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Discontinuous Galerkin Methods for Multi-Pantograph Delay Differential Equations

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Advances in Applied Mathematics and Mechanics 2020年第1期12卷 189-211页

作者： Kun Jiang Qiumei Huang xiuxiu xu College of Applied Sciences Beijing University of TechnologyBeijing 100124China School of Mathematical Sciences Anhui UniversityHefei 230031China

In this paper,the discontinuous Galerkin method is applied to solve the multi-pantograph delay differential *** analyze the optimal global convergence and local superconvergence for smooth solutions under uniform *** to the initial singularity of the forcing term f,solutions of multi-pantograph delay differential equations are *** obtain the relevant global convergence and local superconvergence for weakly singular solutions under graded *** numerical examples are provided to illustrate our theoretical results.

关键词： Multi-pantograph discontinuous Galerkin method global convergence local superconvergence,weakly singular graded meshes

Research on wavelength conversion of triangular pulses with variable symmetry based on SPM effect

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Optoelectronics Letters 2023年第8期19卷 449-454页

作者： YUAN Jin LIU Qisong MEI Ying xu xiuxiu WANG Yujie BA Xinran State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing 100044China

The generation of periodic triangular waveform with variable symmetrical coefficient based on a dual-parallel Mach-Zehnder modulator(DP-MZM) is demonstrated in this *** properly setting the modulation index and bias points of DP-MZM,desired symmetric/asymmetric triangular waveforms can be *** applying the generated triangular waveform into an amplitude modulator(AM),a single-period signal can be extracted to explore the optical wavelength conversion induced by the self-phase modulation(SPM) effect in a high nonlinear fiber(HNLF).Wavelength shifts of triangular waveforms with different coefficients(10%,20%,30%,40% and 50%) are *** addition,the influence of key parameters of HNLF on the wavelength conversion is analyzed in detail.

关键词： modulator triangular effect

Requirement for PBX1 in Natural Killer Cells Promoting Fetal Development

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Requirement for PBX1 in Natural Killer Cells Promoting Fetal...

Transcription factor TF1 regulates homeostasis and function of natural killer cells

第十三届全国免疫学学术大会

作者： Yonggang Zhou xiuxiu xu Rui Sun Binqing Fu Zhigang Tian Haiming Wei Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Science and Medical CenterUniversity of Science and Technology of China

Objective: The dominant natural killer(NK) cell subpopulation promotes fetal development by secreting growth-promoting factors(GPFs) at the maternal-fetal interface during early pregnancy. However, the molecular regulatory mechanisms of NK cells expressing GPFs are ***: Here, we have identified PBX1 as a key transcription factor regulating the expression of GPFs, pleiotrophin and osteoglycin, in decidual NK cells from both humans and mice. After Pbx1 is knocked down on NK cells, NK cells shown a serious decline in the ability of expressing these GPFs. The results of PBX1 ChIP experiments in decidual NK cells show that PBX1 regulates the transcription of pleiotrophin and osteoglycin genes in NK cells via direct binding. Further, conditional inactivation of Pbx1 mice by Vav1–Cre and Ncr1-Cre are employed to study the role of PBX1 in NK cells promoting fetal development. Knockout of Pbx1 in NK cells significantly reduces the expression of GPFs, impaired fetal development, resulting in fetal growth restriction. Furthermore, we identified a new SNP(single nucleotide polymorphism) site in the decidual tissue NK cells of patients with RSA(recurrent spontaneous abortion), resulting in a G mutation to S at the 21 st amino acid sequence of the transcription factor PBX1, suggesting that the abnormality of PBX1 in decidual NK cells is a potential factor for ***: Our study reveals that PBX1 represent a novel regulatory element for supporting the function of NK cells to promote the fetal development by promoting pleiotrophin and osteoglycin expression, and provides the basis for improved approaches to NK cell-based immunotherapy for pregnancy related diseases.

关键词： Decidual NK cell Transcription factor PBX1 GPFs RSA SNP

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Transcription factor TF1 regulates homeostasis and function ...

重组单环刺螠纤溶酶对大鼠急性心肌缺血的保护作用

第十一届全国免疫学学术大会

作者： Zhou Yonggang Fu Binqing xu xiuxiu Tong Xianhong Sun Rui Tian Zhigang Wei Haiming Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Science and Medical CenterUniversity of Science and Technology of China Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China Anhui Provincial Hospital

Background:Maintenance of a pool of NK cells with mature function is essential for the host immune *** latest articles reported that some intracellular growth-promoting factors(GPFs) as a vital new molecular component for NK cell ***,it’s more interesting that our lab recent work show NK cells are potent secretors of an array of GPFs and promote fetal growth at maternal-fetal interface during early ***,GPFs are necessary for NK cells maturation and function of promoting fetal growth by NK cells,but transcriptional regulation mechanism of GPFs genes is ***:To better understand what’s the mechanism for regulating NK cells to express GPFs as a secreted or intracellular isoform,we investigated the potential role of TF1 within the NK cell compartment by using Tf1 gene-targeted ***:We found that TF1 was the key transcriptional factor in regulating NK cells expressing ***1 expressed in GPFs-rich NK cells from decidua was significantly higher than conventional ***1 was knocked down,NK cells were expected to show a serious decline in the ability of expressing ***1 regulated the transcription of GPFs genes via direct binding by using *** the NK cell homeostasis,Tf1-deficient mice harbor reduction of NK cells and defectiveness of mature NK cell in BM niche due to the impairment of intracellular ***,NK cell-conditional deficient Tf1 mice decreases the GPFs-secreting in NK cells impairs fetal development and leads to fetal growth restriction during early ***:Our study indicates that TF1 represent a novel regulatory element for supporting NK cells homeostasis and function of promoting fetal growth by NK cells via promoting GPFs expression in NK cells,and provides the basis for improved approaches to immunotherapy for virus clearance and tumor surveillance even alleviating spontaneous abortion based on TF1 activity.

关键词： TF1 Growth-promoting factors NK cell homeostasis Fetal growth

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中国现代应用药学 2019年第8期36卷 910-915页

作者：许秀秀高壹叶晓通泉州医学高等专科学校福建泉州362011 复旦大学附属金山医院上海200540 福建泉州华诺生物科技有限责任公司福建泉州362011

目的研究重组单环刺螠纤溶酶对大鼠急性心肌缺血的保护作用。方法重组表达单环刺螠纤溶酶,并通过纤维蛋白平板法测定酶活力,体外抗凝试验检测抗凝效果。建立大鼠急性心肌缺血模型,观察并测定重组单环刺螠纤溶酶对大鼠心肌梗死质量比、... 详细信息

目的研究重组单环刺螠纤溶酶对大鼠急性心肌缺血的保护作用。方法重组表达单环刺螠纤溶酶,并通过纤维蛋白平板法测定酶活力,体外抗凝试验检测抗凝效果。建立大鼠急性心肌缺血模型,观察并测定重组单环刺螠纤溶酶对大鼠心肌梗死质量比、血清学生化指标[乳酸脱氢酶(lactate dehydrogenase,LDH)、肌酸激酶(creatine kinase,CK)和天门冬氨酸氨基转移酶(aspartate amino transferase,AST)]、凝血指标[凝血酶原时间(prothrombin time,PT)、部分凝血活酶时间(partial thromboplastin time,APTT)、纤维蛋白原(fibrinogen,FIB)、凝血酶时间(thrombin time,TT)]、组织型纤溶酶原激活物(tissue plasminogen activator,t-PA)及组织型纤溶酶原激活物抑制因子1(tissue plasminogen activator inhibitor,PAI-1)活性的影响。结果与模型组相比,重组单环刺螠纤溶酶能缩小心肌梗死范围,抑制AST、LDH、CK的升高,延长PT、APTT、TT,降低FIB,降低PAI-1活性,升高t-PA活性,均具有显著性差异(P<0.01)。结论重组单环刺螠纤溶酶能明显增强纤溶活性,降低凝血时间,说明其抑制凝血系统、活化纤溶系统的作用机制之一可能是抑制血栓形成、抗心肌缺血。重组单环刺螠纤溶酶可有效预防心肌梗死,此结果可为下一步的临床应用提供一定的理论依据。

关键词：重组单环刺螠纤溶酶心肌缺血凝血纤溶

拟等级网格下非线性延迟微分方程间断有限元法

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计算数学 2016年第3期38卷 281-288页

作者：许秀秀黄秋梅北京工业大学北京科学与工程计算研究院北京100124

本文利用间断有限元法求解非线性延迟微分方程,在拟等级网格下.给出非线性延迟微分方程间断有限元解的整体收敛阶和局部超收敛阶,数值实验验证了理论结果的正确性.

关键词：延迟微分方程拟等级网格间断有限元法整体收敛阶局部超收敛阶

生长分化因子15对过氧化氢诱导的人主动脉内皮细胞凋亡的保护作用

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江苏医药 2014年第10期40卷 1134-1137,I0001页

作者：徐秀秀桂鸣南京医科大学第一附属医院心脏病科江苏省210029

目的研究生长分化因子15(GDF-15)对过氧化氢(H2O2)诱导的人主动脉内皮细胞凋亡的保护作用及其可能的作用机制。方法体外培养人主动脉内皮细胞,随机分为空白对照(A)组、H2O2损伤(B)组、低浓度GDF-15+H2O2(C)组、高浓度GDF-15+H2O2(D)组... 详细信息

目的研究生长分化因子15(GDF-15)对过氧化氢(H2O2)诱导的人主动脉内皮细胞凋亡的保护作用及其可能的作用机制。方法体外培养人主动脉内皮细胞,随机分为空白对照(A)组、H2O2损伤(B)组、低浓度GDF-15+H2O2(C)组、高浓度GDF-15+H2O2(D)组、低浓度GDF-15+H2O2+LY294002(E)组和高浓度GDF-15+H2O2+LY294002(F)组。采用Hoechst3258染色、流式细胞术检测细胞凋亡情况,Western blot检测磷酸化Akt(p-Akt)蛋白相对表达量。结果 B组细胞凋亡率高于A组(P<0.05)。与B组相比,C组、D组细胞凋亡率降低,p-Akt蛋白表达增加,并呈剂量依赖性(P<0.05);而经LY294002预处理后,E组、F组细胞凋亡率增高,p-Akt蛋白表达减少(P<0.05)。结论 GDF-15可拮抗H2O2诱导的内皮细胞凋亡。其作用机制可能与上调p-Akt的表达有关。

关键词：生长分化因子15 人主动脉内皮细胞凋亡

我国高等工程教育研究现状、问题及原因分析——基于《高等工程教育研究》的实证研究

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高等工程教育研究 2008年第3期56卷 65-68页

作者：刘少雪庄丽君徐秀秀上海交通大学高等教育研究所

本文以《高等工程教育研究》为样本,从论文数量、作者群体、论文类型和研究主题等四个方面对1997～2006年该刊所载的与高等工程教育有关的论文进行统计和聚焦分析,通过对我国当前高等工程教育研究现状、存在问题及原因的剖析,为我国高... 详细信息

本文以《高等工程教育研究》为样本,从论文数量、作者群体、论文类型和研究主题等四个方面对1997～2006年该刊所载的与高等工程教育有关的论文进行统计和聚焦分析,通过对我国当前高等工程教育研究现状、存在问题及原因的剖析,为我国高等工程教育改革提供启示。

关键词：《高等工程教育研究》高等工程教育实证研究

上海地区一般本科高校图书馆学科服务工作探究

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图书情报工作 2014年第23期58卷 117-121,125页

作者：徐秀秀杨寅华尚珊珊上海工程技术大学图书馆上海工程技术大学图书馆总支

以上海地区20所一般公办本科院校为研究对象,从网络免费资源和工具利用、学科导航、学科馆员、信息共享空间和信息素养教育等方面进行学科服务实践探究,列举典型案例,提出优化网络资源利用方式、开发学科主题导航、开展特定学科信息共... 详细信息

以上海地区20所一般公办本科院校为研究对象,从网络免费资源和工具利用、学科导航、学科馆员、信息共享空间和信息素养教育等方面进行学科服务实践探究,列举典型案例,提出优化网络资源利用方式、开发学科主题导航、开展特定学科信息共享空间等工作策略,总结主动服务学科建设、优先服务重点学科、分层分步开展学科服务、抓住学科服务时机的经验和启示,为一般高校图书馆创办深层次的学科服务开拓思路,提供借鉴。

关键词：上海地区高校图书馆学科服务实践探索