检索结果-南通市图书馆

BRAF^(V600E) vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ, Ⅲ, and Ⅴ nodules

Cancer Biology & Medicine 2019年第1期16卷 131-138页

作者： Ya Wu Ting xu Xingyue Cao Xin Zhao Hongyan Deng Jianxiang Wang Xiao Li Qing Yao Xinhua Ye Meiping Shen Xiaohong Wu Department of Endocrinology The First Affiliated Hospital of Nanjing Medical University Department of Endocrinology Jiangsu Province Official Hospital Department of Ultrasound The First Affiliated Hospital of Nanjing Medical University Department of Pathology The First Affiliated Hospital of Nanjing Medical University Department of General Surgery The First Affiliated Hospital of Nanjing Medical University

Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ, Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAF^(V600E) mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V ***: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAF^(V600E) mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound ***: In the BSRTC I category, BRAF^(V600E) showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAF^(V600E) were similar to those of TIRADS. In comparison to BRAF^(V600E) alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01; BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01; BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001; 94.2% vs. 81.3%, P < 0.001).Conclusions: BRAF^(V600E) exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ, Ⅲ, and Ⅴ nodules.

关键词： Papillary thyroid carcinoma fine-needle aspiration cytology(FNAC) BRAFV600E thyroid imaging reporting and data system(TIRADS) Bethesda classification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Benzimidazolium Functionalized Polysulfone-based Anion Exchange Membranes with Improved Alkaline Stability

引用

Chinese Journal of Polymer Science 2018年第1期36卷 129-138页

作者： Yu Pan Ting-Yun Wang Xiao-Ming Yan Xiao-Wei xu Qi-Dong Zhang Bao-Lin Zhao Issam El Hamouti Ce Hao Gao-Hong He School of Petroleum and Chemical Engineering State Key Laboratory of Fine ChemicalsDalian University of TechnologyPanjin 124221China School of Chemical Engineering Research and Development Center of Membrane Science and TechnologyDalian University of TechnologyDalian 116024China

The stability of anion exchange membranes(AEMs)is an important feature of alkaline exchange membrane fuel cells(AEMFCs),which has been extensively *** it remains a real challenge due to the harsh working ***,we developed a novel type of polysulfone-based AEMs with three modified 1,2-dimethylbenzimidazoliums containing different substitutes at C4-and *** results showed that the introduction of the substitutes could obviously improve the dimensional and alkaline stabilities of the corresponding *** swelling ratios of resultant AEMs were all lower than 10%after water *** membrane with 4,7-dimethoxy-1,2-dimethylbenzimidazolium group exhibited the highest alkaline *** 9.2%loss of hydroxide conductivity was observed after treating the membrane in 1 mol·L^(-1)KOH solution at 80°C for 336 ***,the density functional theory(DFT)study on the three functional group models showed that the substitutes at C4-and C7-position affected the lowest unoccupied molecular orbital(LUMO)energies of the different 1,2-dimethylbenzimidazolium groups.

关键词： Anion exchange membrane High alkaline stability Benzimidazolium Polysulfone LUMO energy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optomechanical Schrödinger cat states in a cavity Bose-Einstein condensate

引用

Fundamental Research 2023年第1期3卷 15-20页

作者： Baijun Li Wei Qin Ya-Feng Jiao Cui-Lu Zhai xun-Wei xu Le-Man Kuang Hui Jing key laboratory of Low-Dimensional Quantum Structures and Quantum Control of ministry of education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Theoretical Quantum Physics laboratory RIKEN Cluster for Pioneering ResearchWako-shiSaitama 351-0198Japan laboratory of Chemical Biology&Traditional Chinese Medicine Research Ministry of Education College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China

Schrödinger cat states,consisting of superpositions of macroscopically distinct states,provide key resources for a large number of emerging quantum technologies in quantum information *** we propose how to generate and manipulate mechanical and optical Schrödinger cat states with distinguishable superposition components by exploiting the unique properties of cavity optomechanical systems based on Bose-Einstein ***,we show that in comparison with its solid-state counterparts,almost a 3 order of magnitude enhancement in the size of the mechanical Schrödinger cat state could be achieved,characterizing a much smaller overlap between its two superposed coherent-state *** exploiting this generated cat state,we further show how to engineer the quadrature squeezing of the mechanical ***,we also provide an efficient method to create multicomponent optical Schrödinger cat states in our proposed *** work opens up a new way to achieve nonclassical states of massive objects,facilitating the development of fault-tolerant quantum processors and sensors.

关键词： Schrödinger cat state Cavity Optomechanics Bose-Einstein condensate Collective density excitation Squeezing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

钢筋增强超高韧性水泥基复合材料梁的剪切性能试验研究（英文）

引用

Journal of Zhejiang university-Science A(Applied Physics & Engineering) 2015年第4期16卷 251-264页

作者： Li-jun HOU Zhi-yong LUAN Da CHEN Shi-lang xu key laboratory of Coastal Disaster and Defence of ministry of education Hohai University College of Civil Engineering and Architecture Zhejiang University

目的:揭示不同剪跨比和配箍率的钢筋增强超高韧性水泥基复合材料(RUHTCC)梁的抗剪性能,为超高韧性水泥基复合材料(UHTCC)用于结构关键抗剪部位提供参考。方法:基于抗剪试验结果,阐明剪跨比和配箍率对RUHTCC梁抗剪性能的影响,明确UHTCC... 详细信息

目的:揭示不同剪跨比和配箍率的钢筋增强超高韧性水泥基复合材料(RUHTCC)梁的抗剪性能,为超高韧性水泥基复合材料(UHTCC)用于结构关键抗剪部位提供参考。方法:基于抗剪试验结果,阐明剪跨比和配箍率对RUHTCC梁抗剪性能的影响,明确UHTCC与箍筋之间的复合抗剪效应,揭示RUHTCC梁的抗剪机理。方法:以剪跨比和配箍率为变量参数,通过RUHTCC梁在跨中集中荷载作用下的弯曲试验,研究RUHTCC梁的剪切裂缝形态、荷载-挠度行为、破坏模式、开裂剪切强度和极限剪切强度等抗剪性能,并结合试验结果,分析RUHTCC梁的剪力传递机理。结论:***梁呈现出优良的剪切抗力以及稳态的斜裂缝扩展过程和多缝剪切开裂行为。2.配置少量的箍筋可将典型的剪切破坏转变为较为延性的弯剪破坏甚至弯曲破坏。然而,箍筋的配置并未显著提高RUHTCC梁的抗剪能力,同时耦合UHTCC与箍筋也没有表现出协同抗剪效应。3.拉杆-拱模型和桁架-拱模型可用以描述RUHTCC短梁和细长梁的抗剪机理。

关键词： UHTCC 剪跨比箍筋剪切性能抗剪机理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mining hyperspectral data for non-destructive and rapid prediction of nitrite content in ham sausages

引用

International Journal of Agricultural and Biological Engineering 2021年第2期14卷 182-187页

作者： Yadong Zhu Hongju He Shengqi Jiang Hanjun Ma Fusheng Chen Baocheng xu Hong Liu Mingming Zhu Shengming Zhao Zhuangli Kang School of Food Science Henan Institute of Science and TechnologyXinxiang 453003HenanChina Henan Institute of Science and Technology Postdoctoral Research BaseXinxiang 453003HenanChina College of Grain Oiland FoodHenan University of TechnologyZhengzhou 450000China College of Food and Bioengineering Henan University of Science and TechnologyLuoyang 471003HenanChina key laboratory of the ministry of education of Tropical Medicine Hainan Normal UniversityHaikou 570203China

Accurate and rapid determination of nitrite contents is an important step for guaranteeing sausage *** study attempted to mine hyperspectral data in the range of 900-1700 nm for non-destructive and rapid prediction of nitrite contents in *** average spectra of 156 samples were collected to relate to the measured nitrite values by partial least squares(PLS)*** wavelengths were respectively selected by successive projections algorithm(SPA)and regression coefficients(rc)to simplify the PLS *** results indicated that PLS model established with 15 optimal wavelengths(900.5 nm,907.1 nm,908.8 nm,912.1 nm,915.4 nm,920.3 nm,922.0 nm,941.7 nm,979.6 nm,1083.2 nm,1213.2 nm,1353.0 nm,1460.2 nm,1595.6 nm and 1699.9 nm)selected by SPA had better performance with r C,r CV,r P of 0.92,0.89,0.89 and RMSEC,RMSECV,RMSEP of 0.41 mg/kg,0.89 mg/kg,0.49 mg/kg,respectively,for calibration set,cross-validation and prediction *** was concluded that hyperspectral data could be mined by PLS&SPA for realizing the rapid evaluation of nitrite content in ham sausages.

关键词： hyperspectral data ham sausage non-destructive and rapid prediction nitrite partial least squares(PLS)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Promoting the electrochemical hydrogenation of furfural by synergistic Cu^(0)−Cu^(+) active sites

引用

Science china Chemistry 2022年第12期65卷 2588-2595页

作者： Zhongcheng Xia Yingying Li Jingcheng Wu Yu-Cheng Huang Weixing Zhao Yuxuan Lu Yuping Pan xu Yue Yanjing Wang Chung-Li Dong Shuangyin Wang Yuqin Zou State key laboratory of Chem/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringAdvanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha410082China Research Center for X-ray Science&Department of Physics Tamkang UniversityNew Taipei City25137China School of Chemistry and Chemical Engineering Jishou UniversityJishou416000China

Electrochemical hydrogenation(ECH)of furfural,which uses the proton from water and avoids the usage of gaseous hydrogen and high pressure,is an efficient way to utilize biomass ***-based catalysts are promising catalysts for the ECH of ***,their active sites and reaction mechanism have not been fully understood *** work unveils the active oxidation state of Cu-based electrocatalysts for the ECH of *** co-existence of Cu^(+)and Cu^(0) on the CuO surface under the working potential is confirmed by a series of in situ *** poisoning experiment shows that the performance decreased heavily after the Cu^(+)was complexed with SCN−,indicating the decisive role of Cu^(+).Finally,the density functional theory(DFT)calculation suggests that the Cu^(0)−Cu^(+)synergistic effect is beneficial to both kinetics and thermodynamics:Cu^(+)accelerates the second step hydrogenation process of furfural,and Cu^(0) reduces the energy barrier for the desorption of furfuryl *** work demonstrates the synergistic effect of Cu^(0) and Cu^(+)states for the electrochemical hydrogenation of furfural and provides a deeper understanding of the furfural hydrogenation mechanism.

关键词： biomass conversion electrocatalytic hydrogenation furfural CuO synergistic effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and Electronic Structure of Triazasubporphyrin with Peripherally Low Symmetric Push-pull Substitutions

引用

Chinese Journal of Structural Chemistry 2020年第1期39卷 36-40,2页

作者： FAN Yu-xuan YUAN Tai-Yan LV Qing-Yang LI Min-Zhi ZHU Wei-Hua LIANG xu School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China

Peripherally low symmetric substitution with electron-donating(EDG)and electron-withdrawing(EWG)substituents caused the rational modulation of geometric structure and even the electronic structure of triazasubporphyrin,the smallest 14πconjugated *** structural characterization and spectroscopic investigation were discussed to provide an in-depth understanding of the relationship between peripheral push-pull substituents and SubPz core.

关键词： triazasubporphyrin push-pull effect electronic structure seterochemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A study of the initial adhesive force of cells on silk fibroin-based materials using micropipette aspiration

引用

Regenerative Biomaterials 2018年第3期5卷 151-157页

作者： Xiaojie Lian Shichao Liu Liming Liu Rui xu Miaomiao Du Song Wang Hesun Zhu Qiang Lu Quanyou Zhang Yali Wu Di Huang Yan Wei Department of Biomedical Engineering Research Center for Nano-Biomaterials and Regenerative MedicineCollege of MechanicsTaiyuan University of TechnologyTaiyuan 030024China Shanxi key laboratory of Material Strength and Structural Impact Institute of Applied Mechanics and Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Research Center of Materials Science School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China National Engineering laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China

With the development of biomaterials,more attention is paid to the adhesion characteristics between cells and *** is necessary to study the adhesive force with a suitable *** fibroin(SF)is widely investigated in biomedical application due to its novel biocompatibility and mechanical *** this article,the micropipette aspiration method and measurement pattern of uniform cells in round shape(UCR)was used to study the initial adhesive force of three types of cells on pure silk fibroin films(SFFs).We also compared the adhesive forces of modified SFFs with that of pure *** results of adhesive force in the initial adhesive stage were in concordance with the results of MTT assay andmicroscope observation,which were confirmed by the above three cell lines and four kinds of *** results indicated UCR was an efficient and quantitative measurement pattern in initial adhesion *** article also provides a useful method in identifying initial cell-materials interactions.

关键词： silk-based materials cell initial adhesion micropipette uniform cells in round shape

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy and safety of a novel anti-HER2 therapeutic antibody rc48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study

引用

Cancer Communications 2021年第11期41卷 1173-1182页

作者： Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming xu Qingxia Fan Ruihua xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen Department of Gastrointestinal Oncology Key Laboratory of Cancinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijing 100142P.R.China Department of Gastrointestinal Oncology Affiliated Zhongshan Hospital of Fudan UniversityShanghai 200032P.R.China Department of Oncology Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008P.R.China Department of Oncology Weihai Municipal HospitalWeihaiShandong 264299P.R.China Department of Oncology Anhui Provincial Cancer HospitalHefeiAnhui 230031P.R.China Department of Oncology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiangHenan 453100P.R.China Department of Oncology Subei People’s HospitalYangzhouJiangsu 225009P.R.China Department of Abdominal Oncology Fujian Provincial Cancer HospitalFuzhouFujian 350014P.R.China Department of Gastrointestinal Oncology Henan Cancer HospitalZhengzhouHenan 450003P.R.China Department of Oncology Linyi Cancer HospitalLinyiShandong 276002P.R.China Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022P.R.China Department of Oncology Jiangsu Cancer HospitalNanjingJiangsu 210009P.R.China Department of Oncology The Fifth Medical Center of PLA General HospitalBeijing 100039P.R.China Department of Oncology The First Affiliated Hospital of ZhengzhouZhengzhouHenan 450099P.R.China Department of Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Oncology Yantai Yuhuangding HospitalYantaiShandong 264099P.R.China Department of Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShanxi 710061P.R.China Department of Oncology Jinan Central HospitalJinanShandong 250013P.R.China Department of Oncology Weifang People’s HospitalWeifangShandong 261041P.R.China Department of Oncology Peking Union Medical College HospitalBeijing 100005P.R.China Department of Oncology Xuzhou Central

Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical ***,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative ***,we report the efficacy and safety of a novel anti-HER2 antibody rc48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction ***:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received rc482.5 mg/kg alone every 2 *** primary endpoint was the objective response rate(ORR)assessed by an independent review *** endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and ***:Of 179 patients screened,125 were eligible and received rc48 *** ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),*** most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and rc48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not ***:rc48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy.

关键词： antibody-drug conjugate gastric cancer HER2-overexpressing phase II clinical trial rc48 third-line therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The effect of metal electron cloud on the luminescence characteristics of organic ligands:An experimental and theoretical investigation

引用

Chinese Science Bulletin 2011年第6期56卷 479-483页

作者： ZHANG FuJun LIU XiaoJun HUANG Feng ZHUO ZuLiang LU LiFang xu Zheng WANG YongSheng TAO xuTang BIAN WenSheng TANG WeiHua key laboratory of Luminescence and Optical Information (Beijing Jiaotong university) Ministry of Education Beijing 100044 China State key laboratory of Crystal Materials Shandong University Jinan 250100 China Beijing National laboratory for Molecular Sciences Beijing 100109 China key laboratory for Soft Chemistry and Functional Materials of ministry education Nanjing University of Science and Technology Nanjing 210094 China

The luminescence processes of metal complexes are complicated by intramolecular charge (energy) transfer from the metal to the ligand or from the ligand to the metal. The charge transfer strongly influences the excited state of the ligand and its luminescence characteristics. The luminescence characteristics of tris(8-hydroxyquinoline) aluminum (Alq3) and tris(8-hydroxyquinoline) gallium (Gaq3) are investigated to reveal the effect of the metal ion on the ligand. Emission from the complexes shows a significant red shift as the size of the metal ion increases from Al to Ga because of more efficient charge transfer from the metal to the ligand. Theoretical calculations on the structure and transition characteristics of the excited states of Alq3 and Gaq3 were performed. The calculated emission wavelength agrees with the experimental value and the effect of the metal electron cloud on the emission wavelength is clarified.

关键词：金属配合物有机配体发光特性电子云实验值金属离子效应电荷转移羟基喹啉

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：