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红色文献服务平台功能要素识别、层次分析及其建设思考

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情报探索 2024年第5期 60-66页

作者：孙爱华徐孝娟安徽大学管理学院安徽合肥230601

[目的/意义]红色文献服务平台建设方兴未艾。揭示用户心理期望与红色文献服务平台建设现状的精准匹配,有利于当前红色文献服务平台功能服务提升,为红色文献服务平台的规划设计提供决策依据。[方法/过程]首先通过文献研究、网络调查及专... 详细信息

[目的/意义]红色文献服务平台建设方兴未艾。揭示用户心理期望与红色文献服务平台建设现状的精准匹配,有利于当前红色文献服务平台功能服务提升,为红色文献服务平台的规划设计提供决策依据。[方法/过程]首先通过文献研究、网络调查及专家访谈等对现有红色文献服务平台功能要素进行识别,紧接着借助Kano模型与Better-Worse指数分析对功能要素进行分类,并依据优先次序算法(CPO)对功能要素进行排序;最后,结合我国红色文献服务平台的建设现状,给出功能服务提升策略与建议。[结果/结论]构建了5个维度13项二级指标的红色文献服务平台功能要素体系;对功能要素进行需求分类及排序探索,表证了用户需求的层次性、动态性及优先顺序;结合红色文献服务平台实践现状,提出四个维度的建设思考路径。

关键词： Kano模型 Better-Worse指数分析红色文献服务平台功能要素体系

Spectral Studies on the Conformational Transitions of Bovine Insulin During Denaturant-induced Unfolding

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Chemical Research in Chinese Universities 2014年第2期30卷 222-227页

作者： JI xu MA xiaojuan BIAN Liujiao College of Life Science Northwest University Xi@@an 710069 P.R.China

Transitions among various molecule states and conformational changes of bovine insulin were investigated under different denaturing conditions by means of fluorescence phase diagrams,fluorescence quenching,1-anilinonaphthalene-8-sulfonate（ANS） binding assay and circular dichroism（CD） *** both guanidine hydrochloride（GuHCl）-and urea-denatured procedures,the spatial structure of insulin molecules changed from ordered states to relative unordered ones with the increasing of denaturant *** GuHCl-denatured process followed a four-state model,for there were two intermediates existed in 2.0 and 6.0 mol/L GuHC1,*** I1 is more compact than the normal *** intermediate I2 has lost most of the secondary *** GuHCl concentration was above 6.0 mol/L,the fluorophores originally existed in the internal of insulin molecules would expose to the ***,the urea-denatured process followed a three-state model,only one intermediate existed in 2.5 mol/L *** the urea-denatured procedure,the fluorophores originally existed in theinternal of insulin molecules didn＇t expose to the surface.

关键词： Bovine insulin Unfolding Intermediate Guanidine hydrochloride Urea

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NICU早产儿母乳喂养链式管理效果评价

护理学杂志 2024年第7期39卷 31-34页

作者：李士娜蒋虹徐晓娟李桂芹烟台毓璜顶医院新生儿科山东烟台264000

目的观察链式管理对NICU早产儿母乳喂养及喂养并发症的影响。方法将180例NICU早产儿按入院时间分为对照组和试验组各90例。对照组实施常规NICU母乳喂养策略,试验组在对照组基础上进行链式管理,构建并实施产房、产科和NICU间横向管理和... 详细信息

目的观察链式管理对NICU早产儿母乳喂养及喂养并发症的影响。方法将180例NICU早产儿按入院时间分为对照组和试验组各90例。对照组实施常规NICU母乳喂养策略,试验组在对照组基础上进行链式管理,构建并实施产房、产科和NICU间横向管理和各科室内部纵向管理。结果最终对照组82例、试验组81例早产儿完成研究。干预后,试验组纯母乳喂养率显著高于对照组,试验组早产儿喂养不耐受、坏死性小肠结肠炎、宫外发育迟缓和新生儿高胆红素血症发生率显著低于对照组(均P<0.05),试验组恢复至出生体质量日龄显著短于对照组,出院体质量显著大于对照组(均P<0.05)。结论链式管理有利于提高NICU早产儿的纯母乳喂养率,降低喂养并发症发生率,促进新生儿生长发育。

关键词：早产儿 NICU 产科产房链式管理母乳喂养喂养不耐受喂养并发症

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可调节型扩咽器在特殊人群中的应用

首都食品与医药 2024年第3期31卷 91-93页

作者：李娟付鸿雁徐晓涓广东省人民医院赣州医院(赣州市立医院) 江西赣州341000

目的探讨可调节型扩咽器辅助核酸采集在特殊人群中的应用效果。方法回顾性分析2022年6月-2022年12月于赣州市立医院急诊科核酸室进行核酸采样时存在核酸采集困难的特殊人群60例,按照是否使用调节型扩咽器分为观察组(30例)和对照组(30例... 详细信息

目的探讨可调节型扩咽器辅助核酸采集在特殊人群中的应用效果。方法回顾性分析2022年6月-2022年12月于赣州市立医院急诊科核酸室进行核酸采样时存在核酸采集困难的特殊人群60例,按照是否使用调节型扩咽器分为观察组(30例)和对照组(30例)。观察组采用可调节型扩咽器辅助核酸检测,对照组未采用可调节型扩咽器辅助核酸检测。对比两组标本合格率、采样成功情况、采样所消耗时间、受检者满意度和咳嗽呕吐发生率。结果两组送检结果内标均起线,标本合格率为100.00%(30/30);观察组一次采样成功率83.33%、采样所消耗时间1-2min所占比例93.33%、核酸采样满意度96.67%,分别高于对照组的50.00%、73.33%、70.00%(P<0.05);观察组咳嗽呕吐发生率(3.33%)低于对照组(26.67%)(P<0.05)。结论可调节型扩咽器在特殊人群核酸采样中具有较高的应用价值,可提高一次采样成功率,缩短采样时间,降低采样时咳嗽呕吐发生率,获得了较高的采样满意度。

关键词：特殊人群核酸采集可调节型扩咽器一次采样成功率采样所消耗时间满意度

Molecular Weight and Aggregation of Erwinia Gum in Aqueous Solutions

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Chemical Research in Chinese Universities 2000年第2期16卷 156-162页

作者： ZHANG Lina xu xiaojuan ZHU RongPing Iijima Hideki Wuhan Univ Dept Chem Wuhan 430072 Peoples R China Natl Res Ctr Certified Reference Mat Beijing 100013 Peoples R China Asahi Chem Ind Co Ltd Chem Technol Dept 4 Miyazaki 8828847 Japan

Erwinia(E) gum is composed of glucose, fucose, galactose and glucuronic acid. The weightaverage molecular weights M w, numberaverage molecular weights M n and intrinsic viscosities[η] of the four fractions and the unfractionated E gum in aqueous solutions at desired temperatures were studied by light scattering, membrane osmometry, size exclusion chromatography(SEC) and viscometry. The experimental results prove that E gum formed aggregates in the aqueous solution at 25 ℃ and the aggregates were broken gradually with increasing temperature. The dissociation of the aggregates of E gum in the aqueous solution started at 36 ℃, and was completed at around 90 ℃. The [η] values of E gum and its fractions are much higher than those of the conventional polymers with the similar molecular weights, and decrease with increasing NaCl concentration.

关键词： Erwinia gum Light scattering SEC Membrane osmometry Viscometry Molecular weight Aggregation

Theoretical studies on new potential high energy density compounds (HEDCs) adamantyl nitrates from gas to solid

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Science China Chemistry 2008年第5期51卷 427-439页

作者： xu xiaojuan ZHU WeiHua GONG xueDong XIAO HeMing Department of Chemistry Nanjing University of Science and TechnologyNanjing 210094China Department of Chemistry Yancheng Teacher’s CollegeYancheng 224002China

A series of adamantyl nitrates have been theoretically studied from gas to solid to search for new po-tential high energy density compounds (HEDCs). The heats of formation (HOFs) for the 26 title com-pounds were calculated by designing isodesmic reactions at the B3LYP/6-31G level. It was found that the HOFs of the 26 isomers with the same number of —ONO2 groups (n) are not correlated well with the corresponding substituted positions. According to the obtained heats of detonation (Q),detonation velocities (D),and detonation pressures (P) using the Kamlet-Jacobs equations,it was found that when n=7～8,the adamantyl nitrates meet the criterion as an HEDC. The calculations on bond dissociation energies of O—N (EO—N) showed that the adamantyl nitrates with gemi —ONO2 always have the worst stability among the isomers,and all the adamantyl nitrates with gemi —ONO2 have similar stability. Due to the complexity of their structures,values of EO—N do not decrease with the increase of the substituent number n obviously,and the stability of adamantyl nitrates is not determined by only one structural parameter. Considering the stability requirement,only 1,2,4,6,8,9,10-adamantyl heptanitrate is recom-mended as a feasible HEDC. Molecular packing searching for 1,2,4,6,8,9,10-adamantyl heptanitrate among 7 most possible space groups (P21/c,P-1,P212121,P21,Pbca,C2/c,and Pna21) using Compass and Dreiding force fields showed that this compound tends to crystallize in P21/c. Ab initio periodic calculations on the electronic structure of the predicted packing showed that the O—NO2 bond is the trigger bond during thermolysis,which agrees with the result derived from the study of dissociation energies of O—N bonds.

关键词： high energy density compound (HEDC) adamantyl nitrate molecular packing periodic calculation energetic property density of states (DOS)

Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities

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Nano Research 2017年第11期10卷 3775-3789页

作者： Zhaohua Ping Ting Liu Hui xu Yan Meng Wenhua Li xiaojuan xu Lina Zhang College of Chemistry amp Molecular Sciences Wuhan University Wuhan 430072 China Hubei Key Laboratory of Cell Homeostasis College of Life Sciences Wuhan University Wuhan 430072 China

Nanotechnologies have been exploited to develop safe and effective medicines and *** the present study,a novel functional nanomedicine constructed from a bioactive polysaccharide and selenium nanoparficles （SeNPs） was developed.A highly-branched [3-（1→3）-D-glucan （AF1） with high anti-tumor activity was used to self-assemble hollow nanofibers with an apparent average diameter of 92 nm;Se nanopartides were synthesized via the reduction of sodium *** results of light scattering,transmission electron microscopy,and X-ray diffraction demonstrated that the spherical SeNPs with a mean diameter of 46 nm were entrapped in the cavities of the AF1 hollow nanofibers through the formation of Se-O bonds between SeNPs and AF1,leading to the good dispersion and high stability in water for over 16 *** vitro and in vivo assays indicated that the AF1-Se nanocomposite had higher anti-tumor activities against breast ***,AF1-Se displayed a broad-spectrum inhibition against human cancers with low half maximal inhibitory concentration （IC50） values and low toxicity to normal ***,the inhibition ratio of AF1-Se against MCF-7 cancer cells reached 75% at a concentration of 200 μ***-1 with 29 μM Se content,much higher than that by treatment with AF1 alone,suggesting a strong synergic effect and nano ***,we developed a method for increasing the stability,anti-tumor activity,and safety of SeNPs by wrapping with bioactive polysaccharides.

关键词： selenium nanoparticles stability and dispersion bioactive polysaccharide anti-cancer activity synergistic effect

La[N(SiMe3)2]3-Catalyzed Hydroboration of Esters and Other Challenging Unsaturated Groups

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Chinese Journal of Chemistry 2019年第11期37卷 1142-1146页

作者： xiaojuan xu Zihan Kang Dandan Yan Mingqiang xue Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceDushu Lake CampusSoochow UniversitySuzhouJiangsu 215123China

Background and Originality Content Reduction of esters to corresponding alcohols is a fundamental transformation in organic chemistry.111 Conventionally,this transformation is realized by employing hydride sources or hydrogenation mediated by transition metal catalysts.12,31 The major demerit of metal hydride reduction Is the handling of the intrinsically unsafe pyrophoric and moisture sensitive chemical agents,especially at large ***,quenching the excessive reactive metal hydrides during workup and the disposal of the effluent generated may pose additional cumbersome environmental *** For transition metal mediated hydrogenation,usually harsh conditions with elevated reaction temperature accompanying with high pressure are mandatory.

关键词： chemistry. hydride hydrogenation

Detection of Sialylated N-Linked Glycans by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

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Wuhan University Journal of Natural Sciences 2014年第3期19卷 245-252页

作者： PENG Yanfei xu xiaojuan College of Marine Life Sciences Ocean University of China College of Chemistry and Molecular Sciences Wuhan University

Native and methyl-esterified sialylated glycans were analyzed with 2,4,6-trihydroxyacetophenone（THAP）and 2,5-dihydroxybenzoic acid（DHB）as matrix by a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer（MALDI-TOF MS）.High quality negative-ion spectra of commercial sialylated glycan were obtained with THAP as *** limit of the glycan was less than 0.1 *** methyl esterification of sialic acid（SA）residue,sialylated glycans were detected sensitively in the positive-ion mode using DHB as *** and sialylated glycans from the mixture of asialofetuin and fetuin were methylesterified and simultaneously recognized in one *** esterification of SA residue offers a convenient and sensitive way to identify the structure of N-linked glycans for glycan profiling.

关键词： sialic acid glycans methyl esterification matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS)