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Aldehyde oxidase mediated enantioselective metabolic health risk of dinotefuran

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Science China Chemistry 2024年第6期67卷 2079-2091页

作者： Liwei xu Xinxin xu Hua Kuang Chuanlai xu Xiaoling Wu State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan UniversityWuxi214122China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxi214122China

Chiral pollutants often pose significant differential environmental health *** this study,the biotransformation of chiral dinotefuran(DIN)and its enantioselective metabolic toxicity mechanisms have been systemically ***,reversedphase chromatography-high resolution mass spectrometry was developed to quantify the content of DIN R/S chiral enantiomer with pg level sensitivity,revealing a lower elimination rate constant(K_(e))of S-DIN(0.730 h^(-1))than R-DIN(0.746 h^(-1)).Secondly,the interaction mechanism between DIN metabolism and important endogenous bioactive molecules,such as aldehyde oxidase(AOX)and neurotransmitters,was *** DIN nitro-group was converted into a guanidine group by the reducing site of nearby flavin adenine dinucleotide(FAD)in AOX with the preferred higher affinity of ***,the endogenous tryptophan(Trp)aldehyde metabolic intermediate,5-hydroxyindoleacetaldehyde(5-HIAL),provides a persistent electron donor for DIN reduction via the oxidation-catalyzed site in AOX,resulting in remarkable up-regulation of monoamine neurotransmitters such as serotonin and ***,the higher level of neurotransmitters further mediated dysregulation of oxylipin homeostasis via the serotonergic pathway,where S-DIN exhibited more pronounced liver lipid damage and environmental health risk with the accumulated lipid biomarkers,oxidized triglyceride(OxTG)and oxidized sphingomyelin(OxSM).This study elucidates the AOX-mediated enantioselectivity metabolic pathway of DIN,providing a new analytical method for chiral pollutants and paves the way for their health risk assessments.

关键词： neonicotinoid dinotefuran enantiomer aldehyde oxidase metabolomics health risk

Granting strength to aerogel fibers through encapsulation

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Science China Materials 2024年第4期67卷 1365-1366页

作者： Wenhui xu Department of Basic Chemistry School of PharmacyJiangxi University of Chinese MedicineNanchang 330004China

Aerogel fibers, distinguished by their lightweight nature, pronounced porosity, large surface area, and superior thermal insulation properties, have diversified applications in thermal management, energy devices, and environmental remediation[1]. However, compared with monolithic ones, these fibershaped aerogels exhibit limited mechanical strength and resilience due to their one-dimensional small size.

关键词： strength fibers thermal

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私营企业家外部环境风险感知与企业创新投入

科研管理 2021年第3期42卷 160-171页

作者：徐炜锋阮青松王国栋同济大学经济与管理学院上海200092 苏高新集团江苏苏州215011

企业家是私营企业中的灵魂人物,企业家在企业创新战略的制定中发挥了决定性作用。本文使用中国私营企业调查(CPES)数据库,研究了企业家外部环境风险感知对企业创新投入的影响。具体的,我们按照综合因子得分将企业家外部环境风险感知划... 详细信息

企业家是私营企业中的灵魂人物,企业家在企业创新战略的制定中发挥了决定性作用。本文使用中国私营企业调查(CPES)数据库,研究了企业家外部环境风险感知对企业创新投入的影响。具体的,我们按照综合因子得分将企业家外部环境风险感知划分为高值组与低值组,使用PSM的方法,估计了高值组企业与低值组企业创新投入的平均差异水平(ADL)。研究发现:企业家市场环境风险感知越强,企业创新投入水平越高;而企业家制度环境风险感知越强,企业创新投入水平越低;综合来看,企业家外部环境风险感知越强,企业创新投入水平越低。在企业创新投入决策中我国私营企业家风险规避动机强于风险寻求动机,而且低个人地位感知度的企业家的风险规避动机强于高个人地位感知度的企业家。

关键词：私营企业家外部环境风险风险感知创新投入

经膀胱前入路和经膀胱后入路机器人辅助前列腺癌根治术早期效果比较

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中华外科杂志 2021年第11期59卷 902-906页

作者：东洁陈勇吉徐维锋纪志刚中国医学科学院北京协和医学院北京协和医院泌尿外科100730 电子科技大学医学院附属肿瘤医院泌尿外科成都610041

目的探讨不同入路机器人辅助前列腺癌根治术的早期效果。方法回顾性分析2018年3月至2020年3月北京协和医院泌尿外科同一术者完成的44例机器人辅助前列腺癌根治术的病例资料,患者平均年龄65.9岁(范围:46~81岁)。手术经膀胱前入路完成24例... 详细信息

目的探讨不同入路机器人辅助前列腺癌根治术的早期效果。方法回顾性分析2018年3月至2020年3月北京协和医院泌尿外科同一术者完成的44例机器人辅助前列腺癌根治术的病例资料,患者平均年龄65.9岁(范围:46~81岁)。手术经膀胱前入路完成24例(前入路组),经膀胱后入路完成20例(后入路组)。采用t检验、χ^(2)检验和Fisher确切概率法比较两组患者的术前临床资料、围手术期相关结果及术后尿控情况。结果两组患者的年龄、前列腺体积、术前前列腺特异性抗原及Gleason评分均无差异(P值均>0.05)。前入路组与后入路组的手术时间[(184±43)min比(193±42)min,t=-0.599,P=0.55]、术中出血量[(218±88)ml比(225±115)ml,t=-0.244,P=0.81]、病理学分期(T2/T3期:15/9比12/8,χ^(2)=0.029,P=0.87)、切缘阳性率[29.2%(7/24)比30.0%(6/20),χ^(2)=0.004,P=0.95]的差异均无统计学意义。以不使用成人纸尿裤为判断标准,前入路组拔尿管即刻及术后3、6、12个月达到尿控的患者分别为1、6、20、23例,后入路组分别为6、11、19、19例,后入路组拔尿管即刻达到尿控的比例高于前入路组[30.0%(6/20)比4.2%(1/24),P=0.04],两组术后3、6、12个月达到尿控比例的差异均无统计学意义(P值均>0.05)。结论经膀胱后入路行机器人辅助前列腺癌根治术,相较于经膀胱前入路不延长手术时间,不增加出血量,且可提高术后早期尿控恢复比例。

关键词：前列腺肿瘤机器人后入路尿控

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水稻茎秆响应干湿交替灌溉的转录组分析

植物生理学报 2020年第12期56卷 2655-2663页

作者：宋涛阳峰许卫锋张建华香港浸会大学生物系香港999077 福建农林大学生命科学学院福州350002

干湿交替(alternate wetting and drying, AWD)灌溉已被广泛用于取代连续淹水(continuous flooding, CF)灌溉,前者在提高水稻水分生产率的同时不会造成产量损失。然而,关于AWD灌溉如何影响水稻茎秆基因表达,进而调控植物生理响应的研究... 详细信息

干湿交替(alternate wetting and drying, AWD)灌溉已被广泛用于取代连续淹水(continuous flooding, CF)灌溉,前者在提高水稻水分生产率的同时不会造成产量损失。然而,关于AWD灌溉如何影响水稻茎秆基因表达,进而调控植物生理响应的研究目前还鲜有报道。本研究发现,在AWD灌溉条件下,非结构性碳水化合物(non-structural carbohydrate, NSC)含量、淀粉含量显著降低,淀粉酶活性显著提高。进一步分析了AWD和CF灌溉下茎秆转录组学的差异。结果显示差异基因(AWD和CF相比)富集于淀粉和蔗糖代谢通路、植物激素信号转导通路、丝裂原活化蛋白激酶(MAPK)信号通路以及多个转录因子家族。这些差异基因可能参与了茎秆生理表型调控。这为茎秆对AWD灌溉适应提供了有用的信息,可能为开展改善水稻栽培的分子研究提供参考。

关键词：转录组非结构性碳水化合物干湿交替灌溉淀粉酶茎

Distribution of HLA-B*27 subtypes in Southeast Han population of China

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Distribution of HLA-B*27 subtypes in Southeast Han populatio...

Skeletal interoception in osteoarthritis

2015浙江省检验医学学术年会

作者： Zhengbing Zhuge 骆方军 Zhigang Zhao Jie Zhang Jianhang Leng Guozhong Zhou weifeng xu Lirong Shen Sir Run Run Shaw Hospital Zhejiang University School of Medicine Department of Physiology and Pharmacology Karolinska Institutet Department of Clinical Laboratory Zhuji Hospital Affiliated with Wenzhou Medical University Zhejiang Lishui Central Hospital Lishui Hospital of Zhejiang University Shanghai ZJ Bio-Tech Co. Ltd Central Laboratory of Hangzhou First People's Hospital Clinical Laboratory Test Center Shaoxing People's HospitalShaoxing Hospital of Zhejiang University Department of Clinical Laboratory of Lihuili Hospital of Ningbo Medical Center

This study aims to investigate the distribution of HLA-B*27 subtypes in Southeast Han population of China.95 HLA-B*27-positive patients diagnosed with Ankylosing Spondylitis(AS) were selected and compared with 73 HLA-B*27-positive healthy *** the study objects are from four regions(Hangzhou,Lishui,Shaoxing and Zhuji) in Zhejiang ***-B*27 targeted DNA was amplified by Amplification-Refractory Mutation Systems,and then HLA-B*27 subtypes were characterized by using polymerase chain reaction amplification with a sequence-specific *** 25 subtypes screened,four HLAB*27 subtypes were identified:HLA-B*2704,HLA-B*2705,HLA-B*2706 and HLA-B*2715,among which,HLA-B*2704 was the predominant one,with an average of 86.3%(82/95) in AS *** percentages of HLA-B*2704 subtypes varied in four regions:86.4%(19/22) in Hangzhou,74.1%(20/27) in Lishui,96.6%(28/29) in Shaoxing and 88.2%(15/17) in ***-B*2705 was relatively low in patients from four ***-B*2715,a rare allele,was found in 2 patients(2/27) from Lishui but not patients from the other three *** studies show that the overall frequency of HLA-B*2704 and HLA-B*2705 in Zhejiang province is similar as other regions of *** frequency of HLA-B*2704 in Shaoxing is the highest and close to the one in *** study meets our hypothesis that the Chinese population have a large HLA-B*27 genetic diversity,and we observe such diversity within one ***,the finding of HLA-B*2715 only in patients from Lishui,a mountainous region with complex terrains different from other three regions,implies a potential association of HLA-B*2715 to specific geographic areas.

关键词： Human leukocyte antigen Zhejiang HLA-B*27 Subtypes Ankylosing spondylitis

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Bone Research 2024年第2期12卷 241-254页

作者： Dinglong Yang Jiawen xu Ke xu Peng xu Department of Joint Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054China Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengdu 610041China

The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the *** its various forms,skeletal interoception specifically regulates the metabolic homeostasis of ***(OA)is a complex joint disorder involving cartilage,subchondral bone,and *** subchondral bone undergoes continuous remodeling to adapt to dynamic joint *** findings highlight that skeletal interoception mediated by aberrant mechanical loads contributes to pathological remodeling of the subchondral bone,resulting in subchondral bone sclerosis in *** skeletal interoception is also a potential mechanism for chronic synovial inflammation in *** this review,we offer a general overview of interoception,specifically skeletal interoception,subchondral bone microenviroment and the aberrant subchondral *** also discuss the role of skeletal interoception in abnormal subchondral bone remodeling and synovial inflammation in OA,as well as the potential prospects and challenges in exploring novel OA therapies that target skeletal interoception.

关键词： homeostasis inflammation releasing

儿童骨肿瘤术后下肢不等长治疗策略的研究进展

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中华骨科杂志 2024年第10期44卷 700-707页

作者：徐鸿锋刘巍峰首都医科大学附属北京积水潭医院(北京大学第四临床医学院)骨肿瘤科北京100035

过去十年,儿童骨肿瘤领域下肢延长技术研究进展显著,以ilizarov牵张成骨为核心,通过个体化调整牵拉速度促进新生骨生成。外固定装置(如Ilizarov环形架和单边支架)虽操作便捷,但疗程长、并发症多,而优化固定方法和药物辅助再生成为研究... 详细信息

过去十年,儿童骨肿瘤领域下肢延长技术研究进展显著,以ilizarov牵张成骨为核心,通过个体化调整牵拉速度促进新生骨生成。外固定装置(如Ilizarov环形架和单边支架)虽操作便捷,但疗程长、并发症多,而优化固定方法和药物辅助再生成为研究热点。针对特定情况(如骨缺损<5 cm),骨骺生长调节技术可提供治疗选项。可延长假体,尤其是针对大段骨缺损,其微创和无创设计减少了并发症,但仍需改进材料、结构以应对感染和机械故障。髓内延长钉(如Precice钉)表现出高舒适度和低感染风险,但并发症管理不可忽视。目前治疗策略强调个性化,通过改进材料和固定技术缩短治疗周期,降低并发症发生率。未来国产化骨延长技术的发展与成本降低是研究与实践的关键,旨在提升儿童骨肿瘤手术后下肢不等长患儿的生活质量和减少并发症的发生率。

关键词：儿童骨肿瘤下肢骨延长术

Malware Evasion Attacks Against IoT and Other Devices: An Empirical Study

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Tsinghua Science and Technology 2024年第1期29卷 127-142页

作者： Yan xu Deqiang Li Qianmu Li Shouhuai xu School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Computer Science University of Colorado Colorado SpringsColorado SpringsCO 80918USA

The Internet of Things(loT)has grown rapidly due to artificial intelligence driven edge *** enabling many new functions,edge computing devices expand the vulnerability surface and have become the target of malware ***,attackers have used advanced techniques to evade defenses by transforming their malware into functionality-preserving *** systematically analyze such evasion attacks and conduct a large-scale empirical study in this paper to evaluate their impact on *** specifically,we focus on two forms of evasion attacks:obfuscation and adversarial *** the best of our knowledge,this paper is the first to investigate and contrast the two families of evasion attacks *** apply 10 obfuscation attacks and 9 adversarial attacks to 2870 malware *** obtained findings are as follows.(1)Commercial Off-The-Shelf(COTS)malware detectors are vulnerable to evasion attacks.(2)Adversarial attacks affect COTS malware detectors slightly more effectively than obfuscated malware examples.(3)Code similarity detection approaches can be affected by obfuscated examples and are barely affected by adversarial attacks.(4)These attacks can preserve the functionality of original malware examples.

关键词： Android malware obfuscation adversarial examples