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Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal:A nationwide,multicenter study

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Chinese Medical Journal 2024年第15期137卷 1802-1810页

作者： Changyang Xing Xiujing Xie Yu Wu Lei xu Xiangping Guan Fan Li Xiaojun Zhan Hengli Yang Jinsong Li Qi zhou Yuming Mu Qing zhou Yunchuan ding Yingli Wang Xiangzhu Wang Yu Zheng Xiaofeng Sun Hua Li Chaoxue Zhang Cheng Zhao Shaodong Qiu Guozhen Yan Hong Yang Yinjuan Mao Weiwei Zhan Chunyan Ma Ying Gu Wu Chen Mingxing Xie Tianan Jiang Lijun Yuan Department of Ultrasound Medicine Tangdu HospitalAir Force Medical UniversityXi’anShaanxi 710038China Department of Ultrasound Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Ultrasound Xi’an Hospital of Traditional Chinese MedicineXi’anShaanxi 710021China Ultrasound Medical Diagnosis Center Shaanxi Provincial People’s HospitalXi’anShaanxi 710068China Department of Ultrasound Hospital of Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Ultrasound Xi’an No.1 HospitalThe First Affiliated Hospital of Northwest UniversityXi’anShaanxi 710002China Department of Ultrasound Diagnosis The Second Affiliated HospitalXi’an Medical CollegeXi’anShaanxi 710038China Department of Ultrasound Xi’an Gem Flower ChangQing HospitalXi’anShaanxi 710201China Department of Ultrasound The Second Affiliated Hospital of Xi’an Jiaotong UniversityChinaXi’anShaanxi 710004China Department of Echocardiography First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830011China Department of Ultrasound Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Ultrasound Yan’an HospitalThe Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650051China Department of Ultrasound Yan’an University Xianyang HospitalXianyangShaanxi 712000China Department of Function Examination Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Ultrasound Xi’an Central HospitalXi’anShaanxi 710004China Cadre’s Wards Ultrasound Department Diagnostic Ultrasound CenterFirst Hospital of Jilin UniversityChangchunJilin 130000China Department of Echocardiography Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical UniversityUrumqiXinjiang 830002China Department of Ultrasound First Affiliated

Background:Carotid intima-media thickness(IMT)and diameter,stiffness,and wave reflections,are independent and important clinical biomarkers and risk predictors for cardiovascular *** purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical ***:A total of 3053 healthy Han Chinese adults(1922 women)aged 18-79 years were enrolled at 28 collaborating tertiary centers throughout china between April 2021 and July *** real-time tracking of common carotid artery walls was achieved by the radio frequency(RF)ultrasound *** IMT,diameter,compliance coefficient,βstiffness,local pulse wave velocity(PWV),local systolic blood pressure,augmented pressure(AP),and augmentation index(AIx)were then automatically measured and *** were stratified by age groups and *** relationships between age and carotid property parameters were analyzed by Jonckheere-Terpstra test and simple linear *** major clinical determinants of carotid properties were identified by Pearson’s correlation,multiple linear regression,and analyses of ***:All the parameters of carotid properties demonstrated significantly age-related *** showed thinner IMT,smaller carotid diameter,larger AP,and AIx than ***βstiffness and PWV were significantly higher in men than women before forties,but the differences reversed after *** increase rate of carotid IMT(5.5µm/year in women and 5.8µm/year in men)and diameter(0.03 mm/year in both men and women)were similar between men and *** the stiffness and wave reflections,women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes(all P for age by sex interaction<0.05).The blood pressures,body mass index(BMI),and triglyceride levels were identified as major clinical determinants of carotid properties with adjustment of age and ***

关键词： Intima-media thickness Arterial stiffness Reference values Ultrasound radio frequency signal Wave reflections

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Space advanced technology demonstration satellite

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science china(Technological sciences) 2024年第1期67卷 240-258页

作者： ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen xu DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang zhou Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN xuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng xuE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui xu LuXiang xu ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI Zongxuan ding GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of china Beijing 100101China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China school of Earth and Space sciences Peking UniversityBeijing 100871China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space science Center Chinese Academy of SciencesBeijing 100190China Shenyang Institute of Automation Chinese Academy of SciencesShenyang 110016China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Nanyang Technological university Singapore 569830Singapore Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100049China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Institute of Automation Chinese Academy of SciencesBeijing 100190China school of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310058China

The Space Advanced technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch *** as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,*** paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance.

关键词： SATech-01 spacecraft design scientific instruments on-orbit performance

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Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications

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Chemical Research in Chinese Universities 2022年第4期38卷 856-865页

作者： xu Min zhou Baomei ding Yan DU Shanshan SU Mengke LIU Honglin china Light Industry Key Laboratory of Meat Microbial Control and Utilization School of Food and Biological EngineeringHefei University of TechnologyHefei230009P.R.China First Affiliated Hospital of Anhui Medical university Hefei230000P.R.China

Nucleic acids form biological blueprint and polypeptides assist life activities,both of which are indispensable to ***,oligonucleotide-peptide complexes(OPCs)have shown great potential in biomedicine,material chemistry and other fields due to their considerable stability and *** remains a huge challenge to stably and facilely constructing OPCs that also limits the wide *** tutorial review first summarizes the synthesis strategies of OPC conjugation and the corresponding characteristics in detail,then gives examples of the applications of OPCs,and finally presents a prospective overview on challenges and future perspectives of *** review aims to help researchers understand the current situation and challenges in this field,thereby furthering interests in developing novel OPC synthesis techniques.

关键词： Oligonucleotide Peptide Complex

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Coordinated Planning Transmission Tasks in Heterogeneous Space Networks:A Semi-Distributed Approach

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china Communications 2023年第1期20卷 261-276页

作者： Runzi Liu Weihua Wu Zhongyuan Zhao xu ding Di zhou Yan Zhang school of Information and Control Engineering Xi’an University of Architecture and TechnologyXi’an 710055ShaanxiChina State Key Laboratory of ISN School of Telecommunications EngineeringXidian UniversityXi’an 710071ShaanxiChina Key Laboratory of Universal Wireless Communications(Ministry of Education) Beijing University of Posts and TelecommunicationsBeijing 100876China

This paper studies the coordinated planning of transmission tasks in the heterogeneous space networks to enable efficient sharing of ground stations cross satellite ***,we first formulate the coordinated planning problem into a mixed integer liner programming(MILP)problem based on time expanded ***,the problem is transferred and reformulated into a consensus optimization framework which can be solved by satellite systems *** alternating direction method of multipliers(ADMM),a semi-distributed coordinated transmission task planning algorithm is proposed,in which each satellite system plans its own tasks based on local information and limited communication with the coordination *** results demonstrate that compared with the centralized and fully-distributed methods,the proposed semi-distributed coordinated method can strike a better balance among task complete rate,complexity,and the amount of information required to be exchanged.

关键词： heterogeneous space network transmission task task planning coordinated scheduling

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金属有机框架材料MIL-101在吸附去除水中有机污染物中的应用进展

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分析测试学报 2024年第4期43卷 654-662页

作者：兰梓溶清江陈有为许宙陈茂龙文李程云辉丁利长沙理工大学食品科学与生物工程学院湖南长沙410114 上海海关工业品与原材料检测中心上海200135 宁波海关技术中心浙江宁波315012

金属有机框架材料(MOFs)是一种极具前景的水中污染物吸附材料,其中,拉瓦锡研究所材料(MIL)凭借较好的稳定性和较多的可调节位点在众多MOFs中脱颖而出。与其他MILs相比,MIL-101具有比表面积较大和表面活性位点多的特点,在水中的稳定性高... 详细信息

金属有机框架材料(MOFs)是一种极具前景的水中污染物吸附材料,其中,拉瓦锡研究所材料(MIL)凭借较好的稳定性和较多的可调节位点在众多MOFs中脱颖而出。与其他MILs相比,MIL-101具有比表面积较大和表面活性位点多的特点,在水中的稳定性高,已成为一种新兴的吸附材料。鉴于此,该文对近年来MIL-101在水中有机污染物去除领域的应用研究进行了综述,主要对MIL-101结构、改性修饰及其在水污染物吸附去除方面的应用及吸附机理进行了介绍。最后对MIL-101吸附材料的应用前景进行了分析和展望。

关键词： MIL-101 吸附改性修饰有机污染物水

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The modification toward excited-state dynamics and catalytic activity by isomeric Au_(44)clusters

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Nano Research 2023年第8期16卷 11383-11388页

作者： Tongxin Song Jie Kong Shisi Tang Xiao Cai xu Liu Meng zhou Wen Wu xu Weiping ding Yan Zhu school of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China Hefei National Research Center for Physical sciences at the Microscale University of Science and Technology of ChinaHefei 230026China school of Physical science and technology Ningbo UniversityNingbo 315211China

The structure determination of metal nanoclusters protected by ligands is critical in understanding their physical and chemical properties,yet it remains elusive how the metal core and ligand of metal clusters cooperatively contribute to the observed ***,with the successful synthesis of Au_(44)TBPA_(22)Cl_(2)cluster(TBPA=4-tert-butylphenylacetylene),the structural isomer of previously reported Au_(44)L_(28)clusters(L denoted as ligand)is filled,thereby providing an opportunity to explore the property evolution rules imparted by different metal core structures or different surface ***-resolved transient absorption spectroscopy reveals that the difference in the core structure between Au_(44)TBPA_(22)Cl_(2)and Au_(44)L_(28)can bring nearly 360 times variation of excited-state lifetime,while only 3–24 times differences in excited-state lifetimes of the three Au_(44)L_(28)nanoclusters with identical metal core but different ligands are observed,which is due to much stronger impact of the metal core than the surface ligands in the electronic energy bands of the *** addition,the Au_(44)clusters protected by alkyne ligands are shown to be highly effective toward the electrochemical oxidation of ethanol,compared to the Au_(44)clusters capped by thiolates,which is ascribed to smaller charge transfer impedance of the former *** anticipate that the study will enhance the process in controlling the nanomaterial properties by precisely tailoring metal core or surface patterns.

关键词： cluster metal core surface ligand excited-state dynamics catalysis

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Synthesis and Characterization of Disodium Hydrogen Phosphate Dodecahydrate-Lauric-Palmitic Acid Used for Indoor Energy Storage Floor Units

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Journal of Thermal science 2020年第2期29卷 477-485页

作者： xu Qian AKKURT Nevzat ZOU Zhenwei LIU Yang FENG Junxiao YU Chuqiao ding Chong XIONG Yaxuan zhou Jingzhi ZANG Yong ding Yulong school of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering Munzur UniversityTunceli 62000Turkey school of Information and Electronics Communication and Information SystemBeijing Institute of TechnologyBeijing 100081China school of Mathematics Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of HVAC Beijing University of Civil Engineering and ArchitectureBeijing 100044China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China school of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

Organic and inorganic phase change materials(PCMs) are considered potential materials for thermal energy storage(TES) with different phase change characteristics. In this study, a novel organic-inorganic composite phase change material(PCM) called disodium hydrogen phosphate dodecahydrate-lauric-palmitic acid(D-LA-PACM) was prepared. Expanded graphite(EG) was selected as the support material, and the novel organic-inorganic form-stable PCM called D-LA-PAPCM/EG was prepared using the vacuum adsorption method. Differential scanning calorimetry, Fourier transform infrared spectroscopy, X-ray diffraction, leakage testing, melting and solidification cycle testing, thermal conductivity testing, scanning electron microscopy observation of the micromorphology, and other characterization methods were used to study the microstructure and morphology, thermal physical parameters, thermal conductivity, stability of the PCMs, and the comprehensive material properties of D-LA-PAPCM under the composite action of EG. Results indicated that the melting and freezing temperatures and latent heats of D-LA-PAPCM/EG were measured to be 31.6℃ and 34.3℃ and 142.9 and 142.8 J/g, respectively. Although some of the lauric-palmitic acid(LA-PA) and disodium hydrogen phosphate dodecahydrate(DHPD) separated in the multiple porous structures of EG after 1000 cycles, they could still absorb and release latent heats independently, with D-LA-PAPCM/EG still exhibiting good thermal stability. The thermal conductivity of D-LA-PAPCM/EG was 1.361 W/(m·K). Therefore, the material and thermal properties of the prepared D-LA-PAPCM/EG indicate that it could be well used as a feasible material for energy-saving phase change floor units in indoor TES systems.

关键词： organic-inorganic PCM form-stable PCM thermal property energy storage

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Synthesis of Z-scheme g-C3N4 nanosheets/Ag3PO4 photocatalysts with enhanced visible-light photocatalytic performance for the degradation of tetracycline and dye

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Chinese Chemical Letters 2020年第1期31卷 71-76页

作者： Meng ding Juanjuan zhou Hongcen Yang Ruya Cao Shouwei Zhang Minghui Shao Xijin xu school of Physics and technology University of JinanJi'nan 250022China College of Optical and Electronic technology China Jiliang UniversityHangzhou 310018China

Graphene-like C3N4/Ag3PO4 photocatalysts are synthesized by calcination and solutions precipitating *** obtained g-C3N4/Ag3PO4 composites display excellent photocatalytic activity for the degradation of methylene orange(MO),rhodamine B(RhB)and tetracycline(TC)under visible light *** solutions containing RhB(10 mg/L)and MO(10 mg/L)can be efficiently degraded within15 min and 30 ***,nearly 80%of TC(50 mg/L)is degraded within 20 *** are much better than those of pure g-C3N4 nanosheets and Ag3PO4,implying that strong interaction and reasonable energy band alignment in the contact interface can effectively transfer the ***,the g-C3N4/Ag3PO4 composites exhibit the improved stability,and only a slight decrease is observed after three recycling ***,the impact of inorganic ions and PH values on the degradation performance is rather *** Z-scheme photocatalytic mechanism of the g-C3N4/Ag3PO4 composites based on the active species trapping experimental is *** work demonstrates the promising applications of the g-C3N4/Ag3PO4 composites in environmental issues.

关键词： g-C3N4/Ag3PO4 Tetracycline Photocatalytic activity Photocurrent Impedance

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Focus-sensitive relation disambiguation for implicit discourse relation detection

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Frontiers of Computer science 2019年第6期13卷 1266-1281页

作者： Yu HONG Siyuan ding Yang xu Xiaoxia JIANG Yu WANG Jianmin YAO Qiaoming ZHU Guodong zhou Natural Language Processing Lab School of Computer Science&TechnologySoochow UniversitySuzhou 215006China science and technology on Information Systems Engineering Laboratory Nanjing 210007China

We study implicit discourse relation detection,which is one of the most challenging tasks in the field of discourse *** specialize in ambiguous implicit discourse relation,which is an imperceptible linguistic phenomenon and therefore difficult to identify and *** this paper,we first create a novel task named implicit discourse relation disambiguation(IDRD).Second,we propose a focus-sensitive relation disambiguation model that affirms a truly-correct relation when it is triggered by focal sentence *** addition,we specifically develop a topicdriven focus identification method and a relation search system(RSS)to support the relation ***,we improve current relation detection systems by using the disambiguation *** on the penn discourse treebank(PDTB)show promising improvements.

关键词： Implicit discourse relation focus-sensitive implicit relation disambiguation topic-driven focus identification

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Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1159-1174页

作者： Heng xu Hongfang Zhao Chunyong ding Defang Jiang Zijie Zhao Yang Li Xiaoyu ding Jing Gao Hu zhou Cheng Luo Guoqiang Chen Ao Zhang Ying xu Hao Zhang school of Pharmaceutical science and technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Chemical Biology Research Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghai 200025China Pharm-X center College of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China school of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xianlin RoadQixiaNanjing 210023 JiangsuChina university of Chinese Academy of sciences No.19A Yuquan RoadBeijing 100049China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRen-Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor *** clinical application of Celastrol is strictly limited due to its severe side effects,whereas previously revealed targets and mechanism of Celastrol seldom reduce its in vivo toxicity via structural *** identification has a far-reaching influence on the development of innovative drugs,and omics data has been widely used for unbiased target ***,it is difficult to enrich target of specific phenotype from thousands of genes or proteins,especially for natural products with broad promising ***,we developed a text-mining-based web-server tool to enrich targets from omics data of inquired *** peroxiredoxin 1(PRDX1)was identified as the ROS-manipulating target protein of Celastrol in colorectal *** solved high-resolution crystal structure revealed the unique covalent binding mode of Celastrol with *** derivative compound 19-048 with improved potency against PRDX1 and selectivity towards PRDX2~PRDX6 were synthesized based on crystal structure *** Celastrol and 19-048 effectively suppressed the proliferation of colorectal cancer *** anti-tumor efficacy of Celastrol and 19-048 was significantly diminished on xenograft nude mice bearing PRDX1 knock-down colorectal cancer *** downstream genes of p53 signaling pathway were dramatically up-regulated with Celastrol or 19-048 *** findings reveal that the side effects of Celastrol could be reduced via structural modification,and PRDX1 inhibition is promising for the treatment of colorectal cancer.

关键词： colorectal cancer nude

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