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Vascularization ability of glioma stem cells in different three-dimensional microenvironments

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Regenerative Biomaterials 2024年第1期3卷 34-43页

作者： xuanzhi Wang tao xu Chaoshi Niu Department of Neurosurgery The First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui230036China Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072People's Republic of China Center for Bio-intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in ShenzhenTsinghua UniversityShenzhen 518057People's Republicof China

Glioblastoma(GBM)is among the most common and aggressive adult central nervous system *** prominent charac-teristic of GBM is the presence of abnormal microvessels.A significant correlation between angiogenesis and prognosis has been *** reconstructing this neovascula-rization and tumor microenvironment through personalized in vitro disease models presents a significant ***,it is crucial to develop new anti-angiogenic therapies for *** this study,3D bioprinted glioma stem cell(GSC)-laden hydrogel scaffolds,hybrid Gsc hydrogels and ceil-free hydrogel scaffolds were manufactured to investigate the vas-cularization ability of GsCs in varying 3D microenvironments.

关键词： 3D bioprinting xenograft tumors GSC-laden hydrogel scaffold glioblastoma angiogenesis

Primary frequency control considering communication delay for grid-connected offshore wind power systems

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Global Energy Interconnection 2024年第3期7卷 241-253页

作者： xueping Pan Qijie xu tao xu Jinpeng Guo Xiaorong Sun Yuquan Chen Qiang Li Wei Liang School of Electrical and Power Engineering Hohai UniversityNanjing 211100P.R.China Electric Power Research Institute of State Grid Jiangsu Electric Power Co.Ltd Nanjing 211103P.R.China

Offshore wind farms are becoming increasingly distant from onshore centralized control centers,and the communication delays between them inevitably introduce time delays in the measurement signal of the primary frequency *** causes a deterioration in the performance of the primary frequency control and,in some cases,may even result in frequency instability within the power ***,a frequency response model that incorporates communication delays was established for power systems that integrate offshore wind *** Padéapproximation was used to model the time delays,and a linearized frequency response model of the power system was derived to investigate the frequency stability under different time *** influences of the wind power proportion and frequency control parameters on the system frequency stability were *** addition,a Smith delay compensation control strategy was devised to mitigate the effects of communication delays on the system frequency ***,a power system incorporating offshore wind power was constructed using the MATLAB/Simulink *** simulation results demonstrate the effectiveness and robustness of the proposed delay compensation control strategy.

关键词： Offshore wind power Primary frequency control Time delay Padéapproximation Time-delay compensation control

Parental Educational Expectations,Academic Pressure,and Adolescent Mental Health:An Empirical Study Based on CEPS Survey Data

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International Journal of Mental Health Promotion 2024年第2期26卷 93-103页

作者： tao xu Fangqiang Zuo Kai Zheng Department of Social Work College of International Education and Social DevelopmentZhejiang Normal UniversityJinhua321004China Department of Economics and International Trade School of EconomicsManagement&LawHubei Normal UniversityHuangshi435002China

Background:This study aimed to investigate the relationship between parental educational expectations and adolescent mental health problems,with academic pressure as a moderating ***:This study was based on the baseline data of the China Education Panel Survey,which was collected within one school year during 2013–*** included 19,958 samples from seventh and ninth graders,who ranged from 11 to 18 years *** removing missing values and conducting relevant data processing,the effective sample size for analysis was *** OLS(Ordinary Least Squares)multiple linear regression analysis was used to examine the relationship between parental educational expectations,academic pressure,and adolescents’mental health *** addition,we established an interaction term between parents’educational expectations and academic pressure to investigate the moderating effect of academic ***:The study found that adolescents whose parents had high educational expectations reported less mental health problems.(β=−0.195;p<0.001).Additionally,adolescents who had high academic pressure reported more mental health problems.(β=0.649;p<0.001).Furthermore,the study found that academic pressure had a significant moderating effect on the relationship between parental educational expectations and adolescents’mental health problems(β=0.082;p<0.001).Conclusion:Parental educational expectations had a close relationship with adolescents’mental health problems,and academic pressure moderated this *** those adolescents with high levels of academic pressure,the association between high parental educational expectations and mental health problems became *** the contrary,for those adolescents with low levels of academic pressure,the association between high parental educational expectations and mental health problems became *** findings shed new light on how parental educational expectations affected adolescent mental health problems and h

关键词： Parental educational expectations academic pressure adolescent mental health problems

BACNN: Multi-scale feature fusion-based bilinear attention convolutional neural network for wood NIR classification

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Journal of Forestry Research 2024年第4期35卷 202-214页

作者： Zihao Wan Hong Yang Jipan xu Hongbo Mu Dawei Qi College of Science Northeast Forestry UniversityHarbin 150040People’s Republic of China

Effective development and utilization of wood resources is *** modification research has become an integral dimension of wood science research,however,the similarities between modified wood and original wood render it challenging for accurate identification and classification using conventional image classification ***,the development of efficient and accurate wood classification techniques is *** paper presents a one-dimensional,convolutional neural network(i.e.,BACNN)that combines near-infrared spectroscopy and deep learning techniques to classify poplar,tung,and balsa woods,and PVA,nano-silica-sol and PVA-nano silica sol modified woods of *** results show that BACNN achieves an accuracy of 99.3%on the test set,higher than the 52.9%of the BP neural network and 98.7%of Support Vector Machine compared with traditional machine learning methods and deep learning based methods;it is also higher than the 97.6%of LeNet,98.7%of AlexNet and 99.1%of ***,the classification method proposed offers potential applications in wood classification,especially with homogeneous modified wood,and it also provides a basis for subsequent wood properties studies.

关键词： Wood classification Near infrared spectroscopy Bilinear network SE module Anti-noise algorithm

Visualizing the crystallization of sodium chloride under supersaturated condition

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Nano Research 2024年第8期17卷 7786-7792页

作者： Mao Ye tao xu Yuwei Xiong Yatong Zhu Mingrui Zhou Longxiang Han Jinyi Sun Ming Qin Litao Sun SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationSchool of Integrated CircuitsSoutheast UniversityNanjing 210096China

Crystallization in supersaturated solution plays a fundamental role in a variety of natural and industrial ***,a thorough understanding of crystallization phenomena in supersaturated solution is still difficult because the real-time visualization of crystallization processes under supersaturated condition is a great ***,an electron beam-induced crystallization method was carried out in in situ liquid cell transmission electron microscopy(TEM)to visualize the crystallization of NaCl under supersaturated condition in real *** steps and behaviors in the crystallization of NaCl were captured and clarified,including the growth of NaCl nanocrystals with different morphologies,the formation of initial crystalline seeds from amorphous ion clusters,and the non-equilibrium growth behaviors caused by uneven distribution of precursor *** study provides the real-time visualization of detailed nucleation and growth behaviors in NaCl crystallization and brings an ideal strategy for investigating crystallization phenomena under supersaturated condition.

关键词： crystallization in situ liquid cell transmission electron microscopy(TEM) electron-water interaction sodium chloride

Prevalence and risk evaluation of cardiovascular disease in the newly diagnosed prostate cancer population in China:A nationwide,multi-center,population-based cross-sectional study

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Chinese Medical Journal 2024年第11期137卷 1324-1331页

作者： Weiyu Zhang Huixin Liu Ming Liu Shi Ying Renbin Yuan Hao Zeng Zhenting Zhang Sujun Han Zhannan Si Bin Hu Simeng Wen Pengcheng xu Weimin Yu Hui Chen Liang Wang Zhitao Lin tao Dai Yunzhi Lin tao xu Department of Urology Peking University People’s HospitalBeijing 100044China Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijing 100044China Department of Urology Beijing HospitalNational Center of GerontologyBeijing 100005China Institute of Geriatric Medicine Chinese Academy of Medical SciencesBeijing 100005China Department of Urology Wuhan Union HospitalHuazhong University of Science&TechnologyWuhanHubei 430022China Department of Urology The Third People’s Hospital of ChengduChengduSichuan 610014China Department of Urology West China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Urologic Oncology Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Department of Urology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China National Cancer Center Beijing 100021China National Clinical Research Center for Cancer Beijing 100021China Department of Urology Liaoning Cancer HospitalShenyangLiaoning 110801China Department of Urology The Second Hospital of Tianjin Medical UniversityTianjin 300141China Tianjin Institute of Urology Tianjin Medical UniversityTianjin 300141China Department of Urology Lu’an Affiliated Hospital of Anhui Medical UniversityLu’anAnhui 237322China Department of Urology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Urology Harbin Medical University Affiliated Cancer HospitalHarbinHeilongjiang 150081China Department of Urology The Second Hospital of Dalian Medical UniversityDalianLiaoning 116023China Department of Urology Surgery Fujian Cancer HospitalFuzhouFujian 350014China Department of Urology Surgery Hunan Cancer HospitalChangshaHunan 410031China Department of Urology Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China

Background:Cardiovascular disease(CVD)has emerged as the leading cause of death from prostate cancer(PCa)in recent decades,bringing a great disease burden *** with preexisting CVD have an increased risk for major adverse cardiovascular events when treated with androgen deprivation therapy(ADT).The present study aimed to explore the prevalence and risk evaluation of CVD among people with newly diagnosed PCa in ***:Clinical data of newly diagnosed PCa patients were retrospectively collected from 34 centers in China from 2010 to 2022 through convenience *** was defined as myocardial infarction,arrhythmia,heart failure,stroke,ischemic heart disease,and *** risk was estimated by calculating Framingham risk scores(FRS).Patients were accordingly divided into low-,medium-,and high-risk groups.χ2 or Fisher’s exact test was used for comparison of categorical ***:A total of 4253 patients were enrolled in the present study.A total of 27.0%(1147/4253)of patients had comorbid PCa and CVD,and 7.2%(307/4253)had two or more *** enrolled population was distributed in six regions of China,and approximately 71.0%(3019/4253)of patients lived in urban *** imaging and pathological evaluation,most PCa patients were diagnosed at an advanced stage,with 20.5%(871/4253)locally progressing and 20.5%(871/4253)showing *** of them initiated prostatectomy(46.6%,1983/4253)or regimens involving ADT therapy(45.7%,1944/4253)for prostate *** the present PCa cohort,43.1%(1832/4253)of patients had hypertension,and half of them had poorly controlled blood *** FRS stratification,as expected,a higher risk of CVD was related to aging and metabolic ***,we also found that patients with treatment involving ADT presented an originally higher risk of CVD than those without *** was in accordance with clinical practice,i.e.,aged patients or patients at advanced oncological stages were inclined to accept sys

关键词： Prostate cancer Castration Cardiovascular disease Prevalence Cardiovascular risk

The genesis and resource potential of gold deposits in the Liaodong Peninsula

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Science China Earth Sciences 2024年第3期67卷 657-672页

作者： Rixiang ZHU Jin-Hui YANG Gongwen WANG Qingdong ZENG Guoqiang xuE tao xu Xinghui LI Peng ZHANG Da LEI Guang ZHU State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Shenyang Center China Geological SurveyShenyang 110034China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

Plenty of gold deposits related to Late Mesozoic craton destruction are widely distributed in eastern North China Craton. However, significant differences in research degrees, ore-forming characteristics, and proven reserves exist among different regions in the North China Craton. The Liaodong Peninsula has similar regional geological characteristics to those of the Jiaodong Peninsula, with both experiencing craton destruction during Late Mesozoic, but the two areas have substantial differences in terms of gold mineralization and the proven gold resources. Based on regional geology, Mesozoic magmatictectonic evolution and ore geology, combined with integrated geophysical exploration and big data AI resource prediction, in this paper, we propose that the ore-forming materials of Late Mesozoic gold deposits in Liaodong were mainly originated from mantle-derived melts and/or fluids induced by craton destruction. The gold deposits were primarily controlled by NE-NNEtrending faults, mainly classified as fracture-controlled altered rock-type and sulfide-bearing quartz vein-type. Moreover, our study predicts that the Yalu River fault zone and its related secondary faults, as well as the periphery and deeper parts of known goldfields, are the important regions for future gold resource exploration. The Yalu River metallogenic belt has an enormous potential for gold resources, and the Liaodong Peninsula has a potential to add thousands of tons of gold resources.

关键词： Liaodong Peninsula Gold deposit Integrated geophysical exploration Prospecting potential Direction for prospecting breakthroughs

Multistate circularly polarized luminescence switches based on dual stimuli-responsive chiral [2]rotaxanes

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Science China Chemistry 2024年

作者： Wei-tao xu xue Li Xiao-Qin xu xu-Qing Wang Hai-Bo Yang Wei Wang Wuhu Hospital East China Normal University (The Second People's Hospital Wuhu) Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular and Process Engineering School of Chemistry and Molecular Engineering East China Normal University Shanghai Center of Brain-inspired Intelligent Materials and Devices East China Normal University

Aiming at the construction of novel multistate circularly polarized luminescence(CPL) switches, dual stimuli-responsive chiral[2]rotaxanes towards anions and light have been designed and constructed. Through the light-controlled on/off F?rster resonance energy transfer(FRET) switching between the emissive stoppers and anion-induced controllable motions of the chiral wheel for the precise regulations of chirality information transfer from the chiral wheel to the emissive stoppers, precisely switching between four CPL emission states with varied emission wavelengths and dissymmetry factors has been successfully realized,making them a promising platform for practical uses such as information storage and encryption. This proof-of-concept study not only provides a novel design strategy for multistate CPL switching but also contributes excellent candidates for the construction of novel smart chiral luminescent materials.

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The seismicity in the middle section of the Altyn Tagh Fault system revealed by a dense nodal seismic array

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Earthquake Research Advances 2024年第3期4卷 7-15页

作者： Shi Yao tao xu Yingquan Sang Lingling Ye Tingwei Yang Chenglong Wu Minghui Zhang Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen518055China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing100029China University of Chinese Academy of Sciences Beijing100049China School of Information Engineering Shandong University of AeronauticsBinzhou256603China

The left-lateral Altyn Tagh Fault(ATF) system is the northern boundary of the Qinghai-Xizang Plateau, separating the Tarim Basin and the Qaidam Basin. The middle section of ATF has not recorded any large earthquakes since1598 AD, so the potential seismic hazard is unclear. We develope an earthquake catalog using continuous waveform data recorded by the Tarim-Altyn-Qaidam dense nodal seismic array from September 17 to November23, 2021 in the middle section of ATF. With the machine learning-based picker, phase association, location, match and locate workflow, we detecte 233 earthquakes with M_L-1–3, far more than 6 earthquakes in the routine catalog. Combining with focal mechanism solutions and the local fault structure, we find that seismic events are clustered along the ATF with strike-slip focal mechanisms and on the southern secondary faults with thrusting focal mechanisms. This overall seismic activity in the middle section of the ATF might be due to the northeastward transpressional motion of the Qinghai-Xizang Plateau block at the western margin of the Qaidam Basin.

关键词： Altyn Tagh Fault Machine learning Seismicity Dense seismic array