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Influence on the immune function of the human peripheral blood mononuclear cells transfected by retrovirus-mediated HSV-tk gene

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Chinese Medical Journal 2006年第12期119卷 1038-1041页

作者： xue xing-kui SUN Wen-ji HU Jie YAO Hang-ping CAI Zhen Bone Marrow Transplantation Center ＆ Department ofHematology First Affiliated Hospital Institute of Immunology Zhejiang University School of Medicine Hangzhou 310003 China

Graft-versus-host disease （GVHD） is a severe complication and a major source of morbidity and mortality after allogeneic hematopoietic stem cell transplantation （HSCT）. Although T cell depletion of the allogeneic HSCT can efficiently prevent GVHD, it is associated with increased graft rejection and relapse of the malignant disease. To preserve the beneficial effects of donor T cells and avoid their GVHD effects, some approaches have been explored. One of them is to transfer a special suicide gene into the donor T lymphocytes so that they become more sensitive to a specific drug that is ordinarily not toxic. The most commonly used suicide gene is the thymidine kinase-encoding gene of herpes simplex virus （HSV-tk）.

关键词： graft vs host disease genes, transgenic, suicide T-lymphocytes cytotoxicity, immunologic

Vision-based docking system for an aromatic-hydrocarbon-inspired reconfigurable robot

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Science China(Technological Sciences) 2024年第6期67卷 1798-1816页

作者： xing FangYi XU Cheng LIU JinGuo xue ZhiHui State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang110016China School of Automation and Electrical Engineering Shenyang Ligong UniversityShenyang110158China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang110169China University of Chinese Academy of Sciences Beijing100049China

Aromatic hydrocarbons generally refer to compounds containing benzene *** types of isomers can be formed by replacing hydrogen atoms on the benzene *** this paper,an aromatic-hydrocarbon-inspired modular robot(AHIMR)is *** robot can be reassembled into different configurations suitable for various task requirements.A vision-based docking system is designed for the *** system primarily consists of two stages:a remote guidance stage and a precise docking *** the remote guidance stage,an object module is identified using an illumination adaptive target recognition algorithm,and then the active module moves to the docking area through communication with *** the precise docking stage,the active module calculates the relative pose with the object module using a perspective-n-point method and dynamically adjusts its posture to *** this process,a Kalman filter is used to reduce target occlusion and jitter *** addition,the docking system feasibility is verified via several simulation *** module docking accuracy is controlled within 0.01 m,which meets the reconfiguration task requirements of the *** the AHIMR submodule docking experiment,the active module accurately moves to the expected position with a docking success rate of 95%.

关键词： modular robot reconfiguration aromatic hydrocarbon autonomous docking visual identification

Rhodium-Catalyzed N-Arylation Addition of Arylboronic Acids to Ketimines

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Chinese Journal of Chemistry 2024年第18期42卷 2243-2248页

作者： xue-Wei Qian xing-Wen Sun Department of Chemistry Fudan University220 Handan RoadShanghai 200433China

Herein,we report rhodium catalyzed N-arylation via addition of arylboronic acids to electron-deficientα-iminoesters which can be prepared in high efficiency by using easily accessible B-carbonyl *** reaction is highly regiospecific to achieve the N-aryl addition efficiently with up to 99%yield under mild *** corresponding product can be further efficiently converted into indoles andaseries of other important building blocks.

关键词： Rhodium catalyzed N-Arylation addition Amines Umpolung Indole C-C coupling

Potential and application of abortive transcripts as a novel molecular marker of cancers

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World Journal of Experimental Medicine 2024年第2期14卷 53-61页

作者： Tian-Miao Zhang Xiao-Nian Zhu Shao-Wei Qin xue-Feng Guo xue-Kun xing Li-Feng Zhao Sheng-kui Tan Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health Guilin Medical UniversityGuilin 541199Guangxi Zhuang Autonomous RegionChina School of Leisure and Health Guilin Tourism UniversityGuilin 541006Guangxi Zhuang Autonomous RegionChina

Abortive transcript(AT)is a 2-19 nt long non-coding RNA that is produced in the abortive initiation *** initiation was found to be closely related to RNA polymerase through in vitro ***,the distribution of AT length and the scale of abortive initiation are correlated to the promoter,discriminator,and transcription initiation sequence,and can be affected by transcription elongation *** plays an important role in the occurrence and development of various *** we summarize the discovery of AT,the factors responsible for AT formation,the detection methods and biological functions of AT,to provide new clues for finding potential targets in the early diagnosis and treatment of cancers.

关键词： Abortive transcript Abortive initiation RNA polymerase Transcription Tumor marker

Exploring multiple phases and first-order phase transitions in Kármán Vortex Street

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 47-54页

作者： Xu Li xing Xiang Tingting xue Limin Wang Xiaosong Chen School of Systems Science and Institute of Nonequilibrium Systems Beijing Normal UniversityBeijing 100875China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy ofSciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Kármán Vortex Street, a fascinating phenomenon of fluid dynamics, has intrigued the scientific community for a long time. Many researchers have dedicated their efforts to unraveling the essence of this intriguing flow pattern. Here, we apply the lattice Boltzmann method with curved boundary conditions to simulate flows around a circular cylinder and study the emergence of Kármán Vortex Street using the eigen microstate approach, which can identify phase transition and its order-parameter. At low Reynolds number, there is only one dominant eigen microstate W_(1) of laminar flow. At Re_(c)^(1)= 53.6, there is a phase transition with the emergence of an eigen microstate pair W^(2,3) of pressure and velocity fields. Further at Re_(c)^(2)= 56, there is another phase transition with the emergence of two eigen microstate pairs W^(4,5) and W^(6,7). Using the renormalization group theory of eigen microstate,both phase transitions are determined to be first-order. The two-dimensional energy spectrum of eigen microstate for W^(1), W^(2,3) after Re_(c)^(1), W^(4-7) after Re_(c)^(2) exhibit-5/3 power-law behavior of Kolnogorov's K41 theory. These results reveal the complexity and provide an analysis of the Kármán Vortex Street from the perspective of phase transitions.

关键词： Kármán Vortex Street first-order phase transition eigen microstate approach renormalization group theory of eigen microstate

Increasing operational stability of journal bearing in hydraulic suspension micro-pump by herringbone grooved structure

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Science China(Technological Sciences) 2024年第3期67卷 853-862页

作者： HONG Tao xing GuanYing ZUO HuaiYu xue Song LUO XiaoBing State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The operational stability of radial journal bearings is the bottleneck that limits the reliability of hydraulic suspension micropump. Due to self-excited vibrations, the whirl amplitude of the plain journal bearing(PJB) is large at high rotational speeds,which will accelerate wear failure. It has been proven that employing herringbone grooved journal bearing(HGJB) is an effective method to reduce the whirl amplitude and improve operational stability. However, enhancing the stability of journal bearings in micro-pumps by herringbone grooved structures has rarely been studied, and its effect needs to be verified. We validated the mechanism of the stability improvement with the CFD method and compared the dynamic characteristics of HGJB and PJB by rotor dynamics evaluation and experiment. The experimental results show that under the same conditions the whirl amplitude of the HGJB decreases by 29.61% in the x direction and by 24.09% in the y direction compared with that of the PJB. This study reveals the effect of the herringbone grooved structure on the operational stability of bearings and may provide guidance for the reliability improvement of hydraulic suspension micro-pump.

关键词： journal bearing herringbone groove hydrodynamic effect micro-pump

Verification of quantum networks using the GHZ paradox

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Communications in Theoretical Physics 2024年第10期76卷 57-63页

作者： Huan Ye xue Yang Ming-xing Luo School of Information Science and Technology Southwest Jiaotong University School of Computer Science and Cyber Security Chengdu University of Technology

The Greenberger–Horne–Zeilinger(GHZ) paradox shows that it is possible to create a multipartite state involving three or more particles in which the measurement outcomes of the particles are correlated in a way that cannot be explained by classical physics. We extend it to witness quantum networks. We first extend the GHZ paradox to simultaneously verify the GHZ state and Einstein–Podolsky–Rosen states on triangle networks. We then extend the GHZ paradox to witness the entanglement of chain networks consisting of multiple GHZ states. All the present results are robust against the noise.

关键词： GHZ paradox quantum entanglement quantum network

Comparative transcriptomic analysis of ovary and testis reveals sex-related genes in roughskin sculpin Trachidermus fasciatus

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Journal of Oceanology and Limnology 2024年第5期42卷 1673-1682页

作者： Dongxiu xue Sudong XIA Tengfei xing Yuqian GAO Jinxian LIU CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Ecology and Environmental Science Qingdao Marine Science and Technology CenterQingdao 266200China Tianjin Key Lab of Aqua-Ecology and Aquaculture Department of Fishery ScienceTianjin 300380China

The mechanisms underlying sex determination and differentiation have long intrigued researchers in the fields of development and evolutionary *** roughskin sculpin(Trachidermus fasciatus Heckel),displaying sexual dimorphism,provides an ideal model for studying the ***,both genetic and genomic information concerning sex determination and differentiation,such as gonadal transcriptome data in roughskin sculpin,are ***,we present the first gonadal transcriptomes of roughskin sculpin and identify sex-related *** identified 8531 differentially expressed genes(DEGs),among them 4065 were upregulated in the ovary and 4466 upregulated in the *** sex-related gene ontology(GO)terms were enriched in ovary-biased genes,including“binding of sperm to zona pellucida”,“egg coat formation”,“positive regulation of acrosome reaction”,“cell division”,and“cell cycle”,while the GO terms such as“spermatogenesis”,“sperm axoneme assembly”,“cilium assembly”,“cilium movement”,and“cilium movement involved in cell motility”were enriched in testis-biased ***,six KEGG pathways were significantly enriched in the ovary,whereas only one was enriched in the *** these DEGs,40 sex-related genes were identified,which including 26 testis-biased genes(such as Dmrtb 1,Gsdf,Sox 9 b,Wnt 4 b,Tcp 11 l 2,and Efhb),and 14 ovary-biased genes(such as Cyp 19 a 1 a,Foxh 1,Foxr 1,Gdf 3,Hsd 17 b 12,and Igf 2 bp 3).This gonadal transcript dataset would broaden our understanding of sex determination and differentiation mechanisms in roughskin sculpin,expand the genomic database,support future studies on sex-related gene functions,and facilitate molecular biology research into roughskin sculpin.

关键词： Trachidermus fasciatus transcriptome ovary testis sex-related gene

Formation of ZnSe magic-size clusters displaying optical absorption doublets from prenucleation clusters

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Nano Research 2024年第7期17卷 6741-6748页

作者： Dingyu Zhao Shasha Wang Jiawei xue Chunchun Zhang Shanling Wang Xiaoqin Chen Chaoran Luan kui Yu Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China Engineering Research Center in Biomaterials Sichuan UniversityChengdu 610065China Analytical&Testing Center Sichuan UniversityChengdu 610065China College of Biomedical Engineering Sichuan UniversityChengdu 610065China

The formation pathway of colloidal semiconductor ZnSe magic-size clusters(MSCs)in a reaction that display an optical absorption doublet remains poorly *** reaction of Zn(OAc)_(2)/OLA(made from zinc acetate and oleylamine)and tri-noctylphosphine selenide(SeTOP)in OLA in the presence of diphenylphosphine(HPPh_(2))is studied,in which dMSC-345 displays a doublet peaking at 328/345 *** suggest that the development is from the clusters that form in the initial prenucleation stage of the *** clusters are the precursor compound(PC-299)of MSC-299(displaying an absorption singlet peaking at 299 nm).PC-299 transforms to PC-345 at a later *** presence of alcohol(such as methanol or ethylene glycol)promotes another pathway,which is the PC-299 to PC-320 ***-320 transforms to dMSC-320(with a doublet at 305/320 nm),followed by dMSC-345 via *** present study provides additional evidence that clusters(PC-299)form and transform(such as to dMSC-345 via PC-345)in the prenucleation stage of ZnSe quantum dots(QDs).

关键词： magic-size cluster(MSC) prenucleation cluster precursor compound(PC) quantum dot(QD) zinc selenide(ZnSe)