas. The results showed that the HCN breakthrough capacity was enhanced significantly when zeolites were loaded with Cu. The physical and chemical properties of the adsorbents that influence the HCN adsorption capacity were analyzed. The maximal HCN breakthrough capacities were about the same for both zeolites at 2.2 mol of HCN/mol of Cu. The Cu2p XPS spectra showed that the possible species present were Cu2O and CuO. The Nls XPS data and FT-IR spectra indicated that CN- would be formed in the presence of Cu＋/Cu2＋ and oxygen gas, and the reaction product could be adsorbed onto Cu/ZSM-5 zeolite more easily than HCN.

关键词： hydrogen cyanide zeolite removal

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Removal of elemental mercury by photocatalytic oxidation over La_(2)O_(3)/Bi_(2)O_(3)composite

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Journal of Environmental Sciences 2021年第4期33卷 384-397页

作者： Renjun Li Yanan Zhou xueqian wang Langlang wang Ping Ning Lei Tao Jun Cai Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China

La_(2)O_(3)/Bi_(2)O_(3)photocatalysts were prepared by impregnation of Bi_(2)O_(3)with an aqueous solution of lanthanum precursor followed by calcination at different *** composite materials were used for the first time for the photocatalytic removal of Hg~0 from a simulated flue gas under UV light *** results showed that the sample containing 6 wt.%La_(2)O_(3)and calcined at 500°C has the highest dispersion of the active sites,which was promoted by the strong interaction with the support(i.e.,the formation of Bi-O-La species).Since they are fully accessible on the surface,the material also exhibits excellent optical properties while the heterojunction formed in La_(2)O_(3)/Bi_(2)O_(3)promotes the separation and migration of photoelectron-hole pairs and thus Hg~0 oxidation efficiency is *** effects of the various factors(e.g.,the reaction temperature and composition of the simulated flue gas(i.e.,O_(2),NO,H_(2)O,and SO_(2)))on the efficiency of the Hg~0 photocatalytic oxidation were *** results demonstrated that O_(2)and SO_(2)enhanced the efficiency of the reaction while the reaction temperature,NO,and H_(2)O had an inhibitory effect.

关键词： La_(2)O_(3)/Bi_(2)O_(3) Calcination temperature Hg~0 oxidation Photocatalytic oxidation

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Removing carbonyl sulfide with metal-modified activated carbon

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Frontiers of Environmental Science & Engineering 2016年第1期10卷 11-18页

作者： Juan QIU Ping NING xueqian wang Kai LI Wei LIU Wei CHEN Langlang wang Faculty of Environmental Science and Engineering Kunming University of Science and Technology Kunming 650093 China

A Cu-Co-K/activated carbon （AC） adsorbent has been developed for the removal of carbonyl sulfide （COS）. The effects of COS concentration, reaction temperature and relative humidity were closely examined. A breakthrough of 33.23 mg COS .gl adsorbent at 60℃, under 30% relative humidity and in presence of 1.0% oxygen was exhibited in the Cu-Co-K/AC adsorbent prepared. Competitive adsorption studies for COS in the presence of CS2, and H2S were also conducted. TPD analysis was used to identify sulfur-containing products on the carbon surface, and the results indicated that H2S, COS and SO2 were all evident in the effluent gas generated from the exhausted Cu-Co-K/AC. Structure of the activated carbon samples has been characterized using nitrogen adsorption, and their surface chemical structures were also determined with X-ray photoelectron spectroscopy （XPS）. It turns out that the modification with Cu（OH）2CO3- CoPcS-KOH can significantly improve the COS removal capacity, forming SO2/4 species simultaneously. Regenera- tion of the spent activated carbon sorbents by thermal desorption has also been explored.

关键词： carbonyl sulfide activated carbon removal,reactive adsorption

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