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Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng xu Jing-Kai Wang Bo Chen Hao xu Deng Pan Yu-yang Ma Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

MF-CFI:A fused evaluation index for camouflage patterns based on human visual perception

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Defence Technology（防务技术） 2021年第5期17卷 1602-1608页

作者： Xin yang Wei-dong xu Qi jia Jun Liu National Key Laboratory of Lightning Protection and Electromagnetic Camouflage Army Engineering UniversityNanjingJiangsu210007China

The evaluation index of camouflage patterns is important in the field of military *** is the goal that researchers have always pursued to make the computable evaluation indicators more in line with the human visual *** order to make the evaluation method more computationally intelligent,a Multi-Feature Camouflage Fused Index(MF-CFI)is proposed based on the comparison of grayscale,color and texture features between the target and the *** order to verify the effectiveness of the proposed index,eye movement experiments are conducted to compare the proposed index with existing indexes including Universal Image Quality Index(UIQI),Camouflage Similarity Index(CSI)and Structural Similarity(SSIM).Twenty-four different simulated targets are designed in a grassland background,28 observers participate in the experiment and record the eye movement data during the observation *** results show that the highest Pearson correlation coefficient is observed between MF-CFI and the eye movement data,both in the designed digital camouflage patterns and largespot camouflage *** MF-CFI is more in line with the detection law of camouflage targets in human visual perception,the proposed index can be used for the comparison and parameter optimization of camouflage design algorithms.

关键词： Camouflage evaluation Visual perception Effect assessment Fused index Eye movement analysis

施用低温生物炭对土壤镉、铅生物有效性的影响

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江苏农业学报 2022年第6期38卷 1524-1531页

作者：彭红宇聂兆君刘红恩李畅秦世玉张玉鹏刘亥扬许嘉阳赵鹏河南农业大学资源与环境学院河南郑州450002 河南省土壤污染防控与修复重点实验室河南郑州450002

为了研究低温生物炭在土壤污染修复领域的应用潜力,以玉米秸秆和花生壳为原料,在厌氧条件下,分别以250℃、450℃2种炭化温度制备4种生物炭,以1%和2%的生物炭施用量添加至原位镉、铅污染土壤中,短期培养30 d和60 d,研究施用低温生物炭对... 详细信息

为了研究低温生物炭在土壤污染修复领域的应用潜力,以玉米秸秆和花生壳为原料,在厌氧条件下,分别以250℃、450℃2种炭化温度制备4种生物炭,以1%和2%的生物炭施用量添加至原位镉、铅污染土壤中,短期培养30 d和60 d,研究施用低温生物炭对土壤镉、铅生物有效性的影响。结果表明,施用低温生物炭和高温生物炭均可减少土壤有效性镉、铅含量,但对pH值影响不显著;就花生壳生物炭而言,培养30 d后,随着低温生物炭、高温生物炭添加量的增加,土壤有效态镉、铅含量降低,生物炭固定重金属的能力提高;培养60 d后随着低温生物炭添加量的增加,土壤有效态镉、铅含量降低,生物炭固定重金属的能力增强,而高温生物炭则相反,可见培养30 d的试验结果与60 d相反;对于玉米秸秆生物炭,培养30 d后,发现随着低温生物炭添加量的增加,土壤有效态镉、铅含量增加,生物炭固定重金属的能力降低,而高温玉米秸秆生物炭则相反,30 d培养结果与60 d培养结果一致。

关键词：生物炭生物有效性镉铅土壤培养

Electrolyte inhomogeneity induced lithium plating in fast charging lithium-ion batteries

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Journal of Energy Chemistry 2022年第10期31卷 394-399,I0010页

作者： Yi yang Lei xu Shi-Jie yang Chong Yan jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Shanxi Research Institute for Clean Energy Tsinghua UniversityTaiyuan 030032ShanxiChina

Fast charging capability of lithium-ion batteries is in urgent need for widespread economic success of electric vehicles. However, the application of the fast charging technology often leads to the inevitable lithium plating on the graphite anode, which is one of the main culprits that endanger battery safety and shorten battery lifespan. The in-depth understanding of the initiation of lithium metal nucleation and the following plating behavior is a key to the development of fast charging cells. Herein, we investigate the overlooked effect of the non-uniform distribution of electrolyte on lithium plating during fast charging. Prior lithium plating occurs on the saturated lithium-graphite compounds in the anode region with sufficient electrolyte since the lithium-ion transport is blocked in the anode region lacking electrolyte. The uniform distribution of electrolyte is crucial for the construction of safe lithium-ion batteries especially in fast charging scenarios.

关键词： Fast charging Lithium-ion batteries Lithium plating Distribution of electrolyte Inhomogeneity

Recent advances in carbon-based electrocatalysts for oxygen reduction reaction

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Chinese Chemical Letters 2020年第3期31卷 626-634页

作者： Lulu Chen Xiaolong xu Wenxiu yang jianbo jia State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China Department of Materials Science&Engineering&Department of Energy and Resources Engineering College of EngineeringPeking UniversityBeijing 100871China School of Chemical and Environmental Engineering Wuyi UniversityJiangmen 529020China

Fuel cells are one of the most promising clean energy devices to substitute for fossil fuel in the future to alleviate energy crisis and environmental *** the key reaction on the cathode in the fuel cells,oxygen reduction reaction(ORR)still requires efficient noble metal catalysts such as the comme rcial Pt/C to boost the reaction for its sluggish ***,it is critical to design earth-abundant carbonbased catalysts with high efficiency and long-term stability to replace the noble metal-based *** review focuses on the recent progress about carbon-based ORR catalysts including non-metal doped carbon materials,transition metal-nitrogen-carbon species,transition metal carbides/carbon,single atom catalysts,and other carbon *** we further infer that the excellent ORR performances can be achieved by the balance of geometric and electronic structures of catalysts such as conductivity,surface area,hierarchical porous structure,defect and doping ***,the perspective development trend is also proposed to guide the rational designation of carbon-based catalysts for ORR and even extend to other energy storage and conversion fields in the future.

关键词： Oxygen reduction reaction Carbon materials Transition metal catalysts Single atom catalysts Fuel cells

Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin xu xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

Hot spot temperature prediction and operating parameter estimation of racks in data center using machine learning algorithms based on simulation data

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Building Simulation 2023年第11期16卷 2159-2176页

作者： Xianzhong Chen Rang Tu Ming Li xu yang Kun jia School of Civil and Resources Engineering University of Science and Technology BeijingBeijing100083China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China China Electronics Engineering Design Institute CO. LTD.Beijing100142China

In this paper,models to predict hot spot temperature and to estimate cooling air’s working parameters of racks in data centers were established using machine learning algorithms based on simulation ***,simulation models of typical racks were established in computational fluid dynamics(CFD).The model was validated with field test results and results in literature,error of which was less than 3%.Then,the CFD model was used to simulate thermal environments of a typical rack considering different factors,such as servers’power,which is from 3.3 kW to 20.1 kW,cooling air’s inlet velocity,which is from 1.0 m/s to 3.0 m/s,and cooling air’s inlet temperature,which is from 16℃ to 26℃ The highest temperature in the rack,also called hot spot temperature,was selected for each ***,a prediction model of hot spot temperature was built using machine learning algorithms,with servers’power,cooling air’s inlet velocity and cooling air’s inlet temperature as inputs,and the hot spot temperatures as ***,based on the prediction model,an operating parameters estimation model was established to recommend cooling air’s inlet temperatures and velocities,which can not only keep the hot spot temperature at the safety value,but are also energy saving.

关键词： data center CFD simulation hot spot temperature machine learning algorithm prediction and estimation models

彩色多普勒超声联合CT在乳腺癌腋下转移性淋巴结鉴别诊断中的应用

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中国CT和MRI杂志 2021年第8期19卷 95-97页

作者：李延会马雅秀范娜徐嘉阳南阳市第一人民医院超声医学科河南南阳473000

目的探究彩色多普勒超声联合计算机断层扫描(CT)在乳腺癌腋下转移性淋巴结鉴别诊断中的应用价值。方法回顾性分析我院经手术病理证实为乳腺癌的102例患者临床资料,患者术前均行彩色多普勒超声与CT检查,以淋巴结手术病理结果为“金标准”... 详细信息

目的探究彩色多普勒超声联合计算机断层扫描(CT)在乳腺癌腋下转移性淋巴结鉴别诊断中的应用价值。方法回顾性分析我院经手术病理证实为乳腺癌的102例患者临床资料,患者术前均行彩色多普勒超声与CT检查,以淋巴结手术病理结果为“金标准”,评价彩色多普勒超声、CT及彩色多普勒超声联合CT诊断腋下淋巴结转移的诊断效能。结果102例乳腺癌患者经术后病理诊断检出腋下转移性淋巴结33例,未转移69例;多普勒彩超诊断检出转移36例,未转移66例;CT诊断检出转移39例,未转移63例;联合诊断检出转移38例,未转移64例;多普勒彩超、CT及联合诊断腋下转移性淋巴结的灵敏度、特异性、准确率分别为81.82%、93.94%、96.97%、86.96%、88.40%、91.30%;85.29%、90.20%、93.14%,联合诊断各项诊断效能数据最高。结论彩色多普勒超声联合CT对乳腺癌腋下转移性淋巴结的诊断效能较单一检查诊断更高,临床中应综合各检查方式的诊断结果进行判定,为患者临床治疗及预后提供参考。

关键词：彩色多普勒超声 CT 乳腺癌腋下转移性淋巴结鉴别诊断

Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua xu Miao Yu Yuhang Song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable