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SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3098-3110页

作者： Ji zhou xu-Chao Zhang Shan xue Mengdi Dai Yueliang Wang Xia Peng Jianjiao Chen Xinyi Wang Yanyan Shen Hui Qin Bi Chen Yu Zheng Xiwen Gao Zuoquan Xie Jian ding Handong Jiang Yi-Long Wu Meiyu Geng Jing Ai Division of Antitumor Pharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of sciences No.19A Yuquan RoadBeijing100049China Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer Guangdong Lung Cancer InstituteGuangdong Provincial People’s Hospitaland Guangdong Academy of Medical SciencesSchool of MedicineSouth China University of TechnologyGuangzhou510080China Department of Respiratory Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China Department of Neurobiology Brain InstituteUniversity of PittsburghPittsburgh15213USA Department of Respiratory Medicine Affiliated Hospital of Xuzhou Medical UniversityXuzhou221000China Department of Respiratory Medicine Minhang HospitalFudan UniversityShanghai201199China school of Pharmaceutical science and {2. Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310024P.R.China

Genomic MET amplification and exon 14 skipping are currently clinically recognized biomarkers for stratifying subsets of non-small cell lung cancer(NSCLC)patients according to the predicted response to c-Met inhibitors(c-Metis),yet the overall clinical benefit of this strategy is quite ***,c-Met protein overexpression,which occurs in approximately 2.–2.%of NSCLC patients,has not yet been clearly defined as a clinically useful *** optimized strategy for accurately classifying patients with c-Met overexpression for decision-making regarding c-Meti treatment is ***,we found that SYK regulates the plasticity of cells in an epithelial state and is associated with their sensitivity to c-Metis both in vitro and in vivo in PDX models with c-Met overexpression regardless of MET gene ***,TGF-β1 treatment resulted in SYK transcriptional downregulation,increased Sp1-mediated transcription of FRA1,and restored the mesenchymal state,which conferred resistance to ***,a subpopulation of NSCLC patients with c-Met overexpression coupled with SYK overexpression exhibited a high response rate of 73.3%and longer progression-free survival with c-Meti treatment than other *** negativity coupled with TGF-β1 positivity conferred de novo and acquired *** summary,SYK regulates cell plasticity toward a therapy-sensitive epithelial cell ***,our findings showed that SYK overexpression can aid in precisely stratifying NSCLC patients with c-Met overexpression regardless of MET alterations and expand the population predicted to benefit from c-Met-targeted therapy.

关键词： SYK alterations state

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Feature Extraction for Weak Fault of Rolling Bearing Based on Hybrid Signal Processing Technique

Feature Extraction for Weak Fault of Rolling Bearing Based o...

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第37届中国控制会议

作者： Yang Bao-Ping ding Ru-Chun zhou Feng-Xing {2. Bo school of Electronic Information Huang gang Normal University school of Information science and Engineering Wuhan University of Science and Technology

As the core component and the most vulnerable part of mechanical equipment,The rolling bearing is prone to failure during the operation of the *** order to ensure the safe operation of the entire system,it is important to extract fault features of early and weak fault signal which has a very lower signal-noise *** at this problem,a hybrid method that based on Higher-Density Dual-Tree Discrete Wavelet Packet（HDDWP）,Improved Hilbert Huang Transform（IHHT） is ***,using HDDWP to eliminate the high frequency components of the original signal to improve signal-noise *** the original signal is decomposed into a set of the intrinsic mode functions（IMFs） through the Complete Ensemble Empirical Mode Decomposition（CEEMD）,some useful IMFs were collected by using Cross-Correlation function,and then calculated the Marginal Spectrum by Hilbert *** experimental results indicate that the proposed method can effectively extract the early and weak fault features,and thereby to show that the proposed methods are feasible and effective.

关键词： weak fault lower SNR HDDWT HDDWP CEEMD IMF Cross-Correlation Function

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Association between socioeconomic status and chronic obstructive pulmonary disease in Jiangsu province, china: a population-based study

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Chinese Medical Journal 2021年第13期134卷 1552-1560页

作者： Dan-Dan Zhang Jian-Nan Liu Qing Ye Zi Chen Ling Wu xue-Qing Peng Gan Lu Jin-Yi zhou Ran Tao Zhen {2. Fei xu Linfu zhou Department of Respiratory and Critical Care Medicine The First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China Chronic Airway Disease Research Office Department of Respiratory MedicineGeriatric Hospital of Nanjing Medical UniversityNanjingJiangsu 210024China Department of Respiratory Medicine Jiangsu Province Geriatric HospitalNanjingJiangsu 210024China nanjing Municipal Center for Disease Control and Prevention NanjingJiangsu 210037China Department of Pharmacy Geriatric Hospital of Nanjing Medical UniversityNanjingJiangsu 210024China school of Public Health Nanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Provincial Center for Disease Control and Prevention NanjingJiangsu 210009China

Background:Chronic obstructive pulmonary disease(COPD)is a common public health problem *** studies have reported that socioeconomic status(SES)is related to the incidence of *** study aimed to investigate the association between SES and COPD among adults in Jiangsu province,china,and to determine the possible direct and indirect effects of SES on the morbidity of ***:A cross-sectional study was conducted among adults aged 40 years and above between May and December of 2.15 in Jiangsu province,*** were selected using a multistage sampling ***,the outcome variable,was diagnosed by physicians based on spirometry,respiratory symptoms,and risk ***,occupation,and monthly family average income(FAI)were used to separately indicate SES as the explanatory ***-effects logistic regression models were introduced to calculate odds ratios(ORs)and 95%confidence intervals(CIs)for examining the SES-COPD relationship.A pathway analysis was conducted to further explore the pulmonary function impairment of patients with different ***:The mean age of the 2.2. participants was 56.63±9.62.*** prevalence of COPD was 11.8%(95%CI:10.5%–13.1%)among the overall sample *** adjustment for age,gender,residence,outdoor and indoor air pollution,body weight status,cigarette smoking,and potential study area-level clustering effects,educational attainment was negatively associated with COPD prevalence in men;white collars were at lower risk(OR:0.60,95%CI:0.43–0.83)of experiencing COPD than blue collars;compared with those within the lower FAI subgroup,participants in the upper(OR:0.68,95%CI:0.49–0.97)tertiles were less likely to experience *** negative associations between all these three SES indicators and COPD were significant among men ***,FAI,and occupation had direct or indirect effects on pulmonary function inclu{2. post-bronchodilator forced expiratory volume in 1 s/forced

关键词： Socioeconomic status Family average income Smoking Air pollution Body mass index Chronic obstructive pulmonary disease

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Recent advances of medical polyhydroxyalkanoates in musculoskeletal system

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Biomaterials Translational 2023年第4期4卷 234-247页

作者： Chen-Hui Mi Xin-Ya Qi Yan-Wen ding Jing zhou Jin-Wei Dao Dai-{2. Wei Key Laboratory of Resource Biology and Biotechnology in Western china Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’anShaanxi ProvinceChina Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigongSichuan ProvinceChina Dehong Biomedical Engineering Research Center Dehong Teachers’CollegeDehongYunnan ProvinceChina Shaanxi Key Laboratory for Carbon Neutral technology Xi’anShaanxi ProvinceChina

Infection and rejection in musculoskeletal trauma often pose challenges for natural healing,prompting the exploration of biomimetic organ and tissue transplantation as a common alternative ***(PHAs)are a large family of biopolyesters synthesised in microorganism,demonstrating excellent biocompatibility and controllable biodegradability for tissue remodelling and drug *** different monomer-combination and polymer-types,multi-mechanical properties of PHAs making them have great application prospects in medical devices with stretching,compression,twist in long time,especially in musculoskeletal tissue *** review systematically summarises the applications of PHAs in multiple tissues repair and drug release,encompassing areas such as bone,cartilage,joint,skin,tendons,ligament,cardiovascular tissue,and nervous *** also discusses challenges encountered in their application,including high production costs,potential cytotoxicity,and uncontrollable particle size *** conclusion,PHAs offer a compelling avenue for musculoskeletal system applications,striking a balance between biocompatibility and mechanical ***,addressing challenges in their production and application requires further research to unleash their full potential in tackling the complexities of musculoskeletal regeneration.

关键词： drug delivery musculoskeletal system polyhydroxyalkanoate tissue engineering

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central china Normal University Wuhan 430079China Central South University Changsha 410083China china University of Geosciences Wuhan 430074China china University of Mining and technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher school of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of science and technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2.to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2.·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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磁畴壁手性和磁斯格明子的拓扑性表征及其调控

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物理学报 2018年第13期67卷 227-234页

作者：徐桂舟徐展丁贝侯志鹏王文洪徐锋南京理工大学材料科学与工程学院南京210094 中国科学院物理研究所磁学国家重点实验室北京100190

磁性斯格明子由于拓扑的保护性,具有很高的稳定性和较小的临界驱动电流,有望应用于未来的赛道存储器件中.而在中心对称体系,由于偶极作用的各向同性,磁泡的拓扑性和螺旋度都呈现出多样性的特征.其中非平庸的磁泡即等同于磁性斯格明子.... 详细信息

磁性斯格明子由于拓扑的保护性,具有很高的稳定性和较小的临界驱动电流,有望应用于未来的赛道存储器件中.而在中心对称体系,由于偶极作用的各向同性,磁泡的拓扑性和螺旋度都呈现出多样性的特征.其中非平庸的磁泡即等同于磁性斯格明子.我们通过近期实验结果,结合微磁学模拟的方法,发现在中心对称体系中磁斯格明子的拓扑性会受到体系垂直各向异性的调控.另外在加磁场的演变过程中,会很大程度上依赖于基态畴的畴壁特性.磁场的倾斜或者一定的面内各向异性也会改变磁斯格明子的形态.通过对材料的基态磁结构及磁各向异性的调节,辅助以面内分量的控制,可以对基态磁畴、进而对磁斯格明子的拓扑性实现调控.这对磁斯格明子在电流驱动存储器件中的应用具有重要意义.

关键词：磁斯格明子磁畴壁微磁学模拟

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Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 2..0 ng ml^-1

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Asian Journal of Andrology 2015年第6期17卷 1017-1021,I0012页

作者： Rui Chen Li-Qun zhou Xiao-Bing Cai Li-Ping Xie Yi-Ran Huang Da-Lin He xu Gao Chuan-Liang xu Qiang ding Qiang wei Chang-Jun Yin Shan-Cheng Ren Fu-Bo Wang Ye Tian Zhong-Quan Sun Qiang Fu Lu-Lin Ma Jun-Hua Zheng Zhang-Qun Ye ding-Wei Ye Dan-Feng xu Jian-Quan Hou Ke-Xin xu Jian-Lin Yuan Xin Gao Chun-Xiao Liu Tie-Jun Pan Ying-Hao Sun Department of Urology Shanghai Changhai Hospital Second Military Medical University Shanghai 200433 China ~Department of Urology Peking University First Hospital Institute of Urology Peking University National Urological Cancer Center Beijing 100034 China Department of Health Care PLA Headquarters of the General Staff Guard Bureau Beijing 100017 China Department of Urology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 Zhejiang China Department of Urology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Urology First Affiliated Hospital of Medical School Xi'an:liaotong University Xi'an 710061 China Department of Urology Huashan Hospital Fudan University Shanghai 200040 China Department of Urology West China Hospital Sichuan University Chengdu 610041 Sichuan China State Key Laboratory of Reproductive Medicine Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Department of Urology Beijing-Friendship Hospital Capital Medical University Beijing 100050China Department of Urology Huadong Hospital Fudan University Shanghai 20040 China Department of Urology Shanghai :Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China Department of Urology Peking University Third Hospital Beijing 100083 China Department of Urology Tenth People's Hospital Tongji University Shanghai 200072 China Department of Urology Tongji Hospital TongjJ Medical College Huazhong University of Science and TechnologyWuhan 430030 China Fudan University Shanghai Cancer Center Department of Oncology Shanghai 200032 China Department of Urology Shanghai ChangzhengHospital Second Military Medical University Shanghai 200003 China Department of Urology The First Affiliated Hospital of Soochow University Suzhou 215006 China Department of Urology Peking University People's Hospital Beijing 100044 China Department of Urology Xiji

Percent free prostatic-specific antigen （%fPSA） has been introduced as a tool to avoid unnecessary biopsies in patients with a serum PSA level of 4.0-10.0 ng ml^-1, however, it remains controversial whether %fPSA is effective in PSA range of 10.1-2..0 ng ml^-1 in both Chinese and Western population. In this study, the diagnostic performance of %fPSA and serum PSA in predicting prostate cancer （PCa） and high-grade PCa （HGPCa） was analyzed in a multi-center biopsy cohort of 5915 consecutive Chinese patients who underwent prostate biopsy in 2. hospitals across china from January 1, 2.10 to December 31, 2.13. The indication for biopsy was PSA〉4.0 ng ml^-1 or/and suspicious digital rectal examination. Total and free serum PSA determinations were performed by three types of electrochemiluminescence immunoassays with recalibration to the World Health Organization standards. The diagnostics accuracy of PSA, %fPSA and %fPSA in combination with PSA （%fPSA ＋ PSA） was determined by the area under the receivers operating characteristic curve （AUC）. %fPSA was more effective than PSA in men aged ≥60 years old. The AUC was 0.584 and 0.635 in men aged ≥60 years old with a PSA of 4.0-10.0 ng ml^-1 and 10.1-2..0 ng ml^-1, respectively. The AUC of %fPSA was superior to that of PSA in predicting HGPCa in patients ≥60 years old in these two PSA range. Our results indicated that %fPSA is both statistically effective and clinical applicable to predict prostate biopsy outcome in Chinese patients aged ≥60 years old with a PSA of 4.0-10.0 ng ml^-1 and 10.1-2..0 ng ml^-1.

关键词： Chinese population diagnosis percent free prostate-specific antigen prostate cancer prostate carcinoma tumor antigen prostate-specific antigen

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Correlations between the optic nerve head morphology and ocular biometrics in highly myopic eyes

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 997-1001页

作者： Xiu-Juan Zhao Huai-Yan Jiang Yong-Hao Li Bing-Qian Liu Hong-Xia xu Jie zhou Xiao-Hong Chen Can-Can Lyu Wei Ma Jin Ma Xiao-Ling Liang Chen-Jin Jin Xiao-Yan {2. Lin Lu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen Universisty Department of Ophthalmology the First People’s Hospital of Yunnan Province the Affiliated Hospital of Kunming University of Science and Technology school of Public Health Kunming Medical University

AIM： To analyze peripapillary atrophy β/γ zone （PPA-β/γ） and the optic disc ovality index, and to assess their associations with the axial length （AL）, refractive error, best corrected visual acuity （BCVA）, choroidal thickness （CT）, and age in highly myopic eyes. METHODS： This was a retrospective observational case series. The study included 667 patients consecutively examined for highly myopic eyes [spherical equivalent ≤-6.0 diopters （D） and AL≥2. mm] with or without myopic retinopathy. Each patient went through a comprehensive ophthalmological examination that included spectral domain optical coherence tomography （SD-OCT） of the macula, A-mode ultrasonography, and a cycloplegic refraction test. The ovality index and PPA-β/γ area were measured from optic disc photographs. RESULTS： A significant association was seen between PPA-β/γ area and the ovality index （P=0.000, r=-0.2.2.. The PPA-β/γ area increased significantly with a longer AL, older age, worse BCVA, higher refractive error, and thinner choroid （P〈0.01）. The oval disc was significantly correlated with a longer AL, older age, worse BCVA, higher refractive error, larger PPA-β/γ area, and thinner choroid （P〈0.01）. CONCLUSION： The PPA-β/γ zone and ovality index in highly myopic eyes show distinct associations with the AL, refractive error, BCVA, age, and CT.

关键词： peripapillary atrophy high myopia optic disc ovality index

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Adjacent Pt Nanoparticles and Sub-nanometer WO_(x)Clusters Determine Catalytic Isomerization of C_(7)H_(16)

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CCS Chemistry 2022年第8期4卷 2639-2650页

作者： Bin Zhang Wei zhou Jie Zhang Zirui Gao Danyang Cheng Lipeng Tang Xingwu Liu Yueqin Song Chunyang Dong Yao xu Jie Yan Mi Peng Huizhen Liu Mark Douthwaite Meng Wang {2. Ma Beijing National Laboratory for Molecular sciences College of Chemistry and Molecular Engineering and College of Engineeringand BIC-ESATPeking UniversityBeijing 100871 Beijing National Laboratory for Molecular sciences CAS Key Laboratory of Colloid and Interface and ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 Petroleum Processing Research Center East China University of Science and TechnologyShanghai 200237 Cardiff Catalysis Institute School of ChemistryCardiff UniversityCardiff CF103AT

Processes for the isomerization of light alkanes have been commercialized;however,the isomerization of paraffins(C_(n)H_(2.+2.,n≥7)remains a *** mesoporous tungsten-zirconia catalyst supported Pt catalysts(Pt/WZrOx),initial isomerization productivity of 52.9 moli-C7/molPt/h was obtained for n-heptane reforming at 2.5°C and 5 bar of hydrogen.

关键词： WOx monolayers metal–acid catalysis proximity bifunctional catalysis acid quantification

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Basal physiological parameters in domesticated tree shrews(Tupaia belangeri chinensis)

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Zoological Research 2013年第2期34卷 69-74页

作者： Jing WANG Xin-Li xu Ze-Yang ding Rong-Rong MAO Qi-Xin {2. Long-Bao LV Li-Ping WANG Shuang WANG Chen ZHANG Lin xu Yue-Xiong YANG Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and MemoryKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming Primate Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of sciences Beijing 100049China school of Life sciences Anhui UniversityHefei 230601China Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghai 200030China Tree Shrew Inbreeding Center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

Establishing non-human primate models of human diseases is an efficient way to narrow the large gap between basic studies and translational *** advantages such as simplicity of breeding,low cost of feeding and facility of operating make the tree shrew an ideal non-human primate model *** features like vulnerability to stress and spontaneous diabetic characteristics also indicate that the tree shrew could be a potential new animal model of human ***,basal physiological indexes of tree shrew,especially those related to human disease,have not been systematically ***,we established important basal physiological indexes of domesticated tree shrews including several factors:(1)body weight,(2.core body temperature and rhythm,(3)diet metabolism,(4)locomotor rhythm,(5)electroencephalogram,(6)glycometabolism and(7)serum and urinary hormone level and urinary cortisol *** compared the physiological parameters of domesticated tree shrew with that of rats and *** showed that(a)the core body temperature of the tree shrew was 39.59±0.05°C,which was higher than that of rats and macaques;(b)Compared with wild tree shrews,with two activity peaks,domesticated tree shrews had only one activity peak from 17:30 to 19:30;(c)Compared with rats,tree shrews had poor carbohydrate metabolism ability;and(d)Urinary cortisol rhythm indicated there were two peaks at 8:00 and 17:00 in domesticated tree shrews,which matched activity peaks in wild tree *** results provided basal physiological indexes for domesticated tree shrews and laid an important foundation for diabetes and stress-related disease models established on tree shrews.

关键词： Domesticated tree shrew Basal physiological indexes Rhythm Glycometabolism Stress-related hormone

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