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氮肥配施有机肥对半干旱区旱地小麦土壤三大菌群和酶活性及产量的影响

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南京农业大学学报 2025年第1期48卷 144-151页

作者：胡冬平唐江华徐文修房彦飞罗晓颖王怀港王晨新疆农业大学农学院新疆乌鲁木齐830052

[目的]本文旨在探究氮肥配施有机肥对半干旱区旱地冬小麦土壤微生物数量、酶活性及产量的影响。[方法]于2021年采用田间试验与室内试验相结合的方法,设置不施肥(0 kg·hm^(-2)尿素,F1)、单施氮肥(150 kg·hm^(-2)尿素,F2)、单施有机肥(3... 详细信息

[目的]本文旨在探究氮肥配施有机肥对半干旱区旱地冬小麦土壤微生物数量、酶活性及产量的影响。[方法]于2021年采用田间试验与室内试验相结合的方法,设置不施肥(0 kg·hm^(-2)尿素,F1)、单施氮肥(150 kg·hm^(-2)尿素,F2)、单施有机肥(30 t·hm^(-2)有机肥,F3)、氮肥配施有机肥(150 kg·hm^(-2)尿素+30 t·hm^(-2)有机肥,F4)4个施肥处理的田间试验,通过室内试验研究不同处理土壤微生物数量、酶活性、产量及其相关性的变化规律。[结果]各施肥处理较不施肥处理可明显增加土壤细菌数量(26.24%~85.82%)和放线菌数量(13.94%~47.60%),减少真菌数量(26.39%~52.78%),并提高脲酶、蔗糖酶、磷酸酶、过氧化氢酶的活性(3.92%~30.49%、42.06%~133.71%、12.38%~26.34%、173.6%~284.21%)。氮肥配施有机肥处理小麦产量最高,达2 516.43 kg·hm^(-2),比未施肥处理增产55.51%,比单施氮肥和单施有机肥平均增产16.20%。[结论]氮肥配施有机肥更有利于增加半干旱区旱作麦田土壤微生物数量和相关酶的活性,改善土壤环境,提高土壤肥力,进而提高小麦产量。

关键词：旱地小麦土壤微生物数量酶活性产量

铁死亡在新生儿缺氧缺血性脑损伤中的作用机制研究进展

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中国全科医学 2025年第6期28卷 666-672页

作者：张天阳徐文秀秦昕宇邢雪雪毕玫荣山东第二医科大学临床医学院山东省潍坊市261000 山东第一医科大学研究生部山东省济南市250014 山东省济南市中心医院儿科 250014

新生儿缺氧缺血性脑损伤(HIBD)是新生儿期神经系统损伤的常见原因之一,易导致新生儿高致残率、高死亡率,其发病机制复杂且在临床上无特异性治疗方法。铁死亡作为近年新发现的一种非凋亡性细胞死亡类型,受到广泛关注并逐渐成为研究热点... 详细信息

新生儿缺氧缺血性脑损伤(HIBD)是新生儿期神经系统损伤的常见原因之一,易导致新生儿高致残率、高死亡率,其发病机制复杂且在临床上无特异性治疗方法。铁死亡作为近年新发现的一种非凋亡性细胞死亡类型,受到广泛关注并逐渐成为研究热点。关于铁死亡与新生儿HIBD的研究逐年增多,大量研究表明铁死亡与新生儿HIBD的发生、发展密切相关。并且,有研究指出维生素K2,特别是甲萘醌-4(MK-4)可以通过抑制铁死亡发挥其神经保护作用。本文简要综述铁死亡在新生儿HIBD及小胶质细胞中的作用机制,并展望维生素K2,特别是MK-4通过抑制铁死亡改善新生儿HIBD预后的可能,以期提供一种更加经济、安全且更具针对性的治疗方式。

关键词：脑损伤铁死亡新生儿缺氧缺血性脑损伤脂质过氧化作用甲萘醌-4 小胶质细胞综述

Single-atom catalyst application in distributed renewable energy conversion and storage

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SusMat 2023年第2期3卷 160-179页

作者： Xiao Li wenxiu xu Yuhan Fang Riming Hu Jiayuan Yu Hong Liu Weijia Zhou Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJinanChina School of Biological Science and Technology University of JinanJinanChina Institute for Smart Materials&Engineering University of JinanJinanChina State Key Laboratory of Crystal Materials Shandong UniversityJinanChina

In recent years,owing to the depletion of fossil energy and the aggravation of environmental pollution,the conversion and storage of distributed renewable energy(such as solar energy,wind energy,and tidal energy)based on electrochemical technology have attracted extensive *** processes with high efficiency and high selectivity play a key role in clean energy conversion and *** the nearly 100%atomic utilization rate and unique catalytic activity,single-atom catalysts(SACs)have been rapidly developed and widely used in the field of energy conversion and *** this review,we first introduce the characteristics of ***,we focus on the application of SACs in energy conversion,including water electrolysis reaction,nitrogen reduction reaction,nitrate reduction reaction,oxygen reduction reaction,and carbon dioxide reduction *** terms of energy storage,we focus on supercapacitors and Li–S ***,we enumerate some of the methods for the synthesis of SACs in high metal loading or large ***,the main challenges and opportunities for this emerging field in the future are discussed and prospected.

关键词： electrocatalytic energy conversion energy storage single-atom catalysts

Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： WEN YANG BIN TANG DAN xu wenxiu YANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

Strategic Research on Pharmaceutical Enterprises’ Participation in National Drug Centralized Procurement

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Asian Journal of Social Pharmacy 2022年第1期17卷 15-22页

作者： Yang Dianzheng xu wenxiu Qi Yun Yang Yue School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China International Food and Drug Policy and Law Research Center Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China

Objective To study the influence of national drug centralized procurement policy on pharmaceutical enterprises manufacturing generic drugs and original drugs,so as to provide a reference for them to make different strategic *** Through the literature research on the related policies and the bidding data,the national drug centralized policies were studied *** with the bid-winning price and price reduction range of the winning enterprises in the three rounds of centralized procurement,their difficulties,strategic choices and the winning factors were ***,a model was established to clarify the optimal price of enterprises in the process of drug *** and Conclusion The strategic choices of enterprises in participating national drug centralized procurement are influenced by many factors such as the market share of the original varieties,active pharmaceutical ingredients(APIs)and ***,corresponding strategies should be formulated according to the characteristics and interests of enterprises.

关键词： drug centralized procurement pharmaceutical enterprises game strategy

Study on the Application of Quality Risk Management on Drug Collinear Production

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Asian Journal of Social Pharmacy 2022年第1期17卷 39-49页

作者： xu wenxiu Ma Hui Yang Dianzheng Wei Jing School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China Liaoning Certification and Evaluation Institute Shenyang 110036China

Objective To study how to ensure the quality of listed drugs by using quality risk management to control the risks in the drug collinear production because some pharmaceutical companies produce drugs with multiple dosage forms and specifications on the same line to save costs in *** The application status of quality risk management in the production of drugs was analyzed by consulting literature,field investigation and research re-lated *** and Conclusion When introducing co-line products,we should focus on combining prod-uct reality,establish a cross-professional team in comprehensive quality,R&D,equipment,and *** we can coordinate quality risk management to integrate with each other to avoid“shortcomings”in different links,which will affect the effectiveness of risk *** a company conducts co-line production,it should rely on quality risk management theories to establish a scientific quality management system,reasonably use qual-ity risk assessment tools to evaluate the types of co-line production,and control key risk factors *** methods can ensure the risk of co-production within an acceptable range.

关键词： collinear production cross contamination quality risk management

Qinzhi Zhudan formula improves memory and alleviates neuroinflammation in vascular dementia rats partly by inhibiting the TNFR1-mediated TNF pathway

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Journal of Traditional Chinese Medical Sciences 2022年第3期9卷 298-310页

作者： Shuling Liu Fafeng Cheng Beida Ren wenxiu xu Congai Chen Chongyang Ma Xiaole Zhang Feifei Tang Qingguo Wang xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Dongzhizmen Hospital Beijing University of Chinese MedicineBeijing100700China Institute for Brain Disorders Beijing University of Chinese MedicineBeijing100700China School of Traditional Chinese Medicine Capital Medical UniversityBeijing100069China

Objective: The Qinzhi Zhudan formula(QZZD) exhibits a prominent therapeutic effect in the treatment of vascular dementia(VaD). This study combined a network pharmacology approach and experimental validation to identify the underlying biological mechanism of QZZD against ***: Male Wistar rats received bilateral common carotid artery occlusion(BCCAO) surgery, and after4 weeks of intragastric administration of QZZD, the therapeutic effect was assessed using the Morris water maze test and cerebral blood flow(CBF) assessment. Hematoxylin and eosin staining, Nissl staining, and electron microscopy were used to measure the histopathological changes in the neurons of rats. The effect of QZZD treatment on hippocampal neurotransmitters was assessed by high-performance liquid chromatography with electrochemical detection and liquid chromatography mass *** was used to observe VaD-induced microglia activation. The inflammatory cytokine levels were assessed by enzyme linked immunosorbent assay. Western blot was used to examine the TNFR1-mediated TNF pathway, which was screened out by network pharmacology ***: QZZD treatment alleviated pathological changes and neuronal damage in VaD rats and attenuated their cognitive impairment. In addition, QZZD increased CBF and the expression of acetylcholine and 5-hydroxytryptamine in the hippocampal region. Notably, QZZD inhibited microglial activation and the expression of IL-6 and TNF-a. Network pharmacology and western blot indicated that QZZD inhibited the levels of TNFR1, NF-κBp65, p-ERK, TNF-a, and IL-6, which are related to the TNFR1-mediated TNF signaling ***: QZZD clearly improved learning and memory function, reduced brain pathological damage,elevated CBF and hippocampal neurotransmitter levels, and alleviated neuroinflammation of VaD rats partly by inhibiting the TNFR1-mediated TNF pathway, indicating its potential value in the clinical therapy of VaD.

关键词： Vascular dementia Neuroinflammation Inflammatory cytokines Microglia TNF signaling Pathway Network pharmacology Cerebral blood flow Chronic cerebral ischemia

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超声波辅助提取花椒籽油的工艺研究

中国粮油学报 2013年第4期28卷 62-66页

作者：徐文秀翟永亮运城学院生命科学系运城044000

为了提高花椒的经济价值,充分利用花椒籽中的花椒籽油,以脱蜡花椒籽为原材料,利用超声波辅助提取花椒籽油。首先,通过预处理试验确定最佳提取溶剂,然后,通过单因素试验对影响花椒籽油得率的因素(液料比、提取时间、提取温度、超声波功率... 详细信息

为了提高花椒的经济价值,充分利用花椒籽中的花椒籽油,以脱蜡花椒籽为原材料,利用超声波辅助提取花椒籽油。首先,通过预处理试验确定最佳提取溶剂,然后,通过单因素试验对影响花椒籽油得率的因素(液料比、提取时间、提取温度、超声波功率)进行探讨。最后,采用Box-Behnken中心组合试验设计原理,以油脂得率为考察指标,对液料比、超声功率、提取时间进行3因素3水平响应面分析,确定了在该试验中超声波辅助处理提取花椒籽油最佳工艺参数:液料比:21.5∶1(mL/g),提取时间:25 min,提取温度:60℃,超声功率350 W。在此条件下,花椒籽油得率为27.25%。

关键词：超声波辅助提取花椒籽油得率

氧杂蒽类有机染料在可见光诱导有机合成中的应用

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有机化学 2018年第11期38卷 2807-2832页

作者：徐雯秀戴小强徐涵靖翁建全浙江工业大学化学工程学院杭州310014

氧杂蒽类有机染料作为光氧化还原催化剂,因具有廉价易得、水溶性好、反应活性高等优点被广泛应用于可见光诱导的有机合成中.其催化的有机反应类型不断被拓展,有逐渐取代部分过渡金属催化剂的趋势.根据反应类型进行分类,综述了近些年几... 详细信息

氧杂蒽类有机染料作为光氧化还原催化剂,因具有廉价易得、水溶性好、反应活性高等优点被广泛应用于可见光诱导的有机合成中.其催化的有机反应类型不断被拓展,有逐渐取代部分过渡金属催化剂的趋势.根据反应类型进行分类,综述了近些年几种常用氧杂蒽类有机染料在光诱导有机合成中的研究进展,并对其前景进行了展望.

关键词：有机染料光氧化还原有机合成过渡金属