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建筑科学 2008年第9期24卷 68-70页

作者：郭志勇曹小平徐自立西安科技大学力学教研室西安710054

结合工程实际,采用静载荷试验及高、低应变三种不同方法对黄土地区施工的静压预制桩的桩身完整性和极限承载力进行测试,分析讨论施工和测试两方面存在的问题,查明原因,给出预防和解决问题的方法,以更准确地判定和指导施工质量。

关键词：静压预制桩承载力桩身完整性质量检测

Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi li Kaifei xu Guoqing Wang Feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

Tailoring light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao li Hong Zhou Zhihao Ren Cheng xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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新的改进Sharpened CIC滤波器

四川大学学报（自然科学版） 2007年第4期44卷 817-820页

作者：张捷何培宇李心愿徐自励邓方四川大学电子信息学院成都610064

提出了一种改进的积分梳状(CIC)滤波器.在改变传统积分梳状滤波器的延迟因子的同时,将锐化(Sharpen)技术和相位分解技术应用于此滤波器.改进后的滤波器与传统滤波器相比,减少了信号失真,降低了系统功率消耗.仿真结果表明,改进后的滤波... 详细信息

提出了一种改进的积分梳状(CIC)滤波器.在改变传统积分梳状滤波器的延迟因子的同时,将锐化(Sharpen)技术和相位分解技术应用于此滤波器.改进后的滤波器与传统滤波器相比,减少了信号失真,降低了系统功率消耗.仿真结果表明,改进后的滤波器在通带范围内的波动很少,而且,具有较高的阻带衰减.

关键词：积分梳状滤波器锐化相位分解

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei li Qianqian liang li xu Changsheng Ding Yu liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui xu linxi li Yunxiang Ji Yezhong Wang Yingjia li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

2019年安徽省经济落后农村地区小学生营养现况及其影响因素分析

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中国健康教育 2021年第6期37卷 487-491页

作者：徐粒子孟灿魏亚男李卫东安徽省疾病预防控制中心安徽合肥230601 山东省泰安市疾病预防控制中心山东泰安271000

目的了解安徽省经济落后农村地区小学生营养现况并探索其影响因素,为制定营养改善相关政策提供科学依据。方法采取分层随机整群抽样的方法,在经济落后农村地区抽取金寨、颍上和宿松县共2286名小学生测量身高、体重,其中抽取3~6年级1516... 详细信息

目的了解安徽省经济落后农村地区小学生营养现况并探索其影响因素,为制定营养改善相关政策提供科学依据。方法采取分层随机整群抽样的方法,在经济落后农村地区抽取金寨、颍上和宿松县共2286名小学生测量身高、体重,其中抽取3~6年级1516名学生进行问卷调查。结果男生的营养不足率(12.8%)和超重肥胖率(16.4%)均高于女生(9.2%、9.9%),各年级间差异无统计学意义。多元Logistic回归分析显示,小学生营养不足男生的风险高于女生、非留守儿童的风险低于留守儿童[OR (95% CI)分别为2.013 (1.417~2.858)、0.632 (0.433~0.923)];男生、在学校吃饭不会剩饭的学生和营养知识水平较低的学生超重肥胖的风险较高[OR 值(95% CI)分别为 2.466 (1.775~3.426)、0.601 (0.435~0.830)和 1.273 (1.018~1.591)]。结论安徽省经济落后农村地区小学生存在营养不足和超重肥胖双重负担,其中男生尤为突出。营养不足和超重肥胖与学生是否为留守儿童、在校吃饭是否会剩饭以及学生的营养知识水平有关。

关键词：安徽省经济落后农村小学生营养状况影响因素

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基于双阵元的宽带相干信源数估计

四川大学学报（自然科学版） 2018年第3期55卷 494-500页

作者：邱月阳何培宇崔敖徐自励四川大学电子信息学院成都610064

不同噪声条件下,宽带相干信源数估计是阵列信号处理中的难点问题.本文针对宽带信号的特点,利用虚拟阵列扩展技术,将宽带信号的不同频率成分虚拟为不同间距的虚拟阵元,通过空间平滑削弱信号之间的相干性.但由于噪声的功率谱非严格平坦,... 详细信息

不同噪声条件下,宽带相干信源数估计是阵列信号处理中的难点问题.本文针对宽带信号的特点,利用虚拟阵列扩展技术,将宽带信号的不同频率成分虚拟为不同间距的虚拟阵元,通过空间平滑削弱信号之间的相干性.但由于噪声的功率谱非严格平坦,虚拟阵列协方差矩阵的噪声特征值发散程度严重,经典的信息论方法完全失效.基于对角加载技术,提出了一种新的加载量,有效地平滑了噪声特征值,减弱了其发散程度,并在此基础上利用比率准则改进了信息论方法,实现了两阵元对多个信源的数目估计.仿真实验表明,改进后的方法在白噪声和色噪声条件下均具有较好的性能,优于盖氏圆方法.

关键词：信源数估计宽带相干信源虚拟阵列空间平滑对角加载

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang li Xiaomei Tang Jinyu Zeng Yige Song Chao xu Kai Zhao Guoqiang liu Youming Lu Xinyan li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

广州市传统滨水动态人文景观的类型及空间格局

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南方建筑 2018年第6期 103-109页

作者：许自力宫华慧子熊雨华南理工大学建筑学院亚热带建筑科学国家重点实验室华南理工大学建筑学院广州市景观建筑重点实验室

文章从风景园林学科的角度出发,对传统老广州曾经存在的地域人文景观里的典型——滨水动态人文景观进行了初步的全面整理,以日常型滨水动态人文景观和节庆型滨水动态人文景观为两种基本类型,总结梳理出超过25种滨水动态人文景观的主要类... 详细信息

文章从风景园林学科的角度出发,对传统老广州曾经存在的地域人文景观里的典型——滨水动态人文景观进行了初步的全面整理,以日常型滨水动态人文景观和节庆型滨水动态人文景观为两种基本类型,总结梳理出超过25种滨水动态人文景观的主要类型,充分说明了广州市传统滨水动态人文景观的多样性和独特性。并以景观格局的理论视角分析了传统滨水动态人文景观在广州旧城的空间格局,分析得出其两个核心聚集区:以祭祀水神的仁威神庙为精神核心节点的呈圆形扩散的西关功能核心区和以长堤滨江段为中线的呈椭圆形扩散的珠江两岸功能核心区,并总结了促使这种人文景观发展与繁盛的历史经验,为广州地域文化景观的发扬及旧城更新工作提供借鉴。

关键词：滨水动态人文景观广州空间格局