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Advances of radiation oncology in China

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Chinese Medical Journal 2009年第19期122卷 2231-2235页

作者： MENG xue yu jin-ming Department of Radiation Oncology Shandong Cancer Hospital and Institute Medical College of Shandong University Jinan Shandong 250117 China

Radiation therapy is one of the main treatment .modalities used in cancer management. It is the primary curative modality for about 30% of patients with cancer, and more than half of all cancer patients received radiation therapy sometime during the course of their disease. It is estimated that 70% of the patients with cancer required radiation therapy in China.1 Radiation oncology is based on the development of radiological physics, radiological biology and clinical oncology.

关键词： advance radiation oncology China

Prediction of Ocular Irritancy of 26 Chemicals and 26 Cosmetic Products with Isolated Rabbit Eye (IRE) Test

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Biomedical and Environmental Sciences 2012年第3期25卷 359-366页

作者： GUO Xiang YANG Xing Fen YANG Ying HANS Raabe CAI jing Heng xue jin yu TAN Xiao Hua XIE Xiao Ping XIONG Xi Kun HUANG Jun Ming Guangdong Provincial Center for Disease Control China National Institute for Occupational Health and Prevention Guangzhou 510300Guangdongand Poison ControlChinese Center for Disease Control and PreventionBeijing 100050China Institute for in vitro Science Gaithersburg MD 20878MarylandUSA Faculty of Mathematics and Computational Science Sun Yat-sen UniversityGuangzhou 510275GuangdongChina

Objective This study aims to establish and evaluate the methodology of isolated rabbit eye （IRE） test. Methods IRE test was performed according to modifications of the in vitro toxicology （INVITTOX） Protocol No.85： Rabbit enucleated eye test by European Centre for the Validation of Alternative Methods （ECVAM）, and then 26 chemicals and 26 cosmetic products were tested in both in vitro IRE and in vivo Draize tests. A statistical analysis was conducted to determine the relevance of the IRE test to the data generated in the Draize test. Results IRE test was established successfully in our laboratory. It was shown that ranking correlation and class concordance were fairly well between the IRE test and the Draize test for 26 reference chemicals （Fisher＇s Exact Test X2=51.314, P〈0.001; McNemar P=0.261; Gamma=0.960, P〈0.001; Kappa=0.843, P〈0.001） and 26 cosmetic products （Fisher＇s Exact Test X^2=15.522, P〈0.O01; McNemar P=0.311; Gamma=0.967, P〈0.001; Kappa=0.611, P〈0.O01）. Conclusion IRE test was established successfully for in vitro testing of eye irritation as an alternative to Draize test.

关键词： Isolated rabbit eye IRE Eye irritation Alternative testing Draize test

深部开采圆形巷道围岩破损区与支护压力的确定

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岩土力学 2014年第1期35卷 226-231页

作者：李铀袁亮刘冠学金学玉薛俊华余国锋彭意张明中南大学土木工程学院长沙410075 平安煤矿瓦斯治理国家工程研究中心有限责任公司淮南安徽232001

应用经典塑性力学理论确定的圆形巷道围岩弹塑性应力场存在一些问题,这影响深部圆形巷道的稳定性评价及支护设计的合理性。应用塑性力学求解新体系确定的圆形巷道围岩弹塑性应力场准确解,进行了各向同性均质地层中圆形巷道破损区、地层... 详细信息

应用经典塑性力学理论确定的圆形巷道围岩弹塑性应力场存在一些问题,这影响深部圆形巷道的稳定性评价及支护设计的合理性。应用塑性力学求解新体系确定的圆形巷道围岩弹塑性应力场准确解,进行了各向同性均质地层中圆形巷道破损区、地层残余强度与支护压力关系方面的研究,取得了如下成果:(1)破损区随开采深度的增加而增大,它们基本呈线性关系。(2)建立了支护压力与巷道埋深、围岩强度、围岩破坏后残余强度、围岩泊松比和重度之间的关系。研究成果可为支护设计提供重要参考。

关键词：圆形巷道围岩弹塑性应力场破损区支护压力

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao yu-Gui Peng Peng Wu Zong-Lin Li xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Polygalasaponin ⅩⅩⅩⅡ improves hippocampal-dependent learning and memory through synaptic transmission,the MAPK cascade and BDNF

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Polygalasaponin ⅩⅩⅩⅡ improves hippocampal-dependent lear...

慢性心力衰竭老年患者采用硝普钠配合氢氯噻嗪的临床疗效分析

中国药理学会第十次全国学术会议

作者： Wei xue,jin-Feng Hu,yu-He yuan,Jian-Dong Sun,Bo-yu Li,Dong-Ming Zhang,Chuang-Jun Li,Nai-Hong Chen

Aim To investigate the cognition-enhancing activity and underlying mechanisms of a triterpenoid saponin (PolygalasaponinXXXII,PGS32) isolated from the roots of Polygala tenuifolia *** Morris water maze was used to evaluate the spatial learning and memory of *** recording of evoked potential was applied to detect the basic synaptic transmission and LTP(long-term potentiation) in the dentate gynus of *** blotting analysis was used to determine the phosphorylation of ERK,CREB,SynapsinI and the ex- pression of *** When supplied at 0.125,0.5,or 2 mg/kg,PGS32 could significantly prevent scopolamine -induced cognitive impairments in ***(i.c.v.) administration of PGS32 at 1μmol/L greatly enhanced basic synaptic transmission in the dentate gynus of rats and induced *** PC12 cells, as well as in the hippocampus of maze-trained mice,PGS32 was found to activate the MAP kinase cascade by promoting phosphorylation of ERK,CREB and *** of BDNF was also greatly enhanced in the hippocampus. Conclusion Our findings suggest that PGS32 can improve hippocampal-dependent learning and memory, possibly through improvement of synaptic transmission,activation of the MAP kinase cascade and enhancement of the level of ***32 therefore shows promise as a potential cognition-enhancing therapeutic drug.

关键词： Polygala tenuifolia Willd triterpenoid saponin learning and memory synaptic transmission MAP kinase signaling system BDNF

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智慧健康 2019年第21期5卷 145-146页

作者：金雪玉吉林省吉林中西医结合医院重症医学科

目的分析慢性心力衰竭老年患者采用硝普钠配合氢氯噻嗪的临床疗效。方法对照组均给予利尿、营养心肌等常规治疗。观察组加用硝普钠配合氢氯噻嗪。结果治疗后观察组BNP、cTnT、6min步行距离、总有效率均显著好于对照组(P<0.05)。结论慢... 详细信息

目的分析慢性心力衰竭老年患者采用硝普钠配合氢氯噻嗪的临床疗效。方法对照组均给予利尿、营养心肌等常规治疗。观察组加用硝普钠配合氢氯噻嗪。结果治疗后观察组BNP、cTnT、6min步行距离、总有效率均显著好于对照组(P<0.05)。结论慢性心力衰竭老年患者采用硝普钠配合氢氯噻嗪的临床疗效显著,可显著改善心功能。

关键词：慢性心力衰竭老年硝普钠氢氯噻嗪

浅谈ISO9001:2008质量管理体系在建筑企业运行重点

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甘肃冶金 2011年第4期33卷 144-146页

作者：薛金鱼甘肃土木工程科学研究院甘肃兰州730020

通过ISO9000质量管理体系认证,,是提高企业质量管理水平的一个重要手段,准确理解和应用ISO9001:2008质量管理体系标准,建立一套适合建筑企业特性的质量管理体系,使其符合充分性、适应性和有效性的要求,是企业质量管理体系建立、运行、... 详细信息

通过ISO9000质量管理体系认证,,是提高企业质量管理水平的一个重要手段,准确理解和应用ISO9001:2008质量管理体系标准,建立一套适合建筑企业特性的质量管理体系,使其符合充分性、适应性和有效性的要求,是企业质量管理体系建立、运行、改进和提高的关键。

关键词：质量体系建筑企业运行重点

Amino acid assisted aqueous synthesis of highly stable CsPbBr_(3)nanocrystals for cell imaging

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Nano Research 2025年第1期18卷 675-683页

作者： xue Li Yanan Guo Guoying Tan Qingyi Liu Nan Song yu Tang State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China

Lead halide perovskite nanocrystals(NCs)exhibit excellent optoelectronic performance and have drawn great interests in the fields of biological imaging and ***,the poor stability of CsPbX_(3)(X=Cl,Br,I)in water is still a challenge to hinder their practical *** this work,a facile strategy has been developed for aqueous synthesis of CsPbX_(3) nanocrystals,in which L-glutamic acid(LGlu)has been used to replace oleic acid in the synthetic *** from the synergic effects of L-Glu and oleylamine(OAm),CsPbBr_(3)nanocrystals(L-Glu/OAm-CsPbBr_(3)NCs)with high water stability have been directly prepared under a mild condition at room temperature in water,facilitated by the process of crystal phase transformation from Cs_(4)PbBr_(6) to CsPbBr_(3).L-Glu/OAm-CsPbBr_(3)NCs exhibit a high quantum yield of 85%and a narrow full width at half maximum of 16 nm,demonstrating their efficient luminescence in ***,L-Glu on the surface have contributed greatly to an acidic environment and passivation of surface defects,improving the water stability and dispersibility of CsPbBr_(3)***,L-Glu/OAm-CsPbBr_(3)NCs exhibit great biocompatibility due to the presence of L-Glu,resulting in their good performance for HeLa cell ***,we propose a facile and effective method to prepare CsPbBr_(3)nanocrystals with excellent water stability by using L-Glu and OAm as cooperated ligands and expand their application in cell imaging.

关键词： aqueous synthesis cell imaging lead halide perovskite nanocrystals L-glutamic acid phase transformation