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Resistivity and thermal infrared precursors associated with cemented backfill mass

Journal of Central South University 2016年第9期23卷 2329-2335页

作者： xu wen-bin Faculty of Resources & Safety Engineering China University of Mining &Technology Beijing 100083 China State Key Laboratory of Safety and Health for Metal Mines Ma'anshan 243000 China School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China

The stability of cemented backfill mass is important to keep miners and equipment safe in underground backfill *** stress-strain behavior, resistivity and thermal infrared(TIR) characteristics of backfill mass under uniaxial compression were investigated. The monitoring system consisted of a TIR observation system, a stress-strain monitoring system and a resistivity measurement system. Precursory information for impending failure of cemented backfill mass was collected, including TIR, strain and resistivity precursors. The sensitivity and difference of different monitoring information to the same failure event were *** results show that the time-space evolution process of the resistivity and TIR is basically the same as the whole process from compression deformation to failure of backfill mass, and the time variation of resistivity and TIR is obviously characterized by *** resistivity precursor turns out earlier than the TIR and the strain. The resistivity relation with loading compression is anti-symmetry, decreasing as the compression stress increases before the peak strength of backfill mass. However, when the backfill mass enters into the phase of failure, the resistivity starts to increase as the stress increases. The change of the resistivity growth direction can be regarded as the resistivity-caution-point for the failure of backfill mass under uniaxial compression. It is also indicated that the TIR information mainly represents the surface temperature evolution in the process of compression before the backfill enters into the plastic-yield state. It can be a valuable tool to obtain the precursors for failure of cemented backfill mass for backfill mines.

关键词： cemented backfill mass thermal infrared characteristic resistivity uniaxial compression

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Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： wen YANG bin TANG DAN xu wenXIU YANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

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Strength and deformation behaviors of cemented tailings backfill under triaxial compression

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Journal of Central South University 2020年第12期27卷 3531-3543页

作者： xu wen-bin LIU bin WU Wei-lü School of Energy and Mining Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Resources and Environment Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

It is of great significance for safety reason to obtain the triaxial compressive properties of cemented tailings backfill(CTB).The influence of cement content,curing age and confining pressure on strength and deformation properties of CTB was examined and *** indicate that the triaxial compressive and deformation behavior of CTB is strongly affected by the cement content,curing age and confining *** increase in cement content,curing age and confining pressure leads to a change in stress−strain behavior and an increase in the axial strain at failure and post-peak strength *** cohesion of CTB rises as the curing age and cement content ***,the enhancement in internal friction angle is trivial and *** should be noted that the failure pattern of CTB samples in triaxial compression is mainly along a shear plane,the confining pressure restrains the lateral expansion and the bulging failure pattern is dominantly detected in CTB samples as curing age length and cement content *** results will help to better understand the triaxial mechanical and deformation behavior of CTB.

关键词： cemented tailings backfill triaxial compressive strength volumetric strain elastic modulus cohesion friction angle

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Fibromyalgia after severe acute respiratory syndrome: a case report

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Chinese Medical Journal 2006年第10期119卷 875-877页

作者： TIAN Xin-ping ZENG Xiao-feng xu wen-bin Department of Rheumatology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Respiratory Disease Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

S ince November 2002, an infectious disease with unknown cause occurred in China and many countries had been involved. Cases were reported in 28 countries and more than 5050 individuals had been infected. Lung is the most frequently involved organ and can be fatal in severe cases. At the end of February 2003, it was defined as Severe Acute Respiratory Syndrome （SARS） by World Health Or clanization.

关键词： SARS

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土地利用和气候变化对农牧交错带生态系统服务的影响

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环境科学 2023年第9期44卷 5114-5124页

作者：徐文彬饶良懿北京林业大学水土保持学院北京100083 北京林业大学水土保持国家林业和草原局重点实验室北京100083

土地利用和气候变化是驱动生态系统服务变化的重要因素,了解其背后的影响机制对提升生态系统服务至关重要.目前农牧交错带生态系统服务变化和驱动因素的研究较为薄弱.以我国典型农牧交错带内蒙古奈曼旗为研究区,基于InVEST模型、修正风... 详细信息

土地利用和气候变化是驱动生态系统服务变化的重要因素,了解其背后的影响机制对提升生态系统服务至关重要.目前农牧交错带生态系统服务变化和驱动因素的研究较为薄弱.以我国典型农牧交错带内蒙古奈曼旗为研究区,基于InVEST模型、修正风蚀方程(RWEQ)和修正通用土壤流失方程(RUSLE)评估该区2005年和2015年的产水服务、防风固沙服务和土壤保持服务,并运用贡献率公式、地理探测器和皮尔逊相关系数等方法分析土地利用和气候变化对这3项生态系统服务的影响.结果表明:①2005~2015年奈曼旗产水服务和土壤保持服务整体呈上升趋势,分别增加22.41%和6.74%,防风固沙服务则下降了66.24%.②产水服务和防风固沙服务变化主要受气候变化的影响,土壤保持服务变化主要受土地利用变化的影响.③实际蒸散变化和土地利用变化是影响产水服务变化空间分异性的主要因子,其解释力分别为94.50%和50.05%;实际蒸散变化和土地沙化程度是影响防风固沙服务变化空间分异性的主要影响因子,其解释力分别为19.84%和16.15%.④奈曼旗各项生态系统服务之间相关性较弱,只有防风固沙-产水服务呈现弱显著的协同关系.根据研究结果,建议在沙区适当提高灌草植被比例;在牧区实行必要的封禁管理;在农田引进滴灌等节水技术;而城镇则应当继续将生态保护和修复摆在优先位置.

关键词：生态系统服务土地利用变化气候变化农牧交错带内蒙古奈曼旗

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养护龄期、水泥掺量和围压对胶结充填体饱和渗流特性和三轴压缩行为影响

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Journal of Central South University 2023年第5期30卷 1649-1661页

作者：徐文彬吴蔚律刘斌 School of Energy and Mining Engineering China University of Mining&Technology(Beijing)Beijing 100083China

渗流特性是影响地下采场胶结充填体稳定性的重要指标。本文以胶结充填体为研究对象,采用室内实验和微观分析相结合的方法,系统分析和讨论了三轴压缩和非压缩条件下,不同水泥掺量(2%、3%、5%)、养护龄期(3d、7d、28 d)和围压(100、200、... 详细信息

渗流特性是影响地下采场胶结充填体稳定性的重要指标。本文以胶结充填体为研究对象,采用室内实验和微观分析相结合的方法,系统分析和讨论了三轴压缩和非压缩条件下,不同水泥掺量(2%、3%、5%)、养护龄期(3d、7d、28 d)和围压(100、200、300、400 kPa)对胶结充填体渗流特性的影响。研究结果表明:胶结充填体的静态渗流系数随着养护龄期和水泥掺量的增加呈非线性下降趋势,围压升高会对充填体的渗流速率产生抑制作用;胶结充填体的动态渗流系数与其变形过程密切相关;充填体在三轴压缩过程中,随着轴向应变的增加,充填体的渗流系数先降低后升高;围压和水泥掺量越大,充填体的动态渗流系数越小;充填体的体积应变表现为先收缩后膨胀,体积应变演化阐释了动态渗透系数时效性。研究结果可为井下充填采场排水以及充填体稳定性分析与设计提供指导。

关键词：尾砂胶结充填渗流系数养护龄期水泥掺量三轴压缩

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Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期68卷 308-316页

作者： Sili Wang Jiancheng Huang Yanan Du Wei Huang Yufeng xue Xiaokun xu Guannan Zhong Yuanyuan Shi bin Hong Xiaoying Bian wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

关键词： cbl-dependent radical SAM protein biosynthesis chuangxinmycin stereoselective methylation

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Progression of diabetic retinopathy： the Beijing Eye Study

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Chinese Medical Journal 2011年第22期124卷 3635-3640页

作者： TU Ying xu Liang WEI wen-bin WANG Shuang WANG Ya-xing Jost B Jonas Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology ＆ Visual Sciences Key Lab Beijing 100730 China

Background Diabetic retinopathy （DR） has emerged as a leading cause of visual impairment and blindness in the working-aged population worldwide. This study aimed to assess frequency and associated factors of progression of DR in subjects with known diabetes in a population-based setting. Methods The Beijing Eye Study is a population based study performed in Greater Beijing in 2001 and 2006. The present investigation included all subjects with known diabetes mellitus in 2001, who participated in the follow-up examination in 2006. Fundus photographs were assessed. Results The study included 170 subjects; 51 （30%） subjects showed signs of DR in 2001 and were re-examined in 2006, 36 （21.2%） subjects （18 subjects with DR present at baseline, 18 subjects with newly diagnosed DR in 2006） showed a progression of DR during follow-up. Progression of DR was associated with rural region （odds ratio （OR）： 5.43, P=0.001） and self-reported arterial hypertension （OR： 3.85, P=0.023）. In the non-progressive subgroup, presence of DR was associated with different levels of education （〈middle school, middle school, college or higher, OR： 0.30, P=-0.023）, treatment modes of diabetes mellitus （OR： 10.24, P=0.003） and cataract surgery （OR： 9.14, P=0.007）. Conclusions In a population-based setting in Greater Beijing, progression of DR occurred in 35% of subjects with pre-existing DR and overall in 21% of subjects with known diabetes within a 5-year period. Progression of DR was significantly associated with rural region and self-reported arterial hypertension. In the stable subjects, presence of DR was significantly associated with poor educational level, insulin treatment of diabetes and cataract surgery.

关键词： progression diabetic retinopathy Beijing Eye Study

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Efficacy of liver transplantation for acute hepatic failure:asingle-center experience

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Hepatobiliary & Pancreatic Diseases International 2011年第4期10卷 369-373页

作者： Xian-Jie Shi,Hong-bin xu,wen-bin Ji,Yu-Rong Liang,Wei-Dong Duan,Lei He,Ming-Jun Wang and Zhi-Ming Zhao Department of Hepatobiliary Surgery Department of Anesthesiology General Hospital of PLA,Beijing 100853,China Department of Hepatobiliary Surgery General Hospital of PLA Beijing 100853 China Department of Anesthesiology General Hospital of PLA Beijing 100853 China

BACKGROUND:Acute hepatic failure (AHF) is a devastating clinical syndrome with a high mortality *** outcome of AHF varies with etiology,but liver transplantation (LT) can significantly improve the prognosis and survival rate of such *** study aimed to detect the role of LT and artificial liver support systems (ALSS) for AHF patients and to analyze the etiology and outcome of patients with this ***:A retrospective analysis was made of 48 consecutive patients with AHF who fulfilled the Kings College Criteria for LT at our *** analyzed and compared the etiology,outcome,prognosis,and survival rates of patients between the transplantation (LT) group and the non-transplantation (N-LT) ***:AHF was due to viral hepatitis in 25 patients (52.1%;hepatitis B virus in 22),drug or toxic reactions in 14 (29.2%;acetaminophen in 6),Wilson disease in 4 (8.3%),unknown reasons in 3 (6.3%),and miscellaneous conditions in 2 (4.2%).In the LT group,36 patients (7 underwent living donor LT,and 29 cadaveric LT) had an average model for endstage liver disease score (MELD) of ***-eight patients survived with good graft function after a follow-up of 27.3± 4.5 *** the waiting time,6 patients were treated with ALSS and 2 of them died during *** 30-day,12-month,and 18-month survival rates were 77.8%,72.2%,and 66.7%,*** the N-LT group,12 patients had an average MELD score of *** patients were treated with ALSS and all died during *** 90-day and 1-year survival rates were only 16.7% and 8.3%,***:Hepatitis is the most prominent cause of AHF at our *** patients with AHF,who fulfill the Kings College Criteria for LT,did not survive longer without *** did not improve the prognosis of AHF patients,but may extend the waiting time for a ***,LT is still the most effective way to improve the prognosis of AHF patients.

关键词： acute hepatic failure liver transplantation artificial liver support prognosis survival rate etiology

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晚清闽南商人慈善家的兴起:以林瑞岗为中心

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安徽史学 2019年第2期 53-61页

作者：徐文彬中共福建省委党校党史教研部福建福州350001

文章通过分析文献资料与田野调查相结合,以跨区域视角,考察晚清时期闽南著名慈善家林瑞岗。指出他与旅沪慈善家群体交游密切,曾参与华北义赈活动,并效仿江南模式,在家乡创办综合性善堂,其慈善事业呈现赈灾范围跨地域化、慈善机构自治化... 详细信息

文章通过分析文献资料与田野调查相结合,以跨区域视角,考察晚清时期闽南著名慈善家林瑞岗。指出他与旅沪慈善家群体交游密切,曾参与华北义赈活动,并效仿江南模式,在家乡创办综合性善堂,其慈善事业呈现赈灾范围跨地域化、慈善机构自治化、筹募资金网络化、施善主体商人化等近代特征,凸显晚清闽南地方权力结构之转型。林瑞岗热衷慈善,除其个人特殊经历,秉承安海商人尚儒重义之风、深受江南慈善理念的影响外,还得益于官府的鼓励举措。晚清官府治理能力的衰落,海外侨商群体的崛起、交通、信息技术的革新,使林瑞岗实现由商至绅的转变,成为影响颇巨的职业慈善家。

关键词：林瑞岗慈善晚清

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