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Microbial remediation of aromatics-contaminated soil

Frontiers of Environmental Science & Engineering 2017年第2期11卷 1-9页

作者： ying xu ning-yi Zhou State Key Laboratory of Microbial Metabolism & School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200240 China

Aromatics-contaminated soil is of particular environmental concern as it exhibits carcinogenic and mutagenic properties. Bioremediation, a biological approach for the removal of soil contaminants, has several advantages over traditional soil remediation methodologies including high efficiency, complete pollutant removal, low expense and limited or no secondary pollution. Bioaugmentation, defined as the introduction of specific competent strains or consortia of microorganisms, is a widely applied bioremediation technology for soil remediation. In this review, it is concluded which several successful studies of bioaugmentation of aromatics-contaminated soil by single strains or mixed consortia. In recent decades, a number of reports have been published on the metabolic machinery of aromatics degradation by microorganisms and their capacity to adapt to aromatics-contaminated environments. Thus, microorganisms are major players in site remediation. The bioremediation/bioaugmentation process relies on the immense metabolic capacities of microbes for transformation of aromatic pollutants into essentially harmless or, at least, less toxic compounds. Aromatics-contaminated soils are successfully remediated with adding not only single strains but also bacterial or fungal consortia. Furthermore several novel approaches, which microbes combined with physical, chemical or biological factors, increase remediatio.n efl~.ciency of aromatics-contaminated soil. Meanwhile, the environmental factors also have appreciable impacts on the bioaugmentation process. The biostatistics method is recommended for analysis of the effects of bioaugmentation treatments.

关键词： Aromatics-contaminated soilBacteriaBioaugmentationBioremediationFungi

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Intra-specific genetic relationship analyses of Elaeagnus angustifolia based on RP-HPLC biochemical markers

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第4期7卷 272-278页

作者： WANG Qiang RUAN Xiao HUANG Jun-hua xu ning-yi YAN Qi-chuan ningbo Institute of Technology Zhejiang University Ningbo 315100 China School of Forestry Xinjiang Agriculture University Urumqi 830052 China School of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China

Elaeagnus angustifolia Linn. has various ecological, medicinal and economical uses. An approach was established using RP-HPLC （reversed-phase high-performance liquid chromatography） to classify and analyse the intra-specific genetic relationships of seventeen populations of E. angustifolia, collected from the Xinjiang areas of China. Chromatograms of alcohol-soluble proteins produced by seventeen populations of E. angustifolia, were compared. Each chromatogram of alcohol-soluble proteins came from a single seed of one wild plant only. The results showed that when using a Waters Delta Pak. C 18, 5μm particle size reversed phase column （150 mm×3.9mm）, a linear gradient of 25%-60% solvent B with flow rate of 1 ml/min and run time of 67 min, the chromatography yielded optimum separation of E. angustifolia alcohol-soluble proteins. Representative peaks in each population were chosen according to peak area and occurrence in every seed. The converted data on the elution peaks of each population were different and could be used to represent those populations. GSC （genetic similarity coefficients） of 41% to 62% showed a medium degree of genetic diversity among the populations in these eco-areas. Cluster analysis showed that the seventeen populations orE. angustifolia could be divided into six clusters at the GSC=0.535 level and indicated the general and unique biochemical markers of these clusters. We suggest that E. angustifolia distribution in these eco-areas could be classified into six variable species. RP-HPLC was shown to be a rapid, repeatable and reliable method for E. angustifolia classification and identification and for analysis of genetic diversity.

关键词： Elangustifolia Intra-specific genetic relationship Genetic diversity Biochemical marker

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing ning Shi Lv Qian Wang Yuzhen xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu yi-Hua Wang yi-Xin Liu Lu xu Lin Fu ning yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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整合素受体靶向的载胰岛素三甲基壳聚糖纳米给药系统细胞摄取及转运机制

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药学学报 2015年第7期50卷 893-898页

作者：许娟刘冲许艺苧山伟刘敏黄园四川大学华西药学院四川成都610041

本文拟构建整合素配体c RGDyk修饰的三甲基壳聚糖纳米给药系统,以期提高胰岛素的口服生物利用度。采用单因素筛选法对其处方进行优化,筛选最优处方制得非配体修饰纳米粒(TMC NPs)和配体修饰纳米粒(C-TMC NPs),粒径分别为(240.3±4.2)和(... 详细信息

本文拟构建整合素配体c RGDyk修饰的三甲基壳聚糖纳米给药系统,以期提高胰岛素的口服生物利用度。采用单因素筛选法对其处方进行优化,筛选最优处方制得非配体修饰纳米粒(TMC NPs)和配体修饰纳米粒(C-TMC NPs),粒径分别为(240.3±4.2)和(259.5±3.3)nm;电位分别为(33.5±0.8)和(25.7±1.6)m V;包封率分别为(76.0±2.2)%和(74.4±2.0)%;载药量分别为(50.1±2.1)%和(26.1±1.0)%。以Caco-2细胞为模型,考察了TMC NPs和C-TMC NPs的细胞摄取、跨膜及相关转运机制。C-TMC NPs的摄取及药物累计透过量较TMC NPs分别提高了1.98倍和2.84倍。研究发现,TMC NPs和C-TMC NPs的细胞摄取均由网格蛋白、小窝蛋白介导的主动转运及大胞饮参与,且游离的c RGDyk可显著抑制C-TMC NPs的细胞摄取。

关键词： αvβ3整合素受体 c RGDyk多肽三甲基壳聚糖纳米粒

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