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A multi-omics study on cutaneous and uveal melanoma

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 32-41页

作者： Qi Zhang Ze-Nan Lin Jie Chen wen-xu zheng Institute of Pathology and Neuropathology University of TuebingenTuebingen 72076Germany University Eye Hospital Center for OphthalmologyUniversity of TuebingenTuebingen 72076Germany Department of Ophthalmology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Ophthalmology the Second Hospital Affiliated to Jilin UniversityJilin UniversityChangchun 130041Jilin ProvinceChina

AIM:To present the multi-omics landscape of cutaneous melanoma(CM)and uveal melanoma(UM)from The Cancer Genome Atlas(TCGA).METHODS:The differentially expressed genes(DEGs)between CM and UM were found and integrated into a gene ontology enrichment ***,the differentially expressed miRNAs were also *** also compared the methylation level of CM with UM and identified the differentially methylated regions to integrate with the DEGs to display the relationship between the gene expression and DNA *** differentially expressed transcription factors(TFs)were ***:Though CM had more mutational burden than UM,they shared several similarities such as the same rankings in diverse variant *** GNAQ and GNA11,the other top 18 mutated genes of the combined group were mostly detected in CM instead of *** the transcriptomic level,4610 DEGs were found and integrated into a gene ontology enrichment *** also identified 485 differentially expressed *** methylation analysis showed that UM had a significantly higher methylation level than *** integration of differentially methylated regions and DEGs demonstrated that most DEGs were downregulated in UM and the hypo-and hypermethylation presented no obvious difference within these ***,116 hypermethylated TFs and 114 hypomethylated TFs were identified as differentially expressed TFs in CM when compared with ***:This multi-omics study on comparing CM with UM confirms that they differ in all analyzed *** notice,the results also offer new insights with implications for elucidating certain unclear problems such as the distinct role of epithelial mesenchymal transition in two melanomas,the different metastatic routes of CM and UM and the liver tropism of metastatic UM.

关键词： cutaneous melanoma uveal melanoma genomics transcriptomics epigenetics

A rare porous zinc phosphonocarboxylate framework with high thermal stability and interesting structural transformation

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Chinese Chemical Letters 2018年第6期29卷 959-962页

作者： Yan-Jie Qi Jin-Hua Liu wen-xu zheng Xin-Xiong Li Shou-Tian zheng State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

A rare porous zinc-organic framework with ultrahigh thermal stability over 500℃ was obtained, which exhibits a CaF2-type topology formed by 8-connected tetranuclear Zn4 clusters and 4-connected phosphonocarboxylate ligands. Interestingly, the similar reactions to the 2 zinc-organic framework but in the absence of H2 O or by the replacement of Zn2＋with Co2＋can yield three different 3 D cluster-based frameworks but with the same CaF2-type topology.

关键词： Phosphonocarboxylate ligand Metal-organic framework Stability Structural transformation Gas adsorption

Susceptible time window and endurable duration of cotton fiber development to high temperature stress

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Journal of Integrative Agriculture 2017年第9期16卷 1936-1945页

作者： xu Bo ZHOU Zhi-guo GUO Lin-tao xu wen-zheng ZHAO wen-qin CHEN Bing-lin MENG Ya-li WANG You-hua College of Agronomy Nanjing Agricultural UniversityNanjing 210095P.R.China Modern Crop Production Collaborative Innovation Center of Jiangsu Province Nanjing 210095P.R.China

The development of the cotton fiber is very sensitive to temperature variation, and high temperature stress often causes reduced fiber yield and fiber quality. Short-term high temperature stress often occurs during cotton production, but little is known about the specific timing and duration of stress that affects fiber development. To make this clear, pot experiments were carried in 2014 and 2015 in a climate chamber using cotton cultivars HY370WR（less sensitive variety） and Sumian 15（heat sensitive variety）, which present different temperature sensitivities. Changes of the most important fiber quality indices（i.e., fiber length, fiber strength and marcironaire） and three very important fiber development components（i.e., cellulose, sucrose and callose） were analyzed to define the time window and critical duration to the high temperature stress at 34°C（max38°C/min30°C）. When developing bolls were subjected to 5 days of high temperature stress at different days post-anthesis（DPA）, the changes（Δ%） of fiber length, strength and micronire, as a function of imposed time followed square polynomial eq. as y=a＋bx＋cx^2, and the time around 15 DPA was the most sensitive period for fiber quality development in response to heat stress. When 15 DPA bolls were heat-stressed for different durations（2, 3, 4, 5, 6, 7 days）, the changes（Δ%） of fiber length, strength and micronire, as a function of stress duration followed logistic equations y=A_1-A_2/1＋（x/x_0）~p＋A_2. Referred to that 5, 10 and 15% are usually used as criteria to decide whether techniques are effective or changes are significant in crop culture practice and reguard to the fiber quality indices change range, we suggested that 5% changes of the major fiber quality indices（fiber length, fiber strength and micronaire） and 10% changes of fiber development components（cellulose, sucrose and callose） could be taken as criteria to judge whether fiber development and fiber quality have been significantly affected by high temper

关键词： cotton(Gossypium hirsutum L.) fiber quality high temperature stress susceptible time window stress endurable duration

Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage

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Neural Regeneration Research 2023年第3期18卷 560-567页

作者： Liu-Ting Hu Bing-Yang Wang Yu-Hua Fan Zhi-Yi He wen-xu zheng Department of Neurology The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Geriatric Department of Dalian Friendship Hospital DalianLiaoning ProvinceChina

Our previous studies showed that miR-23b was downregulated in patients with intracerebral hemorrhage(ICH). This indicates that miR-23b may be closely related to the patho-physiological mechanism of ICH, but this hypothesis lacks direct evidence. In this study, we established rat models of ICH by injecting collagenase Ⅶ into the right basal ganglia and treating them with an injection of bone marrow mesenchymal stem cell(BMSC)-derived exosomal miR-23b via the tail vein. We found that edema in the rat brain was markedly reduced and rat behaviors were improved after BMSC exosomal miR-23b injection compared with those in the ICH groups. Additionally, exosomal miR-23b was transported to the microglia/macrophages, thereby reducing oxidative stress and pyroptosis after ICH. We also used hemin to mimic ICH conditions in vitro. We found that phosphatase and tensin homolog deleted on chromosome 10(PTEN) was the downstream target gene of miR-23b, and exosomal miR-23b exhibited antioxidant effects by regulating the PTEN/Nrf2 pathway. Moreover, miR-23b reduced PTEN binding to NOD-like receptor family pyrin domain containing 3(NLRP3) and NLRP3 inflammasome activation, thereby decreasing the NLRP3-dependent pyroptosis level. These findings suggest that BMSC-derived exosomal miR-23b exhibits antioxidant effects through inhibiting PTEN and alleviating NLRP3 inflammasome-mediated pyroptosis, thereby promoting neurologic function recovery in rats with ICH.

关键词： bone marrow mesenchymal stem cells exosomal miRNAs intracerebral hemorrhage miR-23b neuroinflammation NLRP3 inflammasome Nrf2 oxidative stress PTEN pyroptosis

Pattern of latest tectonic motion and its dynamics for active blocks in Sichuan-Yunnan region, China

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Science China Earth Sciences 2003年第z2期46卷 210-226页

作者： xu Xiwei (徐锡伟) wen xueze (闻学泽) zheng Rongzhang (郑荣章) MA wentao (马文涛) SONG Fangming (宋方敏) YU Guihua (于贵华) Institute of Geology China Seismological Bureau Beijing 100029 China Seismological Bureau of Sichuan Province Chengdu 610041 China Institute of Geology China Seismological Bureau Beijing 100029 China Institute of Geology China Seismological Bureau Beijing 100029 China Institute of Geology China Seismological Bureau Beijing 100029 China Institute of Geology China Seismological Bureau Beijing 100029 China

Based on the concept of "active blocks" and spatial distribution of historical earthquakes with surface ruptures as well as major and subordinate active faults. The Sichuan-Yunnan region can be divided into four first-order blocks. They are the Markam block (I), the Sichuan-Yunnan rhombic block (II), Baoshan-Pu'er block (III), and Mizhina-Ximeng block (IV). Cut by sub-ordinate NE-trending active faults, the Sichuan-Yunnan rhombic block (II) can be further divided into two sub-blocks: the northwestern Sichuan sub-block (II1) and the middle Yunnan sub-block (II2), while the Baoshan- Pu'er block (III) can be further divided into three sub-blocks: Baoshan sub-block (III1), Jinggu sub-block (III2), and Mengla sub-block (III3). A quantitative study of offset landforms is carried out and the basic types of active faults and their long-term slip rates along the major boundaries of active blocks of different orders in the Sichuan-Yunnan region are determined, through slip vector analysis, the motion states of the active blocks are clarified and the deformation coordination on the block margins is discussed. It is suggested that the tectonic motion of the blocks in this region is a complex or superimposition of three basic types of motions: southeastward sliding, rotating on vertical axis, and uplifting. The Markam block (I), the northwestern Sichuan sub-block (II1), and middle Yunnan sub-block (II2) have a southeastward horizontal sliding rate of 1-5 mm/a, clockwise rotating angular rate of 1.4-4(/Ma, and uplifting rate of about 1 mm/a. The Baoshan-Pu'er (III) and Mizhina-Ximeng (IV) blocks have also been extensively clockwise rotated. This pattern of motion is a strain response to the collision between the Indian and Eurasian plates and the localized deformation and differential slip on the block margins associated with the northward motion of the Indian Plate. Because a set of transverse thrusts between the blocks absorbs and transforms some components of eastward or south

关键词： Sichuan-Yunnan region, active fault, active block, block rotation, tectonic motion.

A study on long-term trends of the ionosphere using observations at Chong-qing, China

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电波科学学报 2004年第Z1期19卷 26-31,40页

作者：吴健 National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave Propagation P. O. Box 6301 102206 Beijing China Department of Physics University of Tromsφ N-9037 Tromsφ Norway

With long-term ionosonde records from 1947 to 2001 at Chong-qing, China, we show long-term trends of the ionospheric parameters, the critical frequencies of E-layer foE, F1-layer foF1 and F2-layer foF2, the E-layer height h'E, and the F2-layer peak height hmF2, respectively. Using an approach of discrete wavelet decomposition arithmetic, we have got the long-term components in the variations of the iono spheric parameters. It does exist nearly linear long-term decreasing trends of above ionospheric parameters from 1947 to 1990, then a nearly linear increase from 1990 to 2001. The decreases are approximately by 0. 35MHz, 0. 4MHz, 2MHz,20km, respectively, for foE, foF1, foF2 and hmF2, but increase by 4km for h'E,from 1947 to 1990. Simultaneously, we find similar long-term trends in the variations of 10.7cm solar radio flux and in sunspot number. The long-term components of the ionospheric parameters have extremely high correlation with those of 10.7cm solar radio flux and sunspot number. This implies that solar activities are the control factor of the long-term trends of the ionosphere. We confirm above conclusions with results from the long-term data at Slough station, UK.

关键词： sunspot number solar radio wavelet decomposition solar activities

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中心城区排水泵站与城市公共空间融合设计

中国给水排水 2024年第12期40卷 73-77页

作者：徐文征上海市政工程设计研究总院<集团>有限公司上海200092

为保障城市排水安全,上海中心城区排水标准拟提高至5年一遇,需新增雨水泵站流量487 m^(3)/s,由于用地紧张,应充分挖掘土地综合效益。以黄浦区浙江中路泵站为例,探索排水泵站结合城市更新、与公共空间融合的建设方案。浙江中路泵站规模为... 详细信息

为保障城市排水安全,上海中心城区排水标准拟提高至5年一遇,需新增雨水泵站流量487 m^(3)/s,由于用地紧张,应充分挖掘土地综合效益。以黄浦区浙江中路泵站为例,探索排水泵站结合城市更新、与公共空间融合的建设方案。浙江中路泵站规模为26 m^(3)/s,用地面积约为2922 m^(2),结合街坊内西侧拟建环卫设施停车场统筹建设。街坊总体采用竖向空间的叠合生长策略进行设计,地面一层为泵站以及环卫设施停车场,地面二层为公共空间,泵站用地面积较常规泵站减少30%~40%,地面二层释放公共空间约1040 m^(2);泵站除臭采用洗涤+离子法+化学滤料吸附工艺,执行上海市《恶臭(异味)污染物排放标准》(DB 31/1025—2016);泵站设置独立的出入口,满足运维管理的安全需要。

关键词：排水泵站中心城区城市更新公共空间融合建设

Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong zheng Du Wang Rongjie Lin Weihong xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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唐代官员的退休制度

陕西师范大学学报（哲学社会科学版） 2006年第3期35卷 96-100页

作者：许正文陕西师范大学学报编辑部陕西西安710062

官员年老退休是我国自古至今对国家官员的一项管理制度。唐代对官员的退休年龄、退休待遇等方面问题都有了明确规定,官员退休后基本都能享受原俸禄的一半以上,中高级官员退休还可享受“荫补”特权,这虽保证了退休官员晚年生活,防止了官... 详细信息

官员年老退休是我国自古至今对国家官员的一项管理制度。唐代对官员的退休年龄、退休待遇等方面问题都有了明确规定,官员退休后基本都能享受原俸禄的一半以上,中高级官员退休还可享受“荫补”特权,这虽保证了退休官员晚年生活,防止了官僚队伍老化,但却形成了唐代中后期中高级官员的世袭制,严重影响了政府机能活力的正常运转。

关键词：唐代社会致仕退休制度