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Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy

Oncology Research 2024年第1期32卷 49-60页

作者： QIUQIANG CHEN xuejun guo WENXUE MA Key Laboratory for Translational Medicine The First Affiliated HospitalHuzhou University School of MedicineHuzhou313000China Department of Hematology Puyang Youtian General HospitalPuyang457001China Department of Medicine Moores Cancer CenterSanford Stem Cell InstituteUniversity of California San DiegoLa JollaSan Diego92093USA

Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer,with the tumor microenvironment(TME)playing a pivotal role in modulating the immune ***47,a cell surface protein,has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer ***,the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely *** comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion,elucidating its impact on various types of immunotherapy outcomes,including checkpoint inhibitors and CAR T-cell ***,CD47-targeted therapies offer a promising avenue for improving cancer treatment outcomes,especially when combined with other immunotherapeutic *** review also discusses current and potential CD47-targeted therapies being explored for cancer treatment and delves into the associated challenges and opportunities inherent in targeting *** the demonstrated effectiveness of CD47-targeted therapies,there are potential problems,including unintended effects on healthy cells,hematological toxicities,and the development if ***,further research efforts are warranted to fully understand the underlying mechanisms of resistance and to optimize CD47-targeted therapies through innovative combination approaches,ultimately improving cancer treatment ***,this comprehensive review highlights the significance of CD47 as a promising target for cancer immunotherapy and provides valuable insight into the challenges and opportunities in developing effective CD47-targeted therapies for cancer treatment.

关键词： CD47 Cancer immunotherapy CD47-targeted therapies Tumor microenvironment Macrophage Cancer cell Immune evasion Checkpoint inhibitors CAR T-cell therapy Cancer treatment outcomes

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龋齿放线菌致乳腺炎1例

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中国感染与化疗杂志 2024年第2期24卷 206-208页

作者：雷莉郭宸君郭学君杨越昆明市第一人民医院乳腺科昆明650032

龋齿放线菌(Actinomyces odontolyticus)是一种罕见的兼性厌氧革兰阳性杆菌,属于放线菌的一个亚种。它属于口咽部的正常菌群,发生感染可累及全身各个部位,包括胸部、头颈部、盆腔及四肢皮下软组织等[1-3]。乳腺龋齿放线菌病罕见,既往仅... 详细信息

龋齿放线菌(Actinomyces odontolyticus)是一种罕见的兼性厌氧革兰阳性杆菌,属于放线菌的一个亚种。它属于口咽部的正常菌群,发生感染可累及全身各个部位,包括胸部、头颈部、盆腔及四肢皮下软组织等[1-3]。乳腺龋齿放线菌病罕见,既往仅见1例文献报告[4]。本文对昆明市第一人民医院收治1例龋齿放线菌感染乳腺炎病例情况进行报告,总结和分享诊治经验。

关键词：龋齿放线菌非哺乳期乳腺炎感染

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企业抢雷策略对消费者宽恕意愿的影响研究——一个有调节的中介效应模型

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福建商学院学报 2024年第1期 46-53,62页

作者：陈荷花郭学军兰州财经大学工商管理学院甘肃兰州730020

基于刺激—加工—响应理论,通过2(抢雷策略:有/无)×2(企业沟通风格:非正式/正式)组间设计,探究抢雷策略对消费者宽恕意愿的影响,并考察心理风险的中介作用和企业沟通风格的调节作用。研究发现,产品质量危机发生后,相比于不抢雷,抢雷策... 详细信息

基于刺激—加工—响应理论,通过2(抢雷策略:有/无)×2(企业沟通风格:非正式/正式)组间设计,探究抢雷策略对消费者宽恕意愿的影响,并考察心理风险的中介作用和企业沟通风格的调节作用。研究发现,产品质量危机发生后,相比于不抢雷,抢雷策略能有效提升消费者宽恕意愿;心理风险在抢雷策略与消费者宽恕意愿之间的中介作用受到企业沟通风格的调节,最终对消费者宽恕意愿形成有调节的中介作用。应在产品质量危机情境下果断抢雷,以尽可能低的成本快速降低消费者的心理风险,从而提升消费者的宽恕意愿,保护品牌资产。

关键词：产品质量危机抢雷策略消费者宽恕意愿心理风险沟通风格

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Advanced regeneration and fixed-bed study of ammonium and potassium removal from anaerobic digested wastewater by natural zeolite

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Journal of Environmental Sciences 2013年第5期25卷 954-961页

作者： xuejun guo Larry Zeng Xin Jin State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal University Environmental Technologies Alberta Research Council Inc.VegrevilleAlberta T9C 1T4Canada

Highly efficient regeneration of natural zeolite was developed in conjunction with the removal of high concentrations of ammonia and potassium from the reverse osmosis effluent of anaerobic-digested wastewater by fixed-bed ion *** elution and uptake behavior of ammonium and potassium in the fixed bed were *** batch desorption tests and on-column regeneration were conducted to develop an optimum regeneration condition compatible with the wastewater *** effectiveness of ammonium elution increased with increasing alkaline *** increase of salt dose significantly enhanced the ammonium maximum in the elution *** ammonium elution was achieved in 6 bed volumes（BV） when the alkaline and salt concentrations were respectively 0.1 mol/L and 18.6 g/L at a flow rate of 2.5-3.0 BV/*** to the higher affinity of potassium with natural clinoptilolite,complete potassium elution was not achieved in all cases.

关键词： regeneration removal ammonium potassium natural zeolite

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肝脏血管周上皮样细胞瘤的CT、MRI表现和病理对照分析

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医学影像学杂志 2024年第1期34卷 57-61页

作者：申美玲郭学军广东省深圳市大鹏新区葵涌人民医院放射科广东深圳518119 北京大学深圳医院放射科广东深圳518036

目的探讨肝脏血管周上皮样细胞瘤(PEComa)患者的CT、MRI影像特征,对照病理分析,以提高对该病诊断的准确性。方法选取经病理证实为肝脏PEComa的8例患者的影像学资料,分析病灶形态及其内部影像学特征及强化特点,与病理对照分析并复习相关... 详细信息

目的探讨肝脏血管周上皮样细胞瘤(PEComa)患者的CT、MRI影像特征,对照病理分析,以提高对该病诊断的准确性。方法选取经病理证实为肝脏PEComa的8例患者的影像学资料,分析病灶形态及其内部影像学特征及强化特点,与病理对照分析并复习相关文献。结果8例(100%)肝脏PEComa均为单发,7例(87.5%)边缘清晰,大小平均为4.5cm,4例(50.0%)病变内部不均匀;影像学检查4例(50.0%)见脂肪成分,其中2例(25.0%)含有大量脂肪成分,5例(62.5%)可见血管畸形,8例(100%)均未见出血、坏死及钙化;增强扫描4例(50.0%)为“快进快出”,2例(25.0%)为“快进慢出”,2例(25.0%)为“持续强化”。结论肝脏PEComa女性多见,多数单发,CT、MRI影像学表现为边界清晰,病变内部不均匀,可含有脂肪及畸形血管,强化方式多样。

关键词：肝脏血管周上皮样细胞瘤体层摄影术,X线计算机磁共振成像病理学

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差序式领导对员工亲上级非伦理行为的影响

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科技和产业 2024年第1期24卷 138-143页

作者：邱子阳郭学军兰州财经大学工商管理学院兰州730020

基于资源保存理论和差序格局理论,采用层次回归的分析方法,对来自企业内部问卷调研的374个样本进行实证分析。研究发现:差序式领导对员工的亲上级非伦理行为有显著正向影响;上下级关系在差序式领导对员工亲上级非伦理行为的影响中起中... 详细信息

基于资源保存理论和差序格局理论,采用层次回归的分析方法,对来自企业内部问卷调研的374个样本进行实证分析。研究发现:差序式领导对员工的亲上级非伦理行为有显著正向影响;上下级关系在差序式领导对员工亲上级非伦理行为的影响中起中介作用;人情导向在差序式领导对员工亲上级非伦理行为的影响中起调节作用。

关键词：差序式领导上下级关系亲上级非伦理行为人情导向

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A review of removal technology for antimony in aqueous solution

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Journal of Environmental Sciences 2020年第4期32卷 189-204页

作者： Xiaojing Long Xin Wang xuejun guo Mengchang He State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China

Antimony(Sb)and its compounds,toxic metalloid,have been classified as high-priority *** Sb released into the water environment by natural processes and anthropogenic activities,which exposure threatens to human health and ***,it is of unquestionable importance to remove Sb from polluted *** in view the extreme importance of this issue,we summarize the source,chemistry,speciation,distribution,toxicity,and polluted situation of Sb about aqueous ***,we provide the recent and common technology to remove Sb,which are based on adsorption,coagulation/flocculation,electrochemical technology,membrane technology,ion exchange,*** this review,we focus in detail on the adsorption method,researchers at present have been investigating to discover more advanced,cost-effective,eco-friendly,reusable ***,to date the Sb-containing wastewater treatment technologies are not sufficiently developed and most of research have been tested only in controlled lab *** reports are available that include field studies and *** critically analyzed the salient features and removal mechanisms,evaluating benefits and limitations of these technologies,hoping to provide more references for further ***,we considered the Fe-or Mn-based technologies was the most promising technique to remove Sb for field application.

关键词： Antimony pollution Removal technology Adsorption Coagulation-flocculation Membrane technology Ion exchange

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pH-dependent release characteristics of antimony and arsenic from typical antimony-bearing ores

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Journal of Environmental Sciences 2016年第6期28卷 171-179页

作者： Xingyun Hu xuejun guo Mengchang He Sisi Li State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University

The pH-dependent leaching of antimony（Sb） and arsenic（As） from three typical Sb-bearing ores（Banxi, Muli and Tongkeng Antimony Mine） in China was assessed using a pH-static leaching experiment. The pH changes of the leached solutions and pH-dependent leaching of Sb and As occurred in different ways. For the Banxi and Muli Sb ores, alkaline conditions were more favorable for the release of Sb compared to neutral and acidic conditions, but the reverse was true for the pH-dependent release of As. For the Tongkeng Sb ore, unlike the previous two Sb-bearing ores, acidic conditions were more favorable for Sb release than neutral and alkaline *** ores with lower Sb and As contents released higher percentages of their Sb and As after 16 day leaching, suggesting that they are the largest potential sources of pollution. This work may provide key information on the geochemistry of Sb and As in the weathering zone.

关键词： Typical antimony ores pH-static leaching Antimony Arsenic

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Reactive oxygen species may play an essential role in driving biological evolution: The Cambrian Explosion as an example

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Journal of Environmental Sciences 2018年第1期30卷 218-226页

作者： Dong Yang xuejun guo Tian Xie Xiaoyan Luo Gene Engineering and Biotechnology Beijing Key Laboratory College of Life Sciences Beijing Normal University State Key Laboratory of Environment Simulation School of Environment Beijing Normal University

The Cambrian Explosion is one of the most significant events in the history of life;essentially all easily fossilizable animal body plans first evolved during this event. Although many theories have been proposed to explain this event, its cause remains ***, we propose that the elevated level of oxygen, in combination with the increased mobility and food intake of metazoans, led to increased cellular levels of reactive oxygen species（ROS）, which drove evolution by enhancing mutation rates and providing new regulatory mechanisms. Our hypothesis may provide a unified explanation for the Cambrian Explosion as it incorporates both environmental and developmental factors and is also consistent with ecological explanations for animal radiation. Future studies should focus on testing this hypothesis, and may lead to important insights into evolution.

关键词： Cambrian Bilaterian Reactive oxygen species Evolution Metazoa

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The densities for 3-ranks of tame kernels of cyclic cubic number fields

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Science China Mathematics 2014年第1期57卷 43-47页

作者： CHENG XiaoYun guo xuejun QIN HouRong Department of Mathematics Nanjing University of Aeronautics and Astronautics Department of Mathematics Nanjing University

Let F be a cubic cyclic field with t(2)ramified *** a finite abelian group G,let r3(G)be the 3-rank of *** 3 does not ramify in F,then it is proved that t-1 r3(K2O F)***,if t is fixed,for any s satisfying t-1 s 2t-1,there is always a cubic cyclic field F with exactly t ramified primes such that r3(K2O F)=*** is also proved that the densities for 3-ranks of tame kernels of cyclic cubic number fields satisfy a Cohen-Lenstra type formula d∞,r=3-r2∞k=1(1-3-k)r k=1(1-3-k)*** suggests that the Cohen-Lenstra conjecture for ideal class groups can be extended to the tame kernels of cyclic cubic number fields.

关键词： densities,tame kernels,cyclic cubic fields

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