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Influence of Incomplete Soil Plugs on Bearing Capacities of Bucket Foundations in Clay

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China Ocean Engineering 2024年第1期38卷 144-155页

作者： LI Hui-shan LIU Run YANG xu LIAN Ji-jian State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China Institute of Marine Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China

Due to the uneven seabed and heaving of soil during pumping,incomplete soil plugs may occur during the installation of bucket foundations,and the impacts on the bearing capacities of bucket foundations need to be *** this paper,the contact ratio(the ratio of the top diameter of the soil plug to the diameter of the bucket)and the soil plug ratio(the ratio of the soil heave height to the skirt height)are defined to describe the shape and size of the incomplete soil ***,finite element models are established to investigate the bearing capacities of bucket foundations with incomplete soil plugs and the influences of the contact ratios,and the soil plug ratios on the bearing capacities are *** results show that the vertical bearing capacity of bucket foundations in homogeneous soil continuously improves with the increase of the contact ***,in normally consolidated soil,the vertical bearing capacity barely changes when the contact ratio is smaller than 0.75,while the bearing capacity suddenly increases when the contact ratio increases to 1 due to the change of failure *** contact ratio hardly affects the horizontal bearing capacity of bucket ***,the moment bearing capacity improves with the increase of the contact ratio for small aspect ratios,but hardly varies with increasing contact ratio for aspect ratios larger than ***,the reduction coefficient method is proposed based on this analysis to calculate the bearing capacities of bucket foundations considering the influence of incomplete soil *** comparison results show that the proposed reduction coefficient method can be used to evaluate the influences of incomplete soil plug on the bearing capacities of bucket foundations.

关键词： bucket foundation incomplete soil plug uniaxial bearing capacity contact ratio soil plug ratio

Indexing dynamic encrypted database in cloud for efficient secure k-nearest neighbor query

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Frontiers of Computer Science 2024年第1期18卷 187-198页

作者： Xingxin LI Youwen ZHU Rui xu jian WANG Yushu ZHANG College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Mathematical Informatics University of TokyoTokyo 113-8654Japan Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin 541004China School of Computer Science China University of GeosciencesWuhan 430074China

Secure k-Nearest Neighbor(k-NN)query aims to find k nearest data of a given query from an encrypted database in a cloud server without revealing privacy to the untrusted cloud and has wide applications in many areas,such as privacy-preservingmachine elearning gand secure biometric *** solutions have been put forward to solve this challenging ***,the existing schemes still suffer from various limitations in terms of efficiency and *** this paper,we propose a new encrypt-then-index strategy for the secure k-NN query,which can simultaneously achieve sub-linear search complexity(efficiency)and support dynamical update over the encrypted database(flexibility).Specifically,we propose a novel algorithm to transform the encrypted database and encrypted query points in the *** indexing the transformed database using spatial data structures such as the R-tree index,our strategy enables sub-linear complexity for secure k-NN queries and allows users to dynamically update the encrypted *** the best of our knowledge,the proposed strategy is the first to simultaneously provide these two *** theoretical analysis and extensive experiments,we formally prove the security and demonstrate the efficiency of our scheme.

关键词： cloud computing secure k-NN query sub-linear complexity dynamicupdate

Difference and Inheritance of the Sterility Maintenance of CMS in Indica Rice

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Agricultural Sciences in China 2002年第8期1卷 945-948页

作者： xu jian-hong and xuE qing-zhong( Department of Agronomy, College of Agriculture and Biotechnology Zhejiang University, Hangzhou 310029, P.R.China) Department of Agronomy College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 P.R. China

The inheritance of the sterility maintenance ability was studied for three types of CMS lines (Zhenshan97A, XieqingzaoA and II-32A) and several lines in indica rice. The result showed that the abilities to keep the male sterility of the maintainer lines strengthened obviously with the progressive backcrossing. The critical stage to maintain the sterility of CMS lines happened usually in BC5-6 generation. The selection of the recurrent parent gave an obvious influence on the pollen fertility distribution of the later generations. The author has discussed ways of improving of the maintainer lines.

关键词： Rice Maintainer Line Cytoplasm male sterile (CMS) Inheritance

Thermal and hydrological processes in permafrost slope wetlands affect thermosyphon embankment stability

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Advances in Climate Change Research 2024年第4期15卷 680-694页

作者： Bo-Wen TAI qing-Bai WU Xiao-Ming xu State Key Laboratory of Frozen Soil Engineering Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

To ensure the long-term service performance of infrastructure such as railways,highways,airports and oil pipelines built on permafrost slope wetland sites,it is imperative to systematically uncover the long-term heat-water changes of soil in slope wetlands environment under climate *** specifically,considering valuable field data from 2001 to 2019,the long-term heat and water changes in active layers of the slope wetland site along the qinghai-Xizang Railway(QXR)are illustrated,the effect of thermosyphon measures in protecting the permafrost environment is evaluated,and the influences of climate warming and hydrological effects on the stability of slope wetland embankments are systematically *** permafrost at the slope wetland site is rapidly degrading,demonstrating a reduction in active layer thickness of>3.7 cm per year and a permafrost temperature warming of>0.006℃ per *** thermosiphon embankment developed by QXR has a specific cooling period;thus,to mitigate the long-term impacts of climate warming on the thermal stability of permafrost foundation,it is essential to implement strengthening measures for the thermosiphon embankment,such as adding a crushed-rock layer or sunshade board on the slope of thermosiphon embankment to creating a composite cooling ***-term seasonal groundwater seepage intensifies frost damage to the slope wetland embankment,while long-term seasonal supra-permafrost water and groundwater seepage exacerbates uneven transverse deformation of slope wetland ***-term climate warming and slope effects have altered the surface water and groundwater hydrological processes of slope wetlands,potentially leading to an increased occurrence of slope embankment *** results are crucial for improving our understanding of heat and water variation processes in the active layer of slope wetland sites located in permafrost regions and ensuring long-term service safety for the QXR.

关键词： Heat and water process Active layer Slope wetland Permafrost environment Thermosyphon embankment

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“一五”时期的投资与制度变革

当代中国史研究 2005年第6期12卷 29-38页

作者：徐建青中国社会科学院经济研究所

“一五”期间,我国资源供求状况及其配置方式发生巨大变化,这些变化与这一时期的投资过热和经济波动存在必然联系.“一五”时期的投资是个连续大起大落的过程,两次冒进间隔时间短,这在建国以来的投资史上是少见的.由于投资规模过大、增... 详细信息

“一五”期间,我国资源供求状况及其配置方式发生巨大变化,这些变化与这一时期的投资过热和经济波动存在必然联系.“一五”时期的投资是个连续大起大落的过程,两次冒进间隔时间短,这在建国以来的投资史上是少见的.由于投资规模过大、增长速度过快,导致生产资料和消费品供求形势全面紧张,促使国家将计划管理的力度和范围不断加大,从而加快了三大改造的步伐,全面建立起了计划经济体制.但自此也形成了追求高速度和外延、粗放型的增长方式.

关键词： “一五”计划时期投资建设制度变革

pH-responsive metal nanoparticles as high contrast theranostic agents for selective imaging and synergistic cancer therapy

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Science China Chemistry 2024年第9期67卷 3063-3070页

作者： Sichao Tian Xiaofeng He Xiao Wu Dongxue Hu qing-Hua xu Department of Chemistry National University of SingaporeSingapore 117543Singapore National University of Singapore(Suzhou)Research Institute Suzhou 215123China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore

The low signal-to-noise ratio(S/N)and single functionality of fluorescence imaging agents have limited their practical *** two-photon excitation(2PE)imaging probes are highly desirable in vivo with larger imaging depth,minor autofluorescence background,and less ***,we developed responsive aggregated gold nanoparticles(Au NPs)as high contrast 2PE imaging agents,capable of emitting red fluorescence upon excitation of near-infrared(NIR)laser and possessing a high signal-to-noise ratio(S/N of 2,475).By forming aggregates in situ inside tumor tissue,doxorubicin hydrochloride(DOX)-loaded mix-charged gold nanoparticles(DOX-MC-Au NPs)were utilized to act as selective fluorescence imaging probes and precise therapy *** high-contrast theranostic agents offer a promising potential for precise cancer imaging and therapy,which might open a new venue to multifunctional and noninvasive theranostics.

关键词： metal nanoparticles two-photon excitation high contrast imaging agents fluorescence imaging cancer therapy

Immunization with HBsAg-Fc fusion protein induces a predominant production of Thl cytokines and reduces HBsAg level in transgenic mice

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Chinese Medical Journal 2012年第18期125卷 3266-3272页

作者： MENG Zhe-feng WANG Hua-jing YAO Xin WANG xuan-yi WEN Yu-mei DAI jian-xin XIE You-hua xu jian-qing Shanghai Public Hlealth Clinical Center Key Lab of MedicalMolecular Virology Shanghai Medical College Institutes ofBiomedical Sciences Fudan University China Shanghai 200433 Intern-ational Joint Cancer Institute & Chinese People's LiberationArmy General Hospital Cancer Center Second Military MedicalUniversity China Shanghai 200433

Background The Fc receptor associated pathway might improve the immune responses against hepatitis B virus （HBV） as previously described by us. In addition, the Fit3 ligand （FL） has been reported to potentiate antigen presenting cells in vivo and may act as a potential adjuvant to boost antigen-specific immune responses. In this study, the immune efficacies of a set of fusion proteins of HBsAg and Fc and/or FL were evaluated in HBsAg transgenic mice. Methods The fusion proteins composed of HBsAg and the Fc domain of murine IgG1 （HBsAg-Fc） and/or the Fit3 ligand, and yeast-derived recombinant HBsAg were used as immunogen to immunize HBsAg transgenic mice, respectively. Serum and liver HBsAg levels, serum anti-HBsAg and cytokine profile, and the activities of alanine aminotransferase （ALT）/AST were investigated after immunization. Results After six injections, the most pronounced decrease in serum and liver HBsAg levels was observed in the HBsAg-Fc immunized group. In addition, serum Thl cytokines and ALT/AST activities were highest in this group, indicating an effective induction of a favorable cellular immune response. Interestingly, the fusion protein containing HBsAg-Fc and the Fit3 ligand stimulated an alternative Thl-type immune response featured with high level productions of tumor necrosis factor a （TNF-a） and monocyte chemoabstractant protein 1 （MCP-1）, causing a more severe cytotoxicity in hepatocytes while showed less effective in reducing serum HBsAg level. Conclusion HBsAg-Fc is effective in eliciting both the humeral and cellular immune responses against HBsAg in HBsAg transgenic mice, which makes it a potential immunogen for the immunotherapy of chronic hepatitis B.

关键词： Fc receptor hepatitis B surface antigen transgenic mice hepatitis B virus therapeutic vaccine

SMA-origami coupling:online configuration switches and stability property modulation

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International Journal of Smart and Nano Materials 2024年第1期15卷 21-41页

作者： Hai Zhou Hongbin Fang Zuolin Liu jian xu School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghaiChina Institute of AI and Robotics Fudan UniversityShanghaiChina Yiwu Research Institute Fudan UniversityYiwuZhejiangChina

Active folding is a crucial requirement for practical applications of multi-stable origami ***,research on integrating active materials with origami structures to enable quick configuration switching and modulation of stability properties is still in its early *** advance the state-of-the-art,we designed a coupled structure comprising a stacked Miura-origami(SMO)structure and two Shape Memory Alloy(SMA)*** actuator is used for extruding the SMO structure while the other is used for retracting,thereby realizing bidirectional reversible active folding of the coupled *** the potential energy of the coupled structure shows that it can be switched between monostable and bistable by heating the SMA *** above findings are also confirmed by experiments conducted on a delicate SMO-SMA coupled structure *** activation of different actuators induces rapid configuration switching of the coupled structure,and the stability profile is qualitatively adjusted by designing the current loading profile to achieve steady-state temperature ***,this study provides a new approach to coupling origami structures with smart materials for active folding and presents a novel method to regulate the stability property of origami structures,thus promoting their practical applications.

关键词： Multistability bistable origami active folding smart material

Proposing a machine learning approach to analyze and predict basic high-temperature properties of iron ore fines and its factors

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Journal of Iron and Steel Research International 2024年第5期31卷 1082-1094页

作者： qing-ke Sun Yao-zu Wang jian-liang Zhang Zheng-jian Liu Le-le Niu Chang-dong Shan Yun-fei Ma Institute of Artificial Intelligence University of Science and Technology BeijingBeijing100083China School of Intelligence Science and Technology University of Science and Technology BeijingBeijing100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

The basic high-temperature properties of iron ore play a crucial role in optimizing sintering and ore blending,but the testing process for these properties is complex and has significant lag time,which cannot meet the actual needs of ore blending.A prediction model for the basic high-temperature properties of iron ore fines was thus proposed based on a combination of machine learning algorithms and genetic ***,the prediction accuracy of different machine learning models for the basic high-temperature properties of iron ore fines was ***,a random forest model optimized by genetic algorithms was built,further improving the prediction accuracy of the *** test results show that the random forest model optimized by genetic algorithms has the highest prediction accuracy for the lowest assimilation temperature and liquid phase fluidity of iron ore,with a determination coefficient of 0.903 for the lowest assimilation temperature and 0.927 for the liquid phase fluidity after *** trained model meets the fluctuation requirements of on-site testing and has been successfully applied to actual production on site.

关键词： Iron ore Basic high-temperature property Machine learning Random forest Genetic algorithm