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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

运载火箭圆柱形贮箱中推进剂大幅晃动的数值模拟

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推进技术 2022年第5期43卷 353-359页

作者：周倩倩谭永华徐自力王珺王振西安交通大学航天航空学院机械结构强度与振动国家重点实验室陕西西安710049 航天推进技术研究院陕西西安710100 西安航天动力研究所陕西西安710100

运载火箭飞行过程中,贮箱内推进剂晃动及波面破碎现象会对燃料贮箱产生较大的干扰力,控制不当会影响飞行稳定性。为了研究推进剂大幅晃动对贮箱结构的影响,建立了圆柱形贮箱内液体晃动非线性动力学模型,利用流体体积函数与水平集法解决... 详细信息

运载火箭飞行过程中,贮箱内推进剂晃动及波面破碎现象会对燃料贮箱产生较大的干扰力,控制不当会影响飞行稳定性。为了研究推进剂大幅晃动对贮箱结构的影响,建立了圆柱形贮箱内液体晃动非线性动力学模型,利用流体体积函数与水平集法解决了大幅晃动过程中产生的破碎波的描述及自由液面的追踪问题,并对三维圆柱形贮箱在多种含液状态下,由俯仰运动产生的大幅晃动进行了数值计算,得到了晃动过程中自由液面的变化、液体对壁面的作用力、液体的晃动速度以及液体质心变化情况。通过对含液率为30%,50%,70%三种含液状态下计算结果的对比,发现飞行中运载火箭贮箱中液体会经历由线性晃动到非线性晃动的变化历程。含液率直接影响晃动的剧烈程度、对壁面的作用力,以及液面破碎等非线性现象的产生,其中含液率为50%的状态是一种相对危险的工作状态。

关键词：液体火箭发动机贮箱晃动波面破碎非线性含液率

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao xu xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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数据关联方法在多点定位系统中的应用

中国测试 2012年第3期38卷 69-71,79页

作者：李恒徐自励金立杰中国民航总局第二研究所四川成都610041

多点定位系统应用于广域目标定位时,可以采用目标气压高度对定位算法进行修正,从而保证算法的收敛性,提高定位精度。但不是所有民航机载二次应答机发送的应答信号模式中都包含目标气压高度,为了解决这个问题,多点定位系统采用了一种数... 详细信息

多点定位系统应用于广域目标定位时,可以采用目标气压高度对定位算法进行修正,从而保证算法的收敛性,提高定位精度。但不是所有民航机载二次应答机发送的应答信号模式中都包含目标气压高度,为了解决这个问题,多点定位系统采用了一种数据关联方法,使得在没有获取到目标气压高度时可以利用关联获得目标上时刻最新高度,由此修正定位算法。此外,通过关联还可以获取目标上时刻最新水平位置,在由于监视区域宽广造成只有3个站来定位目标而出现双解时可利用该水平位置选取正确解。通过实际数据测试验证了该方法的可行性。

关键词：数据关联多点定位精度几何弱化目标AA码信号时间差

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人脸识别信息侵害行为的刑法规制

湖北职业技术学院学报 2024年第2期27卷 64-69页

作者：许自立北京师范大学北京100875

人脸识别信息具有独特性、综合性、易采集性的特征,属于刑事立法规定中的公民个人信息。司法实践中,将人脸识别信息认定为公民个人信息虽已成为司法共识,但也存在人脸识别信息定位不明确、入罪标准不统一、规制行为范围狭窄的问题,应当... 详细信息

人脸识别信息具有独特性、综合性、易采集性的特征,属于刑事立法规定中的公民个人信息。司法实践中,将人脸识别信息认定为公民个人信息虽已成为司法共识,但也存在人脸识别信息定位不明确、入罪标准不统一、规制行为范围狭窄的问题,应当从明确人脸识别信息属于公民个人信息、利用兜底条款确定入罪标准和扩充规制的行为类型等方面予以完善。

关键词：人脸识别信息侵犯公民个人信息罪刑法规制

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公用洗衣机的微电脑控制器

广东工学院学报 1986年第1期 84-92页

作者：许立梓

本文介绍一种由一位微处理器组成的公用洗衣机控制器。设计这个控制系统时、力求硬件结构简单、并尽量用软件代替硬件。这个控制器经试运行表明,系统可靠、稳定,满足设计及用户要求。

关键词：微电脑控制器硬件洗衣机日用电气器具变址寄存器地址位计数器记录仪

3,4-oxo-isopropylidene-shikimic acid inhibits adhesion of polymorphonuclear leukocyte to TNF-α-induced endothelial cells in υitro

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Acta Pharmacologica Sinica 2004年第2期 120-124页

作者： Yi MA, Jian-ning SUN2, Qiu-ping xu, zi-li YOU3, Ya-jian GUO Department of Pharmacology, Beijing University of Chinese Traditional Medicine, Beijing 100102 3School of life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China

AIM: To examine the effect of 3,4-oxo-isopropylidene-shikimic acid (ISA) on human polymorphonuclear leuko- cyte (PMN) adhesion to human umbilical vein endothelial cells (HUVEC) and explore its mechanism. METHODS: Adhesion of PMN to HUVEC was measured by rose bengal staining assay. Cell-EliSA and RT-PCR methods were used to examine the expression of adhesion molecules ICAM-1. Cell viability was detected with MTT assay. RESULTS: ISA (1-100 μmol/L) effectively reduced PMN adhesion to TNF-α-induced HUVEC with the inhibitory rate from 17.2 % to 53.5 %, and exerted no effect on PMN adhesion to normal HUVEC. Adhesion molecule ICAM-1 surface protein and mRNA expression induced by TNF-α (400 kU/L) were significantly inhibited by ISA. In addition, the cell viability of HUVEC was unchanged 48 h after treatment with ISA. CONCLUSION: ISA inhibited TNF-α-stimulated PMN-HUVEC adhesion and expression of ICAM-1.

关键词： oxo-isopropylidene-shikimic acid adhesions vascular endothelium neutrophils intercellular adhesion molecule-1