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Research 2024年第1期2023卷 81-95页

作者： Fangxuan Chu Ruxin Tan Xin Wang Xiaoqing Zhou Ren Ma Xiaoxu Ma ying Li Ruixu Liu Chunlan Zhang xu Liu Tao Yin Zhipeng Liu Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Tianjin Institutes of Health Science Tianjin301600China Neuroscience Center Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing100730China

The neuropathological features of Alzheimer’s disease include amyloid *** emerging evidence suggests that Piezo1,a mechanosensitive cation channel,plays a critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure,but the importance of Piezo1-mediated mechanotransduction in brain functions is less ***,apart from mechanical stimulation,Piezo1 channels are strongly modulated by *** assume that Piezo1 may play a role in converting mechanical and electrical signals,which could induce the phagocytosis and degradation of Aβ,and the combined effect of mechanical and electrical stimulation is superior to single mechanical ***,we design a transcranial magneto-acoustic stimulation(TMAS)system,based on transcranial ultrasound stimulation(TUS)within a magnetic field that combines a magnetoacoustic coupling effect electric field and the mechanical force of ultrasound,and applied it to test the above hypothesis in 5xFAD *** tests,in vivo electrophysiological recordings,Golgi–Cox staining,enzyme-linked immunosorbent assay,immunofluorescence,immunohistochemistry,real-time quantitative PCR,Western blotting,RNA sequencing,and cerebral blood flow monitoring were used to assess whether TMAS can alleviate the symptoms of AD mouse model by activating Piezo1.

关键词： stimulation Alzheimer Piezo1

Laboratory evaluation of high-friction thin overlays for pavement preservation

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 936-948页

作者： Ouming xu Rentao xu Lintong JIN School of Highway Chang’an UniversityXi’an 710064China School of Materials Science and Engineering Chang’an UniversityXi’an 710061China

Traditional asphalt concrete(AC)and stone matrix asphalt(SMA),which are used as thin asphalt overlays,are common maintenance strategies to enhancing ride quality,skid resistance,and ***,several studies have used a novel asphalt mixture known as a high-friction thin overlay(HFTO)to improve surface ***,it remains uncertain whether the laboratory properties of HFTO differ significantly from those of conventional *** study aims to evaluate the laboratory properties of HFTO mixtures and compare them with those of AC and *** mixtures with nominal maximum size of 9.5 mm were produced in the laboratory,and performance tests were conducted,including wheel tracking test,low temperature flexural creep test,moisture susceptibility test,Cantabro Abrasion Test,Marshall Test,sand patch test,British pendulum test,and indoor tire-rollingdown *** results showed that the HFTO exhibited a lower tire/pavement noise than the AC and ***,HFTO had superior high-temperature stability,larger macro texture,and higher skid resistance in comparison to those of AC,but lower than those of ***,HFTO mixtures may be considered a suitable replacement for traditional AC mixtures in regions where skid resistance and noise reduction are concerns.

关键词： road engineering pavement maintenance high friction thin overlay performance skid resistance tire/pavement noise

Phanerozoic Tectonic Evolution,Metallogenesis and Formation of Mineral Systems in China

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 819-842页

作者： CHEN xuanhua HAN Lele DING Weicui xu Shenglin TONG ying ZHANG Yiping LI Bing ZHOU Qi WANG Ye SinoProbe Laboratory Chinese Academy of Geological SciencesBeijing 100037China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

The continental Asia is mainly composed of three major tectonic regimes,the Tethys,Paleo Asian Ocean,and West *** underwent multi-stage plate convergences,ocean-continent transformations,and subductions,collisions and/or collages,and post collisional(orogenic)extensions in *** evolution of the Asia brings up a unique fault system and tectonic geomorphological features in the China's ***,it provides a geodynamic background for the formation and evolution of metallogeneses and mineral systems,resulting in nonuniform distribution of tectono-metallogenic systems and metallogenic *** spatiotemporal distribution of mineral deposits in China and adjacent areas exhibits periodic variation under controlling of the full life Wilson cycle and tectonic evolution,forming the plate convergence-related mineral system in East *** Cu deposits are mainly related to compressional systems in Paleozoic and early Mesozoic,and more closely related to post-collision extensional settings in late Mesozoic and *** Au deposits mainly formed in post-orogeny extensional *** rock related rare earth element deposits formed mainly at margins of the North China and Yangtze ***-pegmatite Li and other rare metal deposits formed mainly in early Mesozoic,related to Indosinian post-orogeny ***-metallogenic systems provide important basis for the prospecting of mineral resources.

关键词： tectonic evolution geodynamic system post-orogenic extension metallogenesis tectono-metallogenic system East Asia

金华猪分子遗传标记及其DNA多态性的研究进展

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中国畜牧杂志 2008年第13期44卷 57-61页

作者：赵青钟土木徐宁迎金华职业技术学院浙江金华321017 浙江加华种猪有限公司浙江金华321053 浙江大学动物科学学院浙江杭州310029

DNA多态性遗传标记可以是单位点和多位点,多态性可根据各种来源和不同的实验室检测技术进行分类,本文对近几年金华猪的一些数量性状位点的研究进展进行了综述,如雌激素受体基因、卵泡刺激素β基因、催乳素受体基因、心脏脂肪酸结合蛋白... 详细信息

DNA多态性遗传标记可以是单位点和多位点,多态性可根据各种来源和不同的实验室检测技术进行分类,本文对近几年金华猪的一些数量性状位点的研究进展进行了综述,如雌激素受体基因、卵泡刺激素β基因、催乳素受体基因、心脏脂肪酸结合蛋白基因、肌细胞生成素等,并提出了今后值得关注的几个研究方向。

关键词： DNA 多态性标记金华猪

Elimination of GGTA1,CMAH,β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions

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Animal Models and Experimental Medicine 2024年第4期7卷 584-590页

作者： Jing xu Jilong Ren Kai xu Minghui Fang Meina Ka Fei xu Xin Wang Jing Wang Zhiqiang Han Guihai Feng ying Zhang Tang Hai Wei Li Zheng Hu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Key Laboratory of Organ Regeneration and Reconstruction Chinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First HospitalJilin UniversityChangchunChina Beijing Farm Animal Research Center Institute of ZoologyChinese Academy of SciencesBeijingChina

Background:Pig organ xenotransplantation is a potential solution for the severe organ shortage in clinic,while immunogenic genes need to be eliminated to im-prove the immune compatibility between humans and *** knockout strat-egies are mainly aimed at the genes causing hyperacute immune rejection(HAR)that occurs in the first few hours while adaptive immune reactions orchestrated by CD4 T cell thereafter also cause graft failure,in which process the MHC II molecule plays critical ***:Thus,we generate a 4-gene(GGTA1,CMAH,β4GalNT2,and CIITA)knockout pig by CRISPR/Cas9 and somatic cell nuclear transfer to compromise HAR and CD4 T cell reactions ***:We successfully obtained 4KO piglets with deficiency in all alleles of genes,and at cellular and tissue ***,the safety of our animals after gene editing was verified by using whole-genome sequencing and *** have survived for more than one year in the barrier,and also survived for more than 3 months in the conventional environment,suggesting that the piglets without MHC II can be raised in the barrier and then gradually mated in the conventional ***:4KO piglets have lower immunogenicity,are safe in genomic level,and are easier to breed than the model with both MHC I and II deletion.

关键词： CD4 T cell genetically edited pig immune rejection major histocompatibility complex II xenotransplantation

Vertebral Artery Stenting for Acute Multiple Cerebral Infarctions Caused by Vertebral Artery Dissection After Massage:A Case Report

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Chinese Medical Sciences Journal 2024年第2期39卷 149-154页

作者： ying-xue Cui Chuan-Jin Song xue-Si Hou Gui-Lin Liu xu Ji Shao-Song Wang Department of Neurology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China

Vertebral artery dissection is a rare pathology that can cause ischemic stroke in young *** massage,especially improper pulling manipulation,is a cause of vertebral artery *** present a case of 32-year old woman who developed acute multiple posterior circulation ischemic cerebral infarctions as a result of left vertebral artery V4 segment dissection after receiving neck *** underwent emergency vertebral artery stent implantation at the site of the *** were relieved the day after *** patient recovered without adverse complications or endovascular restenosis in the following year.

关键词： vertebral artery dissection acute ischemic stroke stent implantation endovascular therapy

Investigation on the Novel High-performance Copper/Graphene Composite Conductor for High Power Density Motor

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 80-85页

作者： Jiaxiao Wang Tingting Zuo Jiangli xue Yadong Ru Yue Wu Zhuang xu Yongsheng Liu Zhaoshun Gao Puqi ning Tao Fan xuhui Wen Li Han Liye Xiao Shanghai University of Electric Power Shanghai 200090Chinaand the Institute of Electrical EngineeringChinese Academy of SciencesShanghai 200090China the Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China with Shanghai University of Electric Power Shanghai 200090China

High-performance Cu/Graphene composite wire synergistically strengthened by nano Cr_(3)C_(2) phase was directly synthesized via hot press sintering followed by severe cold plastic deformation, using liquid paraffin and CuCr alloy powder as the raw materials. Since graphene is in situ formed under the catalysis of copper powder during the sintering process, the problem that graphene is easy to agglomerate and difficult to disperse uniformly in the copper matrix has been solved. The nano Cr_(3)C_(2)-particles nailed at the interface favor to improve the interface bonding. The Cu/Graphene composite possesses high electrical conductivity, hardness, and plasticity. The composite wire exhibits high electrical conductivity of 96.93% IACS, great tensile strength of 488MPa, and excellent resistance to softening. Even after annealing at 400℃ for 1 h, the tensile strength can still reach 268 MPa with a conductivity of about 99.14% *** wire's temperature coefficient of resistance(TCR) is largely reduced to 0.0035/℃ due to the complex structure,which leads the wire to present low resistivity at higher temperatures. Such Cu/Graphene composite wire with excellent comprehensive performance has a good application prospect in high-power density motors.

关键词： Cu/Graphene composite Mechanical properties Electrical property Microstructure Temperature coefficient of resistance

Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

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Bone Research 2024年第2期12卷 270-288页

作者： Leilei Qin Shuhao Yang Chen Zhao Jianye Yang Feilong Li Zhenghao xu Yaji Yang Haotian Zhou Kainan Li Chengdong Xiong Wei Huang ning Hu xulin Hu Department of Orthopaedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Orthopedic Laboratory of Chongqing Medical University Chongqing 400016China Clinical Medical College and Affiliated Hospital of Chengdu University Chengdu UniversityChengduSichuan 610081China University of Chinese Academy of Sciences Bei Jing 101408China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

Osteomyelitis is a devastating disease caused by microbial infection in deep bone *** high recurrence rate and impaired restoration of bone deficiencies are major challenges in *** have evolved numerous mechanisms to effectively evade host intrinsic and adaptive immune attacks to persistently localize in the host,such as drug-resistant bacteria,biofilms,persister cells,intracellular bacteria,and small colony variants(SCVs).Moreover,microbial-mediated dysregulation of the bone immune microenvironment impedes the bone regeneration process,leading to impaired bone defect *** advances in surgical strategies and drug applications for the treatment of bone infections within the last decade,challenges remain in clinical *** development and application of tissue engineering materials have provided new strategies for the treatment of bone infections,but a comprehensive review of their research progress is *** review discusses the critical pathogenic mechanisms of microbes in the skeletal system and their immunomodulatory effects on bone regeneration,and highlights the prospects and challenges for the application of tissue engineering technologies in the treatment of bone *** will inform the development and translation of antimicrobial and bone repair tissue engineering materials for the management of bone infections.

关键词： impaired infections treatment

Phase-locked single-mode terahertz quantum cascade lasers array

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Journal of Semiconductors 2024年第6期45卷 87-91页

作者： Yunfei xu Weijiang Li Yu Ma Quanyong Lu Jinchuan Zhang Shenqiang Zhai ning Zhuo Junqi Liu Shuman Liu Fengmin Cheng Lijun Wang Fengqi Liu Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesBeijing100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Division of Quantum Materials and Devices Beijing Academy of Quantum Information SciencesBeijing 100193China

We demonstrated a scheme of phase-locked terahertz quantum cascade lasers(THz QCLs)array,with a single-mode pulse power of 108 mW at 13 *** device utilizes a Talbot cavity to achieve phase locking among five ridge lasers with first-order buried distributed feedback(DFB)grating,resulting in nearly five times amplification of the single-mode *** to the optimum length of Talbot cavity depends on wavelength,the combination of Talbot cavity with the DFB grating leads to better power amplification than the combination with multimode Fabry-Perot(F-P)*** Talbot cavity facet reflects light back to the ridge array direction and achieves self-imaging in the array,enabling phase-locked operation of *** set the spacing between adjacent elements to be 220μm,much larger than the free-space wavelength,ensuring the operation of the fundamental supermode throughout the laser's dynamic range and obtaining a high-brightness far-field *** scheme provides a new approach for enhancing the single-mode power of THz QCLs.

关键词： quantum cascade lasers phase locking terahertz single mode

金华猪生长激素基因多态性分析及生长曲线比较

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中国兽医学报 2009年第12期29卷 1632-1635页

作者：赵青赵艳钟土木徐宁迎金华职业技术学院浙江金华321017 浙江大学动物科学学院浙江杭州310029 浙江加华种猪有限公司浙江金华321053

采用PCR—RFLP法测定了金华猪生长激素基因ApaⅠ及MspⅠ酶切多态性，并分析了各基因型与生长速度的相关性，进而对金华猪的生长曲线进行了拟合。结果表明，金华猪生长激素基因经ApaI酶切后未出现多态，经MspⅠ酶切后出现了AB（274、238... 详细信息

采用PCR—RFLP法测定了金华猪生长激素基因ApaⅠ及MspⅠ酶切多态性，并分析了各基因型与生长速度的相关性，进而对金华猪的生长曲线进行了拟合。结果表明，金华猪生长激素基因经ApaI酶切后未出现多态，经MspⅠ酶切后出现了AB（274、238、137bp）和BB（238、137bp）2种基因型，且不同基因型间的个体初生体质量、1月龄体质量、2月龄体质量、3月龄体质量、5月龄体质量、6月龄体质量及0～6月龄间平均日增体质量的差异不显著（P〉0．05），而BB基因型4月龄体质量差异高于AB基因型（P〈0．05）。生长曲线拟合结果表明，Bertalanffy模型效果最佳。AB与BB基因型2种生长曲线进行比较，显示出BB基因型具有早期生长速度较快、生长拐点早、拐点体质量小的特点。

关键词：金华猪生长激素基因 PCR—RFLP 生长曲线拟合