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Experimental study on mechanical properties of methane-hydrate-bearing sediments

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Acta Mechanica Sinica 2012年第5期28卷 1356-1366页

作者： xu-hui Zhang xiao-bing Lu Li-Min Zhang shu-Yun Wang Qing-Ping Li Laboratory for Hydrodynamics and Ocean Enginnering Institute of MechanicsChinese Academy of Sciences Department of Civil and Environmental Engineering Hong KongUniversity of Science and Technology Research Centre China Ocean Oil Co.

Mechanical properties of methane hydrate- bearing-sediments （MHBS） are basic parameters for safety analysis of hydrate exploration and exploitation. Young＇s modulus, cohesion, and internal friction angle of hydrate- bearing sediments synthesized in laboratory, are investigated using tri-axial tests. Stress-strain curves and strength parameters are obtained and discussed for different compositions and different hydrate saturation, followed by empirical expressions related to the cohesion, internal friction angle, and modulus of MHBS. Almost all tested MHBS samples exhibit plastic failure. With the increase of total saturation of ice and methane hydrate （MH）, the specimens＇ internal friction angle decreases while the cohesion increases.

关键词： Gas hydrate sediment. Tri-axial test. Cohesion Internal friction angle Elastic modulus

Au@SiO2 @CuInS2–ZnS/Anti-AFP fluorescent probe improves HCC cell labeling

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Hepatobiliary & Pancreatic Diseases International 2019年第3期18卷 266-272页

作者： Yi-Wen Dai Li-Xin Zhu Yan Zhang shu-hui Wang Kui Chen tong-tong Jiang xiao-Liang xu xiao-Ping Geng Division of General Surgery The Second Affiliated Hospital of Anhui Medical University Hefei 230601 China Division of General Surgery The First Affiliated Hospital of Anhui Medical University Hefei 230022 China Key Laboratory of Strongly-Coupled Quantum Matter Physics Chinese Academy of Sciences School of Physical Sciences University of Science and Technology of China Hefei 230026 China Department of Physics Anhui University Hefei 230020 China

Background: Clear tumor imaging is essential to the resection of hepatocellular carcinoma(HCC). This study aimed to create a novel biological probe to improve the HCC imaging. Methods: Au nano-flower particles and CuInS2 –Zn S core-shell quantum dots were synthesized by hydrothermal method. Au was coated with porous SiO2 and combined with anti-AFP antibody. HCC cell line HepG2 was used to evaluate the targeting efficacy of the probe, while flow cytometry and MTT assay were used to detect the cytotoxicity and bio-compatibility of the probe. Probes were subcutaneously injected to nude mice to explore light intensity and tissue penetration. Results: The fluorescence stability of the probe was maintained 100% for 24 h, and the brightness value was 4 times stronger than that of the corresponding CuInS2 –Zn S quantum dot. In the targeting experiment, the labeled HepG2 emitted yellow fluorescence. In the cytotoxicity experiments, MTT and flow cytometry results showed that the bio-compatibility of the probe was fine, the inhibition rate of HepG2 cell with 60% Cu-QDs/Anti-AFP probe and Au-QDs/Anti-AFP probe solution for 48 h were significantly different(86.3%±7.0% vs. 4.9%±1.3%, t = 19.745, P < 0.05), and the apoptosis rates were 83.3%±5.1% vs. 4.4%±0.8%( P < 0.001). In the animal experiment, the luminescence of the novel probe can penetrate the abdominal tissues of a mouse, stronger than that of CuInS2 –ZnS quantum dot. Conclusions: The Au@SiO2 @CuInS2 –ZnS/Anti-AFP probe can targetedly recognize and label HepG2 cells with good bio-compatibility and no toxicity, and the strong tissue penetrability of luminescence may be helpful to surgeons.

关键词： Plasmon enhancement Quantum dots Nanoparticle Luminescence Cytotoxicity

Antibiotic exposure perturbs the bacterial community in the small brown planthopper Laodelphax striatellus

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Insect Science 2020年第5期27卷 895-907页

作者： xu Zhang tong-Pu Li Chun-Ying Zhou Dian-shu Zhao Yu-Xi Zhu xiao-Li bing Hai-Jian Huang xiao-Yue Hong Department of Entomology Nanjing Agricultural UniversityNanjingChina

Bacteria symbionts in herbivores play an important role in host biology and ecology,and are affected by environmental factors such as temperature,diet,habitat,antibiotics and so ***,the effects of antibiotics on the microbiome of the small brown planthopper Laodelphax striatellus(SBPH)remain ***,we studied the effects of tetracycline on the diversity and composition of bacterial colonies in different tissues of SBPH using high throughput sequencing of 16S ribosomal RNA *** results show that Proteobacteria,Firmicutes,Bacteroidetes,Actinobacteria were most abundant in SBPH,and the genera Asaia and Wolbachia were most abundant in all body parts of *** treatment had persistent effects on the composition of the SBPH *** depleted the population of Firmicutes,Bacteroidetes,Tenericutes and Fusobacteria,and nearly 100%eliminated Wolbachia,Bacteroides and Abiotrophia in ***,these results suggest that antibiotic exposure affects the bacteria symbionts of different body parts in SBPH and will facilitate future studies of the bacterial symbionts of arthropod hosts.

关键词： antibiotics gut Laodelphax striatellus microbial structure ovary

Effect of superplastic deformation on the bonding property of 00Cr25Ni7Mo3N duplex stainless steel

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International Journal of Minerals,Metallurgy and Materials 2012年第4期19卷 317-321页

作者： xiao-hui Chen xue-ping Ren hui xu Jian-guo tong Hai-yan Zhang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Sinosteel Equipment ＆ Engineering Co. Ltd. Beijing 100080 China

The superplastic deformation diffusion bonding of 00Cr25Ni7Mo3N duplex stainless steel was performed on a hot simulator. The microstructure of the bonding interface was characterized by scanning electron microscopy （SEM） and electron backscatter diffraction （EBSD）. The mechanical properties of the specimen were investigated by a shear strength test. The results indicated that the shear strength was improved with the increase of superplastic deformation reduction. When the deformation reduction was up to 50%, the shear strength of the specimen achieved 417 Mpa, approaching to that of the base metal. In addtion, the superplastic diffusion bonding technique was not very sensitive to surface roughness levels. When the surface roughness of the bonding specimen surpassed 0.416 pan （level G2）, the shear strength achieved at least 381 MPa.

关键词： stainless steel superplastic deformation diffusion bonding surface roughness shear strength

Forest disturbances and the attribution derived from yearly Landsat time series over 1990–2020 in the Hengduan Mountains Region of Southwest China

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Forest Ecosystems 2021年第4期8卷 974-990页

作者： Yating Li Zhenzi Wu xiao xu hui Fan xiaojia tong Jiang Liu Institute of International Rivers and Eco-Security Yunnan UniversityKunming 650091China Yunnan Key Laboratory of International Rivers and Transboundary Eco-Security Kunming 650091China

Background:Natural forests in the Hengduan Mountains Region(HDMR)have pivotal ecological functions and provide diverse ecosystem *** long-term forest disturbance and drivers at a regional scale is crucial for sustainable forest management and biodiversity ***:We used 30-m resolution Landsat time series images and the LandTrendr algorithm on the Google Earth Engine cloud platform to map forest disturbances at an annual time scale between 1990 and 2020 and attributed causal agents of forest disturbance,including fire,logging,road construction and insects,using disturbance properties and spectral and topographic variables in the random forest ***:The conventional and area-adjusted overall accuracies(OAs)of the forest disturbance map were 92.3% and 97.70%±0.06%,respectively,and the OA of mapping disturbance agents was 85.80%.The estimated disturbed forest area totalled 3313.13 km^(2)(approximately 2.31% of the total forest area in 1990)from 1990 to 2020,with considerable interannual fluctuations and significant regional *** predominant disturbance agent was fire,which comprised approximately 83.33% of the forest area disturbance,followed by logging(12.2%),insects(2.4%)and road construction(2.0%).Massive forest disturbances occurred mainly before 2000,and the post-2000 annual disturbance area significantly dropped by 55% compared with the pre-2000 ***:This study provided spatially explicit and retrospective information on annual forest disturbance and associated agents in the *** findings suggest that China’s logging bans in natural forests combined with other forest sustainability programmes have effectively curbed forest disturbances in the HDMR,which has implications for enhancing future forest management and biodiversity conservation.

关键词： Change detection Disturbance attribution Landsat LandTrendr Hengduan Mountains region

Gut microbiota in obesity

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World Journal of Gastroenterology 2021年第25期27卷 3837-3850页

作者： bing-Nan Liu xiao-tong Liu Zi-Han Liang Ji-hui Wang School of Bioengineering Dalian Polytechnic UniversityDalian 116034Liaoning ProvinceChina Engineering Research Center of Health Food Design&Nutrition Regulation Dongguan University of TechnologyDongguan 523808Guangdong ProvinceChina

Obesity is a major global health problem determined by heredity and environment,and its incidence is increasing *** recent years,increasing evidence linking obesity to the gut microbiota has been *** microbiota management has become a new method of obesity ***,the complex interactions among genetics,environment,the gut microbiota,and obesity remain poorly *** this review,we summarize the characteristics of the gut microbiota in obesity,the mechanism of obesity induced by the gut microbiota,and the influence of genetic and environmental factors on the gut microbiota and obesity to provide support for understanding the complex relationship between obesity and *** the same time,the prospect of obesity research related to the gut microbiota is proposed.

关键词： Gut microbiota Obesity Dysbiosis Genetics Ecology

Estimation of OCDD degradation rate in soil

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Journal of Environmental Sciences 2005年第6期17卷 981-983页

作者： ZHAO Xing-ru ZHENG Ming-hui ZHANG bing QIAN Yong xu xiao-bai State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of ScienceBeijing 100085 China

The current concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans （PCDD/Fs） were determined in soils contaminated with Chinese technical product sodium pentachlorophenate （ Na- PCP）. The estimated half-life of octachlorodioxin （OCDD） was about 14 years in contaminated soils based on the local historical record and mass balance calculation during the past 43 years（ 1960-2003）. The isomer profiles remained the same regardless of paddy field soil or riverbank soil. The results indicated that the congenerspecific information was efficient in estimating the PCDD/Fs fate in contaminated soils.

关键词： OCDD degradation rate Na-PCP

Acute interstitial edematous pancreatitis:Findings on non-enhanced MR imaging

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World Journal of Gastroenterology 2006年第36期12卷 5859-5865页

作者： xiao-Ming Zhang Zhi-Song Feng Qiong-hui Zhao Chun-Ming xiao Donald G Mitchell Jian shu Nan-Lin Zeng xiao-xue xu Jun-Yang Lei xiao-bing Tian Department of Radiology Affiliated Hospital of North Sichuan Medical College Wenhua Road 63 Nanchong 637000 Sichuan Province China Department of Gastroenterology Affiliated Hospital of North Sichuan Medical College Wenhua Road 63 Nanchong 637000 Sichuan Province China Department of General Surgery Affiliated Hospital of North Sichuan Medical College Wenhua Road 63 Nanchong 637000 Sichuan Province China Department of Radiology Thomas Jefferson University Hospital Philadelphia PA United States Department of Statistics North Sichuan Medical College Fujiang Road 234 Nanchong 637007 Sichuan Province China

AIM： To study the appearances of acute interstitial edematous pancreatitis （IEP） on non-enhanced MR imaging. METHODS： A total of 53 patients with IEP diagnosed by clinical features and laboratory findings were underwent MR imaging. MR imaging sequences included fast spoiled gradient echo （FSPGR） fat saturation axial T1-weighted imaging, gradient echo T1-weighted （in phase）, single shot fast spin echo （SSFSE） T2-weighted, respiratory triggered （R-T） T2-weighted with fat saturation, and MR cholangiopancreatography. Using the MR severity score index, pancreatitis was graded as mild （0-2 points）, moderate （3-6 points） and severe （7-10 points）. RESULTS： Among the 53 patients, IEP was graded as mild in 37 patients and as moderate in 16 patients. Forty-seven of 53 （89%） patients had at least one abnormality on MR images. Pancreas was hypointense relative to liver on FSPGR T1-weighted images in 18.9% of patients, and hyperintense in 25% and 30% on SSFSE T2-weighted and R-T T2-weighted images, respectively. The prevalences of the findings of IEP on R-T T2-weighted images were, respectively, 85% for pancreatic fascial plane, 77% for left renal fascial plane, 55% for peripancreatic fat stranding, 42% for right renal fascial plane, 45% for perivascular fluid, 40% for thickened pancreatic Iobular septum and 25% for peripancreatic fluid, which were markedly higher than those on in-phase or SSFSE T2-weighted images （P 〈 0.001）. CONCLUSION： IEP primarily manifests on non- enhanced MR images as thickened pancreatic fascial plane, left renal fascial plane, peripancreatic fat stranding, and peripancreatic fluid. R-T T2-weighted imaging is more sensitive than in-phase and SSFSE T2- weighted imaging for depicting IER

关键词： Pancreas Pancreatitis Inflammation Edema Magnetic resonance

Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice

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Chinese Journal of Natural Medicines 2021年第10期19卷 772-783页

作者： xu xiao-Jing LONG Jin-Bo JIN Kai-Yu CHEN Li-bing LU xiao-Yan FAN xiao-hui Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Danshen-Chuanxiongqin Injection(DCI)is a commonly used traditional Chinese medicine for the treatment of cerebral ischemic stroke in ***,its underlying mechanisms remain completely *** current study was designed to explore the protective mechanisms of DCI against cerebral ischemic stroke through integrating whole-transcriptome sequencing coupled with network pharmacology ***,using a mouse model of cerebral ischemic stroke by transient middle cerebral artery occlusion(tMCAO),we found that DCI(4.10 mL·kg−1)significantly alleviated cerebral ischemic infarction,neurological deficits,and the pathological injury of hippocampal and cortical neurons in ***,the whole-transcriptome sequencing was performed on brain *** cerebral ischemia disease(CID)network was constructed by integrating transcriptome sequencing data and cerebrovascular disease-related *** results showed CID network was imbalanced due to tMCAO,but a recovery regulation was observed after DCI *** analysis of the key genes with recovery efficiency showed that the neuroinflammation signaling pathway was highly enriched,while the TLR2/TLR4-MyD88-NF-κB pathway was predicted to be ***,the in vivo validation experiments confirmed that DCI exhibited protective effects against cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/TLR4-MyD88-NF-κB *** interestingly,DCI markedly suppressed the neutrophils infiltrated into the brain parenchyma via the choroid plexus route and showed anti-neuroinflammation *** conclusion,our results provide dependable evidence that inhibiting neuroinflammation via the TLR2/TLR4-MyD88-NF-κB pathway is the main mechanism of DCI against cerebral ischemic stroke in mice.

关键词： Danshen-Chuanxiongqin Injection Cerebral ischemic stroke Network pharmacology Neuroinflammation Neutrophil Choroid plexus