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Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui xu Linxi Li Yunxiang Ji Yezhong Wang Yingjia Li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

高压开关柜可调节式接地手车与防倾倒转运手车研究

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今日自动化 2023年第11期 106-108页

作者：郝金娜孟圆张语哲李星宇许淑健国网天津宝坻供电分公司天津301800

变电站常用的铠装手车式开关柜在母线停电检修工作中,需要在柜内上口或下口接地,并转运停电的开关手车。提出可调节式接地手车的制造方案,将传统的柜内上口接地和下口接地手车合而为一,并指出防倾倒转运手车的制造原理,有效地避免出现... 详细信息

变电站常用的铠装手车式开关柜在母线停电检修工作中,需要在柜内上口或下口接地,并转运停电的开关手车。提出可调节式接地手车的制造方案,将传统的柜内上口接地和下口接地手车合而为一,并指出防倾倒转运手车的制造原理,有效地避免出现开关柜停电后打开柜内隔离板进行验电的风险情形,同时避免了转运手车过程中的倾覆风险,提升了运维操作班组的工作效率。

关键词：可调节接地手车转运手车安全可靠性

Organic polystyrene and inorganic silica double shell protected lead halide perovskite nanocrystals with high emission efficiency and superior stability

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Nano Research 2023年第7期16卷 10507-10514页

作者： shujian Wang Dejian Chen Kunyuan xu Jie Hu Decai Huang Maochun Hong Haomiao Zhu University of Science and Technology of China Hefei 230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Research Center of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China

The practical application of all-inorganic semiconductor lead halide perovskite nanocrystals(LHP NCs)has been limited by their poor ***,a lot of research on core-shell structure has been done to improve the stability of perovskite NCs,but the effect was far from the application ***,we,for the first time,report a convenient approach to synthesize organic-inorganic double shell CsPbBr_(3)@SiO_(2)@polystyrene(PS)NCs with an inter-core of CsPbBr_(3),the intermediate layer of SiO_(2)shell,and outmost PS ***,the CsPbBr_(3)@SiO_(2)@PS NCs maintained more than 90%of their initial photoluminescence(PL)intensity under one month's ultraviolet lamp irradiation or in 85℃ and 85%relative humidity(RH)*** white-light-emitting-diodes(WLEDs)were fabricated by encapsulating commercial InGaN chip with CsPbBr_(3)@SiO_(2)@PS NCs and K2SiF6:Mn^(4+)(KSF:Mn^(4+))phosphor with a luminous efficacy of~100 lm/W at 20 mA current and a color gamut of 128%of the National Television Standards Committee(NTSC)*** addition,these WLEDs still maintain 91%of the initial luminous efficacy after 1200 h of continuous *** results demonstrated that double shell-protected CsPbBr_(3)perovskite NCs have great potential in the field of WLEDs.

关键词： core-shell structure organic polystyrene(PS)inorganic SiO_(2)double shell CsPbBr_(3)@SiO_(2)@PS nanocrystals(NCs) high stability

Rational design of lipid-activatable NIR-II probes for precisely imaging atherosclerotic plaque

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Science China Chemistry 2025年

作者： Xinyu xu Yuan Ma Hui Cao Li xu Haoming Chen Sulai Liu Wei Sun Guosheng Song Xiaobing Zhang State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University Department of Hepatobiliary Surgery/Central Laboratory Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical University Shenzhen Research Institute of Hunan University

Atherosclerosis(AS) is a prevalent condition associated with cardiovascular and cerebrovascular diseases, featuring lipid-laden plaque; however, the insufficient resolution and low sensitivity of traditional medical imaging techniques limit their application in lipid imaging. Currently, the second near-infrared(NIR-II) fluorescence imaging offers promising sensitivity and convenience. However, existing probes have limitations in terms of signal-to-background ratio, penetration depth, and tissue scattering. Herein, we use a molecular regulatory strategy to design a lipid-activatable probe Rh-965 with high specificity and NIR-II emission for improved imaging potential in deep tissues. The potential of Rh-965 for imaging plaque lipids in mice with AS is demonstrated by localizing carotid artery plaques using NIR-II imaging. The development of more stable lipid-activated NIR-II probes can significantly enhance atherosclerosis diagnosis and facilitate in vivo imaging in deeper tissues.

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High-precision tip positioning composite feedforward control of linear colocated motion systems with Bi-Loop iterative feedforward tuning

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Science China Technological Sciences 2025年

作者： Junyu HU Yourui TAO Shanhu LI xu HAN College of Mechanical and Vehicle Engineering Hunan University State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of Technology

To enhance the tip positioning accuracy and robustness against disturbances of linear colocated motion systems, a novel composite feedforward (COMFF) control with Bi-Loop iterative feedforward tuning (IFFT) is proposed. The tip positioning error consists of the coupled tip residual vibration and linear motor tracking error. Given the influence of nonlinear friction and load flexibility, the topology of COMFF is designed as decoupled structures so that COMFF can suppress the tip residual vibration and compensate for the linear motor tracking error compatibly. Furthermore, Bi-Loop IFFT is built to improve the robustness of COMFF in high-precision motor tracking performance. In the state space of the linear motor tracking error based on the projection theorem, two loops are performed in parallel along the iteration direction. One is the P-type iteration loop that drives linear motor tracking errors to converge to the zero state. The other is the observation loop constructed by the recursive least square with forgetting factors to accelerate the P-type iteration loop. Driven by the P-type iteration loop with the aid of the observation loop, the proposed COMFF is integrated with fast convergence and high robustness when confronted with model disturbances. The effectiveness of the proposed COMFF combined with Bi-Loop IFFT is validated by experiments.

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Effects of mesoscale gravity waves on sporadic E simulated by a one-dimensional dynamic model

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Earth and Planetary Physics 2025年第1期9卷 1-9页

作者： xu Zhou ZeZhong Li XinAn Yue LiBo Liu Key Laboratory of Earth and Planetary Physics/Heilongjiang Mohe National Geophysical Observatory/Beijing National Observatory of Space Environment Institute of Geology and GeophysicsChinese Academy of Sciences(CAS)Beijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China

In addition to being driven by tidal winds,the sporadic E(Es)layers are modulated by gravity waves(GWs),although the effects are not yet comprehensively *** this article,we discuss the effects of mesoscale GWs on the Es layers determined by using a newly developed model,MISE-1D(one-dimensional Model of Ionospheric Sporadic E),with low numerical dissipation and high *** by the wind fields resolved by the high-resolution version of the Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension(WACCM-X),the MISE-1D simulation revealed that GWs significantly influence the evolution of the Es layer above 100 km but have a very limited effect at lower *** effects of GWs are diverse and complex,generally including the generation of fluctuating wavelike structures on the Es layer with frequencies similar to those of the *** mesoscale GWs can also cause increases in the density of Es layers,or they can disperse or diffuse the Es layers and increase their *** addition,the presence of GWs is a key factor in sustaining the Es layers in some cases.

关键词： sporadic E ion tidal layer gravity waves numerical simulation

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健康度驱动的炼油设备动态风险评价方法研究

工业安全与环保 2024年第9期50卷 28-34页

作者：许述剑王庆锋刘晓金刘曦泽宁志康中石化安全工程研究院有限公司山东青岛266100 北京化工大学北京100029

针对传统的设备健康状态评价是基于振动烈度等单一性能指标表征,未全面描述设备性能状态并归一化,以及传统的设备风险评价取决于失效后果和基于历史数据概率统计获得的失效概率,属于静态风险模型,难以评价设备的运行风险,提出一种实时... 详细信息

针对传统的设备健康状态评价是基于振动烈度等单一性能指标表征,未全面描述设备性能状态并归一化,以及传统的设备风险评价取决于失效后果和基于历史数据概率统计获得的失效概率,属于静态风险模型,难以评价设备的运行风险,提出一种实时监测数据健康度驱动的设备动态风险评价模型和方法。创新构建了振动信号谱距离指标/互相关/凝聚系数的转动设备、基于失效敏感特征参数的承压设备的健康度模型,首创实时监测数据健康度驱动的设备动态风险评价方法,依据健康度及风险状况指导企业及时开展设备预知性维修。最后,采用工程案例验证了本文提出的模型和方法,并在试点企业93台设备上开展工业应用,表明本模型比传统的固定阈值限报警提前不低于28 h,预警准确率92.98%,避免了多次非计划停机。

关键词：炼油设备健康度动态风险评价方法数据驱动

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi Lin Ruian xu Lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming