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Multifunctional Peptide-Melanin Hybrid Nanodots with Robust Anti-Cutaneous Photoaging Activity

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Journal of Analysis and Testing 2024年第03期8卷 395-401页

作者： Peizhe Li qiming Zhu Baozhu Wang Shanshan He qi xu Kaiyan Li Yongmiao shen Miao Su Zhijun Zhang Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province School of Chemistry and Chemical Engineering Zhejiang Sci-Tech University College of Textile Science and Engineering (International Silk Institute) Zhejiang Sci-Tech University Shanghai Beautyart Biotechnology Co. Ltd. shengzhou Innovation Research Institute of Zhejiang SciTech University

Skin aging is a systematic and complex process, mainly including intrinsic aging caused by time change and extrinsic aging caused by environmental factors. Photoaging caused by ultraviolet (UV) irradiation is the principle extrinsic factor of skin aging, which can directly or indirectly cause damage to DNA and other biomolecules, generate reactive oxygen species(ROS), and induce a decrease in collagen synthesis and other adverse eff ect. Herein, to address the causative factors and multiple side eff ects of skin photoaging, we constructed multifunctional peptide-melanin hybrid nanodots (PMHDs) to achieve multifaceted synergistic anti-skin aging by using melanin-like nanodots (MDs) and functional peptides as active *** them, the peptide has the activity of promoting collagen synthesis, while the MDs have the function of absorbing UV light and scavenging free radicals. Additionally, the MDs also act as a carrier to increase the cellular uptake of the *** anti-photoaging eff ects of the PMHDs were systematically verifi ed in a multidimensional manner at the biochemical,cellular and small animal levels, respectively.

关键词： Nanodots

Yangtze River Delta Aerosol liquid water in PM_(2.5)and its roles in secondary aerosol formation at a regional site of Yangtze River Delta

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Journal of Environmental Sciences 2024年第4期138卷 684-696页

作者： Ruifang Shi Fei Zhang Yemin shen Jiasi shen Bingye xu Binyu Kuang Zhengning xu Lingling Jin qian Tang xudong Tian Zhibin Wang College of Environmental and Resource Sciences Zhejiang Provincial Key Laboratory of Organic Pollution Process and ControlZhejiang UniversityHangzhou 310058China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Zhejiang Ecological and Environmental Monitoring Center Hangzhou 310012China

Aerosol liquid water content(ALWC)plays an important role in secondary aerosol *** this study,a whole year field campaign was conducted at Shanxi in north Zhejiang Province during *** estimated by ISORROPIA-Ⅱ was then investigated to explore its characteristics and relationship with secondary *** exhibited a highest value in spring(66.38μg/m^(3)),followed by winter(45.08μg/m^(3)),summer(41.64μg/m^(3)),and autumn(35.01μg/m^(3)),*** was supposed that the secondary inorganic aerosols(SIA)were facilitated under higher ALWC conditions(RH>80%),while the secondary organic species tended to form under lower ALWC *** RH(>80%)promoted the NO_(3)^(-)formation via gas-particle partitioning,while SO_(4)^(2-)was generated at a relative lower RH(>50%).The ALWC was more sensitive to NO_(3)^(-)(R=0.94)than SO_(4)^(2-)(R=0.90).Thus,the self-amplifying processes between the ALWC and SIA enhanced the particle mass *** sensitivity of ALWC and OX(NO_(2)+O_(3))to secondary organic carbon(SOC)varied in different seasons at Shanxi,more sensitive to aqueous-phase reactions(daytime R=0.84;nighttime R=0.54)than photochemical oxidation(daytime R=0.23;nighttime R=0.41)in wintertime with a high level of OX(daytime:130-140μg/m^(3);nighttime:100-140μg/m^(3)).The self-amplifying process of ALWC and SIA and the aqueous-phase formation of SOC will enhance aerosol formation,contributing to air pollution and reduction of visibility.

关键词： Aerosol liquid water content Nitrate Sulfate Secondary organic compounds Aqueous-phase reaction

A review of in situ carbon mineralization in basalt

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1467-1485页

作者： Xiaomin Cao qi Li Liang xu Yongsheng Tan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Global warming has greatly threatened the human living environment and carbon capture and storage(CCS)technology is recognized as a promising way to reduce carbon *** storage is considered a reliable option for long-term carbon *** rich in alkaline earth elements facilitates rapid and permanent CO_(2) fixation as ***,the complex CO_(2)-fluid-basalt interaction poses challenges for assessing carbon storage *** different reaction conditions,the carbonation products and carbonation rates *** mineralization reactions also induce petrophysical and mechanical responses,which have potential risks for the long-term injectivity and the carbon storage safety in basalt *** this paper,recent advances in carbon mineralization storage in basalt based on laboratory research are comprehensively *** assessment methods for carbon storage potential are introduced and the carbon trapping mechanisms are investigated with the identification of the controlling *** in pore structure,permeability and mechanical properties in both static reactions and reactive percolation experiments are also *** study could provide insight into challenges as well as perspectives for future research.

关键词： Carbon mineralization Basalt CO_(2)-fluid-basalt interaction Petrophysical evolution Mechanical response Carbon capture and storage(CCS)

Non-uniform thermal behavior of single-layer spherical reticulated shell structures considering time-variant environmental factors: analysis and design

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 223-237页

作者： Wucheng xu Xiaoqing ZHENG xuanhe ZHANG Zhejie LAI Yanbin shen College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China Center for Balance Architecture Zhejiang UniversityHangzhou 310028China Innovation Center of Yangtze River Delta Zhejiang UniversityJiaxing 314100China Zhejiang Provincial Key Laboratory of Space Structures Zhejiang UniversityHangzhou 310058China

Contrary to conventional design methods that assume uniform and slow temperature changes tied to atmospheric conditions,single-layer spherical reticulated shells undergo significant non-uniform and time-variant temperature variations due to dynamic environmental *** differences can affect structural performance and pose safety ***,a systematic numerical method was developed and applied to simulate long-term temperature variations in such a structure under real environmental conditions,revealing its non-uniform distribution characteristics and time-variant regularity.A simplified design method for non-uniform thermal loads,accounting for time-variant environmental factors,was theoretically derived and validated through experiments and *** maximum deviation and mean error rate between calculated and tested results were 6.1℃ and 3.7%,*** temperature fields aligned with simulated ones,with deviations under 6.0℃.Using the design method,non-uniform thermal effects of the structure are *** member stress and nodal displacement under non-uniform thermal loads reached 119.3 MPa and 19.7 mm,representing increases of 167.5%and 169.9%,respectively,compared to uniform thermal *** impacts of healing construction time on non-uniform thermal effects were evaluated,resulting in construction *** methodologies and conclusions presented here can serve as valuable references for the thermal design,construction,and control of single-layer spherical reticulated shells or similar structures.

关键词： Non-uniform temperature field Non-uniform thermal load Non-uniform thermal effect Single-layer spherical reticulated shell Time-variant environmental factor

Alkylene-functionality in bridged and fused nitrogen-rich poly-cyclic energetic materials:Synthesis,structural diversity and energetic properties

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Defence Technology（防务技术） 2024年第5期35卷 18-46页

作者： Man xu Nanxi Xiang Ping Yin qi Lai Siping Pang School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

From the standpoint of chemical structures,the organic backbones of energetic materials can be classified into aromatic rings,nonaromatic rings,and open *** the category of aromatic energetic compounds exhibits several advantages in the regulation of energetic properties,the nonaromatic heterocycles,assembling nitramino explosophores with simple alkyl bridges,still have prevailed in benchmark *** methylene bridge plays a pivotal role in the constructions of the classic nonaromatic heterocycle-based energetic compounds,e.g.,hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX)and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX),whereas ethylene bridge is the core moiety of state-of-the-art explosive 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20).In this context,it is of great interest to employ simple and practical bridges to assemble aromatic and nonaromatic nitrogen-rich heterocycles,thereby expanding the structural diversity of energetic materials,e.g.,bridged and fused nitrogen-rich ***,alkyl-bridged poly-heterocycles highlight the potential for the open chain type of energetic *** this review,the development of alkyl bridges in linking nitrogen-rich heterocycles is presented,and the perspective of the newly constructed energetic backbones is summarized for the future design of advanced energetic materials.

关键词： Energetic materials Alkyl bridge strategy Nitrogen-rich azoles Fused heterocycles Azoles

Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea

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Defence Technology（防务技术） 2024年第1期31卷 179-191页

作者： Shiyu Jia Cheng Wang Wenlong xu Dong Ma Fangfang qi State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute for Advanced Technology Shandong UniversityJinan250061China

In recent years,explosion shock wave has been considered as a signature injury of the current military *** strong shock wave is lethal to the human body,weak shock wave can cause many more lasting *** investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual *** results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not *** shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic *** overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample *** the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three *** this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are *** layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective *** the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm *** overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of s

关键词： Free-field explosion Weak shock wave mitigation Polyurea Polyurethane foam Multi-layered composites

Jet Characteristics and Optimization of a Cavitation Nozzle for Hydraulic Fracturing Applications

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Fluid Dynamics & Materials Processing 2024年第1期20卷 179-192页

作者： Yu Gao Zhenqiang xu Kaixiang shen shenzhen South China Sea Oil Economic Development Co. Ltd.Shenzhen518000China Guangzhou Marine Geological Survey China Geological SurveyGuangzhou511458China National Engineering Research Center of Gas Hydrate Exploration and Development Guangzhou511458China

Hydraulic jetting is a form of fracturing that involves using a high-pressure jet of water to create fractures in the reservoir rock with a nozzle serving as the central component of the hydraulic sandblasting perforation *** this study,the flow behavior of the nozzle is simulated numerically in the framework of a SST k-ωturbulence *** results show that the nozzle structure can significantly influence the jet performance and related cavitation *** orthogonal experiments,the nozzle geometric parameters are optimized,and the following configuration is found accordingly:contraction angle 20°,contraction segment length 6 mm,cylindrical segment diameter 6 mm,cylindrical segment length 12 mm,spread segment length 10 mm,and spread angle 55°.

关键词： Cavitation jet angle nozzle hydraulic characteristics nozzle parameters

Intravitreal conbercept injection with panretinal photocoagulation for high-risk proliferative diabetic retinopathy with vitreous hemorrhage

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1066-1072页

作者： Yao xu qing Ye Wei shen Department of Ophthalmology the Fourth Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedcineSuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

AIM:To assess the clinical efficacy and safety of combining panretinal photocoagulation(PRP)with intravitreal conbercept(IVC)injections for patients with high-risk proliferative diabetic retinopathy(HR-PDR)complicated by mild or moderate vitreous hemorrhage(VH),with or without diabetic macular edema(DME).METHODS:Patients diagnosed with VH with/without DME secondary to HR-PDR and received PRP combined with IVC injections were recruited in this retrospective *** establishing the patient’s diagnosis,an initial IVC was performed,followed by prompt administration of *** cases who significant bleeding persisted and impeded the laser operation,IVC was sustained before supplementing with *** the completion of PRP,patients were meticulously monitored for a minimum of six *** therapy and IVC injections were judiciously adjusted based on fundus fluorescein angiography(FFA)*** effect and the incidence of adverse events were ***:Out of 42 patients(74 eyes),29 were male and 13 were female,with a mean age of 59.17±12.74y(33-84y).The diabetic history was between 1wk and 26y,and the interval between the onset of visual symptoms and diagnosis of HR-PDR was *** affected eye received 2.59±1.87(1-10)IVC injections and underwent 5.5±1.02(4-8)sessions of *** these,68 eyes received PRP following 1 IVC injection,5 eyes after 2 IVC injections,and 1 eye after 3 IVC *** absorption of VH was observed in all 74 eyes 5-50wk after initial treatment,with resolution of DME in 51 eyes 3-48wk after initial treatment.A newly developed epiretinal membrane was noted in one *** acuity significantly improved in 25 *** complications such as glaucoma,retinal detachment,or endophthalmitis were ***:The study suggests that the combination of PRP with IVC injections is an effective and safe modality for treating diabetic VH in patients with HR-PDR.

关键词： conbercept panretinal photocoagulation high-risk proliferative diabetic retinopathy vitreous hemorrhage

Prognostic analysis of related factors of adverse reactions to immunotherapy in advanced gastric cancer and establishment of a nomogram model

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1268-1280页

作者： xu-xu He Bang Du Tao Wu Hao shen Department of Surgery Fudan University Affiliated Zhongshan Hospital(Qingpu Branch)Shanghai 201700China Department of Surgery Anhui Provincial Red Cross Society HospitalHefei 230031Anhui ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Immunotherapy for advanced gastric cancer has attracted widespread attention in recent ***,the adverse reactions of immunotherapy and its relationship with patient prognosis still need further *** order to determine the association between adverse reaction factors and prognosis,the aim of this study was to conduct a systematic prognostic *** comprehensively evaluating the clinical data of patients with advanced gastric cancer treated by immunotherapy,a nomogram model will be established to predict the survival status of patients more *** To explore the characteristics and predictors of immune-related adverse reactions(irAEs)in advanced gastric cancer patients receiving immunotherapy with programmed death protein-1(PD-1)inhibitors and to analyze the correlation between irAEs and patient *** A total of 140 patients with advanced gastric cancer who were treated with PD-1 inhibitors in our hospital from June 2021 to October 2023 were *** were divided into the irAEs group and the non-irAEs group according to whether or not irAEs *** features,manifestations,and prognosis of irAEs in the two groups were collected and analyzed.A multivariate logistic regression model was used to analyze the related factors affecting the occurrence of irAEs,and the prediction model of irAEs was *** receiver operating characteristic(ROC)curve was used to evaluate the ability of different indicators to predict irAEs.A Kaplan-Meier survival curve was used to analyze the correlation between irAEs and *** Cox proportional risk model was used to analyze the related factors affecting the prognosis of *** A total of 132 patients were followed up,of whom 63(47.7%)developed *** looked at the two groups’clinical features and found that the two groups were statistically different in age≥65 years,Ki-67 index,white blood cell count,neutrophil count,and regulatory T cell(Treg)count

关键词： Advanced gastric cancer Prognostic analysis Immunotherapy Nomogram model