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X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway

World Journal of Diabetes 2024年第6期15卷 1299-1316页

作者： Ming-Wei Du Xin-Lin Zhu Dong-Xing Zhang Xian-Zhen Chen Li-Hua Yang Jin-Zhou Xiao Wen-Jie Fang Xiao-Chun xue Wei-Hua Pan Wan-Qing Liao tao Yang Institute of Cardiovascular Disease Shanghai Key Laboratory of Traditional Chinese Clinical MedicineShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Dermatology Shanghai Key Laboratory of Molecular Medical MycologySecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Dongshan HospitalMeizhou 514000Guangdong ProvinceChina Department of Dermatology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Emergency Naval Hospital of Eastern TheaterZhoushan 316000Zhejiang ProvinceChina Department of Pharmacy 905th Hospital of People’s Liberation Army of China(PLA)NavyShanghai 200052China

BACKGROUND Diabetic foot ulcers(DFU),as severe complications of diabetes mellitus(DM),significantly compromise patient health and carry risks of amputation and *** To offer new insights into the occurrence and development of DFU,focusing on the therapeutic mechanisms of X-Paste(XP)of wound healing in diabetic *** Employing traditional Chinese medicine ointment preparation methods,XP combines various medicinal ***-performance liquid chromatography(HPLC)identified XP’s main *** streptozotocin(STZ)-induced diabetic,we aimed to investigate whether XP participated in the process of diabetic wound ***-sequencing analyzed gene expression differences between XP-treated and control *** docking clarified XP’s treatment mechanisms for diabetic wound *** umbilical vein endothelial cells(HUVECs)were used to investigate the effects of Andrographolide(Andro)on cell viability,reactive oxygen species generation,apoptosis,proliferation,and metastasis in vitro following exposure to high glucose(HG),while NF-E2-related factor-2(Nrf2)knockdown elucidated Andro’s molecular *** XP notably enhanced wound healing in mice,expediting the healing ***-sequencing revealed Nrf2 upregulation in DM tissues following XP *** identified 21 primary XP components,with Andro exhibiting strong Nrf2 *** mitigated HG-induced HUVECs proliferation,metastasis,angiogenic injury,and inflammation *** alleviates HG-induced HUVECs damage through Nrf2/HO-1 pathway activation,with Nrf2 knockdown reducing Andro’s proliferative and endothelial protective *** XP significantly promotes wound healing in STZ-induced diabetic *** XP’s key component,Andro activates the Nrf2/HO-1 signaling pathway,enhancing cell proliferation,tubule formation,and inflammation reduction.

关键词： Words:Diabetes mellitus Wound healing NF-E2-related factor-2/HO-1 signaling pathway Andrographolide

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Comparative analysis of two digestive tract reconstruction methods in total laparoscopic radical total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1109-1120页

作者： Tian-Xiang Dong Dong Wang Qun Zhao Zhi-Dong Zhang xue-Feng Zhao Bi-Bo Tan Yu Liu Qing-Wei Liu Pei-Gang Yang Ping-An Ding tao Zheng Yong Li Zi-Jing Liu Third Department of Surgery of the Fourth Hospital of Hebei Medical University Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric CancerShijiazhuang 050011Hebei ProvinceChina

BACKGROUND The incidence of gastric cancer has significantly increased in recent *** resection is the main treatment,but the method of digestive tract reconstruction after gastric cancer surgery remains *** the current study,we sought to explore a reasonable method of digestive tract reconstruction and improve the quality of life and nutritional status of patients after *** this end,we statistically analyzed the clinical results of patients with gastric cancer who underwent jejunal interposition double-tract reconstruction(DTR)and esophageal jejunum Roux-en-Y reconstruction(RY).AIM To explore the application effect of DTR in total laparoscopic radical total gastrectomy(TLTG)and evaluate its safety and *** We collected the relevant data of 77 patients who underwent TLTG at the Fourth Hospital of Hebei Medical University from October 2021 to January *** them,35 cases were treated with DTR,and the remaining 42 cases were treated with traditional *** 1:1 propensity score matching,the cases were grouped into 31 cases per group,with evenly distributed *** clinical characteristics and short-and long-term clinical outcomes of the two groups were statistically *** The two groups showed no significant differences in basic data,intraoperative blood loss,number of lymph node dissections,first defecation time after operation,postoperative hospital stay,postoperative complications,and laboratory examination results on the 1st,3rd,and 5th days after *** operation time of the DTR group was longer than that of the RY group[(307.58±65.14)min vs(272.45±62.09)min,P=0.016],but the first intake of liquid food in the DTR group was shorter than that in the RY group[(4.45±1.18)d vs(6.0±5.18)d,P=0.028].The incidence of reflux heartburn(Visick grade)and postoperative gallbladder disease in the DTR group was lower than that in the RY group(P=0.033 and P=0.038).Although there was no significant difference in bod

关键词： Gastric cancer Jejunal interposition double-tract reconstruction Roux-en-Y reconstruction Laparoscope

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Evolutionary divergence of subgenomes in common carp provides insights into speciation and allopolyploid success

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Fundamental Research 2024年第3期4卷 589-602页

作者： Lin Chen Chengyu Li Bijun Li Xiaofan Zhou Yulin Bai Xiaoqing Zou Zhixiong Zhou Qian He Baohua Chen Mei Wang Yaguo xue Zhou Jiang Jianxin Feng tao Zhou Zhanjiang Liu Peng Xu State Key Laboratory of Mariculture Breeding College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Fujian Key Laboratory of Genetics and Breeding of Marine Organisms College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Integrative Microbiology Research Centre South China Agricultural UniversityGuangzhou 510642China College of Fisheries Henan Normal UniversityXinxiang 453007China Henan Academy of Fishery Science Zhengzhou 450044China Department of Biology College of Arts and SciencesSyracuse UniversitySyracuse 13244USA

Hybridization and polyploidization have made great contributions to speciation,heterosis,and agricultural production within plants,but there is still limited understanding and utilization in *** structure and expression reorganization and cooperation post hybridization and polyploidization are essential for speciation and allopolyploid ***,the mechanisms have not yet been comprehensively assessed in ***,we produced a high-fidelity reference genome sequence for common carp,a typical allotetraploid fish species cultured *** genome enabled in-depth analysis of the evolution of subgenome architecture and expression *** genes were expressed with subgenome biases,with a trend of transition from the expression of subgenome A during the early stages to that of subgenome B during the late stages of embryonic *** subgenome A evolved more rapidly,subgenome B contributed to a greater level of expression during development and under stressful *** dominant patterns for homoeologous gene pairs both during development and under thermal stress suggest a potential fixed heterosis in the allotetraploid *** expressing either copy of a homoeologous gene at higher levels to confer development and response to stress indicates the dominant effect of *** plasticity of subgenomes and their shifting of dominant expression during early development,and in response to stressful conditions,provide novel insights into the molecular basis of the successful speciation,evolution,and heterosis of the allotetraploid common carp.

关键词： Allotetraploid Subgenome structural evolution Homoeologous expression Expression dominance shift Environmental adaptation

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基于多项式混沌展开的交直流系统全纯嵌入概率潮流计算方法

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电力系统自动化 2024年第18期48卷 177-188页

作者：李雪付云跃姜涛李国庆现代电力系统仿真控制与绿色电能新技术教育部重点实验室(东北电力大学) 吉林省吉林市132012

为快速、准确量化分析风电出力不确定性对交直流电力系统潮流分布的影响,提出一种基于多项式混沌展开(PCE)的交直流电力系统全纯嵌入概率潮流计算方法。该方法首先根据风电出力的概率分布特征选择最优正交基函数,构造近似风电出力概率... 详细信息

为快速、准确量化分析风电出力不确定性对交直流电力系统潮流分布的影响,提出一种基于多项式混沌展开(PCE)的交直流电力系统全纯嵌入概率潮流计算方法。该方法首先根据风电出力的概率分布特征选择最优正交基函数,构造近似风电出力概率分布特征的PCE表达式;其次,将该PCE表达式引入交直流电力系统的全纯嵌入潮流方程中,构建基于PCE的交直流电力系统全纯嵌入概率潮流计算模型;再次,通过Galerkin投影将所构建的全纯嵌入概率潮流计算模型转化为高维确定性全纯嵌入潮流计算模型;然后,借助确定性全纯嵌入潮流模型求解方法,实现对所转化的高维确定性全纯嵌入潮流模型的求解,并根据所得PCE逼近系数计算交直流电力系统潮流的概率分布特征;最后,通过修改的PJM 5节点、IEEE 30节点和IEEE 118节点交直流测试系统算例验证所提方法的准确性和有效性。

关键词：概率潮流多项式混沌展开全纯嵌入 Galerkin投影交直流电力系统不确定性

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Prolonged course of Paxlovid administration in a centenarian with COVID-19:A case report

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World Journal of Radiology 2024年第9期16卷 489-496页

作者： Yi-xue Zhang Juan Tang Dan Zhu Chun-Yan Wu Mei-Lan Liang Yuan-tao Huang Department of Healthcare Haikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikou 570208Hainan ProvinceChina Department of Healthcare Hainan Chengmei HospitalHaikou 570000Hainan ProvinceChina

BACKGROUND According to the population statistics in 2023,there were 110000 people aged over 100 years in China,and the experience of using Paxlovid(nirmatrelvir/ritonavir)for centenarians is particularly *** article reports our experience of using Paxlovid in a centenarian with the novel coronavirus disease 2019(COVID-19)*** SUMMARY A 103-year-old female with mild COVID-19 and renal insufficiency was given sufficient Paxlovid for 2 days and a half dose for 3 *** treatment,the patient was complicated with lung infection and heart failure,and nucleic acid remained *** expert consultation,a full dose of Paxlovid was given again on the 9th day of admission for 2 days and a half dose for 3 ***,anti-heart failure and antibiotics were administered;the heart failure and pulmonary infection were ***,on the 33^(th) day of admission,nucleic acid turned negative,body temperature returned to normal,cough and sputum,fatigue,poor appetite and other symptoms basically *** patient was given Paxlovid via nasal feeding for 2 courses without deterioration of liver and kidney function,diarrhea,nausea and vomiting,myalgia,chest tightness and other side effects,and was discharged from hospital with good *** This case suggests that Paxlovid can be used cautiously in centenarians with renal insufficiency and two courses of treatment can be considered in patients with persistent positive nucleic acid.

关键词： COVID-19 Paxlovid Centenarians Renal insufficiency Heart failure Lung infection Case report

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汽车用硫系玻璃元件红外双波段增透膜的研制

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红外技术 2024年第6期46卷 728-734页

作者：薛浙瀛陶长虎陶欣周凯浙江农业商贸职业学院浙江绍兴312000 江苏省射阳中等专业学校江苏盐城224300 中国地质大学(北京)能源学院北京100083 江铃汽车股份有限公司产品研发总院江西南昌330001

基于硫系玻璃IRG206(As40Se60)基底,研制了3.7~4.8μm及7.5~9.5μm双波段增透膜,可用于汽车红外夜视成像系统。采用电子束和电阻蒸发离子辅助沉积技术,结合化学键分析选取连接层材料,提高基底与膜层之间的结合力;利用离子辅助应力调控技... 详细信息

基于硫系玻璃IRG206(As40Se60)基底,研制了3.7~4.8μm及7.5~9.5μm双波段增透膜,可用于汽车红外夜视成像系统。采用电子束和电阻蒸发离子辅助沉积技术,结合化学键分析选取连接层材料,提高基底与膜层之间的结合力;利用离子辅助应力调控技术,优化膜层应力,实现膜层应力的匹配,解决硫系玻璃表面脱膜问题。测试结果表明,该膜层在3.7~4.8μm波段平均透过率为98.31%,在7.5~9.5μm波段平均透过率为97.43%,通过了牢固度、盐雾、高低温、摩擦等环境测试,能够满足汽车红外夜视成像系统的使用要求。

关键词：薄膜硫系玻璃应力调控连接层技术红外夜视成像系统

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基于UPLC-Q-orbitrap-MS技术探究西黄丸抗乳腺增生的作用机制

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药学学报 2024年第1期59卷 214-224页

作者：王婧瑞陶蕊马学莉王俊亮韩涛甘肃中医药大学药学院甘肃兰州730000 甘肃省中药药理与毒理学重点实验室甘肃兰州730000

基于UPLC-Q-orbitrap-MS与生物网络分析工具系统分析西黄丸改善乳腺组织增生的作用机制。肌注苯甲酸雌二醇和黄体酮建立乳腺增生大鼠模型,采用LC-MS的组织代谢组学探索西黄丸改善乳腺组织增生的关键代谢物和代谢途径。整合生物网络分析... 详细信息

基于UPLC-Q-orbitrap-MS与生物网络分析工具系统分析西黄丸改善乳腺组织增生的作用机制。肌注苯甲酸雌二醇和黄体酮建立乳腺增生大鼠模型,采用LC-MS的组织代谢组学探索西黄丸改善乳腺组织增生的关键代谢物和代谢途径。整合生物网络分析工具对西黄丸调节的关键代谢物进行网络分析,聚焦关键代谢通路,挖掘西黄丸改善乳腺组织增生的潜在靶点。与空白组比,模型组大鼠组织中有49种差异代谢物含量有显著差异(P<0.05),西黄丸能显著回调L-丙氨酸、苏氨酸、吲哚-3-羧酸醛、赖氨酸、精氨酸、丙氨酰亮氨酸、甘氨酰络氨酸、γ-谷氨酰亮氨酸、维生素B3、丝氨酰亮氨酸、苏氨酰亮氨酸、异亮氨酰谷氨酸、γ-谷氨酰酪氨酸、癸酰-L-肉碱、2,6,8-三羟基嘌呤、亮氨酰亮氨酸、S-腺苷-蛋氨酸等17种代谢物。对西黄丸调控的关键代谢物进一步网络分析及文献研究表明,晚期糖基化终末产物(AGE)-晚期糖基化终产物受体(RAGE)信号通路可能是西黄丸改善乳腺组织增生的重要通路之一,AGE-RAGE信号通路上的STAT3、MAPK1、EGFR、CASP3、CASP8、PRKCA、JUN等7个蛋白可能为西黄丸改善乳腺组织增生的潜在作用靶点。本文涉及的动物实验操作均遵循甘肃中医药大学动物伦理委员会的规定并通过动物实验伦理审查(批号:2022-705)。

关键词：乳腺增生 UPLC-Q-orbitrap-MS AGE-RAGE信号通路西黄丸

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A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F

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Journal of Biomedical Research 2024年第5期38卷 451-463页

作者： Jing xue Linwei Zhang Jingxian tao xuexue Xie Xi Wang Linlin Wu Shuhu Du Ninghua Tan Yang Jin Jianming Ju Junting Fan Jun Wang Fei Huan Rong Gao Key Laboratory of Modern Toxicology Ministry of EducationDepartment of ToxicologySchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Taizhou Center for Disease Control and Prevention TaizhouJiangsu 225300China Wuxi Center for Disease Control and Prevention WuxiJiangsu 214023China School of Pharmacy Jiangsu Province Engineering Research Center of Antibody DrugNanjing Medical UniversityNanjingJiangsu 211166China School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjingJiangsu 211198China Department of Pharmaceutical Analysis School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Laboratory of Quality and Metabolomics of Traditional Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingJiangsu 210028China Department of Hygienic Analysis and Detection Key Laboratory of Modern ToxicologyMinistry of EducationSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

As a potential endocrine-disrupting chemical,bisphenol F(BPF)may cause nonalcoholic fatty liver disease(NAFLD)-like changes,but the mechanisms under its pathogenesis as well as the intervention strategies remain *** the electron microscopy technology,along with LipidTOX Deep Red neutral and Bodipy 493/503 staining assays,we observed that BPF treatment elicited a striking accumulation of lipid droplets in HepG2 cells,accompanied by an increased total level of *** the molecular level,the lipogenesis-associated mRNAs and proteins,including acetyl-CoA carboxylase,fatty acid synthase,stearoyl-CoA desaturase-1,peroxisome proliferator-activated receptor gamma,and CCAAT-enhancer-binding proteins,increased significantly via the AMP-activated protein kinase(AMPK)-mammalian target of rapamycin(mTOR)signaling regulation in both in vitro and in vivo ***,the immunofluorescence results also showed the robust lipogenesis induced by BPF,evident in its ability to promote the translocation of sterol regulatory element-binding protein-1c from the cytoplasm to the *** investigate the intervention strategies for BPF-induced NAFLD-like changes,we demonstrated that bellidifolin,isolated and purified from Swertia chirayita,significantly attenuated BPF-induced lipid droplet deposition in HepG2 cells and NAFLD-like changes in mice by blocking the expression of lipogenesis-associated ***,the present study elucidates the mechanisms underlying the BPF-induced lipid accumulation in HepG2 cells,while also highlighting the potential of bellidifolin to mitigate BPF-induced NAFLD-like changes.

关键词： bisphenol F lipogenesis non-alcoholic fatty liver disease bellidifolin

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钒基储氢合金的特点和应用前景

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石油炼制与化工 2024年第7期55卷 163-169页

作者：徐睿程涛杨雪荣峻峰中石化石油化工科学研究院有限公司北京100083

钒基储氢合金具有储氢密度高、储放氢反应条件温和、储氢动力学性能优越、抗粉化性能好等优点,是一种优良的储氢材料。但是钒基储氢合金存在放氢平台压低、可逆储氢量低、储放氢滞后现象明显、循环稳定性差、原料价格高、金属成本高等缺... 详细信息

钒基储氢合金具有储氢密度高、储放氢反应条件温和、储氢动力学性能优越、抗粉化性能好等优点,是一种优良的储氢材料。但是钒基储氢合金存在放氢平台压低、可逆储氢量低、储放氢滞后现象明显、循环稳定性差、原料价格高、金属成本高等缺点,制约着钒基储氢合金进一步推广应用。迄今为止,研究者们从元素组成和晶相结构等多种途径对其进行改性,以优化钒基储氢材料性能。基于此,以降低氢化物的放氢平台压和提高材料可逆储氢量为出发点,简述了掺杂Ti,Cr,Mn,Zr等化学元素和对于储氢合金进行特定条件优化改善的研究进展,着重阐述了元素置换、材料热处理和合金活化预处理对钒基储氢合金储氢性能的影响,展望了钒基储氢合金未来发展前景。

关键词：储氢钒基合金掺杂金属元素热处理表面处理

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高校领导干部循证决策能力:结构、功能及提升路径

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黑龙江高教研究 2024年第3期42卷 52-57页

作者：朴雪涛陈浩捷沈阳师范大学辽宁沈阳110034

高校领导干部循证决策能力是其在高校决策过程中体现出的能够有意识地以有效证据为中心开展认知、行为等一系列活动的心理特征。通过分析高校循证决策的内涵和生成过程,将高校领导干部循证决策能力划分为循证认知能力、证据集成能力、... 详细信息

高校领导干部循证决策能力是其在高校决策过程中体现出的能够有意识地以有效证据为中心开展认知、行为等一系列活动的心理特征。通过分析高校循证决策的内涵和生成过程,将高校领导干部循证决策能力划分为循证认知能力、证据集成能力、证据运用能力等三个维度以及十个子要素。高校领导干部循证决策能力是实现大学有效治理的前提,是高校决策科学化的基础,是高校领导干部的专业核心能力,是院校研究决策支持功能实现的重要保障。为进一步提升高校领导干部的循证决策能力,政府和高校要开展循证决策的教育培训工作,建立循证决策证据获取机制,完善循证决策评价考核机制。

关键词：高校领导干部高校治理循证决策循证决策能力

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