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《二十四诗品·自然》的“自然美”

江苏工程职业技术学院学报 2019年第4期19卷 45-48页

作者：薛晓璐华东师范大学国际汉语文化学院

唐代司空图的《二十四诗品》可谓是中国古代美学的代表作,具有丰富的美学价值。康德是德国古典美学的集大成者,"自然美"是其一直追求以及提倡的,其内涵与司空图的"自然"品不谋而合。质、量、关系、模态是康德审美判断力的4个契机,借鉴这... 详细信息

唐代司空图的《二十四诗品》可谓是中国古代美学的代表作,具有丰富的美学价值。康德是德国古典美学的集大成者,"自然美"是其一直追求以及提倡的,其内涵与司空图的"自然"品不谋而合。质、量、关系、模态是康德审美判断力的4个契机,借鉴这4个契机去分析《二十四诗品》,对司空图的"自然美"进行剖析,能揭示"自然美"的内在依据以及"自然美"的本体论本质。

关键词：《二十四诗品》司空图康德自然美审美判断力

基于RANSAC的残缺平面标靶稳健定位方法

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测绘工程 2016年第4期25卷 51-54页

作者：薛晓璐林欢河海大学地球科学与工程学院江苏南京210098

针对圆形有效反射区域的平面标靶拖尾点和因遮挡造成的数据缺失问题,提出一种基于RANSAC的残缺平面标靶稳健定位方法。文中采用RANSAC算法拟合标靶平面,使经过测距误差修正的反射点规整位于标靶平面;利用Givens变换将空间三维圆拟合简... 详细信息

针对圆形有效反射区域的平面标靶拖尾点和因遮挡造成的数据缺失问题,提出一种基于RANSAC的残缺平面标靶稳健定位方法。文中采用RANSAC算法拟合标靶平面,使经过测距误差修正的反射点规整位于标靶平面;利用Givens变换将空间三维圆拟合简化为二维圆RANSAC拟合。采用两个实验分析同一平面标靶因不同遮挡对定位精度的影响。结果表明,该方法能够有效解决拖尾点和数据缺失问题,提高平面标靶定位的鲁棒性。

关键词：平面标靶定位拖尾点数据缺失 RANSAC Givens变换

院前管理平台在泌尿系结石手术患者健康教育中的应用研究

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中华护理教育 2024年第8期21卷 981-985页

作者：卢嫡王璐李葆华乔海芹李丽薛小鹿刘春霞河北医科大学第二医院石家庄市050000 北京大学第三医院北京市100191 郑州市中医院郑州市450007 山西省心血管病医院太原市030024

目的探讨借助院前管理平台对泌尿系结石手术患者进行健康教育的方法及效果,为提升住院时间较短患者的健康教育效果提供借鉴。方法选取2022年8月—12月某三级甲等医院泌尿系上尿路结石拟行输尿管镜/输尿管软镜手术且住院时间≤3 d的患者... 详细信息

目的探讨借助院前管理平台对泌尿系结石手术患者进行健康教育的方法及效果,为提升住院时间较短患者的健康教育效果提供借鉴。方法选取2022年8月—12月某三级甲等医院泌尿系上尿路结石拟行输尿管镜/输尿管软镜手术且住院时间≤3 d的患者作为研究对象。其中,经过该院院前管理平台收治入院的患者为试验组,门诊直接收治入院的患者为对照组。所有患者入院后给予常规健康教育;试验组在院前管理中心进行1次系统性健康教育。比较两组患者出院1个月的疾病知识水平和特异性生活方式依从性。结果试验组患者疾病知识得分高于对照组[17(16,18),12.5(10.5,14);Z=10.162,P<0.001],特异性生活方式依从性得分高于对照组[22(20,24),17(15,20);Z=8.026,P<0.001]。结论基于院前管理平台开展健康教育有助于住院时间短的泌尿系结石手术患者掌握疾病相关知识,改善生活方式。

关键词：健康教育院前管理平台泌尿系结石

体外循环技术在小儿先天性心脏病心内直视手术中的应用进展

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中外医疗 2024年第24期43卷 193-198页

作者：景维娜薛晓露马秀英于长辉新疆维吾尔自治区克孜勒苏柯尔克孜自治州阿图什市克州人民医院麻醉与围术期医学科新疆维吾尔自治区克孜勒苏柯尔克孜自治州845350 新疆维吾尔自治区克孜勒苏柯尔克孜自治州阿图什市克州人民医院心胸外科新疆维吾尔自治区克孜勒苏柯尔克孜自治州845350

本研究主要分析体外循环技术在小儿先天性心脏病心内直视手术中的应用进展,全面概览了小儿先天性心脏病的分类,以及心内直视手术和体外循环技术的相关内容。深入探讨了体外循环的结构组成、血液动力学监测与体温管理的主要原理,并阐述... 详细信息

本研究主要分析体外循环技术在小儿先天性心脏病心内直视手术中的应用进展,全面概览了小儿先天性心脏病的分类,以及心内直视手术和体外循环技术的相关内容。深入探讨了体外循环的结构组成、血液动力学监测与体温管理的主要原理,并阐述了体外循环在术前评估、操作要点及其对手术结果的影响。本研究综合分析了近期技术创新,探讨体外循环技术改进如何提升临床效果,并对风险管理与并发症控制提供见解。通过综述评价体外循环在先天性心脏病治疗中的效能,为该领域未来的研究趋势与技术应用提供了科学依据。

关键词：体外循环技术小儿先天性心脏病心内直视手术血液动力学监测技术进展临床效果

Aerodynamic characteristics of store during lateral jet assisted separation from cavity using free drop technique

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Chinese Journal of Aeronautics 2023年第1期36卷 139-151页

作者： Fei xue Yipeng REN Zheng LI Cong XU Dechen WEI xiaolu MAO Zenghui JIANG China Academy of Aerospace Aerodynamics Beijing 100074China Bejing Institute of Astronautical Systems Engineering Beijing 100076China China Academy of Launch Vehicle Technology Beijing 100076China Institute of Aeronautical Engineering and Technology Binzhou UniversityBinzhou 256600China Nanhang Jincheng College Nanjing 211156China

Aimed at the problem of store separation from internal cavity,this paper innovatively puts forward a separation scheme of using lateral jet to assist store safe *** jet ensures that the store is continuously subjected to down head moment during separation,so as to ensure safe *** wind tunnel free drop test technique with lateral jet is established,which can ensure that there is no support interference in the motion process of the store and more truly simulate the motion of the *** feasibility of the new separation scheme is proved by wind tunnel *** test shows that the new scheme can also change the more dangerous state into a safe *** the analysis of the test data,the pitching moment coefficients of the store under different pressures in the high-pressure cylinder are obtained,and the effects of aircraft and cavity on the pitching moment of the store are *** 3 stages of store passing through cavity shock wave are *** results show that the lateral jet provides the store with continuous head down moment,and makes the store overcome the head up moment caused by the shock wave in front of the cavity,so as to ensure the safety of separation.

关键词： Compressible flow Internal cavity Lateral jet Store separation Unsteady test Wind tunnel free drop test

Organizational Innovation of Apical Actin Filaments Drives Rapid Pollen Tube Growth and Turning

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Molecular Plant 2017年第7期10卷 930-947页

作者： xiaolu Qu Ruihui Zhang Meng Zhang Min Diao Yongbiao xue Shanjin Huang Center for Plant Biology School of Life Sciences Tsinghua University Beijing 100084 China Key Laboratory of Plant Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100101 China

Polarized tip growth is a fundamental cellular process in many eukaryotes. In this study, we examined the dynamic restructuring of the actin cytoskeleton and its relationship to vesicle transport during pollen tip growth in Arabidopsis. We found that actin filaments originating from the apical membrane form a specialized structure consisting of longitudinally aligned actin bundles at the cortex and inner cytoplasmic fila- ments with a distinct distribution. Using actin-based pharmacological treatments and genetic mutants in combination with FRAP （fluorescence recovery after photobleaching） technology to visualize the transport of vesicles within the growth domain of pollen tubes, we demonstrated that cortical actin filaments facilitate tip-ward vesicle transport. We also discovered that the inner apical actin filaments prevent backward movement of vesicles, thus ensuring that sufficient vesicles accumulate at the pollen tube tip to support the rapid growth of the pollen tube. The combinatorial effect of cortical and internal apical actin filaments perfectly explains the generation of the inverted ＂V＂ cone-shaped vesicle distribution pattern at the pollen tube tip. When pollen tubes turn, apical actin filaments at the facing side undergo depolymerization and repolymerization to reorient the apical actin structure toward the new growth direction. This actin restructuring precedes vesicle accumulation and changes in tube morphology. Thus, our study provides new insights into the functional relationship between actin dynamics and vesicle transport during rapid and directional pollen tube growth.

关键词： pollen tube clear zone apical actin structure actin dynamics vesicle trafficking myosin

三级甲等医院57个ICU护理人力资源配置现况研究

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护理管理杂志 2023年第10期23卷 859-862页

作者：李丽张鹤立李宇轩马雪倩薛小鹿卢嫡李葆华北京大学第三医院护理部北京市100191 郑州市中医院护理部 450007 北京大学第三医院康复医学科北京市100191 北京大学第三医院重症医学科北京市100191 山西省心血管病医院神经内科太原市030001 河北医科大学第二医院泌尿外科石家庄市050061

目的调查三级甲等医院ICU护理人力资源配置情况。方法于2022年8月至10月,通过便利抽样法对11个省、市、自治区25所医院57个ICU进行问卷调查,调查问卷为自行设计,包括护士长个人基本信息、医院/ICU基本资料、人力资源配置情况、工作强度... 详细信息

目的调查三级甲等医院ICU护理人力资源配置情况。方法于2022年8月至10月,通过便利抽样法对11个省、市、自治区25所医院57个ICU进行问卷调查,调查问卷为自行设计,包括护士长个人基本信息、医院/ICU基本资料、人力资源配置情况、工作强度与工作质量等。结果57个ICU实际床护比为1︰(2.03±0.82);床护比与意外伤害呈负相关(P<0.05);ICU工作年限<5年的护士比例与非计划拔管、新发压力性损伤、尿路感染、呼吸机相关性肺炎和导管相关性血流感染呈正相关(P<0.05)。结论ICU护理人力资源配置不足,床护比与意外伤害呈正相关,护士工作年限与不良事件相关;未来应进一步加强ICU护理人力配置,提高床护比,优化护士职称结构,保障护理质量及患者安全。

关键词：重症监护室人力资源护理护理管理

The pathogenic mechanism of syndactyly type V identified in aHoxd13Q50R knock-in mice

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Bone Research 2024年第2期12卷 349-360页

作者： Han Wang Xiumin Chen xiaolu Meng Yixuan Cao Shirui Han Keqiang Liu Ximeng Zhao Xiuli Zhao xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Complex Severe and Rare DiseasesDepartment of Medical GeneticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Orthopedics State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifthmetacarpals. In the previous publication, we first identified a heterozygous missense mutation Q50R in homeobox domain (HD) ofHOXD13 in a large Chinese family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlyingpathogenic mechanism causing limb malformation, transcription-activator-like effector nucleases (TALEN) was employed togenerate a Hoxd13Q50R mutant mouse. The mutant mice exhibited obvious limb malformations including slight brachydactyly andpartial syndactyly between digits 2-4 in the heterozygotes, and severe syndactyly, brachydactyly and polydactyly in *** on BMP2 and SHH/GREM1/AER-FGF epithelial mesenchymal (e-m) feedback, a crucial signal pathway for limbdevelopment, we found the ectopically expressed Shh, Grem1 and Fgf8 and down-regulated Bmp2 in the embryonic limb bud atE10.5 to E12.5. A transcriptome sequencing analysis was conducted on limb buds (LBs) at E11.5, revealing 31 genes that exhibitednotable disparities in mRNA level between the Hoxd13Q50R homozygotes and the wild-type. These genes are known to be involvedin various processes such as limb development, cell proliferation, migration, and apoptosis. Our findings indicate that the ectopicexpression of Shh and Fgf8, in conjunction with the down-regulation of Bmp2, results in a failure of patterning along both theanterior-posterior and proximal-distal axes, as well as a decrease in interdigital programmed cell death (PCD). This cascadeultimately leads to the development of syndactyly and brachydactyly in heterozygous mice, and severe limb malformations inhomozygous mice. These findings suggest that abnormal expression of SHH, FGF8, and BMP2 induced by HOXD13Q50R may beresponsible for the manifestation of human SDTY5.

关键词： BMP2 mechanism finding

Application of next-generation sequencing to screen for pathogenic mutations in 123 unrelated Chinese patients with Marfan syndrome or a related disease

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Science China(Life Sciences) 2019年第12期62卷 1630-1637页

作者： Jiacheng Li Chaoxia Lu Wei Wu Yaping Liu Rongrong Wang Nuo Si xiaolu Meng Shuyang Zhang xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100005China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Laboratory of Clinical Genetics Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China

Marfan syndrome(MFS) is a systemic connective tissue disease principally affecting the ocular, skeletal and cardiovascular systems. This autosomal dominant disorder carries a prevalence of 1:3,000 to 1:5,000. This study aims to define the mutational spectrum of MFS related genes in Chinese patients and to establish genotype-phenotype correlations in MFS. Panel-based targeted next-generation sequencing was used to analyze the FBN1, TGFBR1 and TGFBR2 genes in 123 unrelated Chinese individuals with MFS or a related disease. Genotype-phenotype correlation analyses were performed in mutation-positive patients. The results showed that 97 cases/families(78.9%;97/123) harbor at least one(likely) pathogenic mutation, most of which were in FBN1;four patients had TGFBR1/2 mutations;and one patient harbored a SMAD3 mutation. Three patients had two FBN1 mutations, and all patients showed classical MFS phenotypes. Patients with a dominant negative-FBN1 mutation had a higher prevalence of ectopia lentis(EL). Patients carrying a haploinsufficiency-FBN1 mutation tended to have aortic dissection without EL. This study extends the spectrum of genetic backgrounds of MFS and enriches our knowledge of genotype-phenotype correlations.

关键词： Marfan syndrome FBN1 mutation next-generation sequencing genotype-phenotype correlations