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Science China Chemistry 2024年第3期67卷 908-913页

作者： Jun Zhang xuefeng wang Peiqi wang Jiayuan Fang Shaoyu Li Jie Wu School of Pharmaceutical and Chemical Engineering&Institute for Advanced Studies Taizhou UniversityShanghai 200438China Department of Chemistry Fudan UniversityShanghai 200438China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

β-Chiral sulfones are structural motifs widely found in natural products and bioactive molecules, while also serving as important intermediates for the synthesis of valuable chiral scaffolds. In contrast to the rapid growth of sulfur dioxide insertion chemistry over the last decade, enantioselective catalytic variants for accessing β-chiral sulfones, especially those bearing a quaternary carbon stereocenter, remain rare. Herein, we report an enantioselective copper/bisoxazoline catalyzed oxysulfonylation of alkenes to yield isoxazolinyl-containing β-chiral sulfones bearing quaternary carbon stereocenters with moderate to excellent yields and up to 96:4 er. The advantage and irreplaceability of this sulfur dioxide insertion catalytic system have been demonstrated by achieving transformations clearly unavailable with the previously reported sulfonyl chloride system. Additionally,the recoverability of the new-developed bisoxazoline ligand L9 and its reusability without any erosion of the catalytic activity and enantioselectivity further demonstrate the usefulness of the protocol.

关键词： β-chiral sulfones sulfur dioxide insertion oxysulfonylation copper catalysis enantioselectivity

The underappreciated role of fugitive VOCs in ozone formation and health risk assessment emitted from seven typical industries in China

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Journal of Environmental Sciences 2024年第2期136卷 647-657页

作者： Zhiling Liang Yunjiang Yu Bingbing Sun Qian Yao Xihua Lin Yongsheng wang Jianping Zhang Yingzi Li xuefeng wang Zhengzheng Tang Shexia Ma College of Environmental and Chemical Engineering Shanghai University of Electric PowerShanghai 200090China State Environmental Protection Key Laboratory of Environmental Protection Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510535China Henan Jiyuan Ecological Environment Testing Center Jiyuan 454650China Ecological Environment Bureau of Jiyuan Production City Integration Demonstration Zone Jiyuan 454650China

Fugitive emission from industrial sources may result in ozone formation and health risk,while the exact contribution of this source remains incompletely understood.In this study,emission characteristics,ozone formation potential(OFP)and health risk of fugitive VOCs in7 representative industries were investigated.Chemical material industry was the dominant contributor to VOCs of fugitive emission in comparison with other industries.The OFP of VOCs from fugitive emission was in the range of 1.45×10^(3)-3.98×10^(5)μg/m^(3),with a higher value than that of organized emission in seven industries except for the coking industry and the chemical material industry,suggesting that fugitive VOCs should be taken into account while developing control strategies.Acetaldehyde,m,p-xylene,n-nonane,ethylene,vinyl chloridethe and other high OFP-contributing species were the major reactive species that should be targeted.Health risk assessment investigated non-cancer and cancer risks of fugitive VOCs in 7 industries were all above safe level(HR>1 and LCR>1×10^(-4)),posing remarkable health threats to human health.OVOCs were the main contributor to non-cancer risk,while halohydrocarbons and aromatics contributed most to cancer risks,posing remarkable health threat on human health.Our findings highlighted the contribution of fugitive VOCs on ozone formation and health risk was underestimated,indicating which should be considered in emission control strategies of industrial sources.

关键词： Industrial sources Volatile organic compounds Fugitive emission Ozone formation potential Health risk assessment

Cationic ordering transition in oxygen-redox layered oxide cathodes

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Carbon Energy 2024年第1期6卷 197-206页

作者： Xinyan Li Ang Gao Qinghua Zhang Hao Yu Pengxiang Ji Dongdong Xiao xuefeng wang Dong Su Xiaohui Rong Xiqian Yu Hong Li Yong-Sheng Hu Lin Gu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijingChina Beijing National Center for Electron Microscopy and Laboratory of Advanced Materials School of Materials Science and EngineeringTsinghua UniversityBeijingChina Beijing Advanced Innovation Center for Materials Genome Engineering Huairou DivisionInstitute of PhysicsChinese Academy of SciencesBeijingChina

Understanding the structural origin of the competition between oxygen 2p and transition-metal 3d orbitals in oxygen-redox(OR)layered oxides is eminently desirable for exploring reversible and high-energy-density Li/Na-ion cathodes.Here,we reveal the correlation between cationic ordering transition and OR degradation in ribbon-ordered P3-Na_(0.6)Li_(0.2)Mn_(0.8)O_(2) via in situ structural analysis.Comparing two different voltage windows,the OR capacity can be improved approximately twofold when suppressing the in-plane cationic ordering transition.We find that the intralayer cationic migration is promoted by electrochemical reduction from Mn^(4+)to Jahn–Teller Mn^(3+)and the concomitant NaO_(6) stacking transformation from triangular prisms to octahedra,resulting in the loss of ribbon ordering and electrochemical decay.First-principles calculations reveal that Mn^(4+)/Mn^(3+)charge ordering and alignment of the degenerate eg orbital induce lattice-level collective Jahn–Teller distortion,which favors intralayer Mn-ion migration and thereby accelerates OR degradation.These findings unravel the relationship between in-plane cationic ordering and OR reversibility and highlight the importance of superstructure protection for the rational design of reversible OR-active layered oxide cathodes.

关键词： cationic ordering layered oxide cathodes oxygen redox sodium-ion batteries

Research and Application of Caideng Model Rendering Technology for Virtual Reality

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Journal of Computer and Communications 2024年第4期12卷 95-110页

作者： xuefeng wang Yadong Wu Yan Luo Dan Luo School of Automation and Information Engineering Sichuan University of Science & Engineering Yibin China College of Computer Science and Engineering Sichuan University of Science & Engineering Yibin China

With the development of virtual reality (VR) technology, more and more industries are beginning to integrate with VR technology. In response to the problem of not being able to directly render the lighting effect of Caideng in digital Caideng scenes, this article analyzes the lighting model. It combines it with the lighting effect of Caideng scenes to design an optimized lighting model algorithm that fuses the bidirectional transmission distribution function (BTDF) model. This algorithm can efficiently render the lighting effect of Caideng models in a virtual environment. And using image optimization processing methods, the immersive experience effect on the VR is enhanced. Finally, a Caideng roaming interactive system was designed based on this method. The results show that the frame rate of the system is stable during operation, maintained above 60 fps, and has a good immersive experience.

关键词： Virtual Reality Caideng Model Lighting Model Point Light Rendering

Linear and quadratic damping coefficients of a single module of a very large floating structure over variable bathymetry:Physical and numerical free-decay experiments

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Journal of Ocean Engineering and Science 2022年第6期7卷 607-618页

作者： Yiting wang Ziying Tang Lei wang xuefeng wang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China SJTU-Sanya Yazhou Bay Institute of Deepsea Science and Technology Sanya 572024China

The linearity assumption is widely used when acquiring the hydrodynamic coefficients of a floating structure.However,the linear damping is frequently underestimated,especially for the natural frequency.To investigate the sloping seafloor effects on the damping terms of a single module of a semi-submersible Very Large Floating Structure(VLFS),this paper revisits the conventional formulation and further proposes the direct integration method for obtaining the linear and quadratic damping coefficients from free-decay tests.Numerical free-decay simulations of the single module over variable bathymetry are carried out by the CFD numerical tank.Corresponding model tests are also implemented to verify and validate against the numerical solutions.The effects of the sloping seafloor,as well as the water depth,on the hydrodynamic coefficients are investigated based on the validated CFD modeling.Both numerical and experimental results indicate that the acquisition of the linear and quadratic damping coefficients is sensitive to the data-processing and identification approaches.For the case studied in present paper,the identification errors introduced by the conventional method are 1.5%while they are 0.5%using the direct integration method.The quadratic damping coefficient for heave mode decreases about 10.4%when the sloping angle increases from 0 to 6 deg.

关键词： Quadratic damping coefficient Very large floating structure Model tests Numerical simulations

Fabrication and luminescence of highly transparent C12A7:Tb^(3+)glass-ceramics via in-situ crystallization from aerodynamic levitation processed glasses

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Journal of Rare Earths 2023年第11期41卷 1696-1702,I0002页

作者： Yaling Zhang Lingcong Fan xuefeng wang Jiansheng Xie Ying Shi School of Materials Science and Engineering Shanghai UniversityShanghai200444China

Rare earth doped 12CaO·7Al_(2)O_(3)(C12A7)glass-ceramics are one of attractive photonic materials due to their high transparency,high luminescent efficiency and eco-friendly nature.A series of C12A7 glasses with different Tb^(3+)doping concentrations was prepared by aerodynamic levitation method.The C12A7:Tb glass-ceramics were obtained via in-situ growth from the glasses with the identical chemical composition at 800℃.The microstructure observation demonstrates that the elemental distributions of Ca and Al are homogeneous in the glass-ceramics and the grain size of C12A7 is 4-70 nm.The in-line transmittance of glass-ceramics reaches as high as 82%at 1500 nm.The emission spectra of the C12A7:Tb glass-ceramics present characteristic Tb^(3+)emission peaks at 486 nm(^(5)D_(4)→^(7)F_6),541 nm(^(5)D_(4)→^(7)F_(5)),585 nm(^(5)D_(4)→^(7)F_(4))and 621 nm(^(5)D_(4)→^(7)F_(3)).The photolumine scence lifetime of C12A7:0.3%Tb glass-ceramic is 1.9 ms.Compared with the emission intensity of the glasses,that of the glass-ceramics increases due to the reducing in concentration of oxygen vacancy associated with network forming(NWF)cations.The highly transparent C12A7:Tb glass-ceramics may be a promising candidate for green light source in solid state lighting.

关键词： C12A7:Tb Aerodynamic levitation method Glass-ceramics Crystallization Luminescence Rare earths

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Oncology Research 2023年第5期31卷 697-714页

作者： xuefeng wang SICONG JIANG XINHONG ZHOU XIAOFENG wang LAN LI JIANJUN TANG Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanchang UniversityNational Regional Center for Respiratory MedicineNanchang330006China Division of Thoracic and Endocrine Surgery University Hospitals and University of GenevaGenevaSwitzerland Department of Hepatobiliary Surgery Xiantao First People’s Hospital of Yangtze UniversityXiantao433099China Department of Gastrointestinal Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510062China Department of Radiation Oncology The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer HospitalKunming650118China

Pancreatic cancer is associated with high mortality and is one of the most aggressive of malignancies,but studies have not fully evaluated its molecular subtypes,prognosis and response to immunotherapy of different subtypes.The purpose of this study was to explore the molecular subtypes and the key genes associated with the prognosis of pancreas cancer patients and study the clinical phenotype,prognosis and response to immunotherapy using single-cell seq data and bulk RNA seq data,and data retrieved from GEO and TCGA databases.Methods:Single-cell seq data and bioinformatics methods were used in this study.Pancreatic cancer data were retrieved from GEO and TCGA databases,the molecular subtypes of pancreatic cancer were determined using the six cGAS-STING related pathways,and the clinical phenotype,mutation,immunological characteristics and pathways related to pancreatic cancer were evaluated.Results:Pancreatic cancer was classified into 3 molecular subtypes,and survival analysis revealed that patients in Cluster3(C3)had the worst prognosis,whereas Cluster1(C1)had the best prognosis.The clinical phenotype and gene mutation were statistically different among the three molecular subtypes.Analysis of immunotherapy response revealed that most immune checkpoint genes were differentially expressed in the three subtypes.A lower risk of immune escape was observed in Cluster1(C1),indicating higher sensitivity to immunotherapeutic drugs and subjects in this Cluster are more likely to benefit from immunotherapy.The pathways related to pancreatic cancer were differentially enriched among the three subtypes.Five genes,namely SFRP1,GIPR,EMP1,COL17A and CXCL11 were selected to construct a prognostic signature.Conclusions:Single-cell seq data were to classify pancreatic cancer into three molecular subtypes based on differences in clinical phenotype,mutation,immune characteristics and differentially enriched pathways.Five prognosis-related genes were identified for prediction of survival of pancreatic cancer patients and to evaluat

关键词： Pancreatic cancer Molecular subtypes Single-cell sequencing Immune microenvironment Tumor immunity

Centennial-scale monsoon collapses during Marine Isotope Stage(MIS)7e detected in a northern Chinese stalagmite record

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Science China Earth Sciences 2023年第12期66卷 2941-2952页

作者： Wuhui DUAN Ming TAN Lisheng wang xuefeng wang Zhibang MA Linlin CUI Zhengyi XIAO Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences Beijing 100029China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

Occurrence or absence of centennial-scale climatic variability during Marine Isotope Stage(MIS)7e,the first peak interval of the Penultimate Interglacial,remains ambiguous due to the limited available high-resolved records.Here,we present a decadal-resolved stalagmiteδ^(18)O record from northern China spanning from 242.3 to 236.8 ka BP,covering MIS7e.The composite KLSδ^(18)O record,integrating this study with the previous record in the same cave,shows a descending trend from TerminationⅢto MIS7e,which follows the increasing Northern Hemisphere summer insolation(NHSI).This observation further emphasizes the important influence of NHSI on the glacial/interglacial transition.There are more large-amplitude,millennial-to centennial-scale variability occurring during TerminationⅢcompared with MIS7e,implying that ice-sheet decay potentially plays an important role in climatic excursions.Four centennial-scale summer monsoon collapses,peaking at~242.1,~240.8,~239.3 and~238.2 ka BP,are detected in our new record,indicating the pervasiveness of the intra-interglacial climatic instability.Given the lack of solar activity and freshwater outbursts data during MIS7e,it is not possible to conclude about the drivers of the identified abrupt climatic anomalous.Following the dynamic mechanisms of sub-millennial climatic anomalous during early Holocene,we tentatively propose that slowdown of the meridional overturning circulation caused by freshwater fluxes into North Atlantic and/or attenuated solar irradiance is the potential forcing for the abrupt climate events within MIS7e.Additionally,attenuated solar irradiance could also result in climatic anomalies through low-latitude processes.

关键词： Northern China Stalagmiteδ~(18)O record Marine Isotope Stage(MIS)7e Centennial-scale monsoon collapses Freshwater and/or solar activity forcings

Generation of sulfonylureas under photoredox catalysis and their biological evaluations

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Chinese Chemical Letters 2022年第11期33卷 4860-4864页

作者： xuefeng wang Jun Zhang Qi Chen Wei Zhou Jie Wu Taizhou Central Hospital(Taizhou University Hospital)&School of Pharmaceutical and Materials Engineering Taizhou UniversityTaizhou 318000China Department of Chemistry Fudan UniversityShanghai 200438China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Traditional synthesis of sulfonylureas largely depends on nucleophilic addition of arylsulfonamides to presynthesized isocyanates.Now we report a new access to alkylsulfonylureas with good yields and broad substrate scope.With the insertion of commercialized chlorosulfonyl isocyanate under photoredox catalysis,alkylsulfonylureas are synthesized in one-pot from the corresponding anilines and silyl enolates.A reaction mechanism is proposed showing the transformation undergoes a radical process,and the practicality of this methodology is proven via application to bioactive molecules.Additionally,the anti-cancer and anti-virus screening of these compounds is evaluated.

关键词： Sulfonylurea Chlorosulfonyl isocyanate Photocatalysis

A Morphology-Driven Method for Measuring Technology Complementarity:Empirical Study Involving Alzheimer’s Disease

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Journal of Data and Information Science 2022年第3期7卷 20-48页

作者： xuefeng wang Rongrong Li Yuqin Liu Ming Lei School of Management&Economics Beijing Institute of TechnologyHaidian DistrictBeijing 100081China School of Economics and Management China University of Petroleum(East China)QingdaoShandong 266580China School of Journalism and Publication Beijing Institute of Graphic CommunicationDaxing DistrictBeijing 102600China

Purpose:Measuring the exact technology complementarity between different institutions is necessary to obtain complementary technology resources for R&D cooperation.Design/methodology/approach:This study constructs a morphology-driven method for measuring technology complementarity,taking medical field as an example.First,we calculate semantic similarities between subjects(S and S)and action-objects(AO and AO)based on the Metathesaurus,forming clusters of S and AO based on a semantic similarity matrix.Second,we identify key technology issues and methods based on clusters of S and AO.Third,a technology morphology matrix of several dimensions is constructed using morphology analysis,and the matrix is filled with subjects-action-objects(SAO)structures according to corresponding key technology issues and methods for different institutions.Finally,the technology morphology matrix is used to measure the technology complementarity between different institutions based on SAO.Findings:The improved technology complementarity method based on SAO is more of a supplementary and refined framework for the traditional IPC method.Research limitations:In future studies we will reprocess and identify the SAO structures which were not in the technology morphology matrix,and find other methods to characterize key technical issues and methods.Furthermore,we will add the comparison between proposed method and traditional and mostly used complementarity measurement method based on industry chain and industry code.Practical implications:This study takes medical field as an example.The morphology-driven method for measuring technology complementarity can be migrated and applied for any given field.Originality/value:From the perspective of complementary technology resources,this study develops and tests a more accurate morphology-driven method for technology complementarity measurement.

关键词： Technology complementarity SAO structure Technology morphology analysis Alzheimer’s disease