检索结果-南通市图书馆

Bone Research 2024年第1期12卷 107-121页

作者： Feng Gao Qimiao Hu Wenwei Chen Jilong Li Cheng Qi Yiwen Yan Cheng Qian mei Wan James Ficke Junying Zheng xu Cao Department of Orthopedic Surgery Johns Hopkins University School of MedicineBaltimoreMaryland 21205USA Department of Biomedical Engineering Johns Hopkins University School of MedicineBaltimoreMaryland 21205USA

Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading ***,it is unclear whether the signals of bone cells in response to mechanical stress are processed and interpreted in the *** this study,we found that the hypothalamus of the brain regulates bone remodeling and structure by perceiving bone prostaglandin E2(PGE2)concentration in response to mechanical *** PGE2 levels are in proportion to their weight *** weight bearing changes in the tail-suspension mice,the PGE2 concentrations in bones change in line with their weight bearing *** of cyclooxygenase-2(COX2)in the osteoblast lineage cells or knockout of receptor 4(EP4)in sensory nerve blunts bone formation in response to mechanical ***,knockout of TrkA in sensory nerve also significantly reduces mechanical load-induced bone ***,mechanical loading induces cAMP-response element binding protein(CREB)phosphorylation in the hypothalamic arcuate nucleus(ARC)to inhibit sympathetic tyrosine hydroxylase(TH)expression in the paraventricular nucleus(PVN)for ***,we show that elevated PGE2 is associated with ankle osteoarthritis(AOA)and ***,our data demonstrate that in response to mechanical loading,skeletal interoception occurs in the form of hypothalamic processing of PGE2-driven peripheral signaling to maintain physiologic bone homeostasis,while chronically elevated PGE2 can be sensed as pain during AOA and implication of potential treatment.

关键词： pain elevated PGE2

在线全文

学校读者我要写书评

暂无评论

高等教育成本分担理论中国化研究

山西财经大学学报（高等教育版） 2010年第2期13卷 20-24页

作者：徐美娜兰州大学教育学院甘肃兰州730000

高等教育成本分担理论由美国教育经济学家布鲁斯.约翰斯通提出,该理论在具备特定的社会背景条件和假设前提下,为缓解教育经费供给与需求之间的矛盾提供了现实路径。由于中美两国在经济、政治、历史、文化等方面存在较大差异,因此在借鉴... 详细信息

高等教育成本分担理论由美国教育经济学家布鲁斯.约翰斯通提出,该理论在具备特定的社会背景条件和假设前提下,为缓解教育经费供给与需求之间的矛盾提供了现实路径。由于中美两国在经济、政治、历史、文化等方面存在较大差异,因此在借鉴该理论将其应用于中国的实践时,必须结合中国的具体国情,构建具有中国特色的高等教育成本分担机制。

关键词：高等教育成本分担中国化

Modulation of starch synthesis in Arabidopsis via phytochrome B-mediated light signal transduction

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2024年第5期66卷 973-985页

作者： Qingbiao Shi Ying Xia na xue Qibin Wang Qing Tao Mingjing Li Di xu Xiaofei Wang Fanying Kong Haisen Zhang Gang Li national Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai'an 271018China national Key Laboratory of Wheat Improvement College of AgronomyShandong Agricultural UniversityTai'an 271018China

Starch is a major storage carbohydrate in plants and is critical in crop yield and *** synthesis is intricately regulated by internal metabolic processes and external environmental cues;however,the precise molecular mechanisms governing this process remain largely *** this study,we revealed that high red to far-red(high R:FR)light significantly induces the synthesis of leaf starch and the expression of synthesis-related genes,whereas low R:FR light suppress these *** phytochrome B(phyB),the primary R and FR photoreceptor,was identified as a critical positive regulator in this *** of phyB,basic leucine zipper transcription factor ELONGATED HYPOCOTYL5(HY5)was found to enhance starch synthesis,whereas the basic helix-loop-helix transcription factors PHYTOCHROME INTERACTING FACTORs(PIF3,PIF4,and PIF5)inhibit starch synthesis in Arabidopsis ***,HY5 and PIFs directly compete for binding to a shared G-box cis-element in the promoter region of genes encoding starch synthases GBSS,SS3,and SS4,which leads to antagonistic regulation of their expression and,consequently,starch *** findings highlight the vital role of phyB in enhancing starch synthesis by stabilizing HY5 and facilitating PIFs degradation under high R:FR light ***,under low R:FR light,PIFs predominantly inhibit starch *** study provides insight into the physiological and molecular functions of phyB and its downstream transcription factors HY5 and PIFs in starch synthesis regulation,shedding light on the regulatory mechanism by which plants synchronize dynamic light signals with metabolic cues to module starch synthesis.

关键词： Arabidopsis thaliana HY5 light signal phyB PIFs starch synthesis

Efficacy and safety of Tianqi Pingchan Granule,a compound Chinese herbal medicine,for levodopa-induced dyskinesia in Parkinson’s disease:A randomized double-blind placebo-controlled trial

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第5期22卷 545-551页

作者： Yu Zhang Xiao-bo Zhu Yang Zhao Gui-yun Cui Wen-tao Li Can-xing Yuan Jian-ping Huang Ying Wan na Wu Lu Song Jia-hao Zhao Yan Liang Chuan-ying xu mei-juan Liu Chen Gao Xin-xin Chen Zhen-guo Liu Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Neurology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Parkinson’s Disease Center the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Neurology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200071China Department of Neurology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Neurology Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

Background Patients with Parkinson’s disease(PD)undergoing long-term levodopa therapy are prone to develop levodopa-induced dyskinesia(LID).Amantadine is the main drug recommended for the treatment of LID by current guidelines,but it is far from meeting clinical *** Pingchan Granule(TPG),a compound Chinese herbal medicine,has been developed to relieve symptom of *** This randomized controlled trial evaluated the efficacy and safety of the combination of TPG and amantadine for ***,setting,participants and interventions This is a randomized double-blind placebo-controlled trial,conducted from January 2020 to August 2021 at 6 sites in Jiangsu,Zhejiang and Shanghai,*** hundred PD patients with≥0.5 h of LID were randomly assigned to either the TPG plus amantadine group(TPG group)or the placebo plus amantadine group(placebo group),and treated for a period of 12 *** ensure unbiased results,all study participants,investigators and sponsors were unaware of group ***,the data analysts remained blinded until the analysis was *** outcome measures The primary outcome was assessed using the Unified Dyskinesia Rating Scale(UDysRS)(Range 0–104).The key secondary end point was improvement of motor and non-motor *** analyses included all enrolled *** One hundred patients were enrolled and randomized into the two treatment *** changes in UDysRS at week 12 were–11.02 for the TPG group and–4.19 for the placebo group(treatment difference–6.83[–10.53 to–3.12];P=0.0004).Adverse events were reported for 2 of 50 patients(4.0%)in each of the *** This study indicated that a 12-week treatment of amantadine plus TPG effectively reduced UDysRS scores and was well tolerated,demonstrating the efficacy and safety of TPG for the treatment of LID in PD.

关键词： Parkinson’s disease Tianqi Pingchan Granule Levodopa-induced dyskinesia

在线全文

学校读者我要写书评

暂无评论

浅谈小学生数学思维培养

大连教育学院学报 2022年第1期38卷 38-39页

作者：徐美娜大连市普兰店区文化路小学辽宁大连116200

小学生处于形象思维向抽象逻辑思维的过渡期,思维发展表现出不平衡性。数学思维能力的培养是小学数学教育的重要目标,并有助于数学核心素养的形成。教师在教学中要充分利用教材发展学生数学思维能力,充分发展学生的图形思维并利用思维... 详细信息

小学生处于形象思维向抽象逻辑思维的过渡期,思维发展表现出不平衡性。数学思维能力的培养是小学数学教育的重要目标,并有助于数学核心素养的形成。教师在教学中要充分利用教材发展学生数学思维能力,充分发展学生的图形思维并利用思维导图发展学生的分类思维。

关键词：小学生数学思维培养

教师专业发展途径之探讨——基于建构主义理论的思考

在线全文

学校读者我要写书评

暂无评论

教育与教学研究 2009年第7期23卷 4-7页

作者：徐美娜兰州大学教育学院甘肃兰州730000

教师专业发展是教师不断成长、不断接受新知识、提高专业能力的过程,是一个融合职前教育、新教师入职辅导与职后培训为一体的多层面、多领域的动态发展过程。教师是这一过程的主体,培植教师的专业化意识与能力是这一过程的关键。而教师... 详细信息

教师专业发展是教师不断成长、不断接受新知识、提高专业能力的过程,是一个融合职前教育、新教师入职辅导与职后培训为一体的多层面、多领域的动态发展过程。教师是这一过程的主体,培植教师的专业化意识与能力是这一过程的关键。而教师专业化发展的途径、要求、制度保障是影响这一过程的核心问题。建构主义理论对教师专业化发展具有深刻的理论指导价值,为教师专业化发展的途径、要求及制度保障方面提供了设计思路。教师的专业化发展必须走一体化发展型道路。

关键词：建构主义理论教师专业发展反思性教学教师学习共同体

在线全文

学校读者我要写书评

暂无评论

“最近发展区”理论及对教育的影响与启示

教育与教学研究 2010年第5期24卷 14-16,23页

作者：徐美娜兰州大学教育学院甘肃兰州730000

维果茨基是苏俄早期一位杰出的心理学家,社会文化历史学派的创始人。他提出的"最近发展区"理论指出了儿童认知发展的两种水平:实际的发展水平和潜在的发展水平。认为教学应该走在发展的前面,引导发展。在该理论的影响下,新的教育理念与... 详细信息

维果茨基是苏俄早期一位杰出的心理学家,社会文化历史学派的创始人。他提出的"最近发展区"理论指出了儿童认知发展的两种水平:实际的发展水平和潜在的发展水平。认为教学应该走在发展的前面,引导发展。在该理论的影响下,新的教育理念与模式如支架式教学模式、交互式教学模式以及学习能力的动态评估等层出不穷,对教育教学实践产生了巨大而深远的影响,并从理论与实践双重层面给予我们深刻的启示。

关键词：维果茨基最近发展区影响与启示

In situ tracking of the lithiation and sodiation process of disodium terephthalate as anodes for rechargeable batteries by Raman spectroscopy

在线全文

学校读者我要写书评

暂无评论

nano Research 2024年第1期17卷 245-252页

作者： Xiu-mei Lin Chong Han Xin-Tao Yang Jia-Sheng Lin Wei-Qiang Yang Hong-xu Guo Yao-Hui Wang Jin-Chao Dong Jian-Feng Li Department of Chemistry and Environment Science Fujian Province University Key Laboratory of Analytical ScienceMinnan Normal UniversityZhangzhou 363000China College of Energy College of Chemistry and Chemical EngineeringCollege of MaterialsState Key Laboratory of Physical Chemistry of Solid SurfacesiChEMXiamen UniversityXiamen 361005China Institute of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China

Organic compounds represent an appealing group of electrode materials for rechargeable batteries due to their merits of biomass,sustainability,environmental friendliness,and *** terephthalate(na_(2)C_(8)H_(4)O_(4),na_(2)TP),an organic salt with a theoretical capacity of 255 mAh·g^(-1),is electroactive towards both lithium and ***,its electrochemical energy storage(EES)process has not been directly observed via in situ characterization techniques and the underlying mechanisms are still under ***,in situ Raman spectroscopy was employed to track the de/lithiation and de/sodiation processes of *** appearance and then disappearance of the–COOLi Raman band at 1625 cm^(-1) during the de/lithiation,and the increase and then decrease of the–COOna Raman band at 1615 cm^(-1) during the de/sodiation processes of na2TP elucidate the one-step with the 2Li+or 2na+transfer *** also found that the inferior cycling stability of na2TP as an anode for sodium-ion batteries(SIBs)than lithium-ion batteries(LIBs)could be due to the larger ion radium of na+than Li+,which results in larger steric resistance and polarization during *** na2TP,therefore,shows greater changes in spectra during de/sodiation than de/*** expect that our findings could provide a reference for the rational design of organic compounds for EES.

关键词： disodium terephthalate(na_(2)C_(8)H_(4)O_(4) na2TP) in situ Raman spectroscopy de/lithiation de/sodiation mechanisms

Reversible Mn^(2+)/Mn^(4+)double-electron redox in P3-type layer-structured sodium-ion cathode

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第2期89卷 79-88,I0004页

作者： Jie Zeng Jian Bao Ya Zhang xun-Lu Li Cui Ma Rui-Jie Luo Chong-Yu Du xuan xu Zhe mei Zhe Qian Yong-Ning Zhou Department of Materials Science Fudan UniversityShanghai 200433China Shanghai xuanyi New Energy Development Co. LtdShanghai 201800China Global Institute of Future Technology Shanghai Jiao Tong UniversityShanghai 200240China

The balance between cationic redox and oxygen redox in layer-structured cathode materials is an important issue for sodium batteries to obtain high energy density and considerable cycle *** redox can contribute extra capacity to increase energy density,but results in lattice instability and capacity fading caused by lattice oxygen gliding and oxygen *** this work,reversible Mn^(2+)/Mn^(4+)redox is realized in a P3-na_(0.65)Li_(0.2)Co_(0.05)Mn_(0.75)O_(2)cathode material with high specific capacity and structure stability via Co *** contribution of oxygen redox is suppressed significantly by reversible Mn^(2+)/Mn^(4+)redox without sacrificing capacity,thus reducing lattice oxygen release and improving the structure *** X-ray techniques reveal that P3 phase is well maintained in a wide voltage window of 1.5-4.5 V ***^(+)/na even at 10 C and after long-term *** is disclosed that charge compensation from Co/Mn-ions contributes to the voltage region below 4.2 V and O-ions contribute to the whole voltage *** synergistic contributions of Mn^(2+)/Mn^(4+),Co^(2+)/Co^(3+),and O^(2-)/(O_n)^(2-)redox in P3-na_(0.65)Li_(0.2)Co_(0.05)Mn_(0.75)O_(2)lead to a high reversible capacity of 215.0 m A h g^(-1)at 0.1 C with considerable cycle *** strategy opens up new opportunities for the design of high capacity cathode materials for rechargeable batteries.

关键词： Sodium batteries Cathode materials Layered structure Co substitution

Sea-level change in coastal areas of China:Status in 2021

在线全文

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2024年第3期15卷 515-524页

作者： Wen-Shan LI Hui WANG Wen-Xi XIANG Ai-mei WANG Wei-Qing xu Yu-Xi JIANG Xin-Hui WU Meng-Yuan QUAN national Marine Data and Information Service Tianjin 300171China Ocean University of Chin1 Qingdao 266100China University of Michigan‒Shanghai Jiao Tong University Joint Institute Shanghai 200030China

The sea level in coastal areas of China reached the second highest in 2021,just after that recorded in *** force and dynamic analyses based on tide gauges,satellite observations,reanalysis data and regional numerical outputs were conducted to understand these abnormally high sea levels and determine their possible *** show that the coastal sea level of China had increased at an annual rate of 3.4±0.3 mm during 1980-2021,with an acceleration of 0.06±0.02 mm per *** superposition of significant oscillations of quasi-2,3-7,quasi-9,quasi-11,quasi-19 and 20-30 years contributed to the anomalously high sea *** negative-phased El Nino/Southern Oscillation was correlated with the anomalously high sea level and the north-south anti-phase pattern of the coastal sea level in ***,phase lags of 1-4 months occurred with the sea-level *** a decadal timescale,the Pacific Decadal Oscillation(PDO)was negatively correlated with the anomalous mean sea level(MSL),and the negative-phased PDO contributed to the anomalous sea-level change in ***,the monthly MSL peaked in April and July,and the contribution of wind stress to the anomalously high sea level was 38.5%in the south of the Taiwan Strait in April and 30%along the coast of China in *** results were consistent with the tide gauge and satellite *** agreement was also observed between the coastal sea-level fingerprint and the air and sea surface temperatures.

关键词： Sealevel La Nina PDO Wind stress