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LES NUMERICAL SIMULATION OF CAVITATION BUBBLE SHEDDING ON ALE 25 AND ALE 15 HYDROFOILS

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Journal of Hydrodynamics 2009年第6期21卷 807-813页

作者： LIU De-min LIU Shu-hong WU Yu-lin xu hong-yuan State Key Laboratory of Hydro Science and Hydraulic Engineering Department of Thermal Engineering Tsinghua University Beijing 100084 China

A cavitation calculation scheme is developed and applied to ALE 15 and ALE 25 hydrofoils, based on the Bubble Two-phase Flow （BTF） cavity model with a Large Eddy Simulation （LES） methodology. The Navier-Stokes equations including cavitation bubble clusters are solved through the finite-volume approach with a time-marching scheme. Simulations are carried out in a 3-D field with a hydrofoil ALE 15 or ALE 25 at an angle of attack of 8^0 and cavitation number σ = 2.3 with α 2× 10^6, meshing system. With the time-marching, the cavitation bubble gradually grows to a steady lump shape and then produces an irregular small bubble behind the main cavitation bubble, finally shedding from the leading edge of the cloud cavitation structure. The calculated results including velocity field and pressure field are consistent with experiment data at the same Reynolds number and cavitation number. The vortex and reverse flow are observed on the hydrofoil surface.

关键词： cavitation ALE hydrofoil Large Eddy Simulation (LES)

新型R型噬菌体尾样细菌素对MRSA的抗菌活性研究

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中国药理学通报 2024年第9期40卷 1760-1765页

作者：唐伟刘颖唐震海唐颖李昕姚杰李维祖徐元宏周强安徽医科大学第二附属医院检验科安徽合肥230601 中国科学院合肥物质科学研究院强磁场科学中心安徽合肥230031 安徽医科大学科研实验中心安徽合肥230032 皖南医学院临床医学院安徽芜湖241002 安徽医科大学基础医学院药理学教研室安徽合肥230032 安徽医科大学第一附属医院检验科安徽合肥230022

目的探索阴沟肠杆菌SHAMU191747所分泌的新型R型噬菌体尾样细菌素(phage tail-like bacteriocin,PTLB)对耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)的抗菌活性。方法琼脂平板拮抗试验和肉汤微量发酵试验,检测阴沟肠杆菌SHAMU191747对MRSA的拮抗活性。超高速离心法和密度梯度离心法,制备阴沟肠杆菌SHAMU191747发酵上清液粗提物。使用透射电镜检测粗提物中有无新型R型PTLB。琼脂平板点种法,验证粗提物对MRSA的抗菌活性。采用SDS-PAGE电泳检测新型R型PTLB的分子量。结果阴沟肠杆菌SHAMU191747分泌新型R型PTLB,对MRSA具有强拮抗效应。新型R型PTLB的分子量约35 ku,能够高效杀伤MRSA;尾鞘未收缩的功能性分子的物理尺寸为(142.7±4.3)×(13.8±0.6)nm,尾鞘收缩的非功能性分子的物理尺寸为(57.7±1.2)×(20.8±1.5)nm。结论阴沟肠杆菌SHAMU191747产生的新型R型PTLB能够高效杀伤MRSA,具有开发成新型抗菌药物的潜力,临床应用前景很大。

关键词：阴沟肠杆菌细菌素噬菌体尾样细菌素金黄色葡萄球菌耐甲氧西林金黄色葡萄球菌抗菌活性

Photothermal Effect-based Cytotoxic Ability of Melanin from Mytilus edulis Shells to Heal Wounds Infected with Drug-resistant Bacteria in vivo

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Biomedical and Environmental Sciences 2020年第7期33卷 471-483页

作者： LIU Ya Mei MA Wei Shuai WEI Yu Xi xu yuan hong Institute of Biomedical Engineering College of Life SciencesQingdao University\Qingdao 266071ShandongChina Department of Urology Key Laboratory'of Urinary System DiseasesThe A ffiliated Hospital of Qingdao UniversityQingdao 266003ShandongChina

Objective Owing to antibiotic abuse and the subsequent development of antibiotic resistance,bacterial infection has become one of the most persistent unresolved *** antibacterial agents,especially those that are environmental-friendly,are urgently *** Melanin extracted by filtration centrifugation and acid and proteolytic hydrolysis was characterized using UV,FTIR,TEM,and *** conversion was calculated,and the bacteriostatic effects,in vitro and in vivo,were assessed by plate counting and ratios(%)of wound *** Natural melanin hydrolyzed by trypsin had good photothermal conversion effects,which resulted in superior bacteriostatic *** extracted melanin along with laser NIR irradiation at808 nm promoted the healing of wounds infected by drug-resistant bacteria in vivo and was biocompatible according to toxicity tests in vivo and in *** The present findings indicated a safe and efficient method of developing natural antibacterial agents.

关键词： Melanin Photothermal conversion Antibacterial Wound healing

Cavitating Flow over a Mini Hydrofoil

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Chinese Physics Letters 2012年第1期29卷 198-201页

作者： LUO Xian-Wu JI Bin ZHANG Yao xu hong-yuan State Key Laboratory for Hydroscience and Engineering Tsinghua UniversityBeijing 100084 China Ship Development and Design Center Wuhan 430064

We consider a cavitating flow over a mini hydrofoil (foil profile:Clark-Y-11.7) having a 14mm chord length in a cavitation tunnel at various cavitation *** observations show that cavitating flows over a miniature hydrofoil display several types of cavitation behavior,such as cavitation inception,sheet cavitation,cloud cavitation and super cavitation with the decreasing cavitation *** the same cavitation conditions,cavitation over a mini hydrofoil would be suppressed in comparison to cavitation over an ordinary *** cavitation scale effect is suspected to be caused by the Reynolds number.

关键词： number cavitation ordinary

A型肉毒素注射对脑卒中后下肢痉挛患者步行功能的影响

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湖北医药学院学报 2024年第5期43卷 513-517页

作者：全超郑苏徐远红罗秀玲胥婧十堰市太和医院·湖北医药学院附属医院神经康复2病区湖北十堰442000

目的:观察A型肉毒素注射结合康复训练对脑卒中后下肢痉挛患者步行功能的影响,为临床康复治疗提供依据。方法:将2023年2月-2024年2月于十堰市太和医院神经康复科住院治疗的脑卒中患者36例随机分为对照组(18例)和治疗组(18例),对照组给予... 详细信息

目的:观察A型肉毒素注射结合康复训练对脑卒中后下肢痉挛患者步行功能的影响,为临床康复治疗提供依据。方法:将2023年2月-2024年2月于十堰市太和医院神经康复科住院治疗的脑卒中患者36例随机分为对照组(18例)和治疗组(18例),对照组给予常规康复训练(运动疗法+物理治疗),治疗组在常规康复锻炼的基础上给予主要伸肌群A型肉毒素(Botulinum Toxin A,BTX-A)注射。所有患者在治疗前及治疗4周后均采用改良Ashworth分级量表(Modified Ashworth Scale,MAS)行下肢肌肉痉挛程度评价,下肢Fugl-Meyer运动功能量表(Lower Limb Fugl-Meyer Assessment,L-FMA)评分行功能状态评价,表面肌电积分值(Surface EMG integral Values,iEMG)行肌肉状态评价,采取Gait watch三维步态分析系统记录患者下肢各关节活动度及时空参数变化。结果:与治疗前相比,治疗4周后,两组患者的MAS评分、下肢FMA评分、iEMG分值较治疗前均有改善(P<0.05),步频、步幅、步速提高(P<0.05),步长偏差和患侧支撑相均缩短(P<0.05),患侧髋、膝关节的最大伸展度及最大屈曲度受限改善(P<0.05),患者步行能力明显提高;且治疗组的肌肉痉挛程度、运动功能评分、步态时空参数较对照组改善更明显(P<0.05),但髋、膝关节活动度未见明显变化。结论:A型肉毒素注射结合康复训练可显著降低脑卒中后偏瘫患者下肢痉挛肌群的肌张力,能有效纠正其偏瘫步态,提高患者步行能力。

关键词： A型肉毒素脑卒中下肢痉挛步态分析

职业本科人才培养方案制定现状、问题与路径探索——基于6校电子商务专业人才培养方案的实证调查

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职业教育研究 2024年第4期 25-31页

作者：肖云梅刘琼陈小芹袁旭宏湖南软件职业技术大学湖南湘潭411100

文章以我国6所典型职业本科大学电子商务专业为例,对其人才培养方案进行实证研究。研究发现,职业本科人才培养方案的制定应从产业出发,有机融合产业链、人才链,确定职业本科高层次人才培养目标和规格,构建“四突出”课程体系,构建“五... 详细信息

文章以我国6所典型职业本科大学电子商务专业为例,对其人才培养方案进行实证研究。研究发现,职业本科人才培养方案的制定应从产业出发,有机融合产业链、人才链,确定职业本科高层次人才培养目标和规格,构建“四突出”课程体系,构建“五共同”深度产教融合校企合作模式,打造职业本科“双师型”教学团队,建设多维立体化教学资源库,构建适合中国国情的本科层次职业教育人才培养方案,推动人才供给侧结构性改革。

关键词：职业本科人才培养方案课程体系产教融合

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提肛运动训练辅助治疗对混合痔术后皮瓣水肿患者的情况分析

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四川生理科学杂志 2024年第1期46卷 168-170页

作者：侯晶晶许元红朱文亚开封市中医院肛肠科河南开封475000

目的:探究混合痔术后皮瓣水肿患者应用提肛运动训练辅助治疗对炎症介质水平及肛缘水肿的影响。方法:选取我科2019年12月至2021年3月期间105例混合痔术后皮瓣水肿患者作为研究对象,均给予地奥司明片等基础治疗,对照组52例给予康复新液治... 详细信息

目的:探究混合痔术后皮瓣水肿患者应用提肛运动训练辅助治疗对炎症介质水平及肛缘水肿的影响。方法:选取我科2019年12月至2021年3月期间105例混合痔术后皮瓣水肿患者作为研究对象,均给予地奥司明片等基础治疗,对照组52例给予康复新液治疗,观察组53例增加提肛运动训练辅助治疗,1 m后,采用数字评分法(Numerical rating scale,NRS)评分评估两组患者疼痛水平,对比两组患者治疗效果包括肛门疼痛消失时间、切缘水肿消失时间、分泌物消失时间、创面愈合率、创面愈合时间、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)水平变化等,及对比两组不良反应总发生率。结果:干预1 m后,观察组患者肛缘水肿消失时间、分泌物消失时间及疼痛消失时间均少于对照组(P<0.05),干预1 m后,NRS评分低于对照组(P<0.05);干预1 m后,观察组TNF-α及IL-6水平均低于对照组(P<0.05);干预1 m后,观察组患者创面愈合时间少于对照组(P<0.05);干预1 m后,观察组患者不良反应总发生率9.43%低于对照组36.54%(P<0.05)。结论:提肛运动辅助治疗对混合痔术后患者进行干预效果明显,能够有效改善患者切缘水肿情况,有助于缩短创面愈合时间,且不良反应较少。

关键词：康复新液提肛运动训练混合痔皮瓣水肿

Unsteady Cavitating Flow around a Hydrofoil Simulated Using the Partially-Averaged Navier-Stokes Model

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Chinese Physics Letters 2012年第7期29卷 198-202页

作者： JI Bin LUO Xian-Wu WU Yu-Lin xu hong-yuan State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing 100084

Numerical simulations of unsteady cavitating flow around a NACA66-mod hydrofoil were performed using the partially-averaged Navier-Stokes method with different values of the resolution control parameters (f k =1.0-0.2,fε =1).With decreasing fk,the predicted cavitating flow becomes unsteady as the time-averaged turbulent viscosity at the rear part of the attached cavity is gradually *** fk =0.9 and 0.8,the cavity becomes unstable and its length dramatically expands and shrinks,but the calculation fails to predict the vapor cloud shedding behavior observed *** smaller fk less than 0.7,the cloud shedding behavior is simulated numerically and the predicted cavity shedding frequency *** fk =0.2,the whole cavitating flow evolution can be reasonably reproduced including the cavity growth/destabilization observed *** reentrant flow along the suction surface of the hydrofoil is the main trigger to cause the vapor cloud *** wall pressure along the hydrofoil surface oscillates greatly due to the dynamic cavity *** the simulations and experiments,it is confirmed that for the PANS method,resolution control parameters of fk =0.2and fε =1 are recommended for numerical simulations of unsteady cavitating ***,the present study shows that the PANS method is an effective approach for predicting unsteady cavitating flow over hydrofoils.

关键词： unsteady Navier averaged

Direct Synthesis of Bienzyme-like Carbide-derived Carbons via Mild Electrochemical Oxidation of Ti_(3)AlC_(2)MAX

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Biomedical and Environmental Sciences 2022年第3期35卷 215-224页

作者： FANG Yan Feng DING Xiao Teng xu Geng Fang GONG Shi Da NIU Yu Sheng YAO Zi Yu JIN Zhao Yong WANG Yao xu yuan hong Institute of Biomedical Engineering College of Life SciencesQingdao UniversityQingdao 266071ShandongChina Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device School of Chemistry and Chemical EngineeringMedical SchoolSoutheast UniversityNanjing 211189JiangsuChina College of Chemistry and Chemical Engineering Qingdao 266071ShandongChina State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070HubeiChina

Objective To develop effective alternatives to natural enzymes,it is crucial to develop nanozymes that are economical,resource efficient,and environmentally *** nanomaterials that have enzyme-like activities have been extensively developed as substitutes for traditional *** Carbide-derived carbons(CDCs)were directly synthesized via a one-step electrochemical method from a MAX precursor using an ammonium bifluoride electrolyte at ambient *** CDCs were characterized by systematic *** CDCs showed bienzyme-like activities similar to that of peroxidase and superoxide *** systematically studied the dependence of CDC enzyme-like activity on different electrolytes and electrolysis times to confirm activity dependence on CDC ***,the synthesis mechanism and CDC applicability were elaborated and demonstrated,*** The demonstrated synthesis strategy eliminates tedious intercalation and delamination centrifugation steps and avoids using high concentrations of HF,high temperatures,and halogen *** study paves the way for designing two-dimensional material-based nanocatalysts for nanoenzyme and other applications.

关键词： Bienzyme-like Electrochemical Carbide-derived carbons