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Chinese Journal of Structural Chemistry 2007年第8期26卷 877-882页

作者： xu li tang kuan-zhen ma yu-fei tang yu tan min-yu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China

A one-dimensional （1D） supramolecular rare earth complex [Nd（NO3）2L2-（C3H6O）][NdL（NO3）4]} （L=N-（6-（4-methylpyridinyl））ketoacetamide） has been prepared and characterized by elemental analysis, IR and electronic spectroscopy, and single-crystal X-ray diffraction. The crystal crystallizes in the triclinic system, space group P1^- with a=0.9146（6）, b=1.2581（8）, c=2.2316（14） nm, α=99.352（10）,β=97.209（9）, γ=103.935（9）°, V=2.422（3） nm3, Dc=1.776 g/cm^3, C33H42N12Nd2O25, Mr=1295.27, Z=2, F（000）=1288, μ=2.217 mm-1, R=0.0508and wR=0.1046 for 5173 observed reflections （I 〉 2σ（I））. In the structure of the title complex,one-dimensional supramolecular double-chains are formed by intermolecular hydrogen bonding interactions.

关键词： crystal structure rare earth nitrate β-diketone complex supramolecular network

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-yun Zhao Shao-lin Xiong Xiang-Yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo zheng-Hua An Ke Gong Jin-yuan liao Yan-Qiu Zhang yue Huang Lu li Xing Wen fei Zhang Jing Duan Chen-Wei Wang Dong-li Shi Peng Zhang Qi-Bin Yi Chao-Yang li Yan-Bing xu Xiao-Hua liang Ya-Qing liu Da-li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-yu Wang Sheng Yang Xiao-Jing liu min Gao mao-Shun li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen xue Chao zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou yu-Sa Wang Rui Qiao Xiang ma Xiao-Bo li Ping Wang Xin-Ying Song li-ming Song Shi-Jie zheng Bing li Hong-Mei Zhang yue Zhu Wei Chen Jian-Jian He zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-yu Wang Zong-yuan Yang Zhi-Long Wen Zhi Chang yuan-yuan Du Rui Gao Xiao-fei Lan Yan-Guo li Gang li xu-Fang li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-zhen Wang yu-Peng xu Jia-Wei Yang xue-Juan Yang Shuang-Nan Zhang Chao-yue Zhang Cheng-Mo Zhang Zhi-Cheng tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1845-1855页

作者： Huijie Bian Zhao-Hui zheng Ding Wei Aidong Wen zheng Zhang Jian-Qi lian Wen-zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-lin Miao Wen Kang Guoquan li Di Zhang mingru Zhang Xiu-xuan Sun likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin li Yanyan Jia lin-Na liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen yu-Meng Zhu li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-min Yang Jian-Sheng Zhou Yi-Nan ma Ya-Tao Wang xue liang fei Huo Zhe Wang Yang Zhang xu Yang Ye Zhang Lu-Hua Gao ling Wang Xiao-Chun Chen Hao tang Shuang-Shuang liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'anChina Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi'anChina Center for Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Nuclear Medicine Xijing HospitalFourth Military Medical UniversityXi'anChina department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXKanChina College of Military Preventive Medicine Fourth Military Medical UniversityXi'anChina Department of Pharmaceutics Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Pathology Fourth Military Medical UniversityXi'anChina Jiangsu Pacific Meinuoke Biopharmaceutical Co.Ltd ChangzhouChina Department of Foreign Languages Fourth Military Medical UniversityXi'anChina

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 *** is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)***,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 *** phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was *** serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic *** obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each *** biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to *** the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent *** meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control *** results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.

关键词： patients dosage phase

Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： yu Cao Song Chen Yan-Fen Chai Xiao-Hui Chen yu-Guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding Yang Deng Jie Fu Bang-Jiang Fang mai-Ying Fan li Gui Ping Gong Wei Guo Shu-Bin Guo liang Huang Ji-yuan Han Zhong Ji Xian-fei Ji Xin-Cai Ji Hong-xu Jin Xin-Jun Jiang Wang-Xiang Jiang Jia-liang liu Xiao-Ran liu Zhi liu Chuan-Zhu Lv Feng Lu tan-Shi li Xin li Yong li Shang-Lun li Shuang-ming li Xiao-Gang li Bao-Jun li Pei-Wu li Chun-Sheng li Zhi-Jun li Chang-Luo li Xiang-min li Yin-Ping li Zong-Jun Lu Zu-xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-Xing liao Jian-Bo Lei Tao ma yu ma yue-Feng ma Qing-Bian ma lin-Hao ma Jun-Qi ma Shi-Nan Nie Jie-Miao Ou-Yang Peng Peng Qiao Pei Shu-ming Pan Guo-Zhong Qing li-Jie Qin Wu-Ying Qiao fei Shao Wei Song Xing-yue Song zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang Tian Ying-Ping Tian Jian-Guang Tian Chao-Yang Tong Zi-Ren tang Meng-Xiong tang Guo-Ping Wu Zhi Wan Tao Wang Xin Wang Peng Wang Zhong Wang Tong Wang Ri-Xing Wang Yi-Xin Wang Xiao-Dan Wang ling Wu Wei Wei Hua Xiang Feng xu Jun xu Jie xu Miao-Rong Xie Shuo-Gui xu Tie xu Feng yu Wen Yi li-Shan Yang Shi-Jiao Yan Jin-Jian Yao Shou-Chun Yan xue-Zhong yu Xian-Zhi Ye Xian-liang Yan Fu-Bing Zhou Rong-Bin Zhou ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu Hua-Dong Zhu Ji-Hong Zhu Hong Zhang mao Zhang Hua Zhang Na Zhang Guo-Qiang Zhang Guo-Xiu Zhang Jin-Song Zhang Wen-Wu Zhang Wen-Zhong Zhang Jian-Feng Zhang Yi-min Zhu Jun Zeng yuan zheng Zhi-Jie zheng Shen Zhao Yan Zhao min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano max Buesken mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen xurong Chen Yi-Wen Chen Yixue Chen yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering marco Diaz xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov yuri Gornushkin marco Grassi Christian Grewing maxim Gromov Vasily Gromov minghao Gu Xiaofei Gu yu Gu Mengyun Guan Nunzio Guardone maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia Universitélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance xuejun Chang yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen xun Chen xurong Chen Ye Chen Ying Chen yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-yun Dai Xinchen Dai xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Expert consensus on the diagnosis and treatment of solid tumors with BRAF mutations

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The Innovation 2024年第6期5卷 100-116页

作者： Wenxian Wang Bin lian Chunwei xu Qian Wang Ziming li Nan zheng Aijun liu Jinpu yu Wenzhao Zhong Zhijie Wang Yongchang Zhang Jingjing liu Shirong Zhang Xiuyu Cai Anwen liu Wen li lili mao Ping Zhan Hongbing liu tangfeng Lv liyun Miao lingfeng min yu Chen Jingping yuan Feng Wang Zhansheng Jiang Gen lin Long Huang Xingxiang Pu Rongbo lin Weifeng liu Chuangzhou Rao Dongqing Lv Zongyang yu Xiaoyan li Chuanhao tang Chengzhi Zhou Junping Zhang Junli xue Hui Guo Qian Chu Rui Meng xuewen liu Jingxun Wu Rui Zhang Jin Zhou zhengfei Zhu Yongheng li Hong Qiu Fan Xia yuanyuan Lu Xiaofeng Chen Jian Feng Rui Ge Enyong Dai yu Han Weiwei Pan fei Pang Xin Huang Meizhen Hu Qing Hao Kai Wang Fan Wu Binbin Song Bingwei xu liping Wang Youcai Zhu li lin Yanru Xie Xinqing lin Jing Cai ling xu Jisheng li Xiaodong Jiao Kainan li Jia Wei Huijing Feng lin Wang Yingying Du Wang Yao xuefei Shi Xiaomin Niu Dongmei yuan Yanwen Yao Jianhui Huang yue Feng Yinbin Zhang Pingli Sun Hong Wang mingxiang Ye Dong Wang Zhaofeng Wang yue Hao zhen Wang Bin Wan Donglai Lv Shengjie Yang Jin Kang Jiatao Zhang Chao Zhang Wenfeng li Jianfei Fu lizhi Wu Shijie Lan Juanjuan Ou lin Shi Zhanqiang Zhai Yina Wang Bihui li Zhang Zhang Ke Wang xuelei ma Zhongwu li Zhefeng liu Nong Yang lin Wu Huijuan Wang Gu Jin Guansong Wang Jiandong Wang Hubing Shi Meiyu Fang Yong Fang yuan li Xiaojia Wang Jing Chen Yiping Zhang Xixu Zhu Yi Shen Shenglin ma Biyun Wang Yong Song zhengbo Song Wenfeng Fang yuanzhi Lu Lu Si Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital)HangzhouZhejiang 310022P.R.China Key Laboratory of Carcinogenesis and Translational Research(ministry of Education/Beijing) Department of Melanoma and SarcomaPeking University Cancer Hospital&InstituteBeijing 100142P.R.China Institute of Cancer and Basic Medicine(ICBM) Chinese Academy of SciencesHangzhouZhejiang 310022P.R.China Department of Respiratory Medicine Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210002P.R.China Department of Respiratory Medicine Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210029P.R.China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030P.R.China Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 200030China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 200030China Senior Department of Pathology the 7th Medical Center of PLA General HospitalBeijing 100700P.R.China Department of Cancer Molecular Diagnostics Core Tianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China Guangdong Lung Cancer Institute Guangdong Provincial Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSchool of MedicineGuangzhouGuangdong 510080P.R.China State Key Laboratory of Molecular Oncology Department of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Medical Oncology Lung Cancer and Gastrointestinal UnitHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School

The BRAF gene is an important signaling molecule in human cells that is involved in the regulation of cell growth,differentiation,and *** the BRAF gene mutates,it can lead to abnormal activation of the signaling pathway,which promotes cell proliferation,inhibits cell apoptosis,and ultimately contributes to the occurrence and development of *** mutations are widely present in various cancers,including malignant melanoma,thyroid cancer,colorectal cancer,non-small cell lung cancer,and hairy cell leukemia,among *** is an important target for the treatment of various solid tumors,and targeted combination therapies,represented by BRAF inhibitors,have become one of the main treatment modalities for a variety of BRAF-mutation-positive solid tumors.

关键词： BRAF diagnosis treatment

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen xurong Chen Yixue Chen yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering marco Diaz xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang marco Fargetta Dmitry Fedoseev zhengyong fei li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Nunzio Giudice maxim Gonchar Guanghua Gong Hui Gong yuri Gornushkin Alexandre Göttel marco Grassi Vasily Gromov minghao Gu Xiaofei Gu yu Gu Mengyun Guan yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth yuekun Heng Rafael Herrera yuenKeung Ho Yerevan Physics Institute YerevanArmenia Universiélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

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2005年中国城市CO2排放数据集

中国人口·资源与环境 2018年第4期28卷 1-7页

作者：蔡博峰刘晓曼陆军王金南刘红光陈洋陈占明丛建辉崔志鹏代春艳董会娟方恺冯彤郭杰李芬孟凡鑫唐伟王庚哲谢运生张建军阿依吐尔逊·沙木西布买日也木·买买提蔡伟光曾胜常盼陈前利陈振国单钰理丁冠乔独威范敏冯相昭干晓宇高壮飞谷雨何凌昊何姚胡鸣明黄丽珍黄桥贾小平菊春燕蓝菁李爽李松李耀光李照令刘合林刘婧文刘庆燕刘竹逯飞马贤磊欧金沛潘栋沈杨税月孙露谭效时唐敏唐袆祺王柯王思亓王香爱王晓培吴家杰吴雪萍肖连香邢文婷徐丽笑叶瑞克袁子坤张飞云张袆张明张琦峰张曦文张宇赵晶赵胜男郑思伟周来友朱天琦曹丽斌冯乐李栋李一静龙瀛孙瑞红环境保护部环境规划院北京100012 中国科学院大气物理研究所北京100029 南京农业大学公共管理学院江苏南京210095 上海财经大学城市与区域科学学院上海200433 中国人民大学经济学院北京100872 山西大学经济与管理学院山西太原030006 E20环境平台咨询部北京100195 重庆工商大学长江上游经济研究中心重庆400067 上海交通大学环境科学与工程学院上海200240 浙江大学公共管理学院浙江杭州310058 天津大学管理与经济学部天津300072 南京农业大学土地管理学院江苏南京210095 深圳市建筑科学研究院股份有限公司北京研创中心广东深圳518049 华南理工大学环境与能源学院广东广州510006 杭州市环境保护科学研究院环境政策研究中心浙江杭州310014 埃因霍芬理工大学建筑学院荷兰埃因霍芬5616SC 江西省科学院能源研究所江西南昌330000 中国地质大学(北京)土地科学技术学院北京100083 新疆农业大学管理学院新疆乌鲁木齐830052 重庆大学建设管理与房地产学院重庆400044 重庆工商大学财政金融学院重庆400067 东安格利亚大学国际发展学院英国诺维奇NR47TJ 环境保护部环境发展中心北京100029 环境保护部环境与经济政策研究中心北京100029 四川大学建筑与环境学院四川成都610065 浙江工业大学政治与公共管理学院浙江杭州310023 美国绿色建筑委员会城市与社区部北京100085 挪威科技大学工程学院挪威约尔维克2815 北京师范大学统计学院北京100875 青岛科技大学环境学院山东青岛266000 北京大学遥感与地理信息系统研究所北京100871 北京师范大学环境学院北京100875 筑波大学日本筑波305-0005 华中科技大学建筑与城市规划学院湖北武汉430074 美国东北大学工学院美国波士顿02115 河北省环境科学研究院规划所河北石家庄050037 中山大学地理科学与规划学院广东广州北京林业大学环境科学与工程学院北京宁波职业技术学院商贸外语学院浙江宁波重庆工商大学土地管理学院重庆日本国立环境研究所社会环境系统研究中心日本筑波中国船舶重工集团公司第七一四研究所北京重庆工商大学管理学院重庆渭南师范学院化学与材料学院陕西渭南福州大学经济与管理学院福建福州扬州大学环境科学与工程学院江苏扬州中国矿业大学管理学院江苏徐州北京大学城市与环境学院北京内蒙古大学公共管理学院内蒙古呼和浩特江苏大学财经学院江苏镇江赤峰学院资源与环境科学学院内蒙古赤峰新余学院经济管理学院江西新余北京市环境保护科学研究院生态与城市环境研究所北京北京清华同衡规划设计研究院有限公司技术创新中心北京100085 北京大学汇丰商学院英国校区华威大学交叉学科研究方法中心英国牛津100871 清华大学建筑学院北京100062 上海工程技术大学管理学院上海021620

2005年是中国承诺碳减排目标的基准年份,因而也是中国城市碳减排战略制定和近中期低碳转型的基准年份和对照年份。中国城市2005年CO_2排放数据的一致性、全面性和精准性对于中国所有城市和每个具体城市的目标考核和评估都有重要意义。... 详细信息

2005年是中国承诺碳减排目标的基准年份,因而也是中国城市碳减排战略制定和近中期低碳转型的基准年份和对照年份。中国城市2005年CO_2排放数据的一致性、全面性和精准性对于中国所有城市和每个具体城市的目标考核和评估都有重要意义。基于中国高空间分辨率网格数据(CHRED 2.0)、城市层面统计数据以及大量现场调研和走访,建立2005年中国城市CO_2排放数据集,包括工业能源排放、工业过程排放、农业排放、服务业排放、城镇生活排放、农村生活排放、交通排放7个部门的直接排放数据和间接排放数据。该数据集的建立汇总了86名研究人员的工作成果,在企业、城市不同行业与部门、城市工业和城市总化石能源等不同层面进行了大量的交叉验证和数据分析,有效保障了数据的精确性和准确性。结果显示,2005年中国城市碳排放呈现出较大的体量差异和空间格局差异。排放前10的城市几乎比排放后10的城市的排放量高出两个数量级。高排放城市基本都是城市群的核心城市。东部城市直接排放占全国直接排放比例最高,达到44.59%,其次是西部城市21.76%,中部城市22.70%,东北城市10.95%。

关键词：城市 CO 2排放数据集中国高空间分辨率网格

云南和广西传染病干预措施效果评估的程度分析

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卫生软科学 2020年第6期34卷 74-77页

作者：范兆雅蒲川陈菲唐晓君张政徐凌忠李力陈任李伯阳冯占春胡志沈群红林振平于芳田壮马东平陈政钱东福李程跃郝模张帆重庆医科大学公共卫生与管理学院重庆400016 健康相关重大社会风险预警协同创新中心上海200032 健康相关重大社会风险预警协同创新中心重医分中心重庆400016 复旦大学卫生发展战略研究中心上海200032 山东大学公共卫生学院山东济南250012 安徽医科大学安徽合肥230032 华中科技大学同济医学院医药卫生管理学院湖北武汉430030 清华大学公共管理学院北京100084 南京医科大学医政学院江苏南京211166 潍坊医学院公共卫生与管理学院山东潍坊261053 济宁医学院公共卫生学院山东济宁272067 中华预防医学会公共卫生管理分会基层公共卫生管理学组上海201800

[目的]分析云南和广西开展传染病干预措施效果评估的程度,为更好地开展传染病防治工作提供参考。[方法]收集2004-2017年云南和广西所有涉及传染病应对措施的公开信息和文献,采用开展干预措施效果评估的程度值对结果进行评判(0分表示程... 详细信息

[目的]分析云南和广西开展传染病干预措施效果评估的程度,为更好地开展传染病防治工作提供参考。[方法]收集2004-2017年云南和广西所有涉及传染病应对措施的公开信息和文献,采用开展干预措施效果评估的程度值对结果进行评判(0分表示程度最差,100%表示程度最好)。并运用Spearman相关分析探讨评估的程度值与传染病发病率之间的关系。[结果]2004-2017年,云南开展干预效果评估的程度值均处在0.1%及以下。广西开展评估的程度从2004年到2007年基本呈现下降趋势;2008年快速上升到4.32%后基本呈现下降趋势,但每年均维持在3.04%及以上。两省开展效果评估的程度与传染病发病率之间无统计学相关(云南r=-0.062,P=0.833;广西r=0.549,P=0.052);但2008-2017年,广西开展评估的程度与发病率呈显著正相关(r=0.850,P=0.004<0.05)。[结论]云南和广西开展传染病干预效果评估的工作亟待加强,云南比广西薄弱。

关键词：传染病干预措施效果评估发病率云南广西