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A phase separation-fortified bi-specific adaptor for conditional tumor killing

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Science China(Life Sciences) 2024年第7期67卷 1385-1397页

作者： Yuyan Liu Yuting zhu Weifan xu Pilong Li State Key Laboratory of Membrane Biology Frontier Research Center for Biological StructureTsinghua University-Peking University Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China

A common approach in therapeutic protein development involves employing synthetic ligands with multivalency,enabling sophisticated control of signal *** the emerging concept of liquid-liquid phase separation(LLPS)and its ability to organize cell surface receptors into functional compartments,we herein have designed modular ligands with phase-separation modalities to engineer programmable interreceptor communications and precise control of signal pathways,thus inducing the rapid,potent,and specific apoptosis of tumor *** their simplicity,these“triggers”,named phase-separated Tumor Killers(hereafter referred to as psTK),are sufficient to yield interreceptor clustering of death receptors(represented by DR5)and tumor-associated receptors,with notable features:LLPSmediated robust high-order organization,well-choreographed conditional activation,and broad-spectrum capacity to potently induce apoptosis in tumor *** development of novel therapeutic proteins with phase-separation modalities showcases the power of spatially reorganizing signal *** approach facilitates the diversification of cell fate and holds promising potential for targeted therapies against challenging tumors.

关键词： phase separation therapeutic proteins receptor-ligand interactions DR5 tumor apoptosis

Computation of the exact time delay margin for vehicle platoon under generic communication topologies

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 761-775页

作者： xu zhu Maode Yan Panpan Yang Yongtao Liu School of Electronic and Control Engineering Chang'an UniversityXi'an 710064China School of Automobile Chang'an UniversityXi'an 710064China

Due to the limited bandwidth and transmission congestion of the vehicle platoon's communication,it is inevitable to induce time delay,which significantly degrades the control performance of the vehicle platoon,even resulting in *** paper focuses on analyzing the internal stability under generic communication topologies and presents a method of computing the exact time delay margin(ETDM).The proposed method can offer a necessary and sufficient internal stability condition with no ***,to reduce the analytical complexity and computational burden elegantly,we decompose the closed-loop platoon dynamics into a set of individual subsystems via similarity transformation and matrix *** decomposition approach is applicable for any general communication ***,an explicit formula is deduced to compute the ETDM by surveying the characteristic roots'distribution of all these individual *** is further demonstrated that only the positive purely imaginary roots need to be considered to compute the ***,simulations are conducted to demonstrate the effectiveness of the theoretical claims.

关键词： Vehicle platoon Exact time delay margin Generic communication topologies System decomposition Characteristic roots'distribution

Significantly enhanced performance and conductivity mechanism in Nb/Mn co-doped CaBi_(4)Ti_(4)O_(15)ferroelectrics

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Journal of Materiomics 2024年第3期10卷 652-669页

作者： Jiageng xu Shaoxiong xie Qian xu Jie xing Qingyuan Wang Jianguo zhu School of Aeronautics and Astronautics Sichuan UniversityChengdu610000China Institute for Advanced Study Chengdu UniversityChengdu610106China Department of Mechanical Engineering Kyushu UniversityFukuoka819-0395Japan College of Architecture and Environment Sichuan UniversityChengdu610065China College of Material Science and Engineering Sichuan UniversityChengdu610065China

With the rapid development of high-end industries,the demand for high-temperature piezoelectric materials is significantly ***,realizing the ultra-high performance to meet more ap-plications still faces major scientific and engineering challenges of our ***,a new Nb/Mn co-doped CaBi_(4)Ti_(4)O_(15)(CBT)high-temperature piezoelectric material system of CaBi_(4)Ti_(4-x)(Nb_(2/3)Mn_(1/3))_(x)O_(15)was synthesized by the conventional solid-state sintering *** results show that the addition of the dopants tends to break the long-range ferroelectric chain and soften the flexibility of polarization,resulting in more distorted crystal structure and better ferroelectric properties of CBT *** ultra-high piezoelectric constant(d_(33)=26.8 pC/N)is thus attained in CBT-based ceramics with x=0.12,which is about several times larger than that of pure CBT ***,numerous nano-sized layered domain structures that lie on the lateral plane of grains are observed in ceramics,with lower domain wall energy and better dynamic features under electric fields,mainly responsible for the origin of enhanced ***,excess dopants could make the conductivity mechanism of CBT ceramics transform from p-type to n-type,and also result in a shift of conduction relaxation mechanism from defect dipole rotation polarization to electron relaxation *** work not only provides a promising candidate for high-temperature piezoelectric materials,but also opens a window for opti-mizing performance by tailoring domain structures using chemical modification.

关键词： CaBi_(4)Ti_(4)O_(15) Lattice distortion Electrical performance Domain structure Conductivity mechanism

The Effectiveness of Antiviral Treatment in Severe COVID-19 Patients in Wuhan,China:A Multicenter Study

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Biomedical and Environmental Sciences 2022年第1期35卷 58-63页

作者： ZHOU xian Long DING Guo Yong YANG Lu Yu LIU Rui Ning HOU Hai Feng WANG Ping MA Min HU zhuan zhuan HUANG Lei xu xi zhu HU Quan ZHAO Yan xiNG Wei Jia ZHAO Zhi Gang Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesTai’an 271016ShandongChina Intensive Care Unit Wuhan Third HospitalWuhan 430060HubeiChina Intensive Care Unit Huazhong University of Science and Technology Union Jiangbei HospitalWuhan 430100HubeiChina Intensive Care Unit The first people's Hospital of Jiangxia DistrictWuhan 430200HubeiChina Hubei Clinical Research Center for Emergency and Resuscitation Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina

Coronavirus disease 2019(COVID-19)has inarguably caused the most challenging *** less than 2 years,greater than 200 million cases of COVID-19 and 4.5 million deaths have been reported worldwide[1].The treatment strategy of an emerging infectious disease is a huge challenge for clinical practitioners because of missing key knowledge about the disease.

关键词： Patients clinical COV

Chain Rule for Extracting Resilience Procurement Costs from Locational Marginal Prices

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1342-1355页

作者： Yifei Wang Tong zhu Tiancong Chen Mohammad Shahidehpour Qingshan xu College of Electrical Engineering Southeast UniversityNanjing 210096China Henan Mechanical&Electrical Vocational College Xinzheng 451191China Illinois Institute of Technology ChicagoIllinois 60616USA IEEE CSEE

Power system resilience procurement costs in N-k contingencies have gained more prominence as number of extreme events continues to increase.A chain rule is presented in this paper for extracting resilience procurement costs from a fully decomposed locational marginal price(LMP)***,power transfer distribution factor(PTDF)matrices with AC power flow(i.e.,AC-PTDF)are ***-PTDF and AC-LODF(line outage distribution factor)equations are derived for N-k contingencies and a fully decomposed LMP model is developed where generation and transmission security components are established for specific ***,resilience procurement costs can be measured at different buses for the proposed security *** of N-k contingencies on resilience procurement costs at specific buses can be determined as proposed security components will gain more insight for resilience procurement in power *** modified IEEE 6-bus and 118-bus systems are adopted to verify effectiveness of the proposed resilience procurement method.

关键词： Line outage distribution factors locational marginal price power system resilience power transfer distribution factor security components

Topological non-reciprocal robust waveguide transport

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 39-45页

作者： Ruizhi Dong Yihuan zhu Dongxing Mao xu Wang Yong Li Institute of Acoustics Tongji UniversityShanghai 200092China

Devices that surpass the restriction of reciprocity of classical physical waves have brought intriguing possibilities for wave ***-reciprocal acoustic devices that rely on the viscosity of the medium or nonlinear effect have low efficiency and distortion problems respectively,and poor immunity to *** appearance of acoustic topological insulators achieves nonreciprocal transport with high ***,the local nature of topological states means that their appearance depends on a system with a larger *** is,most of the area of a topological device is occupied by useless lattices that do not directly contribute to non-reciprocal *** extra cost of topology protection severely limits the application scenarios of topology states,decreases the cost-effectiveness of topology devices,and is not conducive to device miniaturization and *** this work,we construct an acoustic three-layer heterojunction by introducing two types of domain walls into a conventional quantum Hall effect acoustic topological insulator,and successfully construct a non-reciprocal scattering network that forms topological modes spanning the interlayer *** extended states are still protected by bulk-band topology,making their non-reciprocity robust against *** structure flawlessly realizes the path broadening in a two-dimensional topological system and can accomplish functions such as non-reciprocal acoustic splitting and multichannel *** work opens up opportunities for developing topological-insulator-based non-reciprocal devices in acoustics.

关键词： reciprocal topological topology

Sulfur vacancies and heterogeneous interfaces promote high performance sodium storage of bimetallic chalcogenide hollow nanospheres

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Journal of Energy Chemistry 2024年第8期95卷 596-610,I0013页

作者： Shiyue Cao xiaoting xu Qiming Liu Huijuan zhu Ting Hu Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina

Transition metal sulfides have high theoretical capacities and are considered as potential anode materials for sodium-ion ***,due to low inherent conductivity and significant volume expansion,the electrochemical performance is greatly *** this study,a nickel/manganese sulfide material(Ni_(0.96)S_(x)/MnS_(y)-NC)with adjustable sulfur vacancies and heterogeneous hollow spheres was prepared using a simple *** introduction of a concentration-adjustable sulfur vacancy enables the generation of a heterogeneous interface between bimetallic sulfide and sulfur *** interface collectively creates an internal electric field,improving the mobility of electrons and ions,increasing the number of electrochemically active sites,and further optimizing the performance of Na~+*** direction of electron flow is confirmed by Density functional theory(DFT)*** hollow nano-spherical material provides a buffer for expansion,facilitating rapid transfer *** innovative discovery involves the interaction between the ether-based electrolyte and copper foil,leading to the formation of Cu_9S_5,which grafts the active material and copper current collector,reinforcing mechanical *** results in a new heterostructure of Cu_9S_5 with Ni_(0.96)S_(x)/MnS_(y),contributing to the stabilization of structural integrity for long-cycle ***,Ni_(0.96)S_(x)/MnS_(y)-NC exhibits excellent electrochemical properties following our modification *** stability performance,Ni0_(.96)S_(x)/MnS_(y)-NC demonstrates an average decay rate of 0.00944%after 10,000 cycles at an extremely high current density of 10000 mA g^(-1),A full cell with a high capacity of 304.2 mA h g^(-1)was also successfully assembled by using Na_(3)V_(2)(PO_(4))_(3)/C as the *** study explores a novel strategy for interface/vacancy co-modification in the fabrication of high-performance sodium-ion batteries electrode.

关键词： Sulfur vacancies Heterogeneous interface Interactions Sodium ion batteries

Fiber Bundle Topology Optimization for Surface Flows

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 236-264页

作者： Yongbo Deng Weihong Zhang Jihong zhu Yingjie xu Jan G Korvink State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China State IJR Center of Aerospace Design and Additive Manufacturing Northwestern Polytechnical UniversityXi’an 710072China Institute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtzplatz 176344 Eggenstein-LeopoldshafenGermany

This paper presents a topology optimization approach for the surface flows on variable design *** this approach,the matching between the pattern of a surface flow and the 2-manifold used to define the pattern can be optimized,where the 2-manifold is implicitly defined on another fixed 2-manifold named as the base *** fiber bundle topology optimization approach is developed based on the description of the topological structure of the surface flow by using the differential geometry concept of the fiber *** material distribution method is used to achieve the evolution of the pattern of the surface *** evolution of the implicit 2-manifold is realized via a homeomorphous *** design variable of the pattern of the surface flow and that of the implicit 2-manifold are regularized by two sequentially implemented surface-PDE *** two surface-PDE filters are coupled,because they are defined on the implicit 2-manifold and base manifold,*** surface Navier-Stokes equations,defined on the implicit 2-manifold,are used to describe the surface *** fiber bundle topology optimization problem is analyzed using the continuous adjoint method implemented on the first-order Sobolev *** numerical examples have been provided to demonstrate this approach,where the combination of the viscous dissipation and pressure drop is used as the design objective.

关键词： Fiber bundle Topology optimization 2-manifold Surface flow Material distribution method Porous medium model

Review on Lithium-ion Battery PHM from the Perspective of Key PHM Steps

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 1-22页

作者： Jinzhen Kong Jie Liu Jingzhe zhu xi Zhang Kwok-Leung Tsui Zhike Peng Dong Wang School of Mechanical Engineering Hebei University of TechnologyTianjin 300401China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Grado Department of Industrial and Systems Engineering Virginia Polytechnic Institute and State UniversityBlacksburg 24061USA School of Mechanical Engineering Ningxia UniversityNingxia 750021China

Prognostics and health management(PHM)has gotten considerable attention in the background of Industry *** PHM contributes to the reliable and safe operation of electric ***,relevant reviews are still continuously updated over *** this paper,we browsed extensive literature related to battery PHM from 2018to 2023 and summarized advances in battery PHM field,including battery testing and public datasets,fault diagnosis and prediction methods,health status estimation and health management *** last topic includes state of health estimation methods,remaining useful life prediction methods and predictive maintenance *** of these categories is introduced and discussed in *** on this survey,we accordingly discuss challenges left to battery PHM,and provide future research *** research systematically reviews recent research about battery PHM from the perspective of key PHM steps and provide some valuable prospects for researchers and practitioners.

关键词： Lithium-ion batteries Prognostics and health management Remaining useful life State of health Predictive maintenance