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Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 51-64页

作者： Mingming xu Zhaoliang LIU Wenhua HU Ying HAN Zhen WU Sufeng CHEN Peng xia Jing DU xumin ZHANG Piliang HAO Jun xia Shuang YANG Center for Clinical Mass Spectrometry College of Pharmaceutical SciencesSoochow UniversitySuzhou215123China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China State Key Laboratory of Genetic Engineering Department of BiochemistrySchool of Life SciencesFudan UniversityShanghai200438China Department of Clinical Laboratory Center Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou310014China

Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival ***,no methods have been derived that can reliably identify early precursors of development into ***,it is urgent to discover early molecular changes during pancreatic *** aberrant glycosylation is closely associated with cancer progression,numerous efforts have been made to mine glycosylation changes as biomarkers for diagnosis;however,detailed glycoproteomic information,especially site-specific N-glycosylation changes in pancreatic cancer with and without drug treatment,needs to be further ***,we used comprehensive solid-phase chemoenzymatic glycoproteomics to analyze glycans,glycosites,and intact glycopeptides in pancreatic cancer cells and patient *** profiling of N-glycans in cancer cells revealed an increase in the secreted glycoproteins from the primary tumor of MIA PaCa-2 cells,whereas human sera,which contain many secreted glycoproteins,had significant changes of glycans at their specific *** results indicated the potential role for tumor-specific glycosylation as disease *** also found that AMG-510,a small molecule inhibitor against Kirsten rat sarcoma viral oncogene homolog(KRAS)G12C mutation,profoundly reduced the glycosylation level in MIA PaCa-2 cells,suggesting that KRAS plays a role in the cellular glycosylation process,and thus glycosylation inhibition contributes to the anti-tumor effect of AMG-510.

关键词： Pancreatic cancer Glycosylation Biomarker Glycoproteomics Mass spectrometry

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Advances in mesenchymal stem cells therapy for tendinopathies

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Chinese Journal of Traumatology 2024年第1期27卷 11-17页

作者： xu-Feng Mao Xi-Qian Zhang Zhe-Yu Yao hai-Jiao Mao Department of Orthopaedic Surgery The First Affiliated Hospital of Ningbo UniversityNingbo315010Zhejiang provinceChina

Tendinopathies are chronic diseases of an unknown etiology and associated with *** stem cells(MSCs)have emerged as a viable therapeutic option to combat the pathological progression of tendinopathies,not only because of their potential for multidirectional differentiation and self-renewal,but also their excellent immunomodulatory *** immunomodulatory effects of MSCs are increasingly being recognized as playing a crucial role in the treatment of tendinopathies,with MSCs being pivotal in regulating the inflammatory microenvironment by modulating the immune response,ultimately contributing to improved tissue *** review will discuss the current knowledge regarding the application of MSCs in tendinopathy treatments through the modulation of the immune response.

关键词： Mesenchymal stem cells Tendinopathy Immunomodulation Treatment Review

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Morphology-dependent activation of hydrogen peroxide with Cu_(2)O for tetracycline hydrochloride degradation in bicarbonate aqueous solution

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Journal of Environmental Sciences 2024年第3期137卷 567-579页

作者： Xiuying Liu Qianna xia Jiao Zhou Bowen Li Shuaiqi Zhao Long Chen Aimal Khan xiaoxia Li Aihua xu School of Chemistry and Chemical Engineering Wuhan Textile UniversityWuhan 430200China Hubei Key Laboratory of Biomass Fibers and Eco-Dyeing and Finishing Wuhan Textile UniversityWuhan 430200China School of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

The design of efficient heterogeneous catalysts in bicarbonate-activated hydrogen peroxide systems(BAP)is a hot topic in wastewater *** this work,Cu_(2)O nanoparticles with different morphologies including cubic shape(c-Cu_(2)O),octahedron shape(o-Cu_(2)O)and spherical shape(s-Cu_(2)O),were applied in BAP for the first time to degrade tetracycline hydrochloride(TC).Compared with Cu^(2+)ions and CuO,TC degradation was boosted in the presence of Cu_(2)O in the BAP system,with the degradation rate following the order c-Cu_(2)O>o-Cu_(2)O>s-Cu_(2)*** morphology-dependent effects could be linearly correlated with the ratio of surface oxygen species(O_S),but not with the surface area or Cu(Ⅰ)*** c-Cu_(2)O catalyst with exposure of(100)facets contained 76.6%O_Sas the active site for H_(2)O_(2)adsorption and activation,while the value was much lower for o-Cu_(2)O and s-Cu_(2)O with dominant(111)*** presence of HCO_(3)-enhanced the interactions among Cu_(2)O,H_(2)O_(2)and TC,leading to facile oxidation of Cu(Ⅰ)to Cu(Ⅱ)by H_(2)O_(2),and the formation of various reactive species such as hydroxyl radicals and Cu(Ⅲ)contributed to TC *** work provides a new method for enhancing H_(2)O_(2)activation with heterogeneous catalysts by crystal facet engineering.

关键词： Hydrogen peroxide Bicarbonate Cu_(2)O Morphology-dependent effects

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The RFI Fast Mitigation Algorithm Based on Block LMS Filter

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Research in Astronomy and Astrophysics 2024年第1期24卷 265-272页

作者： Han Wu hai-Long Zhang Ya-Zhou Zhang Jie Wang xu Du Ting Zhang Xin-Chen Ye Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China

The radio telescope possesses high sensitivity and strong signal collection *** receiving celestial radiation signals,it also captures Radio Frequency Interferences(RFIs)introduced by human ***,as signals originating from sources other than the astronomical targets,significantly impacts the quality of astronomical *** paper presents an RFI fast mitigation algorithm based on block Least Mean Square(LMS)*** enhances the traditional adaptive LMS filter by grouping L adjacent time-sampled points into one block and applying the same filter coefficients for filtering within each *** transformation reduces multiplication calculations and enhances algorithm efficiency by leveraging the time-domain convolution *** algorithm is tested using baseband data from the Parkes 64 m radio telescope's pulsar observations and simulated *** results confirm the algorithm's effectiveness,as the pulsar profile after RFI mitigation closely matches the original pulsar profile.

关键词： methods:data analysis techniques:interferometric (stars:)pulsars:individual(J0437-4715)

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AdaPIP: Adaptive picture-in-picture guidance for 360 ◦ film watching

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Computational Visual Media 2024年第3期10卷 487-503页

作者： Yi-xiao Li Guan Luo Yi-Ke xu Yu He Fang-Lue Zhang Song-hai Zhang Department of Computer Science and Technology Tsinghua UniversityBeijingChinaand Beijing National Research Center for Information Science and Technology(BNRist)Tsinghua UniversityBeijingChina Key Laboratory of Space Utilization Technology and Engineering Center for Space UtilizationChinese Academy of SciencesBeijingChina Victoria University of Wellington WellingtonNew Zealand

360◦videos enable viewers to watch freely from different directions but inevitably prevent them from perceiving all the helpful *** mitigate this problem,picture-in-picture(PIP)guidance was proposed using preview windows to show regions of interest(ROIs)outside the current view *** identify several drawbacks of this representation and propose a new method for 360◦ﬁlm watching called *** enhances traditional PIP by adaptively arranging preview windows with changeable view ranges and *** addition,AdaPIP incorporates the advantage of arrow-based guidance by presenting circular windows with arrows attached to them to help users locate the corresponding ROIs more *** also adapted AdaPIP and Outside-In to HMD-based immersive virtual reality environments to demonstrate the usability of PIP-guided approaches beyond 2D *** user experiments on 2D screens,as well as in VR environments,indicate that AdaPIP is superior to alternative methods in terms of visual experiences while maintaining a comparable degree of immersion.

关键词： 360◦videos picture-in-picture(PIP) virtual reality(VR) visual guidance

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Transparent micropatterned conductive films based on highlyordered nanowire network

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Nano Research 2024年第5期17卷 4288-4297页

作者： Xin-Ran Zhang hai-Tao Deng xu Zeng Yi-Lin Wang Peng Huang xiao-Sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Transparent conductive films that are based on nanowire networks are essential to construct flexible,wearable,and even stretchable ***,large-scale precise micropatterning,especially with regard to the controllability of the organizing orientation of nanowires,is a critical ***,we proposed a liquid film rupture self-assembly approach for manufacturing transparent conductive films with microstructure arrays based on a highly ordered nanowire *** large-scale microstructure conductive films were fabricated through air-liquid interface self-assembly and liquid film rupture *** typical micropattern morphologies,including square,hexagon,circle,serpentine,etc.,were prepared to reveal the universal applicability of the proposed *** homogeneity and controllability of this approach were verified for multiple *** the assembly cycles increasing,the optical transmittance decreases *** addition,theoretical model analysis is carried out,and the analytical formula of the speed of the film moving with the surface tension and the density of the liquid film is ***,the feasibility of this approach for piezoresistive strain sensors is *** fabrication approach demonstrated a cost-effective and efficient method for precisely arranging nanowires,which is useful in transparent and wearable applications.

关键词： flexible electronics transparent conductive network micropatterning nanowires micro electromechanical systems(MEMS)

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Study on Shear Strength Characteristics of Basalt-Concrete Bonding Interface Based on in-situ Direct Shear Test

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Journal of Earth Science 2024年第2期35卷 553-567页

作者： Peng xia Xinli Hu Chunye Ying Shuangshuang Wu Chu xu xuan Wang Hao Chen Hang Duan College of Harbour and Coastal Engineering Jimei UniversityXiamen361021China Faculty of Engineering China University of GeosciencesWuhan430074China China Three Gorges Construction Group Ltd.Beijing100038China

In rock engineering,the shear strength of the basalt-concrete bonding interface is a key factor affecting the shear performance of hydroelectric dam foundations,embedded rock piles and rock *** this study,30 sets of in-situ direct shear tests were conducted on the basalt-concrete bond interface in the Baihetan dam area to investigate the shear strength characteristics of the basalt-concrete bonding *** bonding interface contains two states,i.e.,the bonding interface is not sheared,termed as se(symbolic meaning see Table 1);the bonding interface is sheared with rupture surface,termed as *** effects of lithology,Joints structure,rock type grade and concrete compressive strength on the shear strength of the concrete-basalt contact surface were *** test results show that the shear strength of the bonding interface(s_(e)&s_(i))of columnar jointed basalt with concrete is greater than that of the bonding interface(s_(e)&s_(i))of non-columnar jointed one with the same rock type *** the rock type grade isⅢ_(2),fcol is 1.22 times higher than fncol and ccol is 1.13 times greater than *** shear strength parameters of the basalt-concrete bonding interface differ significantly for different *** cohesion of the bonding interface(s_(i))of cryptocrystalline basalt with concrete is 2.05 times higher than that of the bonding interface(s_(i))of breccia lava with concrete under the same rock type grade *** type grade has a large influence on the shear strength of the non-columnar jointed basalt-concrete bonding interface(s_(e)&s_(i)).cnol increases by 33%when the grade of rock type rises fromⅢ_(1)toⅡ_(1).the rock type grade has a greater effect on bonding interface(s_(i))cohesion than the coefficient of *** the rock type grade is reduced fromⅢ_(2)toⅢ_(1),f_(ncol)′increases by 2%and c_(ncol)′improves by 44%.The shear strength of the non-columnar jointed basalt-concrete bonding interface(s_(e)&s_(i))increases wit

关键词： direct shear test basalt-concrete bonding interface shear strength parameters engineering geogolgy

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Application of multidisciplinary in situ simulation training in the treatment of acute ischemic stroke: a quality improvement project

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World Journal of Emergency Medicine 2024年第1期15卷 41-46页

作者： Ganying Huang Huijie Yang Huan Yao Xinxin Fan Wenqin xia Yuansheng xu xiaoling Shen xue Zhao Fourth School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Emergency Medicine Departent Hangzhou First People's HospitalHangzhou 310006China

BACKGROUND:Ischemic stroke refers to a disorder in the blood supply to a local area of brain tissue for various reasons and is characterized by high morbidity,mortality,and *** reperfusion of brain tissue at risk of injury is crucial for the treatment of acute ischemic *** purpose of this study was to evaluate comfort levels in managing acute stroke patients with hypoxemia who required endotracheal intubation after multidisciplinary in situ simulation training and to shorten the door-to-image ***:This quality improvement project utilized a comprehensive multidisciplinary in situ simulation exercise.A total of 53 participants completed the two-day in situ simulation *** main outcome was the self-reported comfort levels of participants in managing acute stroke patients with hypoxemia requiring endotracheal intubation before and after simulation training.A 5-point Likert scale was used to measure participant comfort.A paired-sample t-test was used to compare the mean self-reported comfort scores of participants,as well as the endotracheal intubation time and door-to-image time on the fi rst and second days of in situ simulation *** door-to-image time before and after the training was also ***:The findings indicated that in situ simulation training could enhance participant comfort when managing acute stroke patients with hypoxemia who required endotracheal intubation and shorten door-to-image *** the emergency management of hypoxemia or tracheal intubation,the mean post-training self-reported comfort score was signifi cantly higher than the mean pre-training comfort score(hypoxemia:4.53±0.64 vs.3.62±0.69,t=-11.046,P<0.001;tracheal intubation:3.98±0.72 vs.3.43±0.72,t=-6.940,P<0.001).We also observed a decrease in the tracheal intubation and door-to-image time and a decreasing trend in the door-to-image time,which continued after the ***:Our study demonstrates that the implementation of in s

关键词： Ischemic stroke Endotracheal intubation Door-to-image time In situ simulation Multidisciplinary approach

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Novel de novo TRPV4 mutation identified in a Chinese family with metatropic dysplasia inhibits chondrogenic differentiation

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Genes & Diseases 2024年第3期11卷 83-86页

作者： Ping Wei Weizhe Shi Tianying Nong Caixia xian xia Li Zhaohui Li Xin Li Jianping Wu Liyuan Shang Fulong xu Yibo xu Hongwen xu Mingwei Zhu Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China Department of Pediatric Orthopedics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China

Metatropicdysplasia(MD,MIM156530)is a rare congenital bone dysplasia primarily characterized by severe platyspondyly with long and wide vertebral bodies and dumbbell deformity of the tubular *** can be caused by heterozygous mutations in the gene encoding transient receptor potential vanilloid family member 4(TRPV4).We identifieda novel de novo mutation,c.2353T>C,in the TRPV4 gene,in a Chinese family with mild MD.

关键词： TRPV4 dysplasia congenital

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A Neural-network-based Alternative Scheme to Include Nonhydrostatic Processes in an Atmospheric Dynamical Core

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Advances in Atmospheric Sciences 2024年第6期41卷 1083-1099,I0002,I0003页

作者： Yang xia Bin WANG Lijuan LI Li LIU Jianghao LI Li DONG Shiming xu Yiyuan LI Wenwen xia Wenyu HUANG Juanjuan LIU Yong WANG Hongbo LIU Ye PU Yujun HE Kun xia Ministry of Education Key Laboratory for Earth System Modeling and Department of Earth System ScienceTsinghua UniversityBeijing 100084China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Innovation Group 311020008 Southern Marine Science and Engineering Guangdong LaboratoryZhuhai 519000China Shanghai Ecological Forecasting and Remote Sensing Center Shanghai 200030China Key Laboratory of Earth System Modeling and Prediction China Meteorological AdministrationBeijing 100081China College of Ocean Sciences University of Chinese Academy of SciencesBeijing 100049China

Here,a nonhydrostatic alternative scheme(NAS)is proposed for the grey zone where the nonhydrostatic impact on the atmosphere is evident but not large enough to justify the necessity to include an implicit nonhydrostatic solver in an atmospheric dynamical *** NAS is designed to replace this solver,which can be incorporated into any hydrostatic models so that existing well-developed hydrostatic models can effectively serve for a longer *** advances in machine learning(ML)provide a potential tool for capturing the main complicated nonlinear-nonhydrostatic *** this study,an ML approach called a neural network(NN)was adopted to select leading input features and develop the *** NNs were trained and evaluated with 12-day simulation results of dry baroclinic-wave tests by the Weather Research and Forecasting(WRF)*** forward time difference of the nonhydrostatic tendency was used as the target variable,and the five selected features were the nonhydrostatic tendency at the last time step,and four hydrostatic variables at the current step including geopotential height,pressure in two different forms,and potential temperature,***,a practical NAS was developed with these features and trained layer by layer at a 20-km horizontal resolution,which can accurately reproduce the temporal variation and vertical distribution of the nonhydrostatic *** by the NN-based NAS,the improved hydrostatic solver at different horizontal resolutions can run stably for at least one month and effectively reduce most of the nonhydrostatic errors in terms of system bias,anomaly root-mean-square error,and the error of the wave spatial pattern,which proves the feasibility and superiority of this scheme.

关键词： neural network nonhydrostatic alternative scheme atmospheric model dynamical core

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