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Genotyping Characteristics of Human Fecal Escherichia coli and Their Association with Multidrug Resistance in Miyun District, Beijing

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Biomedical and Environmental Sciences 2023年第5期36卷 406-417页

作者： ZHANG Wei Wei ZHU Xiao lin DENG Le Le HAN Ya Jun LI Zhuo Wei WANG Jin Long CHEN Yong Liang WANG Ao lin TIAN Er Li CHENG Bin xu lin hua CHEN Yi Cong TIAN Li Li HE Guang xue National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Miyun District Center for Disease Control and Prevention Beijing 101520China Berger Bioengineering Co. LtdShanghai 201401China Xicheng District Commission of Health of Beijing Municipality Beijing 100044China Miyun District Hospital Beijing 101520China Hebei North University Zhangjiakou 075000HeibeiChina

Objective To explore the genotyping characteristics of human fecal Escherichia coli(E. coli) and the relationships between antibiotic resistance genes(ARGs) and multidrug resistance(MDR) of E. coli in Miyun District, Beijing, an area with high incidence of infectious diarrheal cases but no related *** Over a period of 3 years, 94 E. coli strains were isolated from fecal samples collected from Miyun District Hospital, a surveillance hospital of the National Pathogen Identification Network. The antibiotic susceptibility of the isolates was determined by the broth microdilution method. ARGs,multilocus sequence typing(MLST), and polymorphism trees were analyzed using whole-genome sequencing data(WGS).Results This study revealed that 68.09% of the isolates had MDR, prevalent and distributed in different clades, with a relatively high rate and low pathogenicity. There was no difference in MDR between the diarrheal(49/70) and healthy groups(15/24).Conclusion We developed a random forest(RF) prediction model of TEM.1 + baeR + mphA + mphB +QnrS1 + AAC.3-IId to identify MDR status, highlighting its potential for early resistance identification. The causes of MDR are likely mobile units transmitting the ARGs. In the future, we will continue to strengthen the monitoring of ARGs and MDR, and increase the number of strains to further verify the accuracy of the MDR markers.

关键词： E.coli Multidrug resistance Whole-genome sequencing Antibiotic resistance genes Randomforest

Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng Du Wang Rongjie lin Weihong xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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域内海量数据中热点话题及其特征词抽取方法

管理工程学报 2018年第4期32卷 133-140页

作者：袁华徐华林钱宇罗谦电子科技大学经济与管理学院四川成都611731 四川旅游学院信息与工程学院四川成都610100 中国民用航空总局第二研究所四川成都610041

在特定信息域内的网络文档中,主题及其特征词的抽取工作是近年人工语言处理研究的重点,其研究结果具有显著的管理决策意义。本研究提出一种新的数据挖掘方法用于从海量UGC中分析出其"热点话题词"和"局部特征词"之间的关联关系。首先,利... 详细信息

在特定信息域内的网络文档中,主题及其特征词的抽取工作是近年人工语言处理研究的重点,其研究结果具有显著的管理决策意义。本研究提出一种新的数据挖掘方法用于从海量UGC中分析出其"热点话题词"和"局部特征词"之间的关联关系。首先,利用网页抓取工具从网上获得某个域相关的文档,并对文档内容实施分词操作。然后,基于分词结果,抽取网页文档中存在的域内信息词并组成新的数据集。最后,我们提出一种基于热点话题词和语义分隔符号的数据集切分方法来获得每个热点话题词相关的本地特征词数据集。并且在该数据集上,可以分析出特征词对于热点话题词的依赖关系,从而找到每个话题词最恰当的特征词集合。该方法算法简单,尤为重要的是它能很好屏蔽那些不相关的高频共现词对特征抽取的影响,可广泛应用于文本相关的在线信息检索任务,为管理决策和电子商务活动服务。

关键词：在线信息检索频繁模式挖掘最大置信度信息域特征抽取

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福田红树林湿地生态系统EWE模型构建

生态学杂志 2014年第5期33卷 1413-1419页

作者：丑庆川徐华林刘军史秀华深圳大学生命科学学院广东深圳518060 广东内伶仃福田国家级自然保护区广东深圳518048 内蒙古农业大学生态与环境学院呼和浩特010019 深圳大学高尔夫学院广东深圳518060

以福田红树林湿地生态系统为研究对象,将其生物组成分为红树植物、底栖动物、浮游植物、浮游动物、鸟类和碎屑等15个功能组,运用Ecopath with Ecosim(EWE)软件,构建了福田红树林湿地生态系统的EWE模型,探讨了红树林湿地生态系统的状态... 详细信息

以福田红树林湿地生态系统为研究对象,将其生物组成分为红树植物、底栖动物、浮游植物、浮游动物、鸟类和碎屑等15个功能组,运用Ecopath with Ecosim(EWE)软件,构建了福田红树林湿地生态系统的EWE模型,探讨了红树林湿地生态系统的状态、特征及不同物种之间的营养关系,并评价红树林湿地生态系统当前的健康状况。分析表明,福田红树林湿地生态系统能流的最主要来源是碎屑,能流主要在营养级Ⅰ到Ⅳ之间流动,转化效率最高发生在第Ⅰ和第Ⅱ营养级之间(28.8%),总体转化效率为11.2%,且系统对营养级Ⅱ的利用最为充分。处于低营养级的功能组在系统能量传递的过程中起着非常关键的作用,并且对整个系统的影响强烈。生态系统总体特征参数生物量/总流量(TB/TT)、连接指数(CI)和系统杂食性指数(SOI)分别为0.163、0.123和0.018,综合分析表明,福田红树林湿地生态系统目前有退化的趋势。

关键词：红树林湿地生态通道能量流动

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Fate of Fertilizer Nitrogen Applied to Crops Grown on Fluvo-Aquic Soil in huang-huai-Hai Plain

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Pedosphere 1991年第2期1卷 145-155页

作者： WANGXIAN－ZHONG ZHANGSHAO－lin 等 InstituteofSoilScience AcademiaSinicaP.O.Box821Nanjing（China） InstituteofSoilScience AcademiaSinica

The fate of urea-and ammonium bicarbonate (ABC)-nitrogen (N) applied by prevailing traditional techniques to winter wheat (Triticum aestivum L.) or maize (Zea mays L.) grown in the fields of Fluvo-aquic soil was investigated using 15N tracer-micro-plot technique. Results show that:(1) at maturity of wheat, N recovery in plants and N losses of urea and ABC applied at seeding in autumn were 31-39%, and 34-46%, respectively, while the corresponding figures for side-banding at 10 cm depth in early spring were 51-57%, and 5-12%; surface-broadcast of urea followed by irrigation at early spring was as efficient as the side-banding in improving N recovery in plants and reducing N loss, however, such technique was found less satisfactory with ABC. (2) At the maturity of maize, N recovery in the plants and N loss of urea and ABC sidebanded at seedling stage or prior to tasseling ranged from 23% to 57%, and 9% to 26%, respectively. (3) Either in Wheat or in maize experiment, the majority of residual fertilizer N in soil profile (0-60 cm) was in the form of biologically immobilized organic N, however, the contribution of ammonium fixation by clay minerals increased markedly with depth in soil profile. (4) Though the proportion of residual fertilizer N was generally highest in the top 20 cm soil layer, considerable reaidual N (mostly 6-11 % of the N applied) was found in 60-100 cm soil layers.

关键词： ammonium bicarbonate fate of fertilizer N urea maize wheat

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高深宽比金属光栅制备及中红外波段传感特性

红外与毫米波学报 2013年第2期32卷 154-159页

作者：郑改革陈云云徐林华赖敏南京信息工程大学物理与光电工程学院应用物理系江苏南京210044

利用纳米压印结合溅射和反应离子刻蚀工艺制备了具有高深宽比的金光栅,使用傅里叶变换红外光谱仪测得了反射谱线.测量结果显示,只在p偏振光垂直于光栅矢量方向入射条件下才存在共振反射峰,证明了"伪表面等离子体激元波"的存在.基于严格... 详细信息

利用纳米压印结合溅射和反应离子刻蚀工艺制备了具有高深宽比的金光栅,使用傅里叶变换红外光谱仪测得了反射谱线.测量结果显示,只在p偏振光垂直于光栅矢量方向入射条件下才存在共振反射峰,证明了"伪表面等离子体激元波"的存在.基于严格耦合波分析理论计算了金属光栅的反射率,研究了其作为中红外波段波长调制型表面等离子体共振传感器的可行性.数值计算表明负级次衍射光波对应的共振反射峰的移动能获得较高的波长灵敏度.对于深宽比为10的金光栅结构,+1级次和-3级次衍射光波对应的波长灵敏度分别为1600 nm/RIU和5000 nm/RIU,品质因子分别为20 RIU-1和60 RIU-1.

关键词：高深宽比金属光栅表面等离子体共振传感器严格耦合波理论

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping lin Jun xu Delong Jiang Jiayang Hou Ying Liang Zhongyue Zou xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Contrastive Learning

亚波长金属光栅结构的制备与矢量衍射理论分析

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发光学报 2013年第7期34卷 935-939页

作者：郑改革詹煜曹焜徐林华南京信息大学物理与光电工程学院江苏南京210044

利用纳米压印结合溅射和反应离子刻蚀工艺制备了周期为1μm、占空比为0.2的亚波长金属光栅,利用紫外-可见-近红外光谱仪测量了光栅的0级反射光谱。在严格耦合波分析的基础上,把光栅区域电磁场的空间谐波通过勒让德多项式展开,使用多项... 详细信息

利用纳米压印结合溅射和反应离子刻蚀工艺制备了周期为1μm、占空比为0.2的亚波长金属光栅,利用紫外-可见-近红外光谱仪测量了光栅的0级反射光谱。在严格耦合波分析的基础上,把光栅区域电磁场的空间谐波通过勒让德多项式展开,使用多项式展开的谱分析法求解常微分方程,计算了该亚波长金属光栅的反射光谱及磁场分布。实验测量结果同矢量衍射理论计算结果都显示,该光栅在近红外、中红外波段具有表面等离子体共振现象。数值计算结果还表明,对于此类亚波长金属光栅,当光栅的深宽比增加时,其反射光谱中会出现更多的反射谷。

关键词：亚波长金属光栅纳米压印表面等离子体