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铁死亡在急性呼吸窘迫综合征中的基础研究和临床应用进展

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海军军医大学学报 2024年第2期45卷 212-218页

作者：王培郁景文张立奚望薛小飞张宇峰肖健杨潜王志农海军军医大学(第二军医大学)第二附属医院胸心外科上海200003

铁死亡是一种独特的调节性细胞死亡形式,特点是铁依赖的、脂质过氧化物的过量累积。铁死亡在形态学、生物学和遗传学等方面明显不同于凋亡、坏死、自噬及其他形式的细胞死亡。铁、脂肪、氨基酸代谢及其他信号通路与铁死亡密切相关。铁... 详细信息

铁死亡是一种独特的调节性细胞死亡形式,特点是铁依赖的、脂质过氧化物的过量累积。铁死亡在形态学、生物学和遗传学等方面明显不同于凋亡、坏死、自噬及其他形式的细胞死亡。铁、脂肪、氨基酸代谢及其他信号通路与铁死亡密切相关。铁死亡与癌症、炎症、神经变性、肝肾损伤和缺血再灌注损伤等的病理过程密切相关。急性呼吸窘迫综合征(ARDS)是严重威胁人类生命健康的肺部炎症性疾病,发病率和死亡率高。近年来,人们对肺损伤发病机制和修复途径有了长足的认识,针对通气诱发肺损伤的疗法对ARDS患者是有益的,但仍缺乏有效的药物治疗方法。在全球范围内大流行的新型冠状病毒感染令ARDS的形势更加严峻,亟待进一步探索其在细胞、分子水平的机制并研发新的疗法。本文对铁死亡的定义、机制及其在ARDS中的基础研究和临床应用进展进行综述。

关键词：铁死亡急性呼吸窘迫综合征肺损伤代谢通路

An eco-friendly and highly sensitive loofah@CF/CNT 3D piezoresistive sensor for human activity monitoring and mechanical cotrol

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Science China(Technological Sciences) 2022年第11期65卷 2667-2674页

作者： ZHU Jie SONG YongTao xue xiaofei LIU ZhiLong MAO QingYuan JIA ZhenHua School of Computer Science and Engineering North China Institute of Aerospace EngineeringLangfang 065000China

Three-dimensional(3D)porous piezoresistive sensors are widely used because of their simple fabrication and convenient signal ***,because of the dependence on organic skeleton materials and the complexity of conductive coating preparation,the electrical and mechanical properties of 3D wearable piezoresistive sensors have gradually failed to accommodate many emerging ***,a new flexible 3D piezoresistive sensor(NF3PS)with high sensitivity and a wide measurement range is proposed,which comprises a natural porous loofah as a flexible framework and carbon fiber/carbon nanotube(CF/CNT)multiscale composite as a conductive *** of cellulose and lignin,the irregular,porous loofah has excellent mechanical strength,elasticity,and toughness,ensuring a repeated compression/recovery behavior of the *** addition,compared with the single-size carbon coating,the coupling of multiscale CF/CNT composite coating improves sensitivities over a range of *** NF3PS demonstrates a sensitivity of 6.94 kPa^(-1) with good linearity in the pressure range of 0–11.2 kPa and maintains a sensitivity of 0.28 kPa^(-1) in an ultrawide measurement range of 11.2–84.6 *** flexibility,robustness,and wide-ranging linear resistance variation,the feasibility of the NF3PS in human activity monitoring,mechanical control,and smart homes is *** work provides a novel strategy for a new generation of 3D flexible pressure sensors for improving sensitivity and measurement range and demonstrates attractive applications in wearable sensors.

关键词： 3D piezoresistive sensor loofah framework CF/CNT multiscale composite high sensitivity human activity monitoring mechanical control

The Hemodynamic Study on the Effects of Entry Tear and Coverage in Aortic Dissection

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Computer Modeling in Engineering & Sciences 2019年第12期121卷 929-945页

作者： Zhenxia Mu xiaofei xue Minrui Fu Dawei Zhao Bin Gao Yu Chang School of Life Science and BioEngineering Beijing University of TechnologyBeijing100124China

In this work,the hemodynamic effects of the type-A aortic dissection in different entry and covering entry tear positions were mainly *** provides a new method or idea in the field of the aortic dissection hemodynamics,and it is of profound significance to provide basic theoretical research on the development of aortic dissection in the aspect of clinical *** type-A aortic dissection models with different entry tear positions(Model 1:The entry tear was located at the entrance of the ascending aorta,Model 2:The entry tear was located at the starting position of the descending aorta)were reconstructed according to the computed tomography(CT)images of the *** our study,the thoracic aortic endovascular repair was simulated by covering the entry tear(Model 3).To clarify the hemodynamic effects of entry tear and coverage,the comparative study on the true lumen(TL)and false lumen(FL)blood flow patterns of three models were carried out *** velocity vector,flow ratio,pressure,time-averaged wall shear stress(TAWSS)and relative residence time(RRT)were calculated to evaluate the hemodynamic *** results of this work indicated that(I)the velocity of entry tear at the aorta entrance was higher;(II)The helical development of the TL and FL might be related to the helical nature of aortic arch;(III)The blood flow which passing the FL of Model 1,Model 2 and Model 3 in one cardiac cycle were approximately 26.63%,13.39%and 1%,respectively;(IV)The difference in intima wall pressure of the TL and FL were showed a strong pulsation;(V)The TAWSS distribution in TL and FL were completely different(the TAWSS in TL intima>8 Pa,the TAWSS in FL intima<4 Pa).In brief,the aortic morphology and location of the entry tear were found to have a significant effect on the hemodynamics of the aortic *** addition,the CFD method is used to obtain multi-dimensional hemodynamic information such as velocity field,pressure,TAWSS and RRT,which can help clinic

关键词： Computational fluid dynamics(CFD) aortic dissection hemodynamic TEVAR

低温条件下UCT-MBR处理工艺同步脱氮除磷优化研究

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水处理技术 2024年第3期50卷 127-132页

作者：姚晓琰李凌云薛晓飞王建利赵有生曹之淇北控水务(中国)投资有限公司北京100102

随着地表水准Ⅳ类处理标准的全面推广,北方地区低COD/TN(C/N)、冬季低温严重影响污水处理厂出水稳定达标。本研究构建了UCT-MBR在冬季开展中试,通过调整C/N、回流比,系统考察了该工艺脱氮除磷效果。运行结果表明,在低温时,C/N为6.0、无... 详细信息

随着地表水准Ⅳ类处理标准的全面推广,北方地区低COD/TN(C/N)、冬季低温严重影响污水处理厂出水稳定达标。本研究构建了UCT-MBR在冬季开展中试,通过调整C/N、回流比,系统考察了该工艺脱氮除磷效果。运行结果表明,在低温时,C/N为6.0、无需投加除磷药剂、缺氧池至厌氧池回流比100%、好氧池至缺氧池回流比260%、膜池至好氧池回流比200%,系统脱氮除磷效果优异,出水COD平均为20 mg/L、NH_(4)^(+)-N、TN、TP平均质量浓度分别为0.4、8.5、0.2 mg/L,稳定达到地表准Ⅳ类出水标准。厌氧和缺氧池ORP与系统脱氮除磷效果呈现负相关性,厌氧和缺氧池ORP分别在(-283±51) mV和(-144±42) mV,同步脱氮除磷效果最佳,在工程应用可根据ORP值预测处理效果,并指导生产运行。提高C/N,有助于反硝化聚磷菌(DPAOs)富集,C/N为6.0时,缺氧池除磷率达到73.5%,TP平均去除率93.5%。高通量测序结果表明,系统中属于DPAOs的Dechloromonas和Candidatus Accumulibacter富集效果显著,两者丰度之和是普通聚磷菌的2倍。

关键词： UCT-MBR 低C/N 低温反硝化除磷同步脱氮除磷

网络媒体平台管控行为的随机演化博弈决策研究

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科技情报研究 2024年第2期6卷 72-87页

作者：王仪雯谭春辉薛晓斐王学东华中师范大学信息管理学院武汉430079 武汉工商学院电子商务学院武汉430065

[目的/意义]网络媒体平台在突发公共事件中发挥着重要作用。通过对不确定环境下网络媒体平台管控行为的随机演化博弈分析,为网络媒体平台舆论管控提供建议。[方法/过程]基于Moran过程的随机演化模型,将自然选择规则作为策略更新规则,探... 详细信息

[目的/意义]网络媒体平台在突发公共事件中发挥着重要作用。通过对不确定环境下网络媒体平台管控行为的随机演化博弈分析,为网络媒体平台舆论管控提供建议。[方法/过程]基于Moran过程的随机演化模型,将自然选择规则作为策略更新规则,探讨了影响网络媒体平台管控行为的因素,分析了外部随机性因素和内部因素主导情境下的均衡结果。[结果/结论]研究发现,网络媒体平台管控行为主要受外部随机性因素、平台数量规模、不同管控行为的成本收益影响。外部随机性越小、平台管控收益越大且成本越小,积极管控的扎根概率就越大,平台数量规模存在着一个能够有效管控突发公共事件的临界值,能为突发公共事件中网络媒体平台管控提供新思路。

关键词：突发公共事件网络媒体平台随机演化博弈管控行为

Large-scale manufacturing of functional single-atom ink for convenient glucose sensing

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Nano Research 2024年第8期17卷 7256-7263页

作者： Muyu Yan xiaofei Zhu Can Xiong Xiao Han Zhenggang xue Yuen Wu Department of Endocrinology Institute of Endocrine and Metabolic DiseasesThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Deep Space Exploration Laboratory University of Science and Technology of ChinaHefei 230026China NEST Laboratory Department of PhysicsDepartment of ChemistryCollege of ScienceShanghai UniversityShanghai 200444China Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China

Printing techniques hold great potential in the manufacture of electronics such as sensors,micro-supercapacitors,and flexible ***,developing large-scale functional conductive inks with appropriate rheological properties and active components still remains a ***,through optimizing the formulations of ink,iron single sites supported N-doped carbon black(Fe_(1)-NC)inks can serve as both conductive electrodes and high-reactive catalysts to realize convenient glucose detection,which pronouncedly reduces the dosage of enzyme and simplifies the sensors *** detail,utilizing in-situ pyrolysis method,Fe_(1)-NC single-atom catalysts(SACs)are prepared in bulk(dekagram-level).The batched Fe_(1)-NC SACs materials can be uniformly mixed with modulated ink to realize the screen printing with high resolution and ***,the whole scalable preparation and ink-functional process can be extended to various metals(including Co,Ni,Cu,and Mn).The introduction of highly active Fe_(1)-NC sites reduces the amount of enzyme used in glucose detection by at least 50%,contributing to the cost reduction of *** strategy in harnessing the SACs onto the carbon inks thus provides a broad prospect for the low-cost and large-scale printing of sensitive sensing devices.

关键词： large-scale manufacturing single-atom inks screen printing glucose sensing low enzyme dosage

The Hemodynamic Study on the Effects of Entry Tear and Coverage in Aortic Dissection

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医用生物力学 2019年第A1期34卷 87-88页

作者： Zhenxia Mu xiaofei xue Minrui Fu Dawei Zhao Bin Gao Yu Chang College of Life Science and Bioengineering Beijing University of Technology

Nowadays,cardiovascular disease has gradually become the number one killer of human *** Stanford type-A aortic dissection is a relatively common cardiovascular disease with potential *** disease is caused by a partialtearing of the aortic *** endovascular aortic repair(TEVAR)is one of the most effective treatment for type A aortic dissection and has been widely used clinically to achieve thrombosis and reduce pressure by covering the incision tear in the ***,the effect of entry tear location on type-A aortic dissection and the prognosis of TEVAR intervention are *** this work,the hemodynamic effects of the type-A aortic dissection in different entry and covering entry tear position were mainly *** can provide a new method or idea in the field of the aortic dissection hemodynamics,which is of great significance to provide a basic theoretical research on the development of aortic dissection in the aspect of clinical *** type-A aortic dissection models with different entry tear positions(Model 1:the entry tear was located at the entrance of the ascending aorta,Model 2:the entry tear was located at the starting position of the descending aorta)were reconstructed according to the computed tomography(CT)images of the *** our study,the thoracic aortic endovascular repair was simulated by covering the entry tear(Model 3).Then,the semi-automatic adaptive technology HyperMeshl0.0(Altair HyperWorks,Troy,Ml,USA)mesh generator was used to generate the high-quality tetrahedral 3D *** clarify the hemodynamic effects of entry tear and coverage in aortic blood flow pattern,the comparative study on the true lumen(TL)and false lumen(FL)blood flow patterns of three models were carried out numerically(the time-dependent pulsatile waveform of pressure boundary conditions used at the aortic inlet were consistent with Rapezzis’s work,time-dependent pulsatile waveform of velocity at the descending aorta outlet and the time

关键词： computational fluid dynamics(CFD) aortic dissection hemodynamic TEVAR

The regulatory network behind maize seed germination: Effects of temperature, water, phytohormones, and nutrients

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The Crop Journal 2021年第4期9卷 718-738页

作者： xiaofei xue Shangyi Du Fuchao Jiao Menghan Xi Aiguo Wang Haicheng Xu Qiqing Jiao Xin Zhang Hao Jiang Jingtang Chen Ming Wang College of Agronomy Qingdao Agricultural UniversityQingdao 266109ShandongChina Administrative Committee of Yellow River Delta Agri-High-Tech Industry Demonstration Zone Dongying 257347ShandongChina Shandong Institute of Pomology Tai’an 271000ShandongChina Jinan Fruit Research Institute All China Federation of Supply and Marketing Co-operativesJinan 250000ShandongChina Productivity Promotion Center of Zoucheng Jining 273500ShandongChina

Seed germination is the process by which an organism grows from a seed. It requires suitable conditions and environmental factors. Maize is one of the most important crops worldwide. Germination influences both final maize yield and quality. Seed germination is regulated by a complex gene network. It is also influenced by endogenous(phytohormones and nutrients) and exogenous(temperature and water)inputs, involving molecular networks only partly identified to date. This review describes current understanding of the influence of temperature, water, phytohormones, and nutrients in regulating maize seed germination, and indicates knowledge gaps that should be addressed.

关键词： Germination of maize seed Temperature Water Phytohormones Nutrients

商业银行绿色供应链金融的实践思考:模式、问题及对策

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新金融 2022年第3期 41-47页

作者：薛小飞福建华通银行股份有限公司

绿色供应链金融是绿色金融理念植根于供应链金融的一个细分方向,是商业银行践行绿色发展理念的重要路径。国外绿色供应链金融以“绿色供应链+供应链金融”的组合模式为主,侧重于产业端;国内商业银行在开展绿色供应链金融方面进行了大量... 详细信息

绿色供应链金融是绿色金融理念植根于供应链金融的一个细分方向,是商业银行践行绿色发展理念的重要路径。国外绿色供应链金融以“绿色供应链+供应链金融”的组合模式为主,侧重于产业端;国内商业银行在开展绿色供应链金融方面进行了大量实践,但由于其依托产业的多样性和金融业务的特殊性,尚未形成公认的模式。总体上,我国绿色供应链金融业务存在发展模式粗放、动力不足和评价机制缺乏等方面的问题,制约了绿色供应链金融的发展。基于此,本文提出绿色银行、投研银行、数字银行和敏捷银行的建设思路,以推动绿色供应链金融发展。

关键词：供应链金融绿色金融碳达峰碳中和 ESG