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Syntheses and Crystal Structures of Methyl 2-(4,5-Dibromo-1-methylpyrrole-2-carbonylamino)-3-phenylpropanoate and 4,5-Dibromo-1-methyl-2- trichloroacetylpyrrole

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Chinese Journal of Structural Chemistry 2006年第2期25卷 153-158页

作者： ZENG Xiang-Chao GU Jian xu shi-hai LIU Po-Run Department of Chemistry Jinan University Guangzhou 510632 China

4,5-Dibromo-1-methyl-2-trichloroacetylpyrrole Ⅰ, prepared by the reaction of 1-methyl-2-trichloroacetylpyrrole with Br2 in 98.6 % yield, was condensed with methyl L-2-amino-3- phenylpropanoate to afford methyl 2-（4,5-dibromo-1-methylpyrrole-2-carboxmido）-3-phenylpropanoate Ⅱ in 90.8% yield. Crystal data for Ⅰ： monoclinic system, space group P21/c with a = 8.595（3）, b = 10.900（4）, c = 12.321（5） ,A°,β = 92.292（7）°, V = 1153.4（8）A°^3, Dc = 2.213 g/cm^3, F（000） = 728, CTH4Br2Cl3NO, Mr = 384.28, λ = 0.71073 A°, μ（MoKa） = 7.688 mm^-1, Z = 4, R = 0.0338 and wR2 = 0.0840 for 1963 observed reflections with I 〉 2a（I）. Crystal data for Ⅱ： monoclinic system, space group P21 with a = 4.886（2）, b = 15.921（8）, c = 11.635（6） A°,β = 101.803（9）°, V = 885.9（7） A°^3, Dc = 1.665 g/cm^3, F（000） = 440, C16H16Br2N2O3, Mr = 444.13, λ = 0.71073 A°, μ（MoKa） = 4.590 mm^-1, Z = 2, R = 0.0335 and wR2 = 0.0837 for 3191 observed reflections with I 〉 2σ（I）. The crystal structure reveals that compound Ⅱ forms the one-dimensional chain structure via the intermolecular hydrogen bonds of N（2）-H…O（1）.

关键词： methyl 2-(4,5-dibromo-1-methylpyrrole-2-carbonylamino)-3-phenylpropanoate,synthesis crystal structure 4,5-dibromo-1-methyl-2-trichloroacetylpyrrole

Synthesis and Crystal Structure of 3-(Pyrrole-2′-carboxamido)propanoic Acid·(1/2)H_(2)O

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Chinese Journal of Structural Chemistry 2005年第7期24卷 779-782,737页

作者： ZENG Xiang-Chao xu shi-hai GU Jian LIU Po-Run Department of Chemistry Jinan UniversityGuangzhou 510632China

3-(Pyrrole-2?-carboxamido)propanoic acid I has been synthesized from the reaction of β-alanine methyl ester with 2-trichloroacetylpyrrole followed by saponifying and acidating in 85.4% yield, and the crystal structure of 3-(pyrrole-2?-carboxamido)propanoic acid· (1/2)H2O (C8H11N2O3.5, Mr = 191.19) was obtained and determined by X-ray diffraction method. The crystal is of monoclinic, space group C2/c with a = 19.010(4), b = 8.3515(17), c = 13.788(3) ?, β = 125.88(3)o, V = 1773.6(6) ?3, Z = 8, Dc = 1.432 g/cm3, λ = 0.71073 ?, μ(MoKα) = 0.114 mm?1 and F(000) = 768. The structure was refined to R = 0.0354 and wR = 0.0942 for 1642 observed reflections with I > 2σ(I). It is revealed that the title compound has one pyrrole ring and one propionic acid subchain linked by an amido bond at C(4), and there are 8 molecules of com- pound I and 4 crystal water molecules in each unit cell. The supramolecular layers are stabilized by the hydrogen bonds of N(2) H…O(2), N(1) H…O(4), O(4) H(1W)…O(2) and O(3) H…O(1).

关键词： 3-(pyrrole-2′-carboxamido)propanoic acid 2-trichloroacetylpyrrole crystal structure

Failure behavior of protective organic coatings under corrosive conditions

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中国有色金属学会会刊：英文版 2004年第z1期14卷 395-404页

作者： ZHANG Xian-cheng xu Bin-shi WANG hai-dou WU Yi-xiong National Key Laboratory of Remanufacturing Academy of Armored Forces Engineering Beijing 100072 China National Key Laboratory of Remanufacturing Academy of Armored Forces Engineering Beijing 100072 China National Key Laboratory of Remanufacturing Academy of Armored Forces Engineering Beijing 100072 China School of Materials Science and Engineering Shanghai Jiaotong University Shanghai 200030 China

Recent research activities on the formation of micro-defects and porosity in organic coatings were reviewed. The mechanisms of aggressive ionic conduction through organic coatings were analyzed. The micro-mechanisms for the failure behavior of coatings under corrosive environments were discussed in detail. These mechanisms included blistering (i. e. osmotic blistering, anodic blistering and cathodic blistering) in the coating, wet-adhesion loss at the substrate/coating interface, cathodic delamination of coating from the substrate. Based on these researches, it was found that the failure behavior of organic coatings is closely related to the micro-defects in coatings, regardless of the failure mode. Additionally, the general failure mode of a coating system was proposed to interpret the failure behavior of organic in corrosion environments. The topics discussed can provide some insights into the development of a methodology for designing fail-safe coating systems.

关键词： organic coating micro-defect porosity failure mechanism failure mode

Isolation and Identification of Two New Polyhydroxylated Sterols from Soft Coral Sinularia sp.

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Chemical Research in Chinese Universities 2011年第2期27卷 217-220页

作者： LIAO Xiao-jian TANG Li-dan LIANG Yuan-wei GENG Hua-wei xu shi-hai Department of Chemistry Jinan University Guangzhou 510632 P. R. China

Two new polyhydroxysteroids, 12β,16β,20-trihydroxycholesta-1,4-dien-3-one 16-acetate（1） and 24- methyl-12β,16β,20-trihydroxycholesta-1,4-dien-3-one（2） were isolated from octocoral Sinularia sp. Their structures were elucidated primarily on the basis of 1D and 2D NMR and the mass spectroscopic studies. The cytotoxicity of these compounds against three tumor cell lines was also reported.

关键词： Sinularia sp. Polyhydroxysteroid Cytotoxic activity

兰坪盆地银铜钴镍多金属矿床黝铜矿系列矿物学特征及其成因意义

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成都理工大学学报（自然科学版） 2005年第6期32卷 556-564页

作者：徐仕海成都理工大学成都610059

云南兰坪盆地内的银铜多金属矿床以产大量黝铜矿系列矿物为特征.黝铜矿系列矿物是主要的载银矿物,大多属银黝铜矿系列,Ag含量最高可达46.4%,Ag原子数最高为6.64.存在四大系列黝铜矿,即:(1)锑砷黝铜矿系列,置换Cu元素的主要为Fe和Zn,其... 详细信息

云南兰坪盆地内的银铜多金属矿床以产大量黝铜矿系列矿物为特征.黝铜矿系列矿物是主要的载银矿物,大多属银黝铜矿系列,Ag含量最高可达46.4%,Ag原子数最高为6.64.存在四大系列黝铜矿,即:(1)锑砷黝铜矿系列,置换Cu元素的主要为Fe和Zn,其中Fe的原子数低于Zn,Zn明显优势于Fe;(2)砷黝铜矿系列,置换Cu元素的主要为Fe和Zn,二者含量及原子数变化较大,其中金满铜矿床中出现大量的块状铁砷黝铜矿;(3)锑铋砷黝铜矿的Sb原子数可以很低,置换Cu元素的主要是Fe和Zn,Zn的原子数大于Fe;(4)砷锑黝铜矿系列,该类矿物主要产于富隆厂矿段中,与独立银矿物辉银矿、自然银、螺状硫银矿等共生.黝铜矿各元素含量和原子数之间的变化特征表明,Ag-Cu, Ag-As, Ag-Fe之间存在明显的负相关,而Ag-Sb、部分矿区Ag-Zn之间存在明显的正相关.热液脉型矿床产出的黝铜矿显示为Zn原子数高、Fe原子数低,Fe原子数一般小于0.8,Zn原子数一般在1～2之间.当Fe原子数小于 0.5时,Ag原子数高,最高达6.64,其中富隆厂矿段的黝铜矿的Ag原子数平均达0.94.整个盆地内银铜多金属矿床的黝铜矿系列矿物的As-Sb原子数呈极好的线性负相关,大部分黝铜矿的As原子数大于1,以砷黝铜矿占优势.当Sb原子数大于0.5时,有利于Ag占据更高的黝铜矿原子数,并具显著的正相关关系.

关键词：兰坪盆地白秧坪银铜多金属矿床黝铜矿系列热液脉型

三个新的海绵Spongia suriganensis神经酰胺

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有机化学 2006年第1期26卷 56-59页

作者：徐石海杨凯暨南大学生命科学技术学院广州510632

报道从中国南海硇洲岛产海绵Spongiasuriganensis的乙醇浸提物中分离得到3个新的同系列神经酰胺2-N-(1,3,4-三羟基-17-甲基)十八烷基-2'-羟基-18-甲基二十碳酰胺(1),2-N-(1,3,4-三羟基-17-甲基)十八烷基-2'-羟基-19-甲基二十一碳酰胺(2)... 详细信息

报道从中国南海硇洲岛产海绵Spongiasuriganensis的乙醇浸提物中分离得到3个新的同系列神经酰胺2-N-(1,3,4-三羟基-17-甲基)十八烷基-2'-羟基-18-甲基二十碳酰胺(1),2-N-(1,3,4-三羟基-17-甲基)十八烷基-2'-羟基-19-甲基二十一碳酰胺(2)和2-N-(1,3,4-三羟基-17-甲基)十八烷基-2'-羟基-20-甲基二十二碳酰胺(3),其结构经过MS,IR,1HNMR,13CNMR(DEPT),HMQC及HMBC等现代光谱手段和水解化学方法来确定.

关键词：海绵 Spongia surigranensis 神经酰胺

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning shi Lv Qian Wang Yuzhen xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

柔荑软珊瑚Nephthea sp.中两种具有细胞毒活性的甾醇化合物

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有机化学 2008年第5期28卷 861-864页

作者：徐石海廖小建林慧暨南大学化学系广州510632

采用抗肿瘤活性追踪法对采自中国南海西沙群岛永兴岛柔荑软珊瑚Nephthea sp.中抗肿瘤活性成分进行研究,报道了两种具有细胞毒活性的甾醇化合物,经过MS,IR,1H NMR,13C NMR(DEPT),HSQC和HMBC等光谱技术鉴定为:24-甲基胆甾-5-烯-3β,8β-二... 详细信息

采用抗肿瘤活性追踪法对采自中国南海西沙群岛永兴岛柔荑软珊瑚Nephthea sp.中抗肿瘤活性成分进行研究,报道了两种具有细胞毒活性的甾醇化合物,经过MS,IR,1H NMR,13C NMR(DEPT),HSQC和HMBC等光谱技术鉴定为:24-甲基胆甾-5-烯-3β,8β-二醇(1)和24-亚甲基胆甾-4-烯-3β,6β-二醇(2),化合物1为新化合物,利用X-ray单晶衍射技术验证化合物2的立体结构.化合物1对肝癌细胞(BEL-7402),小鼠白血瘤细胞(P388)和人结肠癌细胞(LOVO)作用的IC50值分别为18.0,25.5和20.6μg/mL;化合物2对肿瘤细胞P388和人乳腺癌细胞(MCF)作用的IC50值分别为1.0和2.5μg/mL.

关键词：软珊瑚 Nephthea sp 甾醇抗肿瘤活性

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《珍稀中医稿钞本丛刊·新安卷》医著选评

中华中医药杂志 2019年第3期34卷 1019-1022页

作者：许仕海澳洋医院中西医结合科江苏张家港215600

《珍稀中医稿钞本丛刊·新安卷》是新近出版的一部有关新安医学的大型丛书。该套丛书以新安医家的手稿本及精钞本为主,含括了内、外、妇、儿、医案医话等在内五十五种医著。笔者现择选卷九《新安四家医案》中洪月芬、洪竹潭、洪韵澜三... 详细信息

《珍稀中医稿钞本丛刊·新安卷》是新近出版的一部有关新安医学的大型丛书。该套丛书以新安医家的手稿本及精钞本为主,含括了内、外、妇、儿、医案医话等在内五十五种医著。笔者现择选卷九《新安四家医案》中洪月芬、洪竹潭、洪韵澜三家医案及《文涛兄遗案》、卷五《仙方遗跡》、卷十二《民国婺源医家日记》四部医著,或从学术临床价值,或从文献版本价值,或从史学文化价值等不同角度,试探讨新安医家在家族传承、师承授受、日常行医、医家手迹及地域交流等方面的特色与成就。

关键词：中医稿钞本丛刊新安医学书评