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Total neoadjuvant treatment for MRI-stratified high-risk rectal cancer:a single-center,single-arm,prospective Phase II trial(PKUCH-R02)

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Gastroenterology Report 2023年第1期11卷 282-290页

作者： Peng-Ju Chen lin wang Ting-Ting Sun yun-feng Yao Yi-Fan Peng Jun zhao tian-Cheng Zhan jia–Hua Leng yong Cai yong-Heng li Xiao-yan Zhang Ying-Shi Sun Zhong-wu li wei-Hu wang Ai-Wen wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Gastrointestinal Cancer Unit IIIPeking University Cancer Hospital&InstituteBeijingP.R.China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Radiation OncologyPeking University Cancer Hospital&InstituteBeijingP.R.China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of RadiologyPeking University Cancer Hospital&InstituteBeijingP.R.China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital&InstituteBeijingP.R.China

Background:Induction chemotherapy combined with neoadjuvant chemoradiotherapy has been recommended for patients with high-risk,locally advanced rectal ***,the benefit of more intensive total neoadjuvant treatment(TNT)is *** study aimed to assess the safety and efficacy of induction chemotherapy combined with chemoradiotherapy and consolidation chemotherapy for magnetic resonance imaging-stratified high-risk rectal ***:This was a single-center,single-arm,prospective Phase II trial in Peking University Cancer Hospital(Beijing,China).Patients received three cycles of induction oxaliplatin and capecitabine(CapeOX)followed by chemoradiotherapy and two cycles of consolidation *** primary end point was adverse event rate and the second primary end points were 3-year disease-free survival rate,completion of TNT,and pathological downstaging ***:Between August 2017 and August 2018,68 rectal cancer patients with at least one high risk factor(cT3c/3d/T4a/T4b,cN2,mesorectal fascia involvement,or extramural venous invasion involvement)were *** overall compliance of receiving the entire treatment was 88.2%(60/68).All 68 patients received induction chemotherapy,65 received chemoradiotherapy,and 61 received consolidation *** Grade 3–4 adverse event rate was 30.8%(21/68).Nine patients achieved clinical complete response and then watch and *** patients(7.4%)developed distant metastasis during TNT and received palliative *** patients underwent surgical *** complete response rate was 27.9%.After a median follow-up of 49.2 months,the overall 3-year disease-free survival rate was 69.7%.Conclusions:For patients with high-risk rectal cancer,this TNT regimen can achieve favorable survival and complete response rates but with high ***,it is necessary to pay attention to the possibility of distant metastasis during the long treatment period.

关键词： rectal cancer neoadjuvant chemoradiotherapy MRI prognosis pathological complete response

Growth,Characterization and Fermi Surface of Heavy Fermion CeCoIn_(5) Superconductor

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Chinese Physics Letters 2011年第5期28卷 226-229页

作者： jia Xiao-Wen liU yan YU li HE Jun-feng zhao lin ZHANG Wen-Tao liU Hai-yun liU Guo-dong HE Shao-Long ZHANG Jun LU wei wu Yue dong-Xiao-li SUN li-ling wang Gui-ling zhu yong wang Xiao-yang PENG Qin-Jun wang Zhi-Min ZHANG Sheh-Jin yanG feng xu Zu-yan CHEN Chuang-tian ZHOU xing-jiang National Lab for Superconductivity Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190 Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190

High quality single crystals of heavy Fermion CeCoIn_(5) superconductor have been grown by flux method with a typical size of(1-2)×(1-2)×(~0.1)mm^(3).The single crystals are characterized by structural analysis from x-ray diffraction and Laue diffraction,as well as compositional *** and electrical measurements on the single crystals show a sharp superconducting transition with a transition temperature at T_(c,onset)~2.3 K and a transition width of~0.15 *** resistivity of the CeCoIn_(5) crystal exhibits a hump at~45 K,which is typical of a heavy Fermion *** resolution angle-resolved photoemission spectroscopy(ARPES)measurements of CeCoIn_(5) reveal clear Fermi surface sheets that are consistent with the band structure calculations when assuming itinerant Ce 4f electrons at low *** work provides important information on the electronic structure of heavy Fermion CeCoIn_(5) *** also lays a foundation for further studies on the physical properties and superconducting mechanism of the heavy Fermion superconductors.

关键词： temperature Fermi transition

Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： Xiao-dong Song Fei yang Hua-yong wu Jing Zhang De-Cheng li feng liu Yu-Guo zhao Jin-ling yang Bing Ju Chong-Fa Cai Biao Huang Huai-Yu Long Ying Lu Yue-Yu Sui Qiu-Bing wang Ke-ning wu feng-Rong Zhang Ming-Kui Zhang Zhou Shi Wan-zhu Ma Gang Xin Zhi-Ping Qi Qing-Rui Chang En Ci Da-Gang Yuan yang-zhu Zhang Jun-Ping Bai jia-Ying Chen Jie Chen Yin-Jun Chen yun-Zhong dong Chun-Lan Han ling li li-Ming liu jian-Jun Pan Fu-Peng Song Fu-Jun Sun Deng-feng wang tian-wei wang Xiang-Hua wei Hong-Qi wu Xia zhao Qing Zhou Gan-lin Zhang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of Resources and Environment Huazhong Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural Resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of Land and Environment Shenyang Agricultural University School of Land Science and Technology China University of Geosciences College of Land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural Resources and Environment Northwest A & F University College of Resources and Environment Southwest University College of Resources Sichuan Agricultural University College of Resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and Resources Research Shanxi Academy of Agricultural Sciences College of Resources and Environment Henan Agricultural University College of Resources and Environment China Agricultural University College of Resources and Environmental Sciences Nanjing Agricultural University College of Resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2010 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： China soil inorganic carbon stocks global change carbonate soil acidification

Alphaherpesvirus-vectored vaccines against animal diseases: Current progress

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Journal of Integrative Agriculture 2020年第8期19卷 1928-1940页

作者： HU yang wang Ming-shu CHENG An-chun jia Ren-yong yanG Qiao wu Ying liU Ma-feng zhao Xin-xin zhu De-kang CHEN Shun ZHANG Sha-qiu wang Yin GAO Qun OU xu-min MAO Sai WEN xing-jian xu Zhi-wen CHEN Zheng-li zhu ling LUO Qi-hui tian Bin PAN Lei-chang Mujeeb Ur REHMAN liU yun-ya YU yan-ling ZHANG ling CHEN Xiao-yue Institute of Preventive Veterinary Medicine Sichuan Agricultural UniversityChengdu 611130P.R.China Key Laboratory of Animal Disease and Human Health of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China Avian Disease Research Center College of Veterinary MedicineSichuan Agricultural UniversityChengdu 611130P.R.China

Recombinant virus-vectored vaccines are novel agents that can effectively activate specific and nonspecific immunity,are multivalent and multieffective,and have high safety *** alphaherpesviruses have a large genome,contain multiple nonessential regions that do not affect viral replication and are capable of accepting the insertion of an exogenous gene and expressing the antigen ***,animal alphaherpesviruses have a wide host spectrum,can replicate in the host and continuously stimulate the animal to produce immunity to the corresponding pathogen,thus making them ideal carriers for recombinant virus-vectored *** the development of gene-editing technology,recombinant viruses capable of expressing foreign genes can be constructed by various ***,studies on recombinant virusvectored vaccines constructed based on animal alphaherpesviruses have involved poultry,pigs,cattle,sheep,and companion *** have shown that the construction of recombinant animal alphaherpesviruses enables the acquisition of immunity to multiple *** article mainly summarizes the current progress on animal alphaherpesvirus-vectored vaccines,aiming to provide reference for the development of new animal alphaherpesvirus-vectored vaccines.

关键词： recombinant vectored-vaccine recombinant alphaherpesviruses immunity gene-editing exogenous gene

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo yong-Heng zhao Gang zhao li-Cai Deng Xiao-wei liu Yi-Peng Jing Gang wang Hao-Tong Zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai Yue wu yan Cai Shu-yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-Jun Chen Kun-Xin Chen li Chen xue-Lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb jia-Ru Chu Chen-Zhou Cui Yi-Qiao dong Bing Du dong-wei Fan Lei feng jian-ning Fu Peng Gao xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou yong-Hui Hou Wen Hou Hong-zhuan Hu ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-wei li Hai-ning li jian li Qi li Shuang li Sha-Sha li Xin-Nan li yan li Yin-Bi li Ye-Ping li Yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni zhao-Xiang Qi yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan tian Dan wang Da-Qi wang feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang jian wang jia-ning wang jian-ling wang jian-Ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng wei Ming-Zhi wei Hong wu Ke-Fei wu xue-Bing wu Yu-Zhong wu Xiao-Zheng xing ling-Zhe xu Xin-Qi xu yan xu Tai-Sheng yan De-Hua yang Hai-feng yang Hui-Qin yang Ming yang Zheng-Qiu Yao yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan wei-Min Yuan Chao Zhai En-Peng Zhang Hua-wei Zhang jian-Nan Zhang li-Pin Zhang wei Zhang yong Zhang yan-Xia Zhang Zheng-Chao Zhang Ming zhao Fang Zhou xu Zhou Jie zhu yong-tian zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia xue-feng wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei wang En-Tao li Chang-Fa Fan Ke Song Yuan-Guo li Run-Ze Ye Fang-xu li Dai-yun zhu Jie Zhang zhuang-zhuang Shi Ming-zhu Zhang liang-Jing li Shi-Jing Shen Song Jin Ya-wei Zhang wei-Guang Fu lin zhao Wen-Hao wang Tie-Cheng wang You-Chun wang jia-Fu jiang yan-ling Hu Na jia Yu-wei Gao wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China life Sciences Institute Guangxi Medical UniversityNanning 530020China College of life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： zhu Yuan Yue ZHENG Rui Zhi wang Gui Xia CHEN li SHI li Xin SU Qing xu Min xu Yu CHEN Yu Hong YU xue feng yan li wang tian Ge zhao Zhi yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan li Qiang YE Zhen ZHANG Yin Fei liU Chao wang You Min wu Sheng li yanG Tao DENG Hua Cong zhao jia Jun CHEN Lu Lu MU Yi Ming TANG xu Lei HU Ru Ying wang wei Qing ning Guang li Mian LU Jie li BI Yu Fang Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of Jilin University Changchun 130021JinlinChina Qilu Hospital of Shandong University Jinan 250012ShandongChina Affiliated Hospital of Guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to Shanghai jiaotong University School of Medicine Shanghai 200092China Tongji Hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical University Luzhou 646099SichuanChina Fujian Provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical University Nanning 530021GuangxiChina jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical University Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central Hospital of Shanghai jiading District Shanghai 201800China jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical University Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62,361 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

Measurement of the neutron total cross section of carbon at the Back-n white neutron beam of CSNS

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Nuclear Science and Techniques 2019年第9期30卷 73-82页

作者： xing-yan liu Yi-wei yang Rong liu Jie Wen Zhong-wei Wen Zi-Jie Han Zhi-Zhou Ren Qi An Huai-yong Bai Jie Bao Ping Cao Qi-Ping Chen yong-Hao Chen Pin-Jing Cheng Zeng-Qi Cui Rui-Rui Fan Chang-Qing feng Min-Hao Gu feng-Qin Guo Chang-Cai Han Guo-zhu He yong-Cheng He Yue-feng He Han-Xiong Huang wei-ling Huang Xi-Ru Huang Xiao-Lu Ji xu-yang Ji Hao-Yu jiang wei jiang Han-Tao Jing ling Kang Ming-Tao Kang Bo li Lun li Qiang li Xiao li yang li yang li Shu-Bin liu Guang-Yuan Luan Ying-lin Ma Chang-Jun ning Bin-Bin Qi Jie Ren Xi-Chao Ruan zhao-Hui Song Hong Sun Xiao-yang Sun Zhi-jia Sun Zhi-Xin Tan Hong-Qing Tang Jing-Yu Tang Peng-Cheng wang Qi wang Tao-feng wang yan-feng wang zhao-Hui wang Zheng wang Qing-Biao wu Xiao-Guang wu xuan wu li-Kun Xie Han Yi li Yu Tao Yu yong-Ji Yu Guo-Hui Zhang Jing Zhang lin-Hao Zhang li-Ying Zhang Qing-Min Zhang Qi-wei Zhang Xian-Peng Zhang Yu-liang Zhang Zhi-yong Zhang Ying-Tan zhao liang Zhou Zu-Ying Zhou Dan-yang zhu Ke-Jun zhu Peng zhu Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics State Key Laboratory of Particle Detection and Electronics Chinese Academy of Sciences(CAS) Department of Modern Physics University of Science and Technology of China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking University Key Laboratory of Nuclear Data China Institute of Atomic Energy Institute of High Energy Physics Chinese Academy of Sciences(CAS) Spallation Neutron Source Science Center University of South China Northwest Institute of Nuclear Technology Department of Engineering and Applied Physics University of Science and Technology of China Beihang University Xi’an jiaotong University

To verify the performance of the neutron total cross-sectional spectrometer, the neutron total cross section of carbon is initially measured in the energy range of 1 eV to 20 MeV using the time-of-flight method. The measurement is performed at the Back-n white neutron source with a 76-m time-of-flight path using the China Spallation Neutron Source. A multilayer fast fission chamber with 235U and 238U is employed as the neutron detector. The diameter and thickness of the natural graphite sample are 70 mm and 40 mm, respectively. Signal waveforms are collected using a data acquisition system. Off-line data processing was used to obtain the neutron time-of-flight spectra and transmissions. The uncertainty of the counting statistics is generally approximately 3% for each bin in the energy range of 1–20 MeV. It is determined that the results for the neutron total cross section of carbon obtained using ^235U cells are in good agreement with the results obtained using 238U cells within limits of statistical uncertainty. Moreover, the measured total cross sections show good agreement with the broadening evaluated data.

关键词： CSNS Back-n white neutron source NTOX Neutron total cross section Carbon Multilayer fast fission chamber

Anatomical variation of infra-pyloric artery origination： A prospective multicenter observational study (IPA-Origin)

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Chinese Journal of Cancer Research 2018年第5期30卷 500-507页

作者： Rulin Miao jianjun Qu Zhengrong li Daguang wang jiang Yu weidong Zang yong li fenglin liu jian Zhang wu Song Kai Ye Su yan wei wang Shuangyi Ren Lu Zang Changqing Jing li Zhang Kuan wang weihua Fu lin Fan Bin liang Gang zhao Jun Cai li yang jiaming zhu Jun You Kun yang Qingxing Huang zhaojian Niu ning ning xingfeng Qiu Gang Ji feng liang Hua Huang Chao Gao Fei Shan Shuangxi li yongning jia lianhai Zhang Xiangji Ying yan Zhang zhaode Bu Xiangqian Su Gang zhao Ziyu li jiafu Ji Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Beijing 100142 China Department of Surgical Oncology Weifang People's Hospital Weifang 261000 China Department of General Surgery the First Affiliated Hospital of Nanchang University Nanchang 330006 China Department of Gastrointestinal Surgery the First Hospital of Jilin University Changehun 130021 China Department of General Surgery Nanfang Hospital Southern Medical University Guangzhou 510515 China Department of Gastrointestinal Cancer Surgery Fujian Provincial Cancer Hospital Fuzhou 350014 China Department of General Surgery Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou 510080 China Department of General Surgery Zhongshan Hospital Fudan University Shanghai 200032 China Department of Gastrointestinal Surgery Hangzhou First People's Hospital Hangzhou 310006 China Department of Gastrointestinal Surgery the First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 China Department of Surgical Oncology the Second Affiliated Hospital of Fujian Medical University Quanzhou 362000 China Department of Surgical Oncology Affiliated Hospital of Qinghai University Xining 810001 China Department of Gastrointestinal Surgery Guangdong Provincial Hospital of Chinese Medicine Guangzhou 510120 China Department of General Surgery the Second Hospital of Dalian Medical University Dalian 116023 China Department of General Surgery Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 China Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021 China Department of Gastrointestinal Surgery Harbin Medical University Cancer Hospital Harbin 150081 China Department of General Surgery Tianjin Medical University General Hospital Tianjin 300052 China Department of General Surgery the Firs

Objective： Infra-pyloric artery （IPA） is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA. Methods： We did this prospective, multicenter, open-label, observational study at gastric surgery departments of 34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ2 tests and Fisher＇s tests were used to analyze the differences between groups. The study is registered at *** （No. NCT03071237）. Results： Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419 （97.7%） patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398 （95.0%） patients, including gastroduodenal artery （GDA） in 154 （36.8%） patients, anterior superior pancreaticoduodenal artery （ASPDA） in 130 （31.0%） patients, and right gastroepiploic artery （RGEA） in 114 （27.2%） patients. Fifteen （3.6%） patients were identified with multiple IPA and 6 （1.4%） patients were identified as IPA absence. The differences in the distribution of surgical approach （P=0.003） and geographic area （P=0.030） were statistically significant. No difference was shown in sex, age, gastrectomy type, tumor location, and clinical T, N and M stage. Conclusions： Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions. Laparoscopic surgery may be more

关键词： Infra-pyloric artery origination anatomy gastric cancer